| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Commodore Capital LP | 0 | 2,185,000 | +2,185,000 | 0.00 | 4.72 | +4.72 | buy |
| BANK OF AMERICA CORP /DE/ | 404,902 | 1,135,592 | +730,690 | 0.00 | 0.00 | +0.00 | buy |
| SCS Capital Management LLC | 0 | 611,098 | +611,098 | 0.00 | 0.23 | +0.23 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 303,000 | 743,000 | +440,000 | 0.02 | 0.04 | +0.02 | buy |
| Polar Capital Holdings Plc | 627,036 | 1,002,036 | +375,000 | 0.12 | 0.18 | +0.06 | buy |
| ORBIMED ADVISORS LLC | 26,700 | 325,500 | +298,800 | 0.02 | 0.23 | +0.21 | buy |
| STATE STREET CORP | 2,152,277 | 2,449,479 | +297,202 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 0 | 276,578 | +276,578 | 0.00 | 1.54 | +1.54 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 125,678 | 386,523 | +260,845 | 0.02 | 0.05 | +0.03 | buy |
| Erste Asset Management GmbH | 2,009,900 | 2,229,900 | +220,000 | 0.81 | 0.84 | +0.03 | buy |
| MACQUARIE GROUP LTD | 1,684,993 | 1,850,544 | +165,551 | 0.07 | 0.07 | +0.00 | buy |
| GW&K Investment Management, LLC | 683,463 | 817,526 | +134,063 | 0.19 | 0.22 | +0.03 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 200,481 | 331,643 | +131,162 | 0.02 | 0.04 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 104,922 | 204,242 | +99,320 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 5,016,260 | 5,108,746 | +92,486 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 567,170 | 658,652 | +91,482 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 942,189 | 1,025,719 | +83,530 | 0.08 | 0.08 | +0.00 | buy |
| Caligan Partners LP | 626,280 | 701,280 | +75,000 | 5.21 | 4.29 | -0.92 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 72,302 | +72,302 | 0.00 | 0.03 | +0.03 | buy |
| ALGERT GLOBAL LLC | 12,240 | 74,810 | +62,570 | 0.01 | 0.05 | +0.04 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 54,651 | +54,651 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 175,377 | 225,119 | +49,742 | 0.02 | 0.02 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,349,651 | 1,394,581 | +44,930 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 0 | 44,105 | +44,105 | 0.00 | 0.50 | +0.50 | buy |
| D. E. Shaw & Co., Inc. | 516,475 | 554,820 | +38,345 | 0.02 | 0.02 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,015,360 | 1,049,360 | +34,000 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 34,808 | 68,137 | +33,329 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 32,000 | +32,000 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 22,196 | 53,073 | +30,877 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 27,900 | +27,900 | 0.00 | 0.16 | +0.16 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 5,674,466 | 5,700,466 | +26,000 | 0.98 | 0.90 | -0.08 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 122,835 | 147,276 | +24,441 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 83,515 | 107,367 | +23,852 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 70,313 | 93,627 | +23,314 | 0.01 | 0.01 | +0.00 | buy |
| BIT Capital GmbH | 0 | 21,468 | +21,468 | 0.00 | 0.08 | +0.08 | buy |
| AQR CAPITAL MANAGEMENT LLC | 30,864 | 51,489 | +20,625 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 20,381 | +20,381 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 121,732 | 139,732 | +18,000 | 1.50 | 1.69 | +0.20 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 21,800 | 39,261 | +17,461 | 0.01 | 0.01 | +0.00 | buy |
| Granahan Investment Management, LLC | 115,687 | 132,108 | +16,421 | 0.16 | 0.19 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 43,330 | 58,722 | +15,392 | 0.04 | 0.04 | +0.01 | buy |
| Centiva Capital, LP | 0 | 15,032 | +15,032 | 0.00 | 0.03 | +0.03 | buy |
| CIBC WORLD MARKETS CORP | 0 | 12,541 | +12,541 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 165,672 | 178,072 | +12,400 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 0 | 11,622 | +11,622 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 11,200 | +11,200 | 0.00 | 0.09 | +0.09 | buy |
| ExodusPoint Capital Management, LP | 0 | 10,553 | +10,553 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 104,837 | 114,947 | +10,110 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 122,094 | 131,571 | +9,477 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 251,774 | 261,221 | +9,447 | 0.25 | 0.26 | +0.02 | buy |
| Virtus Investment Advisers, LLC | 0 | 9,408 | +9,408 | 0.00 | 0.07 | +0.07 | buy |
| Capula Management Ltd | 20,849 | 29,749 | +8,900 | 0.00 | 0.01 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 8,750 | +8,750 | 0.00 | 0.01 | +0.01 | buy |
| COMMERCE BANK | 0 | 8,199 | +8,199 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 39,262 | 46,811 | +7,549 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 28,248 | 35,289 | +7,041 | 0.01 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 2,782 | 8,558 | +5,776 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 14,177 | 19,582 | +5,405 | 0.02 | 0.02 | +0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 13,703 | 18,755 | +5,052 | 0.00 | 0.01 | +0.00 | buy |
| EDGEWOOD MANAGEMENT LLC | 30,000 | 35,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 4,544 | +4,544 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 9,272 | 13,801 | +4,529 | 0.03 | 0.02 | -0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 220,569 | 224,173 | +3,604 | 0.01 | 0.01 | -0.00 | buy |
| Atria Investments, Inc | 11,365 | 14,595 | +3,230 | 0.00 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,407 | 43,327 | +2,920 | 0.00 | 0.00 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 2,658 | +2,658 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 13,691 | 15,885 | +2,194 | 0.00 | 0.00 | +0.00 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 2,111 | +2,111 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 6,820 | 8,784 | +1,964 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 33,767 | 35,729 | +1,962 | 0.05 | 0.05 | -0.00 | buy |
| Gallagher Fiduciary Advisors, LLC | 11,110 | 12,830 | +1,720 | 0.07 | 0.01 | -0.06 | buy |
| FRANKLIN RESOURCES INC | 66,461 | 68,072 | +1,611 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 1,365 | +1,365 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 68,321 | 69,684 | +1,363 | 0.01 | 0.01 | -0.00 | buy |
| NewEdge Advisors, LLC | 0 | 1,355 | +1,355 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 663 | 1,659 | +996 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 110,000 | 110,720 | +720 | 0.02 | 0.02 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 3,083 | 3,582 | +499 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 18,979 | 19,408 | +429 | 0.00 | 0.00 | -0.00 | buy |
| Hurley Capital, LLC | 0 | 366 | +366 | 0.00 | 0.01 | +0.01 | buy |
| NBC SECURITIES, INC. | 0 | 345 | +345 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,197 | 1,460 | +263 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 555 | 805 | +250 | 0.00 | 0.00 | +0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 38,869 | 39,087 | +218 | 0.10 | 0.10 | -0.00 | buy |
| Optiver Holding B.V. | 0 | 215 | +215 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 87 | 279 | +192 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 13,601 | 13,747 | +146 | 0.00 | 0.00 | -0.00 | buy |
| Kestra Investment Management, LLC | 0 | 139 | +139 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 1,207 | 1,314 | +107 | 0.01 | 0.01 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 1,069,754 | 1,069,854 | +100 | 1.46 | 1.43 | -0.03 | buy |
| ROTHSCHILD INVESTMENT LLC | 25 | 110 | +85 | 0.00 | 0.00 | +0.00 | buy |
| MATHER GROUP, LLC. | 0 | 80 | +80 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 483 | 559 | +76 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 263 | 314 | +51 | 0.00 | 0.00 | +0.00 | buy |
| First Horizon Advisors, Inc. | 504 | 544 | +40 | 0.00 | 0.00 | -0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 20 | 38 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,900 | 1,917 | +17 | 0.00 | 0.00 | -0.00 | buy |
| Stephens Consulting, LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 492 | 504 | +12 | 0.00 | 0.00 | -0.00 | buy |