| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 10,599,660 | 10,511,166 | -88,494 | 0.12 | 0.18 | +0.06 | sell |
| FMR LLC | 2,894,148 | 9,617,863 | +6,723,715 | 0.00 | 0.02 | +0.02 | buy |
| BlackRock, Inc. | 8,100,461 | 7,869,352 | -231,109 | 0.00 | 0.01 | +0.00 | sell |
| VANGUARD GROUP INC | 6,613,368 | 6,309,229 | -304,139 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 3,217,839 | 4,756,666 | +1,538,827 | 0.00 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 3,794,615 | 4,278,180 | +483,565 | 2.62 | 2.99 | +0.37 | buy |
| ARMISTICE CAPITAL, LLC | 6,724,000 | 3,763,891 | -2,960,109 | 5.04 | 3.52 | -1.52 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,552,000 | 2,927,000 | -625,000 | 0.13 | 0.17 | +0.03 | sell |
| Polar Capital Holdings Plc | 0 | 2,500,000 | +2,500,000 | 0.04 | 0.02 | -0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,752,114 | 2,246,779 | +494,665 | 0.06 | 0.13 | +0.08 | buy |
| Rock Springs Capital Management LP | 2,164,773 | 2,210,322 | +45,549 | 3.02 | 4.33 | +1.31 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,138,030 | 2,143,495 | +5,465 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,273,903 | 1,868,212 | +594,309 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 1,398,930 | 1,850,355 | +451,425 | 0.00 | 0.01 | +0.00 | buy |
| Stephens Investment Management Group LLC | 1,599,668 | 1,721,623 | +121,955 | 0.50 | 0.86 | +0.36 | buy |
| EMERALD ADVISERS, LLC | 2,146,767 | 1,594,184 | -552,583 | 1.64 | 1.88 | +0.23 | sell |
| MORGAN STANLEY | 1,117,037 | 1,415,897 | +298,860 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 1,417,204 | 1,174,968 | -242,236 | 2.59 | 2.52 | -0.08 | sell |
| TWO SIGMA INVESTMENTS, LP | 928,998 | 1,156,807 | +227,809 | 0.03 | 0.07 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 663,252 | 1,094,556 | +431,304 | 0.01 | 0.03 | +0.02 | buy |
| Nuveen, LLC | 1,078,691 | 993,613 | -85,078 | 0.01 | 0.01 | +0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,200,942 | 948,459 | -252,483 | 1.48 | 1.77 | +0.28 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 707,460 | 901,404 | +193,944 | 0.12 | 0.23 | +0.11 | buy |
| DEUTSCHE BANK AG\ | 1,599,295 | 881,680 | -717,615 | 0.01 | 0.01 | -0.00 | sell |
| Fiera Capital Corp | 0 | 874,053 | +874,053 | 0.00 | 0.11 | +0.11 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 883,672 | 867,622 | -16,050 | 0.07 | 0.12 | +0.05 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 848,356 | 808,189 | -40,167 | 0.00 | 0.00 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 852,202 | 805,215 | -46,987 | 0.03 | 0.05 | +0.02 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,977,000 | 800,000 | -1,177,000 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,201,469 | 798,984 | -402,485 | 0.01 | 0.01 | +0.00 | sell |
| NORTHERN TRUST CORP | 832,079 | 761,473 | -70,606 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 696,700 | 725,500 | +28,800 | 0.03 | 0.05 | +0.02 | buy |
| TANG CAPITAL MANAGEMENT LLC | 700,000 | 700,000 | 0 | 0.64 | 1.32 | +0.68 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 565,597 | 665,795 | +100,198 | 0.01 | 0.02 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 857,899 | 623,390 | -234,509 | 0.06 | 0.06 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 569,695 | 587,354 | +17,659 | 0.05 | 0.08 | +0.02 | buy |
| Legal & General Group Plc | 520,592 | 536,925 | +16,333 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 684,384 | 534,614 | -149,770 | 0.02 | 0.02 | +0.00 | sell |
| Aberdeen Group plc | 967,385 | 518,357 | -449,028 | 0.04 | 0.03 | -0.01 | sell |
| Kynam Capital Management, LP | 949,727 | 517,884 | -431,843 | 1.69 | 1.29 | -0.40 | sell |
| Invesco Ltd. | 627,902 | 474,075 | -153,827 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 512,681 | 468,556 | -44,125 | 0.06 | 0.09 | +0.03 | sell |
| UBS Group AG | 493,073 | 422,619 | -70,454 | 0.00 | 0.00 | +0.00 | sell |
| Assenagon Asset Management S.A. | 93,355 | 417,742 | +324,387 | 0.00 | 0.02 | +0.02 | buy |
| Qube Research & Technologies Ltd | 571,997 | 406,221 | -165,776 | 0.02 | 0.02 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 79,444 | 394,844 | +315,400 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 392,273 | +392,273 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 349,002 | 369,530 | +20,528 | 0.00 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 313,377 | 352,717 | +39,340 | 0.00 | 0.01 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 172,430 | 341,724 | +169,294 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 493,841 | 321,615 | -172,226 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 114,477 | 319,658 | +205,181 | 0.01 | 0.02 | +0.02 | buy |
| Affinity Asset Advisors, LLC | 500,000 | 300,000 | -200,000 | 1.11 | 0.82 | -0.29 | sell |
| Russell Investments Group, Ltd. | 222,257 | 285,311 | +63,054 | 0.01 | 0.01 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 318,146 | 268,926 | -49,220 | 0.03 | 0.04 | +0.01 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 328,654 | 268,045 | -60,609 | 0.00 | 0.01 | +0.00 | sell |
| JENNISON ASSOCIATES LLC | 1,084,350 | 256,335 | -828,015 | 0.02 | 0.01 | -0.01 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 27,814 | 249,557 | +221,743 | 0.00 | 0.01 | +0.01 | buy |
| Frazier Life Sciences Management, L.P. | 392,092 | 241,592 | -150,500 | 0.28 | 0.25 | -0.03 | sell |
| LOOMIS SAYLES & CO L P | 0 | 238,924 | +238,924 | 0.00 | 0.01 | +0.01 | buy |
| Impax Asset Management Group plc | 475,000 | 225,000 | -250,000 | 0.07 | 0.05 | -0.01 | sell |
| Bank of New York Mellon Corp | 237,243 | 219,996 | -17,247 | 0.00 | 0.00 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 137,611 | 219,745 | +82,134 | 0.00 | 0.01 | +0.01 | buy |
| Neuberger Berman Group LLC | 211,667 | 218,027 | +6,360 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 590,051 | 217,171 | -372,880 | 0.02 | 0.01 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 145,927 | 215,951 | +70,024 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 213,918 | 202,222 | -11,696 | 0.01 | 0.01 | +0.00 | sell |
| APIS CAPITAL ADVISORS, LLC | 166,000 | 186,002 | +20,002 | 0.88 | 1.24 | +0.36 | buy |
| Knott David M Jr | 260,000 | 186,000 | -74,000 | 2.60 | 3.29 | +0.69 | sell |
| Hillsdale Investment Management Inc. | 178,400 | 177,220 | -1,180 | 0.13 | 0.19 | +0.06 | sell |
| Point72 Asset Management, L.P. | 0 | 173,383 | +173,383 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 90,250 | 169,208 | +78,958 | 0.01 | 0.02 | +0.02 | buy |
| F/m Investments LLC | 196,074 | 168,416 | -27,658 | 0.18 | 0.24 | +0.06 | sell |
| Swiss National Bank | 163,600 | 167,100 | +3,500 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 89,328 | 164,264 | +74,936 | 0.01 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 74,683 | 158,834 | +84,151 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 161,988 | 158,709 | -3,279 | 0.59 | 0.92 | +0.33 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 194,854 | 155,895 | -38,959 | 0.00 | 0.01 | +0.00 | sell |
| ALGERT GLOBAL LLC | 153,648 | 149,938 | -3,710 | 0.06 | 0.09 | +0.03 | sell |
| PDT Partners, LLC | 281,458 | 148,721 | -132,737 | 0.42 | 0.37 | -0.06 | sell |
| GW&K Investment Management, LLC | 117,869 | 141,180 | +23,311 | 0.02 | 0.05 | +0.02 | buy |
| Lisanti Capital Growth, LLC | 129,512 | 138,482 | +8,970 | 0.76 | 1.25 | +0.50 | buy |
| Palisades Investment Partners, LLC | 0 | 137,768 | +137,768 | 0.00 | 1.99 | +1.99 | buy |
| Engineers Gate Manager LP | 39,690 | 136,608 | +96,918 | 0.01 | 0.06 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 133,869 | 136,065 | +2,196 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 135,919 | 135,822 | -97 | 0.01 | 0.02 | +0.01 | sell |
| SEI INVESTMENTS CO | 49,432 | 133,595 | +84,163 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 322,115 | 125,069 | -197,046 | 0.00 | 0.00 | -0.00 | sell |
| Palo Alto Investors LP | 110,719 | 110,719 | 0 | 0.49 | 0.59 | +0.10 | hold |
| RHUMBLINE ADVISERS | 130,021 | 109,767 | -20,254 | 0.00 | 0.00 | +0.00 | sell |
| Informed Momentum Co LLC | 0 | 109,404 | +109,404 | 0.00 | 0.47 | +0.47 | buy |
| Voleon Capital Management LP | 0 | 102,553 | +102,553 | 0.00 | 0.08 | +0.08 | buy |
| Hennion & Walsh Asset Management, Inc. | 36,810 | 99,229 | +62,419 | 0.03 | 0.13 | +0.10 | buy |
| FRED ALGER MANAGEMENT, LLC | 122,029 | 94,832 | -27,197 | 0.01 | 0.01 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 34,724 | 93,702 | +58,978 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 84,097 | 91,536 | +7,439 | 0.11 | 0.19 | +0.08 | buy |
| Exome Asset Management LLC | 156,917 | 89,052 | -67,865 | 2.48 | 1.68 | -0.80 | sell |
| Legato Capital Management LLC | 71,030 | 87,536 | +16,506 | 0.18 | 0.29 | +0.10 | buy |
| Parkman Healthcare Partners LLC | 339,764 | 86,297 | -253,467 | 0.89 | 0.31 | -0.58 | sell |
| Penserra Capital Management LLC | 80,556 | 79,747 | -809 | 0.02 | 0.04 | +0.01 | sell |