| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 313,242 | 2,217,975 | +1,904,733 | 0.04 | 0.32 | +0.28 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,590,377 | 2,174,213 | +583,836 | 0.09 | 0.13 | +0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,875,014 | 2,409,514 | +534,500 | 0.04 | 0.07 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 1,840,069 | 2,278,375 | +438,306 | 0.04 | 0.05 | 0.00 | buy |
| Kynam Capital Management, LP | 1,371,511 | 1,802,750 | +431,239 | 1.49 | 2.07 | +0.58 | buy |
| PRUDENTIAL FINANCIAL INC | 603,941 | 969,141 | +365,200 | 0.01 | 0.02 | 0.00 | buy |
| Rock Springs Capital Management LP | 4,684,476 | 4,973,649 | +289,173 | 2.13 | 3.30 | +1.17 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 677,452 | 417,253 | +260,199 | 0.01 | 0.01 | -0.00 | sell |
| EMERALD ADVISERS, LLC | 1,960,659 | 2,125,744 | +165,085 | 1.06 | 1.43 | +0.37 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 525,381 | 426,726 | +98,655 | 0.04 | 0.03 | -0.00 | sell |
| Rafferty Asset Management, LLC | 91,771 | 176,425 | +84,654 | 0.00 | 0.01 | +0.01 | buy |
| Crestline Management, LP | 120,725 | 185,840 | +65,115 | 0.09 | 0.11 | +0.02 | buy |
| Walleye Capital LLC | 488,453 | 427,230 | +61,223 | 0.09 | 0.08 | 0.00 | sell |
| Semanteon Capital Management, LP | 36,699 | 84,783 | +48,084 | 0.35 | 0.79 | +0.44 | buy |
| Parkman Healthcare Partners LLC | 1,086,067 | 1,117,792 | +31,725 | 1.94 | 2.59 | +0.65 | buy |
| PROFUND ADVISORS LLC | 18,900 | 34,081 | +15,181 | 0.01 | 0.02 | 0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 27,951 | 15,996 | +11,955 | 0.00 | 0.00 | 0.00 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 12,180 | 19,072 | +6,892 | 0.03 | 0.06 | +0.03 | buy |
| Quarry LP | 7,500 | 12,000 | +4,500 | 0.03 | 0.04 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,712 | 18,206 | +3,494 | 0.02 | 0.03 | +0.01 | buy |
| Diversified Trust Co | 11,532 | 14,701 | +3,169 | 0.00 | 0.01 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 94,736 | 92,658 | -2,078 | 0.07 | 0.09 | +0.02 | sell |
| OAK RIDGE INVESTMENTS LLC | 55,339 | 52,599 | -2,740 | 0.07 | 0.07 | +0.00 | sell |
| Bellevue Group AG | 31,000 | 23,100 | -7,900 | 0.01 | 0.01 | +0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 332,939 | 322,235 | -10,704 | 0.24 | 0.24 | -0.01 | sell |
| PDT Partners, LLC | 264,273 | 247,109 | -17,164 | 0.33 | 0.38 | +0.05 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | 376,800 | -23,200 | 0.01 | 0.01 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 45,490 | 19,523 | -25,967 | 0.30 | 0.14 | -0.16 | sell |
| Knott David M Jr | 258,231 | 228,000 | -30,231 | 1.27 | 1.44 | +0.17 | sell |
| Brevan Howard Capital Management LP | 61,695 | 30,953 | -30,742 | 0.01 | 0.00 | -0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,185,709 | 1,101,774 | -83,935 | 0.86 | 1.17 | +0.31 | sell |
| Logos Global Management LP | 1,100,000 | 1,000,000 | -100,000 | 1.72 | 2.04 | +0.31 | sell |
| GW&K Investment Management, LLC | 497,925 | 328,177 | -169,748 | 0.06 | 0.05 | -0.01 | sell |
| ARMISTICE CAPITAL, LLC | 7,648,000 | 7,358,000 | -290,000 | 1.71 | 1.75 | +0.04 | sell |
| Eversept Partners, LP | 869,913 | 490,296 | -379,617 | 0.83 | 0.76 | -0.08 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 843,300 | 393,300 | -450,000 | 0.03 | 0.01 | -0.01 | sell |
| Woodline Partners LP | 4,340,340 | 2,114,056 | -2,226,284 | 0.51 | 0.25 | -0.26 | sell |