| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,012,993 | 2,777,259 | +764,266 | 0.01 | 0.01 | +0.01 | buy |
| Frazier Life Sciences Management, L.P. | 523,166 | 871,974 | +348,808 | 0.65 | 1.76 | +1.11 | buy |
| PRUDENTIAL FINANCIAL INC | 194,132 | 107,852 | +86,280 | 0.01 | 0.01 | 0.00 | sell |
| TD ASSET MANAGEMENT INC | 156,418 | 210,472 | +54,054 | 0.00 | 0.01 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 79,906 | 30,013 | +49,893 | 0.17 | 0.08 | 0.00 | sell |
| Allianz Asset Management GmbH | 150,984 | 111,558 | +39,426 | 0.01 | 0.01 | +0.00 | sell |
| Caligan Partners LP | 484,711 | 514,711 | +30,000 | 3.75 | 5.19 | +1.44 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 55,262 | 78,700 | +23,438 | 1.05 | 2.86 | +1.81 | buy |
| PROFUND ADVISORS LLC | 34,714 | 14,773 | +19,941 | 0.04 | 0.02 | 0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 19,276 | 32,770 | +13,494 | 0.07 | 0.11 | +0.03 | buy |
| NEOS Investment Management LLC | 9,724 | 21,745 | +12,021 | 0.02 | 0.04 | +0.02 | buy |
| ALPS ADVISORS INC | 39,640 | 44,292 | +4,652 | 0.01 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 707,342 | 709,912 | +2,570 | 0.01 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 42,366 | 40,256 | +2,110 | 0.05 | 0.06 | 0.00 | sell |
| Inspire Investing, LLC | 12,202 | 8,115 | -4,087 | 0.04 | 0.04 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 10,780 | 6,670 | -4,110 | 0.04 | 0.04 | +0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 40,043 | 35,236 | -4,807 | 0.12 | 0.14 | +0.03 | sell |
| E Fund Management Co., Ltd. | 10,453 | 4,668 | -5,785 | 0.02 | 0.01 | -0.01 | sell |
| VIRTUS ADVISERS, LLC | 16,395 | 7,042 | -9,353 | 0.25 | 0.15 | -0.11 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 45,407 | 35,293 | -10,114 | 0.03 | 0.03 | +0.01 | sell |
| PDT Partners, LLC | 93,404 | 75,280 | -18,124 | 0.26 | 0.31 | +0.05 | sell |
| Allen Investment Management, LLC | 43,571 | 21,781 | -21,790 | 0.02 | 0.01 | -0.00 | sell |
| Erste Asset Management GmbH | 2,279,900 | 2,254,900 | -25,000 | 0.91 | 1.29 | +0.38 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 266,588 | 224,855 | -41,733 | 0.01 | 0.01 | +0.00 | sell |
| SECTOR GAMMA AS | 164,378 | 121,844 | -42,534 | 1.35 | 1.96 | +0.61 | sell |
| GW&K Investment Management, LLC | 649,385 | 595,066 | -54,319 | 0.17 | 0.23 | +0.07 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 159,288 | 83,661 | -75,627 | 0.10 | 0.08 | -0.02 | sell |
| Laurion Capital Management LP | 364,762 | 248,395 | -116,367 | 0.09 | 0.13 | +0.04 | sell |
| Bellevue Group AG | 4,006,000 | 3,879,548 | -126,452 | 1.79 | 2.72 | +0.93 | sell |
| Rafferty Asset Management, LLC | 221,209 | 76,853 | -144,356 | 0.02 | 0.01 | -0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,108,613 | 911,175 | -197,438 | 0.09 | 0.10 | +0.02 | sell |
| Hudson Bay Capital Management LP | 407,500 | 115,000 | -292,500 | 0.07 | 0.02 | -0.04 | sell |
| ArrowMark Colorado Holdings LLC | 1,519,163 | 1,019,357 | -499,806 | 0.50 | 0.52 | +0.03 | sell |
| Rock Springs Capital Management LP | 1,764,505 | 1,044,261 | -720,244 | 1.31 | 1.36 | +0.05 | sell |
| ARMISTICE CAPITAL, LLC | 2,964,000 | 2,079,151 | -884,849 | 1.15 | 1.13 | -0.02 | sell |