| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 0 | 1,190,107 | +1,190,107 | 0.00 | 1.44 | +1.44 | buy |
| MARSHALL WACE, LLP | 277,996 | 1,133,735 | +855,739 | 0.01 | 0.07 | +0.06 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,012,993 | 2,777,259 | +764,266 | 0.01 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 464,121 | +464,121 | 0.00 | 0.16 | +0.16 | buy |
| LOOMIS SAYLES & CO L P | 0 | 448,863 | +448,863 | 0.00 | 0.03 | +0.03 | buy |
| Parkman Healthcare Partners LLC | 0 | 446,416 | +446,416 | 0.00 | 2.62 | +2.62 | buy |
| Frazier Life Sciences Management, L.P. | 523,166 | 871,974 | +348,808 | 0.65 | 1.76 | +1.11 | buy |
| Candriam S.C.A. | 0 | 322,882 | +322,882 | 0.00 | 0.08 | +0.08 | buy |
| Artisan Partners Limited Partnership | 0 | 320,467 | +320,467 | 0.00 | 0.02 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 362,134 | 678,234 | +316,100 | 0.01 | 0.04 | +0.03 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 43,213 | 320,531 | +277,318 | 0.00 | 0.05 | +0.05 | buy |
| CenterBook Partners LP | 0 | 249,311 | +249,311 | 0.00 | 0.67 | +0.67 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 174,870 | +174,870 | 0.00 | 0.04 | +0.04 | buy |
| Granahan Investment Management, LLC | 0 | 136,838 | +136,838 | 0.00 | 0.24 | +0.24 | buy |
| FIRST TRUST ADVISORS LP | 0 | 130,411 | +130,411 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 0 | 113,378 | +113,378 | 0.00 | 0.05 | +0.05 | buy |
| Trexquant Investment LP | 60,689 | 155,076 | +94,387 | 0.04 | 0.10 | +0.07 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 47,461 | 125,470 | +78,009 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 74,142 | +74,142 | 0.00 | 0.52 | +0.52 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,282,915 | 1,351,430 | +68,515 | 0.00 | 0.01 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 5,590,602 | 5,654,502 | +63,900 | 0.96 | 1.44 | +0.48 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 60,000 | +60,000 | 0.00 | 0.06 | +0.06 | buy |
| TD ASSET MANAGEMENT INC | 156,418 | 210,472 | +54,054 | 0.00 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 124,535 | 176,815 | +52,280 | 0.00 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 89,009 | 137,844 | +48,835 | 0.00 | 0.01 | +0.00 | buy |
| Edgestream Partners, L.P. | 0 | 42,076 | +42,076 | 0.00 | 0.09 | +0.09 | buy |
| Invesco Ltd. | 76,202 | 118,020 | +41,818 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 69,226 | 109,881 | +40,655 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 37,281 | +37,281 | 0.00 | 0.01 | +0.01 | buy |
| Caligan Partners LP | 484,711 | 514,711 | +30,000 | 3.75 | 5.19 | +1.44 | buy |
| Bank of New York Mellon Corp | 195,958 | 223,151 | +27,193 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 25,945 | +25,945 | 0.00 | 0.06 | +0.06 | buy |
| Tower Research Capital LLC (TRC) | 579 | 24,750 | +24,171 | 0.00 | 0.02 | +0.02 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 55,262 | 78,700 | +23,438 | 1.05 | 2.86 | +1.81 | buy |
| SEI INVESTMENTS CO | 0 | 23,378 | +23,378 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 11,184 | 33,164 | +21,980 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 17,592 | +17,592 | 0.00 | 0.16 | +0.16 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 440,232 | 457,527 | +17,295 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,617 | 38,195 | +15,578 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 80,616 | 94,486 | +13,870 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 19,276 | 32,770 | +13,494 | 0.07 | 0.11 | +0.03 | buy |
| NOMURA HOLDINGS INC | 0 | 12,106 | +12,106 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 9,724 | 21,745 | +12,021 | 0.02 | 0.04 | +0.02 | buy |
| Headlands Technologies LLC | 0 | 11,450 | +11,450 | 0.00 | 0.05 | +0.05 | buy |
| GROUP ONE TRADING LLC | 0 | 10,103 | +10,103 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 539,582 | 549,003 | +9,421 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 8,800 | +8,800 | 0.00 | 0.01 | +0.01 | buy |
| Atria Investments, Inc | 0 | 7,210 | +7,210 | 0.00 | 0.00 | +0.00 | buy |
| Gallagher Fiduciary Advisors, LLC | 0 | 6,940 | +6,940 | 0.00 | 0.07 | +0.07 | buy |
| FMR LLC | 4,970 | 11,847 | +6,877 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 6,818 | +6,818 | 0.00 | 0.06 | +0.06 | buy |
| COMMERCE BANK | 0 | 6,239 | +6,239 | 0.00 | 0.00 | +0.00 | buy |
| NORTHCAPE WEALTH MANAGEMENT, LLC | 0 | 5,670 | +5,670 | 0.00 | 0.09 | +0.09 | buy |
| XTX Topco Ltd | 0 | 5,333 | +5,333 | 0.00 | 0.02 | +0.02 | buy |
| Russell Investments Group, Ltd. | 671 | 5,818 | +5,147 | 0.00 | 0.00 | +0.00 | buy |
| NORTH STAR ASSET MANAGEMENT INC | 0 | 5,000 | +5,000 | 0.00 | 0.01 | +0.01 | buy |
| Bridgefront Capital, LLC | 0 | 4,965 | +4,965 | 0.00 | 0.09 | +0.09 | buy |
| Virtu Financial LLC | 0 | 4,960 | +4,960 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 39,640 | 44,292 | +4,652 | 0.01 | 0.01 | +0.00 | buy |
| Handelsbanken Fonder AB | 12,023 | 16,123 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 29,063 | 32,663 | +3,600 | 0.01 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 707,342 | 709,912 | +2,570 | 0.01 | 0.01 | +0.00 | buy |
| Creative Planning | 9,244 | 11,520 | +2,276 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 69,872 | 71,889 | +2,017 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 0 | 2,004 | +2,004 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 1,136 | +1,136 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 12,286 | 13,394 | +1,108 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 1,100 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 919 | +919 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 864 | +864 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 492 | +492 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 55,486 | 55,737 | +251 | 0.00 | 0.00 | +0.00 | buy |
| Sunbelt Securities, Inc. | 0 | 225 | +225 | 0.00 | 0.00 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 169 | 331 | +162 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 24,417 | 24,531 | +114 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 14 | 122 | +108 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 86 | +86 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,867 | 1,950 | +83 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 791 | 849 | +58 | 0.00 | 0.00 | +0.00 | buy |
| MATHER GROUP, LLC. | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| Stephens Consulting, LLC | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| Twin Tree Management, LP | 0 | 52 | +52 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 73 | 100 | +27 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 48 | 72 | +24 | 0.00 | 0.00 | +0.00 | buy |
| INNEALTA CAPITAL, LLC | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 3,489 | 3,506 | +17 | 0.00 | 0.00 | +0.00 | buy |
| CVA Family Office, LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 5 | 20 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 4 | 12 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 11 | 16 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,519 | 5,519 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ASSETMARK, INC | 555 | 555 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,444 | 11,444 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 31,920 | 31,920 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 204 | 204 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 29,360 | 29,360 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Allworth Financial LP | 60 | 60 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JFS WEALTH ADVISORS, LLC | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |