| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 5,700,466 | 5,767,466 | +67,000 | 0.90 | 0.87 | -0.03 | buy |
| VANGUARD GROUP INC | 5,604,591 | 5,682,019 | +77,428 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 5,108,746 | 4,833,760 | -274,986 | 0.00 | 0.00 | -0.00 | sell |
| Bellevue Group AG | 3,515,150 | 3,590,150 | +75,000 | 2.31 | 2.63 | +0.32 | buy |
| Erste Asset Management GmbH | 2,229,900 | 2,326,489 | +96,589 | 0.84 | 0.65 | -0.19 | buy |
| Commodore Capital LP | 2,185,000 | 2,325,000 | +140,000 | 4.72 | 5.46 | +0.74 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,301,353 | 2,274,249 | -27,104 | 0.01 | 0.01 | +0.00 | sell |
| STATE STREET CORP | 2,449,479 | 1,951,113 | -498,366 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 1,850,544 | 1,900,596 | +50,052 | 0.07 | 0.08 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,394,581 | 1,405,755 | +11,174 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 1,069,854 | 1,279,754 | +209,900 | 1.43 | 1.70 | +0.27 | buy |
| ARMISTICE CAPITAL, LLC | 2,048,000 | 1,168,000 | -880,000 | 1.60 | 1.47 | -0.13 | sell |
| Paradigm Biocapital Advisors LP | 0 | 1,142,511 | +1,142,511 | 0.00 | 1.62 | +1.62 | buy |
| BANK OF AMERICA CORP /DE/ | 1,135,592 | 1,120,308 | -15,284 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,262,073 | 1,106,093 | -155,980 | 0.01 | 0.01 | -0.00 | sell |
| CITADEL ADVISORS LLC | 863,499 | 1,081,470 | +217,971 | 0.02 | 0.03 | +0.01 | buy |
| Caligan Partners LP | 701,280 | 1,071,258 | +369,978 | 4.29 | 6.92 | +2.63 | buy |
| JPMORGAN CHASE & CO | 1,049,360 | 1,027,417 | -21,943 | 0.00 | 0.00 | +0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,025,719 | 1,016,891 | -8,828 | 0.08 | 0.08 | +0.00 | sell |
| Rock Springs Capital Management LP | 342,180 | 989,745 | +647,565 | 0.57 | 2.05 | +1.48 | buy |
| DEUTSCHE BANK AG\ | 928,970 | 921,586 | -7,384 | 0.01 | 0.01 | +0.00 | sell |
| Fisher Asset Management, LLC | 959,339 | 877,540 | -81,799 | 0.01 | 0.01 | -0.00 | sell |
| GW&K Investment Management, LLC | 817,526 | 868,618 | +51,092 | 0.22 | 0.26 | +0.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 743,000 | 791,000 | +48,000 | 0.04 | 0.04 | +0.00 | buy |
| TCG Crossover Management, LLC | 0 | 697,003 | +697,003 | 0.00 | 2.65 | +2.65 | buy |
| MARSHALL WACE, LLP | 520,873 | 684,669 | +163,796 | 0.02 | 0.03 | +0.01 | buy |
| ArrowMark Colorado Holdings LLC | 827,623 | 658,691 | -168,932 | 0.39 | 0.39 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 658,652 | 648,061 | -10,591 | 0.00 | 0.00 | -0.00 | sell |
| SCS Capital Management LLC | 611,098 | 604,085 | -7,013 | 0.23 | 0.22 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 554,820 | 596,202 | +41,382 | 0.02 | 0.02 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 325,500 | 557,900 | +232,400 | 0.23 | 0.47 | +0.24 | buy |
| NORTHERN TRUST CORP | 576,258 | 556,805 | -19,453 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 386,523 | 505,225 | +118,702 | 0.05 | 0.06 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 464,958 | 476,041 | +11,083 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 261,221 | 447,019 | +185,798 | 0.26 | 0.45 | +0.19 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 24,462 | 422,129 | +397,667 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 410,672 | 389,984 | -20,688 | 0.02 | 0.02 | -0.00 | sell |
| Eagle Health Investments LP | 330,830 | 330,830 | 0 | 2.52 | 2.72 | +0.20 | hold |
| MILLENNIUM MANAGEMENT LLC | 53,073 | 300,203 | +247,130 | 0.00 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 310,781 | 294,740 | -16,041 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 294,623 | 291,965 | -2,658 | 0.00 | 0.00 | +0.00 | sell |
| Palo Alto Investors LP | 276,578 | 268,783 | -7,795 | 1.54 | 1.90 | +0.36 | sell |
| Bank of New York Mellon Corp | 263,450 | 266,654 | +3,204 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 108,509 | 243,063 | +134,554 | 0.20 | 0.45 | +0.25 | buy |
| Woodline Partners LP | 20,381 | 233,068 | +212,687 | 0.00 | 0.04 | +0.04 | buy |
| AXA S.A. | 225,119 | 225,367 | +248 | 0.02 | 0.02 | -0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 224,173 | 224,746 | +573 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 147,276 | 217,402 | +70,126 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 0 | 189,866 | +189,866 | 0.00 | 0.06 | +0.06 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 331,643 | 187,395 | -144,248 | 0.04 | 0.02 | -0.01 | sell |
| BARCLAYS PLC | 113,153 | 180,704 | +67,551 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 178,072 | 168,194 | -9,878 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 204,242 | 158,359 | -45,883 | 0.01 | 0.01 | -0.00 | sell |
| Patient Square Capital LP | 139,732 | 139,732 | 0 | 1.69 | 1.68 | -0.02 | hold |
| Allianz Asset Management GmbH | 92,233 | 138,898 | +46,665 | 0.00 | 0.01 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 32,000 | 134,200 | +102,200 | 0.04 | 0.11 | +0.07 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 131,571 | 132,083 | +512 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 110,720 | 130,000 | +19,280 | 0.02 | 0.03 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 114,947 | 127,647 | +12,700 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 83,409 | 119,580 | +36,171 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 131,642 | 118,834 | -12,808 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 107,367 | 112,617 | +5,250 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 99,460 | 109,460 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Casdin Capital, LLC | 250,000 | 100,000 | -150,000 | 0.60 | 0.30 | -0.30 | sell |
| Trexquant Investment LP | 0 | 98,401 | +98,401 | 0.00 | 0.04 | +0.04 | buy |
| AQR CAPITAL MANAGEMENT LLC | 51,489 | 96,896 | +45,407 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 86,842 | 89,881 | +3,039 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 74,810 | 88,830 | +14,020 | 0.05 | 0.06 | +0.01 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 82,679 | 82,679 | 0 | 0.02 | 0.02 | +0.00 | hold |
| MOORE CAPITAL MANAGEMENT, LP | 60,000 | 80,000 | +20,000 | 0.06 | 0.05 | -0.01 | buy |
| HighVista Strategies LLC | 44,105 | 70,127 | +26,022 | 0.50 | 0.86 | +0.36 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 72,302 | 68,502 | -3,800 | 0.03 | 0.03 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 81,962 | 68,103 | -13,859 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 127,980 | 67,379 | -60,601 | 0.01 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 60,043 | 64,305 | +4,262 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 61,478 | 61,470 | -8 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 69,684 | 59,100 | -10,584 | 0.01 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 58,722 | 56,810 | -1,912 | 0.04 | 0.05 | +0.01 | sell |
| CITIGROUP INC | 176,128 | 56,489 | -119,639 | 0.00 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 54,651 | 55,284 | +633 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 46,811 | 52,252 | +5,441 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 68,072 | 50,108 | -17,964 | 0.00 | 0.00 | -0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 39,261 | 49,661 | +10,400 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 93,627 | 49,403 | -44,224 | 0.01 | 0.01 | -0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 46,988 | 47,659 | +671 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 47,221 | 47,190 | -31 | 0.01 | 0.01 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 23,600 | 46,346 | +22,746 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 132,108 | 41,886 | -90,222 | 0.19 | 0.06 | -0.14 | sell |
| DekaBank Deutsche Girozentrale | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 43,327 | 39,579 | -3,748 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 39,093 | 39,093 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 68,137 | 37,694 | -30,443 | 0.00 | 0.00 | -0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 39,087 | 37,252 | -1,835 | 0.10 | 0.09 | -0.01 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 35,729 | 37,024 | +1,295 | 0.05 | 0.05 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 62,953 | 36,705 | -26,248 | 0.04 | 0.03 | -0.01 | sell |
| FIRST TRUST ADVISORS LP | 37,330 | 36,427 | -903 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 27,900 | 35,900 | +8,000 | 0.16 | 0.19 | +0.04 | buy |
| EDGEWOOD MANAGEMENT LLC | 35,000 | 35,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 34,032 | 34,032 | 0 | 0.01 | 0.01 | +0.00 | hold |
| JANE STREET GROUP, LLC | 126,104 | 33,489 | -92,615 | 0.01 | 0.00 | -0.00 | sell |