| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 5,235,429 | 5,754,957 | +519,528 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 5,159,505 | 5,684,000 | +524,495 | 0.73 | 1.14 | +0.41 | buy |
| STATE STREET CORP | 3,108,145 | 3,364,879 | +256,734 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 3,036,000 | 2,716,000 | -320,000 | 2.02 | 3.03 | +1.01 | sell |
| Erste Asset Management GmbH | 2,804,900 | 2,704,900 | -100,000 | 0.64 | 0.74 | +0.10 | sell |
| D. E. Shaw & Co., Inc. | 1,837,186 | 2,681,169 | +843,983 | 0.04 | 0.07 | +0.03 | buy |
| Lynx1 Capital Management LP | 79,624 | 2,611,568 | +2,531,944 | 0.44 | 13.96 | +13.52 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,360,730 | 1,580,840 | +220,110 | 0.04 | 0.06 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 892 | 1,488,740 | +1,487,848 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,413,538 | 1,467,910 | +54,372 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,142,432 | 1,344,953 | +202,521 | 0.04 | 0.06 | +0.02 | buy |
| MPM BioImpact LLC | 1,303,373 | 1,306,261 | +2,888 | 4.06 | 3.41 | -0.65 | buy |
| Frazier Life Sciences Management, L.P. | 1,279,754 | 1,256,080 | -23,674 | 0.94 | 1.09 | +0.16 | sell |
| GW&K Investment Management, LLC | 1,207,301 | 1,214,901 | +7,600 | 0.28 | 0.36 | +0.08 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,004,341 | 1,151,614 | +147,273 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 894,037 | 967,525 | +73,488 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,033,974 | 805,776 | -228,198 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 799,163 | 799,163 | 0 | 1.12 | 1.59 | +0.48 | hold |
| Nuveen, LLC | 297,908 | 722,348 | +424,440 | 0.00 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 1,121,050 | 685,240 | -435,810 | 0.04 | 0.02 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 597,826 | 641,486 | +43,660 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,348,968 | 619,613 | -729,355 | 0.02 | 0.01 | -0.01 | sell |
| SCS Capital Management LLC | 598,765 | 612,850 | +14,085 | 0.17 | 0.22 | +0.05 | buy |
| Foresite Capital Management VI LLC | 530,000 | 525,000 | -5,000 | 4.36 | 3.86 | -0.50 | sell |
| NORTHERN TRUST CORP | 511,901 | 509,272 | -2,629 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 539,341 | 507,900 | -31,441 | 0.00 | 0.00 | +0.00 | sell |
| Artisan Partners Limited Partnership | 504,485 | 481,516 | -22,969 | 0.02 | 0.03 | +0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 482,622 | 477,032 | -5,590 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 562,642 | 450,093 | -112,549 | 0.04 | 0.04 | -0.01 | sell |
| Vestal Point Capital, LP | 325,000 | 450,000 | +125,000 | 0.32 | 0.43 | +0.10 | buy |
| MARSHALL WACE, LLP | 353,639 | 448,118 | +94,479 | 0.01 | 0.02 | +0.01 | buy |
| Legal & General Group Plc | 328,211 | 423,915 | +95,704 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 466,151 | 403,590 | -62,561 | 0.28 | 0.36 | +0.08 | sell |
| Parkman Healthcare Partners LLC | 99,604 | 403,525 | +303,921 | 0.26 | 1.42 | +1.16 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 242,670 | 327,457 | +84,787 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 637,886 | 298,783 | -339,103 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 65,655 | 275,456 | +209,801 | 0.04 | 0.20 | +0.16 | buy |
| ALGERT GLOBAL LLC | 414,218 | 268,435 | -145,783 | 0.18 | 0.14 | -0.04 | sell |
| TWO SIGMA INVESTMENTS, LP | 300,156 | 251,636 | -48,520 | 0.01 | 0.01 | -0.01 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 250,461 | +250,461 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 79,840 | 238,468 | +158,628 | 0.01 | 0.03 | +0.02 | buy |
| Palo Alto Investors LP | 212,499 | 213,601 | +1,102 | 0.81 | 1.11 | +0.30 | buy |
| Squarepoint Ops LLC | 121,763 | 208,888 | +87,125 | 0.01 | 0.02 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 200,061 | +200,061 | 0.00 | 0.06 | +0.06 | buy |
| Eversept Partners, LP | 0 | 200,000 | +200,000 | 0.00 | 0.45 | +0.45 | buy |
| HRT FINANCIAL LP | 146,469 | 195,432 | +48,963 | 0.01 | 0.02 | +0.00 | buy |
| Qube Research & Technologies Ltd | 378,373 | 187,667 | -190,706 | 0.01 | 0.01 | -0.01 | sell |
| Bank of New York Mellon Corp | 196,893 | 186,791 | -10,102 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 166,614 | 173,279 | +6,665 | 0.13 | 0.19 | +0.06 | buy |
| TFG Asset Management GP Ltd | 162,018 | 164,839 | +2,821 | 0.93 | 1.10 | +0.17 | buy |
| XTX Topco Ltd | 46,039 | 160,880 | +114,841 | 0.03 | 0.09 | +0.06 | buy |
| JPMORGAN CHASE & CO | 251,777 | 151,558 | -100,219 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 142,580 | 151,430 | +8,850 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 144,297 | +144,297 | 0.00 | 0.01 | +0.01 | buy |
| Edgestream Partners, L.P. | 167,998 | 143,731 | -24,267 | 0.13 | 0.16 | +0.03 | sell |
| ADAR1 Capital Management, LLC | 188,000 | 140,672 | -47,328 | 0.38 | 0.29 | -0.10 | sell |
| UBS Group AG | 126,665 | 132,540 | +5,875 | 0.00 | 0.00 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 35,788 | 129,531 | +93,743 | 0.01 | 0.04 | +0.03 | buy |
| Pictet Asset Management Holding SA | 205,019 | 128,814 | -76,205 | 0.01 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 136,942 | 125,060 | -11,882 | 1.84 | 2.49 | +0.65 | sell |
| AMERICAN CENTURY COMPANIES INC | 151,486 | 120,253 | -31,233 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 106,996 | 110,679 | +3,683 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 108,860 | 108,860 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 0 | 103,177 | +103,177 | 0.00 | 0.55 | +0.55 | buy |
| Rafferty Asset Management, LLC | 107,490 | 102,741 | -4,749 | 0.01 | 0.01 | +0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 0 | 100,000 | +100,000 | 0.00 | 0.17 | +0.17 | buy |
| Knott David M Jr | 18,000 | 93,058 | +75,058 | 0.23 | 1.87 | +1.65 | buy |
| Trexquant Investment LP | 226,600 | 75,298 | -151,302 | 0.05 | 0.02 | -0.04 | sell |
| Woodline Partners LP | 74,423 | 74,423 | 0 | 0.01 | 0.01 | +0.00 | hold |
| RHUMBLINE ADVISERS | 74,153 | 73,369 | -784 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53,239 | 68,564 | +15,325 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 110,440 | 67,153 | -43,287 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 14,352 | 63,550 | +49,198 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 61,494 | 61,494 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 60,560 | 60,679 | +119 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 52,739 | 59,257 | +6,518 | 0.12 | 0.23 | +0.11 | buy |
| TUDOR INVESTMENT CORP ET AL | 61,345 | 58,151 | -3,194 | 0.01 | 0.01 | +0.00 | sell |
| SG Americas Securities, LLC | 46,451 | 57,247 | +10,796 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 320,352 | 52,438 | -267,914 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 100,000 | 51,830 | -48,170 | 0.02 | 0.01 | -0.01 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 51,707 | 51,707 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 122,875 | 50,384 | -72,491 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 70,256 | 50,046 | -20,210 | 0.00 | 0.00 | -0.00 | sell |
| Capital International Investors | 703,865 | 48,616 | -655,249 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 47,881 | 47,701 | -180 | 0.01 | 0.01 | +0.00 | sell |
| PROFUND ADVISORS LLC | 39,850 | 45,794 | +5,944 | 0.03 | 0.06 | +0.02 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 37,228 | 43,005 | +5,777 | 0.08 | 0.12 | +0.04 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 39,455 | 42,071 | +2,616 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 24,679 | 39,710 | +15,031 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 41,361 | 39,061 | -2,300 | 0.01 | 0.01 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 6,209 | 37,462 | +31,253 | 0.00 | 0.04 | +0.03 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 36,472 | +36,472 | 0.00 | 0.08 | +0.08 | buy |
| AQR CAPITAL MANAGEMENT LLC | 27,926 | 36,410 | +8,484 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 35,814 | +35,814 | 0.00 | 0.03 | +0.03 | buy |
| EDGEWOOD MANAGEMENT LLC | 35,000 | 35,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Hennion & Walsh Asset Management, Inc. | 33,470 | 33,868 | +398 | 0.03 | 0.04 | +0.01 | buy |
| MetLife Investment Management, LLC | 32,217 | 32,858 | +641 | 0.00 | 0.01 | +0.00 | buy |
| Legato Capital Management LLC | 0 | 32,373 | +32,373 | 0.00 | 0.10 | +0.10 | buy |
| MILLENNIUM MANAGEMENT LLC | 398,267 | 32,144 | -366,123 | 0.01 | 0.00 | -0.01 | sell |
| Virtus Investment Advisers, LLC | 25,060 | 30,959 | +5,899 | 0.19 | 0.29 | +0.10 | buy |