| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 7,557,453 | 8,018,292 | +460,839 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 7,648,000 | 7,358,000 | -290,000 | 2.80 | 2.98 | +0.18 | sell |
| VANGUARD GROUP INC | 6,902,150 | 6,742,165 | -159,985 | 0.00 | 0.00 | +0.00 | sell |
| Rock Springs Capital Management LP | 4,684,476 | 4,973,649 | +289,173 | 2.13 | 3.30 | +1.17 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 4,771,000 | +4,771,000 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 4,272,914 | 4,259,557 | -13,357 | 0.06 | 0.09 | +0.03 | sell |
| JANUS HENDERSON GROUP PLC | 31,813 | 4,058,632 | +4,026,819 | 0.00 | 0.04 | +0.04 | buy |
| STATE STREET CORP | 2,736,696 | 3,767,235 | +1,030,539 | 0.00 | 0.00 | +0.00 | buy |
| VIKING GLOBAL INVESTORS LP | 0 | 2,901,925 | +2,901,925 | 0.00 | 0.16 | +0.16 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,875,014 | 2,409,514 | +534,500 | 0.04 | 0.06 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 1,840,069 | 2,278,375 | +438,306 | 0.03 | 0.04 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 313,242 | 2,217,975 | +1,904,733 | 0.04 | 0.32 | +0.28 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,590,377 | 2,174,213 | +583,836 | 0.09 | 0.13 | +0.05 | buy |
| EMERALD ADVISERS, LLC | 1,960,659 | 2,125,744 | +165,085 | 1.06 | 1.43 | +0.37 | buy |
| Woodline Partners LP | 4,340,340 | 2,114,056 | -2,226,284 | 0.51 | 0.25 | -0.26 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,731,045 | 1,842,301 | +111,256 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 1,371,511 | 1,802,750 | +431,239 | 1.49 | 2.07 | +0.58 | buy |
| JANE STREET GROUP, LLC | 2,633,000 | 1,708,000 | -925,000 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 1,349,408 | 1,650,603 | +301,195 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,714,620 | 1,331,388 | -383,232 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 1,209,810 | +1,209,810 | 0.00 | 0.02 | +0.02 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,150,000 | +1,150,000 | 0.00 | 0.27 | +0.27 | buy |
| FMR LLC | 147,416 | 1,120,016 | +972,600 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 1,086,067 | 1,117,792 | +31,725 | 1.94 | 2.59 | +0.65 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,185,709 | 1,101,774 | -83,935 | 0.86 | 1.17 | +0.31 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 753,795 | 1,007,197 | +253,402 | 0.04 | 0.06 | +0.02 | buy |
| Logos Global Management LP | 1,100,000 | 1,000,000 | -100,000 | 1.72 | 2.04 | +0.31 | sell |
| PRUDENTIAL FINANCIAL INC | 603,941 | 969,141 | +365,200 | 0.01 | 0.02 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 720,400 | 967,500 | +247,100 | 0.02 | 0.04 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 702,606 | 931,012 | +228,406 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 365,206 | 858,942 | +493,736 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 816,399 | +816,399 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 678,037 | 754,395 | +76,358 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 762,908 | 709,390 | -53,518 | 0.01 | 0.01 | +0.00 | sell |
| UBS Group AG | 326,235 | 709,357 | +383,122 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 360,083 | 693,016 | +332,933 | 0.01 | 0.03 | +0.02 | buy |
| FEDERATED HERMES, INC. | 623,815 | 668,315 | +44,500 | 0.02 | 0.03 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 567,409 | 661,603 | +94,194 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 114,613 | 626,056 | +511,443 | 0.00 | 0.01 | +0.01 | buy |
| TORONTO DOMINION BANK | 0 | 624,000 | +624,000 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 748,558 | 611,658 | -136,900 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 775,089 | 579,136 | -195,953 | 0.01 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 675,085 | 532,031 | -143,054 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 1,374,522 | 530,513 | -844,009 | 0.04 | 0.02 | -0.02 | sell |
| Eversept Partners, LP | 869,913 | 490,296 | -379,617 | 0.93 | 0.88 | -0.05 | sell |
| Walleye Capital LLC | 488,453 | 427,230 | -61,223 | 0.07 | 0.07 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 525,381 | 426,726 | -98,655 | 0.04 | 0.03 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 194,663 | 424,024 | +229,361 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 677,452 | 417,253 | -260,199 | 0.01 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 168,768 | 396,570 | +227,802 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 843,300 | 393,300 | -450,000 | 0.03 | 0.01 | -0.01 | sell |
| Aberdeen Group plc | 0 | 392,000 | +392,000 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | 376,800 | -23,200 | 0.01 | 0.01 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 320,333 | 335,162 | +14,829 | 0.02 | 0.03 | +0.01 | buy |
| GW&K Investment Management, LLC | 497,925 | 328,177 | -169,748 | 0.06 | 0.05 | -0.01 | sell |
| READYSTATE ASSET MANAGEMENT LP | 332,939 | 322,235 | -10,704 | 0.24 | 0.24 | -0.01 | sell |
| Impax Asset Management Group plc | 0 | 300,000 | +300,000 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 122,701 | 285,350 | +162,649 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 356,708 | 280,217 | -76,491 | 0.06 | 0.06 | -0.01 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 277,365 | +277,365 | 0.00 | 1.08 | +1.08 | buy |
| PDT Partners, LLC | 264,273 | 247,109 | -17,164 | 0.33 | 0.38 | +0.05 | sell |
| Knott David M Jr | 258,231 | 228,000 | -30,231 | 1.27 | 1.44 | +0.17 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 220,700 | +220,700 | 0.00 | 0.71 | +0.71 | buy |
| Bank of New York Mellon Corp | 209,350 | 216,863 | +7,513 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.54 | +0.54 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 222,470 | 199,672 | -22,798 | 0.00 | 0.00 | +0.00 | sell |
| Crestline Management, LP | 120,725 | 185,840 | +65,115 | 0.10 | 0.11 | +0.02 | buy |
| J. Goldman & Co LP | 0 | 181,174 | +181,174 | 0.00 | 0.11 | +0.11 | buy |
| Rafferty Asset Management, LLC | 91,771 | 176,425 | +84,654 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 161,266 | 165,929 | +4,663 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 163,175 | 161,603 | -1,572 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 134,700 | 151,900 | +17,200 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 148,000 | 148,000 | 0 | 1.79 | 2.10 | +0.30 | hold |
| CITIGROUP INC | 57,601 | 137,156 | +79,555 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 118,608 | 121,248 | +2,640 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 0 | 111,158 | +111,158 | 0.00 | 0.07 | +0.07 | buy |
| Palo Alto Investors LP | 110,719 | 110,719 | 0 | 0.20 | 0.30 | +0.10 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,297 | 106,045 | +67,748 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 50,880 | 102,756 | +51,876 | 0.00 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 58,111 | 101,772 | +43,661 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.15 | +0.15 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 94,736 | 92,658 | -2,078 | 0.07 | 0.09 | +0.02 | sell |
| Man Group plc | 25,443 | 88,241 | +62,798 | 0.00 | 0.00 | +0.00 | buy |
| Semanteon Capital Management, LP | 36,699 | 84,783 | +48,084 | 0.35 | 0.79 | +0.44 | buy |
| Legal & General Group Plc | 80,958 | 78,963 | -1,995 | 0.00 | 0.00 | +0.00 | sell |
| Jump Financial, LLC | 276,530 | 76,842 | -199,688 | 0.08 | 0.03 | -0.05 | sell |
| Verition Fund Management LLC | 60,871 | 76,308 | +15,437 | 0.01 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 74,356 | +74,356 | 0.00 | 0.10 | +0.10 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 65,151 | 72,192 | +7,041 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 71,000 | 71,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 70,630 | 70,630 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANE STREET GROUP, LLC | 311,260 | 65,690 | -245,570 | 0.01 | 0.00 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 39,732 | 57,448 | +17,716 | 0.00 | 0.00 | +0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 55,339 | 52,599 | -2,740 | 0.07 | 0.07 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,465 | 49,946 | +9,481 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 48,037 | +48,037 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 41,143 | 44,711 | +3,568 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 38,144 | 43,213 | +5,069 | 0.01 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 43,182 | 43,182 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 281,349 | 39,604 | -241,745 | 0.00 | 0.00 | -0.00 | sell |