| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 0 | 1,142,511 | +1,142,511 | 0.00 | 1.62 | +1.62 | buy |
| TCG Crossover Management, LLC | 0 | 697,003 | +697,003 | 0.00 | 2.65 | +2.65 | buy |
| Rock Springs Capital Management LP | 342,180 | 989,745 | +647,565 | 0.57 | 2.05 | +1.48 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 24,462 | 422,129 | +397,667 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 701,280 | 1,071,258 | +369,978 | 4.29 | 6.92 | +2.63 | buy |
| MILLENNIUM MANAGEMENT LLC | 53,073 | 300,203 | +247,130 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 325,500 | 557,900 | +232,400 | 0.23 | 0.47 | +0.24 | buy |
| CITADEL ADVISORS LLC | 863,499 | 1,081,470 | +217,971 | 0.02 | 0.03 | +0.01 | buy |
| Woodline Partners LP | 20,381 | 233,068 | +212,687 | 0.00 | 0.04 | +0.04 | buy |
| Frazier Life Sciences Management, L.P. | 1,069,854 | 1,279,754 | +209,900 | 1.43 | 1.70 | +0.27 | buy |
| BAKER BROS. ADVISORS LP | 0 | 189,866 | +189,866 | 0.00 | 0.06 | +0.06 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 261,221 | 447,019 | +185,798 | 0.26 | 0.45 | +0.19 | buy |
| MARSHALL WACE, LLP | 520,873 | 684,669 | +163,796 | 0.02 | 0.03 | +0.01 | buy |
| Commodore Capital LP | 2,185,000 | 2,325,000 | +140,000 | 4.72 | 5.46 | +0.74 | buy |
| CenterBook Partners LP | 108,509 | 243,063 | +134,554 | 0.20 | 0.45 | +0.25 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 386,523 | 505,225 | +118,702 | 0.05 | 0.06 | +0.01 | buy |
| CANTOR FITZGERALD, L. P. | 32,000 | 134,200 | +102,200 | 0.04 | 0.11 | +0.07 | buy |
| Trexquant Investment LP | 0 | 98,401 | +98,401 | 0.00 | 0.04 | +0.04 | buy |
| Erste Asset Management GmbH | 2,229,900 | 2,326,489 | +96,589 | 0.84 | 0.65 | -0.19 | buy |
| VANGUARD GROUP INC | 5,604,591 | 5,682,019 | +77,428 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 3,515,150 | 3,590,150 | +75,000 | 2.31 | 2.63 | +0.32 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 147,276 | 217,402 | +70,126 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 113,153 | 180,704 | +67,551 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 5,700,466 | 5,767,466 | +67,000 | 0.90 | 0.87 | -0.03 | buy |
| GW&K Investment Management, LLC | 817,526 | 868,618 | +51,092 | 0.22 | 0.26 | +0.04 | buy |
| MACQUARIE GROUP LTD | 1,850,544 | 1,900,596 | +50,052 | 0.07 | 0.08 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 743,000 | 791,000 | +48,000 | 0.04 | 0.04 | +0.00 | buy |
| Allianz Asset Management GmbH | 92,233 | 138,898 | +46,665 | 0.00 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 51,489 | 96,896 | +45,407 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 554,820 | 596,202 | +41,382 | 0.02 | 0.02 | +0.00 | buy |
| Nuveen, LLC | 83,409 | 119,580 | +36,171 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 29,177 | +29,177 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 44,105 | 70,127 | +26,022 | 0.50 | 0.86 | +0.36 | buy |
| Schonfeld Strategic Advisors LLC | 23,600 | 46,346 | +22,746 | 0.00 | 0.01 | +0.01 | buy |
| Savvy Advisors, Inc. | 0 | 21,781 | +21,781 | 0.00 | 0.05 | +0.05 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 8,784 | 29,414 | +20,630 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 60,000 | 80,000 | +20,000 | 0.06 | 0.05 | -0.01 | buy |
| Hudson Bay Capital Management LP | 110,720 | 130,000 | +19,280 | 0.02 | 0.03 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 17,707 | +17,707 | 0.00 | 0.10 | +0.10 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 15,005 | +15,005 | 0.00 | 0.02 | +0.02 | buy |
| Polar Asset Management Partners Inc. | 0 | 14,700 | +14,700 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 74,810 | 88,830 | +14,020 | 0.05 | 0.06 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 114,947 | 127,647 | +12,700 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,394,581 | 1,405,755 | +11,174 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 464,958 | 476,041 | +11,083 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 39,261 | 49,661 | +10,400 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 99,460 | 109,460 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 8,646 | +8,646 | 0.00 | 0.04 | +0.04 | buy |
| IEQ CAPITAL, LLC | 0 | 8,086 | +8,086 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 27,900 | 35,900 | +8,000 | 0.16 | 0.19 | +0.04 | buy |
| Jain Global LLC | 0 | 7,749 | +7,749 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,336 | 11,908 | +7,572 | 0.00 | 0.00 | +0.00 | buy |
| Savant Capital, LLC | 0 | 6,883 | +6,883 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 6,789 | +6,789 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 877 | 6,440 | +5,563 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 46,811 | 52,252 | +5,441 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 107,367 | 112,617 | +5,250 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 60,043 | 64,305 | +4,262 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,659 | 5,286 | +3,627 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,836 | 16,396 | +3,560 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 9,408 | 12,881 | +3,473 | 0.07 | 0.14 | +0.07 | buy |
| Bank of New York Mellon Corp | 263,450 | 266,654 | +3,204 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 86,842 | 89,881 | +3,039 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 14,698 | 16,676 | +1,978 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 10,715 | 12,644 | +1,929 | 0.04 | 0.05 | +0.01 | buy |
| KLP KAPITALFORVALTNING AS | 10,000 | 11,800 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 13,813 | 15,405 | +1,592 | 0.00 | 0.00 | +0.00 | buy |
| COMMERCE BANK | 8,199 | 9,604 | +1,405 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 35,729 | 37,024 | +1,295 | 0.05 | 0.05 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 1,130 | +1,130 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 11,922 | 12,839 | +917 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 12,032 | 12,923 | +891 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 3,582 | 4,419 | +837 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 17,806 | 18,592 | +786 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 8,558 | 9,292 | +734 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 46,988 | 47,659 | +671 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 54,651 | 55,284 | +633 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 224,173 | 224,746 | +573 | 0.01 | 0.01 | +0.00 | buy |
| Sterling Capital Management LLC | 975 | 1,515 | +540 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 131,571 | 132,083 | +512 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,917 | 2,237 | +320 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 316 | +316 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 373 | 669 | +296 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 291 | +291 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 19,408 | 19,663 | +255 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 225,119 | 225,367 | +248 | 0.02 | 0.02 | -0.00 | buy |
| COMERICA BANK | 190 | 353 | +163 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 15,247 | 15,408 | +161 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 805 | 955 | +150 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,493 | 11,632 | +139 | 0.03 | 0.04 | +0.01 | buy |
| Farther Finance Advisors, LLC | 12 | 151 | +139 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 215 | 305 | +90 | 0.00 | 0.00 | +0.00 | buy |
| Bell Investment Advisors, Inc | 237 | 298 | +61 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 477 | 513 | +36 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 41 | 62 | +21 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 30 | 45 | +15 | 0.00 | 0.00 | +0.00 | buy |
| JFS WEALTH ADVISORS, LLC | 5 | 16 | +11 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 559 | 569 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 15,032 | 15,040 | +8 | 0.03 | 0.03 | +0.01 | buy |
| Fortitude Family Office, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |