| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Rock Springs Capital Management LP | 342,180 | 989,745 | +647,565 | 0.57 | 2.05 | +1.48 | buy |
| Caligan Partners LP | 701,280 | 1,071,258 | +369,978 | 4.29 | 6.85 | +2.56 | buy |
| ORBIMED ADVISORS LLC | 325,500 | 557,900 | +232,400 | 0.23 | 0.47 | +0.24 | buy |
| Woodline Partners LP | 20,381 | 233,068 | +212,687 | 0.00 | 0.04 | +0.04 | buy |
| Frazier Life Sciences Management, L.P. | 1,069,854 | 1,279,754 | +209,900 | 1.43 | 1.70 | +0.27 | buy |
| Commodore Capital LP | 2,185,000 | 2,325,000 | +140,000 | 4.72 | 5.46 | +0.74 | buy |
| CenterBook Partners LP | 108,509 | 243,063 | +134,554 | 0.20 | 0.45 | +0.25 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 386,523 | 505,225 | +118,702 | 0.05 | 0.06 | +0.01 | buy |
| CANTOR FITZGERALD, L. P. | 32,000 | 134,200 | +102,200 | 0.02 | 0.08 | +0.06 | buy |
| Erste Asset Management GmbH | 2,229,900 | 2,326,489 | +96,589 | 0.84 | 0.65 | -0.19 | buy |
| Bellevue Group AG | 3,515,150 | 3,590,150 | +75,000 | 2.31 | 2.63 | +0.32 | buy |
| GW&K Investment Management, LLC | 817,526 | 868,618 | +51,092 | 0.22 | 0.26 | +0.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 743,000 | 791,000 | +48,000 | 0.04 | 0.04 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 204,242 | 158,359 | +45,883 | 0.01 | 0.01 | 0.00 | sell |
| HighVista Strategies LLC | 44,105 | 70,127 | +26,022 | 0.50 | 0.86 | +0.36 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 60,000 | 80,000 | +20,000 | 0.04 | 0.03 | -0.00 | buy |
| ALGERT GLOBAL LLC | 74,810 | 88,830 | +14,020 | 0.05 | 0.06 | 0.00 | buy |
| ALPS ADVISORS INC | 42,219 | 31,274 | +10,945 | 0.01 | 0.01 | 0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 39,261 | 49,661 | +10,400 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 27,900 | 35,900 | +8,000 | 0.16 | 0.19 | +0.04 | buy |
| Virtus Investment Advisers, LLC | 9,408 | 12,881 | +3,473 | 0.07 | 0.14 | +0.07 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 58,722 | 56,810 | +1,912 | 0.14 | 0.10 | 0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 35,729 | 37,024 | +1,295 | 0.05 | 0.05 | 0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 224,173 | 224,746 | +573 | 0.01 | 0.01 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 83,157 | 82,679 | +478 | 0.02 | 0.02 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 11,493 | 11,632 | +139 | 0.03 | 0.04 | +0.01 | buy |
| Bell Investment Advisors, Inc | 237 | 298 | +61 | 0.00 | 0.00 | 0.00 | buy |
| Riggs Asset Managment Co. Inc. | 41 | 3 | -38 | 0.00 | 0.00 | -0.00 | sell |
| Inspire Investing, LLC | 11,768 | 11,728 | -40 | 0.04 | 0.04 | +0.00 | sell |
| Gallagher Fiduciary Advisors, LLC | 12,830 | 11,473 | -1,357 | 0.01 | 0.01 | +0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 39,087 | 37,252 | -1,835 | 0.10 | 0.09 | -0.01 | sell |
| SCS Capital Management LLC | 611,098 | 604,085 | -7,013 | 0.23 | 0.22 | -0.01 | sell |
| Palo Alto Investors LP | 276,578 | 268,783 | -7,795 | 1.54 | 1.90 | +0.36 | sell |
| PROFUND ADVISORS LLC | 19,582 | 10,851 | -8,731 | 0.02 | 0.01 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 178,072 | 168,194 | -9,878 | 0.00 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 21,468 | 2,230 | -19,238 | 0.05 | 0.00 | -0.05 | sell |
| Artisan Partners Limited Partnership | 410,672 | 389,984 | -20,688 | 0.02 | 0.02 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 62,953 | 36,705 | -26,248 | 0.04 | 0.03 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,301,353 | 2,274,249 | -27,104 | 0.01 | 0.01 | +0.00 | sell |
| Rafferty Asset Management, LLC | 93,627 | 49,403 | -44,224 | 0.01 | 0.01 | -0.01 | sell |
| Fisher Asset Management, LLC | 959,339 | 877,540 | -81,799 | 0.01 | 0.01 | -0.00 | sell |
| Granahan Investment Management, LLC | 132,108 | 41,886 | -90,222 | 0.19 | 0.06 | -0.14 | sell |
| Casdin Capital, LLC | 250,000 | 100,000 | -150,000 | 0.60 | 0.30 | -0.30 | sell |
| ArrowMark Colorado Holdings LLC | 827,623 | 658,691 | -168,932 | 0.39 | 0.39 | +0.00 | sell |
| ARMISTICE CAPITAL, LLC | 2,048,000 | 1,168,000 | -880,000 | 0.90 | 0.67 | -0.23 | sell |