| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 5,590,602 | 5,654,502 | +63,900 | 0.96 | 1.44 | +0.48 | buy |
| VANGUARD GROUP INC | 5,572,021 | 5,496,737 | -75,284 | 0.00 | 0.00 | +0.00 | sell |
| Bellevue Group AG | 4,006,000 | 3,879,548 | -126,452 | 1.79 | 2.72 | +0.93 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,012,993 | 2,777,259 | +764,266 | 0.01 | 0.01 | +0.01 | buy |
| Erste Asset Management GmbH | 2,279,900 | 2,254,900 | -25,000 | 0.91 | 1.29 | +0.38 | sell |
| DIMENSIONAL FUND ADVISORS LP | 2,578,558 | 2,196,085 | -382,473 | 0.02 | 0.02 | +0.00 | sell |
| STATE STREET CORP | 3,138,197 | 2,114,949 | -1,023,248 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 2,964,000 | 2,079,151 | -884,849 | 2.31 | 2.35 | +0.04 | sell |
| JPMORGAN CHASE & CO | 2,472,690 | 1,776,145 | -696,545 | 0.01 | 0.01 | +0.00 | sell |
| MACQUARIE GROUP LTD | 1,959,657 | 1,729,729 | -229,928 | 0.06 | 0.09 | +0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,282,915 | 1,351,430 | +68,515 | 0.00 | 0.01 | +0.00 | buy |
| BVF INC/IL | 0 | 1,190,107 | +1,190,107 | 0.00 | 1.44 | +1.44 | buy |
| MARSHALL WACE, LLP | 277,996 | 1,133,735 | +855,739 | 0.01 | 0.07 | +0.06 | buy |
| Rock Springs Capital Management LP | 1,764,505 | 1,044,261 | -720,244 | 1.31 | 1.36 | +0.05 | sell |
| ArrowMark Colorado Holdings LLC | 1,519,163 | 1,019,357 | -499,806 | 0.50 | 0.52 | +0.03 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,108,613 | 911,175 | -197,438 | 0.09 | 0.10 | +0.02 | sell |
| Frazier Life Sciences Management, L.P. | 523,166 | 871,974 | +348,808 | 0.65 | 1.76 | +1.11 | buy |
| Fisher Asset Management, LLC | 707,342 | 709,912 | +2,570 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 362,134 | 678,234 | +316,100 | 0.01 | 0.04 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 667,297 | 662,236 | -5,061 | 0.01 | 0.01 | +0.00 | sell |
| MORGAN STANLEY | 1,180,326 | 596,675 | -583,651 | 0.00 | 0.00 | -0.00 | sell |
| GW&K Investment Management, LLC | 649,385 | 595,066 | -54,319 | 0.17 | 0.23 | +0.07 | sell |
| NORTHERN TRUST CORP | 590,493 | 586,266 | -4,227 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 539,582 | 549,003 | +9,421 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 484,711 | 514,711 | +30,000 | 3.75 | 5.19 | +1.44 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 464,121 | +464,121 | 0.00 | 0.16 | +0.16 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 440,232 | 457,527 | +17,295 | 0.00 | 0.00 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 0 | 448,863 | +448,863 | 0.00 | 0.03 | +0.03 | buy |
| Parkman Healthcare Partners LLC | 0 | 446,416 | +446,416 | 0.00 | 2.62 | +2.62 | buy |
| Pictet Asset Management Holding SA | 1,005,626 | 422,044 | -583,582 | 0.03 | 0.02 | -0.01 | sell |
| Eagle Health Investments LP | 330,830 | 330,830 | 0 | 1.84 | 2.55 | +0.71 | hold |
| BANK OF AMERICA CORP /DE/ | 381,733 | 326,780 | -54,953 | 0.00 | 0.00 | +0.00 | sell |
| Candriam S.C.A. | 0 | 322,882 | +322,882 | 0.00 | 0.08 | +0.08 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 43,213 | 320,531 | +277,318 | 0.00 | 0.05 | +0.05 | buy |
| Artisan Partners Limited Partnership | 0 | 320,467 | +320,467 | 0.00 | 0.02 | +0.02 | buy |
| CenterBook Partners LP | 0 | 249,311 | +249,311 | 0.00 | 0.67 | +0.67 | buy |
| Laurion Capital Management LP | 364,762 | 248,395 | -116,367 | 0.30 | 0.35 | +0.05 | sell |
| NORGES BANK | 262,457 | 242,734 | -19,723 | 0.00 | 0.00 | +0.00 | sell |
| AXA S.A. | 265,373 | 238,682 | -26,691 | 0.02 | 0.03 | +0.01 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 266,588 | 224,855 | -41,733 | 0.01 | 0.01 | +0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 268,979 | 223,979 | -45,000 | 0.22 | 0.29 | +0.08 | sell |
| Bank of New York Mellon Corp | 195,958 | 223,151 | +27,193 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 156,418 | 210,472 | +54,054 | 0.00 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 124,535 | 176,815 | +52,280 | 0.00 | 0.01 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 174,870 | +174,870 | 0.00 | 0.04 | +0.04 | buy |
| Trexquant Investment LP | 60,689 | 155,076 | +94,387 | 0.04 | 0.10 | +0.07 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 89,009 | 137,844 | +48,835 | 0.00 | 0.01 | +0.00 | buy |
| Granahan Investment Management, LLC | 0 | 136,838 | +136,838 | 0.00 | 0.24 | +0.24 | buy |
| Assenagon Asset Management S.A. | 454,801 | 134,980 | -319,821 | 0.04 | 0.01 | -0.02 | sell |
| FIRST TRUST ADVISORS LP | 0 | 130,411 | +130,411 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 47,461 | 125,470 | +78,009 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,002,461 | 123,840 | -878,621 | 0.03 | 0.01 | -0.02 | sell |
| SECTOR GAMMA AS | 164,378 | 121,844 | -42,534 | 1.35 | 1.96 | +0.61 | sell |
| Invesco Ltd. | 76,202 | 118,020 | +41,818 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 407,500 | 115,000 | -292,500 | 0.10 | 0.04 | -0.07 | sell |
| Woodline Partners LP | 0 | 113,378 | +113,378 | 0.00 | 0.05 | +0.05 | buy |
| Allianz Asset Management GmbH | 150,984 | 111,558 | -39,426 | 0.01 | 0.01 | +0.00 | sell |
| BARCLAYS PLC | 69,226 | 109,881 | +40,655 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 194,132 | 107,852 | -86,280 | 0.01 | 0.01 | -0.00 | sell |
| RHUMBLINE ADVISERS | 102,150 | 101,180 | -970 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 109,860 | 99,460 | -10,400 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 80,616 | 94,486 | +13,870 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 159,288 | 83,661 | -75,627 | 0.10 | 0.08 | -0.02 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 55,262 | 78,700 | +23,438 | 1.05 | 2.86 | +1.81 | buy |
| Rafferty Asset Management, LLC | 221,209 | 76,853 | -144,356 | 0.02 | 0.01 | -0.01 | sell |
| PDT Partners, LLC | 93,404 | 75,280 | -18,124 | 0.26 | 0.31 | +0.05 | sell |
| Informed Momentum Co LLC | 0 | 74,142 | +74,142 | 0.00 | 0.52 | +0.52 | buy |
| AMERIPRISE FINANCIAL INC | 69,872 | 71,889 | +2,017 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 170,885 | 69,359 | -101,526 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 71,222 | 65,122 | -6,100 | 0.00 | 0.00 | +0.00 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 60,000 | +60,000 | 0.00 | 0.06 | +0.06 | buy |
| Legal & General Group Plc | 55,486 | 55,737 | +251 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,837 | 49,830 | -6,007 | 0.00 | 0.00 | +0.00 | sell |
| State of New Jersey Common Pension Fund D | 84,822 | 48,943 | -35,879 | 0.01 | 0.01 | +0.00 | sell |
| ALPS ADVISORS INC | 39,640 | 44,292 | +4,652 | 0.01 | 0.01 | +0.00 | buy |
| Edgestream Partners, L.P. | 0 | 42,076 | +42,076 | 0.00 | 0.09 | +0.09 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 78,488 | 41,793 | -36,695 | 0.01 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 50,701 | 41,772 | -8,929 | 0.00 | 0.00 | +0.00 | sell |
| ALGERT GLOBAL LLC | 42,366 | 40,256 | -2,110 | 0.05 | 0.06 | +0.01 | sell |
| DekaBank Deutsche Girozentrale | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 66,245 | 39,979 | -26,266 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,617 | 38,195 | +15,578 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 37,281 | +37,281 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 36,818 | 36,498 | -320 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 39,844 | 36,419 | -3,425 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 98,152 | 35,634 | -62,518 | 0.00 | 0.00 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 45,407 | 35,293 | -10,114 | 0.03 | 0.03 | +0.01 | sell |
| OAK RIDGE INVESTMENTS LLC | 40,043 | 35,236 | -4,807 | 0.12 | 0.14 | +0.03 | sell |
| AQR CAPITAL MANAGEMENT LLC | 11,184 | 33,164 | +21,980 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 19,276 | 32,770 | +13,494 | 0.07 | 0.11 | +0.03 | buy |
| MetLife Investment Management, LLC | 29,063 | 32,663 | +3,600 | 0.01 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 31,920 | 31,920 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 47,601 | 31,087 | -16,514 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 79,906 | 30,013 | -49,893 | 0.07 | 0.04 | -0.03 | sell |
| EDGEWOOD MANAGEMENT LLC | 30,000 | 30,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 29,360 | 29,360 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Y-Intercept (Hong Kong) Ltd | 0 | 25,945 | +25,945 | 0.00 | 0.06 | +0.06 | buy |
| JANUS HENDERSON GROUP PLC | 29,581 | 25,897 | -3,684 | 0.00 | 0.00 | +0.00 | sell |
| Engineers Gate Manager LP | 36,570 | 25,806 | -10,764 | 0.03 | 0.03 | -0.00 | sell |
| Qube Research & Technologies Ltd | 43,244 | 24,830 | -18,414 | 0.00 | 0.00 | -0.00 | sell |