| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 0 | 4,771,000 | +4,771,000 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 31,813 | 4,058,632 | +4,026,819 | 0.00 | 0.04 | +0.04 | buy |
| VIKING GLOBAL INVESTORS LP | 0 | 2,901,925 | +2,901,925 | 0.00 | 0.16 | +0.16 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 313,242 | 2,217,975 | +1,904,733 | 0.04 | 0.32 | +0.28 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 1,209,810 | +1,209,810 | 0.00 | 0.02 | +0.02 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,150,000 | +1,150,000 | 0.00 | 0.27 | +0.27 | buy |
| STATE STREET CORP | 2,736,696 | 3,767,235 | +1,030,539 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 147,416 | 1,120,016 | +972,600 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 816,399 | +816,399 | 0.00 | 0.01 | +0.01 | buy |
| TORONTO DOMINION BANK | 0 | 624,000 | +624,000 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,590,377 | 2,174,213 | +583,836 | 0.09 | 0.13 | +0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,875,014 | 2,409,514 | +534,500 | 0.04 | 0.06 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 114,613 | 626,056 | +511,443 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 365,206 | 858,942 | +493,736 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 7,557,453 | 8,018,292 | +460,839 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,840,069 | 2,278,375 | +438,306 | 0.03 | 0.04 | +0.01 | buy |
| Kynam Capital Management, LP | 1,371,511 | 1,802,750 | +431,239 | 1.49 | 2.07 | +0.58 | buy |
| Aberdeen Group plc | 0 | 392,000 | +392,000 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 326,235 | 709,357 | +383,122 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 603,941 | 969,141 | +365,200 | 0.01 | 0.02 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 360,083 | 693,016 | +332,933 | 0.01 | 0.03 | +0.02 | buy |
| MORGAN STANLEY | 1,349,408 | 1,650,603 | +301,195 | 0.00 | 0.00 | +0.00 | buy |
| Impax Asset Management Group plc | 0 | 300,000 | +300,000 | 0.00 | 0.02 | +0.02 | buy |
| Rock Springs Capital Management LP | 4,684,476 | 4,973,649 | +289,173 | 2.13 | 3.30 | +1.17 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 277,365 | +277,365 | 0.00 | 1.08 | +1.08 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 753,795 | 1,007,197 | +253,402 | 0.04 | 0.06 | +0.02 | buy |
| TWO SIGMA ADVISERS, LP | 720,400 | 967,500 | +247,100 | 0.02 | 0.04 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 194,663 | 424,024 | +229,361 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 702,606 | 931,012 | +228,406 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 168,768 | 396,570 | +227,802 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 220,700 | +220,700 | 0.00 | 0.71 | +0.71 | buy |
| Affinity Asset Advisors, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.54 | +0.54 | buy |
| J. Goldman & Co LP | 0 | 181,174 | +181,174 | 0.00 | 0.11 | +0.11 | buy |
| EMERALD ADVISERS, LLC | 1,960,659 | 2,125,744 | +165,085 | 1.06 | 1.43 | +0.37 | buy |
| AMERIPRISE FINANCIAL INC | 122,701 | 285,350 | +162,649 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,731,045 | 1,842,301 | +111,256 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 0 | 111,158 | +111,158 | 0.00 | 0.07 | +0.07 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.15 | +0.15 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 567,409 | 661,603 | +94,194 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 91,771 | 176,425 | +84,654 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 57,601 | 137,156 | +79,555 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 678,037 | 754,395 | +76,358 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 74,356 | +74,356 | 0.00 | 0.10 | +0.10 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,297 | 106,045 | +67,748 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 120,725 | 185,840 | +65,115 | 0.10 | 0.11 | +0.02 | buy |
| Man Group plc | 25,443 | 88,241 | +62,798 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 50,880 | 102,756 | +51,876 | 0.00 | 0.01 | +0.00 | buy |
| Semanteon Capital Management, LP | 36,699 | 84,783 | +48,084 | 0.35 | 0.79 | +0.44 | buy |
| Qube Research & Technologies Ltd | 0 | 48,037 | +48,037 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 623,815 | 668,315 | +44,500 | 0.02 | 0.03 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 58,111 | 101,772 | +43,661 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 36,238 | +36,238 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 33,493 | +33,493 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 32,616 | +32,616 | 0.00 | 0.04 | +0.04 | buy |
| Aquatic Capital Management LLC | 0 | 31,967 | +31,967 | 0.00 | 0.02 | +0.02 | buy |
| Parkman Healthcare Partners LLC | 1,086,067 | 1,117,792 | +31,725 | 1.94 | 2.59 | +0.65 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 25,708 | +25,708 | 0.00 | 0.08 | +0.08 | buy |
| US BANCORP \DE\ | 7,509 | 31,795 | +24,286 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 22,600 | +22,600 | 0.00 | 0.11 | +0.11 | buy |
| IEQ CAPITAL, LLC | 0 | 20,749 | +20,749 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 20,600 | +20,600 | 0.00 | 0.15 | +0.15 | buy |
| WELLS FARGO & COMPANY/MN | 39,732 | 57,448 | +17,716 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 17,615 | +17,615 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 134,700 | 151,900 | +17,200 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 6,902 | 23,318 | +16,416 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 16,167 | +16,167 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 60,871 | 76,308 | +15,437 | 0.01 | 0.01 | +0.00 | buy |
| SYON CAPITAL LLC | 0 | 15,435 | +15,435 | 0.00 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 18,900 | 34,081 | +15,181 | 0.01 | 0.02 | +0.01 | buy |
| XTX Topco Ltd | 14,205 | 29,133 | +14,928 | 0.01 | 0.04 | +0.03 | buy |
| PANAGORA ASSET MANAGEMENT INC | 320,333 | 335,162 | +14,829 | 0.02 | 0.03 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 6,866 | 21,367 | +14,501 | 0.00 | 0.01 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 12,481 | +12,481 | 0.00 | 0.01 | +0.01 | buy |
| Entropy Technologies, LP | 0 | 12,300 | +12,300 | 0.00 | 0.02 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 20,226 | 32,476 | +12,250 | 0.00 | 0.01 | +0.00 | buy |
| Baader Bank Aktiengesellschaft | 0 | 11,000 | +11,000 | 0.00 | 0.02 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 10,463 | +10,463 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 10,169 | +10,169 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,465 | 49,946 | +9,481 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 209,350 | 216,863 | +7,513 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 65,151 | 72,192 | +7,041 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 18,451 | 25,347 | +6,896 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 12,180 | 19,072 | +6,892 | 0.03 | 0.06 | +0.03 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 17,205 | 22,935 | +5,730 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 5,717 | +5,717 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 38,144 | 43,213 | +5,069 | 0.01 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 161,266 | 165,929 | +4,663 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 7,500 | 12,000 | +4,500 | 0.03 | 0.04 | +0.01 | buy |
| CWM, LLC | 4,999 | 9,406 | +4,407 | 0.00 | 0.00 | +0.00 | buy |
| Gen-Wealth Partners Inc | 0 | 4,210 | +4,210 | 0.00 | 0.03 | +0.03 | buy |
| MetLife Investment Management, LLC | 41,143 | 44,711 | +3,568 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,712 | 18,206 | +3,494 | 0.02 | 0.03 | +0.01 | buy |
| Diversified Trust Co | 11,532 | 14,701 | +3,169 | 0.00 | 0.01 | +0.00 | buy |
| Arizona State Retirement System | 19,730 | 22,396 | +2,666 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 118,608 | 121,248 | +2,640 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 246 | 2,361 | +2,115 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 7,923 | 9,518 | +1,595 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 23,938 | 25,460 | +1,522 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 7,238 | 7,905 | +667 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 590 | +590 | 0.00 | 0.00 | +0.00 | buy |