| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 303,000 | 743,000 | +440,000 | 0.02 | 0.04 | +0.02 | buy |
| Polar Capital Holdings Plc | 627,036 | 1,002,036 | +375,000 | 0.12 | 0.18 | +0.06 | buy |
| ORBIMED ADVISORS LLC | 26,700 | 325,500 | +298,800 | 0.02 | 0.23 | +0.21 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 125,678 | 386,523 | +260,845 | 0.02 | 0.05 | +0.03 | buy |
| Erste Asset Management GmbH | 2,009,900 | 2,229,900 | +220,000 | 0.81 | 0.84 | +0.03 | buy |
| GW&K Investment Management, LLC | 683,463 | 817,526 | +134,063 | 0.19 | 0.22 | +0.03 | buy |
| BNP Paribas Asset Management Holding S.A. | 942,189 | 1,025,719 | +83,530 | 0.08 | 0.08 | +0.00 | buy |
| Caligan Partners LP | 626,280 | 701,280 | +75,000 | 5.21 | 4.29 | -0.92 | buy |
| ALGERT GLOBAL LLC | 12,240 | 74,810 | +62,570 | 0.01 | 0.05 | 0.00 | buy |
| Walleye Capital LLC | 199,538 | 150,511 | +49,027 | 0.07 | 0.06 | 0.00 | sell |
| Rafferty Asset Management, LLC | 70,313 | 93,627 | +23,314 | 0.01 | 0.01 | +0.00 | buy |
| Patient Square Capital LP | 121,732 | 139,732 | +18,000 | 1.50 | 1.69 | +0.20 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 21,800 | 39,261 | +17,461 | 0.01 | 0.01 | 0.00 | buy |
| Granahan Investment Management, LLC | 115,687 | 132,108 | +16,421 | 0.16 | 0.19 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 43,330 | 58,722 | +15,392 | 0.11 | 0.14 | 0.00 | buy |
| TD ASSET MANAGEMENT INC | 165,672 | 178,072 | +12,400 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 53,229 | 41,029 | +12,200 | 0.14 | 0.12 | 0.00 | sell |
| Capula Management Ltd | 20,849 | 29,749 | +8,900 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 14,177 | 19,582 | +5,405 | 0.02 | 0.02 | +0.01 | buy |
| EDGEWOOD MANAGEMENT LLC | 30,000 | 35,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 220,569 | 224,173 | +3,604 | 0.01 | 0.01 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 33,767 | 35,729 | +1,962 | 0.05 | 0.05 | 0.00 | buy |
| Gallagher Fiduciary Advisors, LLC | 11,110 | 12,830 | +1,720 | 0.07 | 0.01 | -0.06 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,197 | 1,460 | +263 | 0.00 | 0.00 | +0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 38,869 | 39,087 | +218 | 0.10 | 0.10 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 1,069,754 | 1,069,854 | +100 | 1.46 | 1.43 | -0.03 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 83,157 | 82,679 | -478 | 0.02 | 0.02 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 12,092 | 11,493 | -599 | 0.04 | 0.03 | -0.01 | sell |
| Inspire Investing, LLC | 12,384 | 11,768 | -616 | 0.05 | 0.04 | -0.00 | sell |
| Fisher Asset Management, LLC | 960,661 | 959,339 | -1,322 | 0.01 | 0.01 | -0.00 | sell |
| ALPS ADVISORS INC | 46,111 | 42,219 | -3,892 | 0.01 | 0.01 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 111,098 | 62,953 | -48,145 | 0.08 | 0.04 | -0.04 | sell |
| Cutter Capital Management, LP | 301,623 | 235,350 | -66,273 | 4.06 | 3.00 | -1.06 | sell |
| Artisan Partners Limited Partnership | 499,134 | 410,672 | -88,462 | 0.02 | 0.02 | -0.01 | sell |
| ArrowMark Colorado Holdings LLC | 917,420 | 827,623 | -89,797 | 0.41 | 0.39 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,423,537 | 2,301,353 | -122,184 | 0.01 | 0.01 | -0.00 | sell |
| Rock Springs Capital Management LP | 471,086 | 342,180 | -128,906 | 0.59 | 0.57 | -0.02 | sell |
| CenterBook Partners LP | 305,599 | 108,509 | -197,090 | 0.60 | 0.20 | -0.40 | sell |
| ARMISTICE CAPITAL, LLC | 2,264,304 | 2,048,000 | -216,304 | 1.02 | 0.90 | -0.12 | sell |