| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 5,754,957 | 6,455,997 | +701,040 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 5,684,000 | 5,917,400 | +233,400 | 1.14 | 1.29 | +0.15 | buy |
| STATE STREET CORP | 3,364,879 | 3,533,633 | +168,754 | 0.00 | 0.00 | -0.00 | buy |
| Lynx1 Capital Management LP | 2,611,568 | 3,408,937 | +797,369 | 13.96 | 14.62 | +0.65 | buy |
| D. E. Shaw & Co., Inc. | 2,681,169 | 3,107,005 | +425,836 | 0.07 | 0.07 | -0.00 | buy |
| ARMISTICE CAPITAL, LLC | 2,716,000 | 2,400,000 | -316,000 | 3.03 | 2.46 | -0.57 | sell |
| Erste Asset Management GmbH | 2,704,900 | 2,154,900 | -550,000 | 0.74 | 0.64 | -0.10 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,467,910 | 1,574,268 | +106,358 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,344,953 | 1,375,558 | +30,605 | 0.06 | 0.05 | -0.01 | buy |
| ADAR1 Capital Management, LLC | 140,672 | 1,288,053 | +1,147,381 | 0.29 | 2.25 | +1.96 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,580,840 | 1,280,044 | -300,796 | 0.06 | 0.05 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,151,614 | 1,248,738 | +97,124 | 0.01 | 0.01 | +0.00 | buy |
| GW&K Investment Management, LLC | 1,214,901 | 1,206,615 | -8,286 | 0.36 | 0.35 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 805,776 | 1,150,932 | +345,156 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 132,540 | 985,831 | +853,291 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 967,525 | 963,256 | -4,269 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 722,348 | 873,560 | +151,212 | 0.01 | 0.01 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 250,461 | 810,530 | +560,069 | 0.00 | 0.01 | +0.01 | buy |
| Foresite Capital Management VI LLC | 525,000 | 785,000 | +260,000 | 3.86 | 4.53 | +0.67 | buy |
| CITADEL ADVISORS LLC | 619,613 | 732,687 | +113,074 | 0.01 | 0.02 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 36,410 | 684,340 | +647,930 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 403,525 | 669,046 | +265,521 | 1.42 | 2.55 | +1.13 | buy |
| SCS Capital Management LLC | 612,850 | 612,850 | 0 | 0.22 | 0.21 | -0.00 | hold |
| Qube Research & Technologies Ltd | 187,667 | 597,638 | +409,971 | 0.01 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 509,272 | 554,709 | +45,437 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 538,128 | +538,128 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 477,032 | 538,128 | +61,096 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 251,636 | 536,380 | +284,744 | 0.01 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 799,163 | 532,563 | -266,600 | 1.59 | 0.96 | -0.63 | sell |
| Schonfeld Strategic Advisors LLC | 200,061 | 520,083 | +320,022 | 0.06 | 0.10 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 507,900 | 507,869 | -31 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 506,344 | +506,344 | 0.00 | 0.03 | +0.03 | buy |
| JANE STREET GROUP, LLC | 685,240 | 492,598 | -192,642 | 0.02 | 0.01 | -0.01 | sell |
| Legal & General Group Plc | 423,915 | 434,719 | +10,804 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 238,468 | 373,931 | +135,463 | 0.03 | 0.04 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 275,456 | 373,230 | +97,774 | 0.20 | 0.25 | +0.05 | buy |
| JPMORGAN CHASE & CO | 151,558 | 359,756 | +208,198 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 450,093 | 359,550 | -90,543 | 0.04 | 0.03 | -0.01 | sell |
| Squarepoint Ops LLC | 208,888 | 321,138 | +112,250 | 0.02 | 0.02 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 6,570 | 297,630 | +291,060 | 0.00 | 0.02 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 327,457 | 269,383 | -58,074 | 0.01 | 0.01 | -0.00 | sell |
| ALGERT GLOBAL LLC | 268,435 | 248,007 | -20,428 | 0.14 | 0.11 | -0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 298,783 | 218,966 | -79,817 | 0.00 | 0.00 | -0.00 | sell |
| Palo Alto Investors LP | 213,601 | 213,601 | 0 | 1.11 | 1.10 | -0.01 | hold |
| TFG Asset Management GP Ltd | 164,839 | 205,579 | +40,740 | 1.10 | 1.24 | +0.15 | buy |
| Bank of New York Mellon Corp | 186,791 | 198,685 | +11,894 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 182,773 | +182,773 | 0.00 | 0.06 | +0.06 | buy |
| Invesco Ltd. | 151,430 | 168,153 | +16,723 | 0.00 | 0.00 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 165,587 | +165,587 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 195,432 | 160,759 | -34,673 | 0.02 | 0.01 | -0.01 | sell |
| GROUP ONE TRADING LLC | 173,279 | 151,994 | -21,285 | 0.19 | 0.16 | -0.03 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 149,886 | +149,886 | 0.00 | 0.10 | +0.10 | buy |
| MARSHALL WACE, LLP | 448,118 | 138,800 | -309,318 | 0.02 | 0.00 | -0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 120,253 | 134,512 | +14,259 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 144,297 | 124,466 | -19,831 | 0.01 | 0.01 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 403,590 | 117,714 | -285,876 | 0.36 | 0.18 | -0.18 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 110,679 | 116,909 | +6,230 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 128,814 | 111,861 | -16,953 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 108,860 | 111,660 | +2,800 | 0.00 | 0.00 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 129,531 | 104,080 | -25,451 | 0.04 | 0.03 | -0.01 | sell |
| Assenagon Asset Management S.A. | 67,153 | 103,955 | +36,802 | 0.00 | 0.01 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 60,679 | 99,726 | +39,047 | 0.00 | 0.01 | +0.00 | buy |
| Knott David M Jr | 93,058 | 95,058 | +2,000 | 1.87 | 1.86 | -0.01 | buy |
| Trexquant Investment LP | 75,298 | 93,539 | +18,241 | 0.02 | 0.02 | +0.00 | buy |
| Jain Global LLC | 0 | 91,647 | +91,647 | 0.00 | 0.04 | +0.04 | buy |
| CITIGROUP INC | 17,096 | 89,167 | +72,071 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 73,369 | 79,441 | +6,072 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 73,095 | +73,095 | 0.00 | 0.14 | +0.14 | buy |
| Exome Asset Management LLC | 125,060 | 70,500 | -54,560 | 2.49 | 1.61 | -0.88 | sell |
| Edgestream Partners, L.P. | 143,731 | 70,195 | -73,536 | 0.16 | 0.08 | -0.08 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 68,564 | 66,796 | -1,768 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 39,710 | 66,235 | +26,525 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 58,151 | 65,779 | +7,628 | 0.01 | 0.01 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 50,384 | 62,228 | +11,844 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 61,494 | 61,864 | +370 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 47,701 | 60,059 | +12,358 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 102,741 | 55,580 | -47,161 | 0.01 | 0.00 | -0.01 | sell |
| Engineers Gate Manager LP | 28,920 | 53,912 | +24,992 | 0.01 | 0.03 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 22,763 | 53,240 | +30,477 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 160,880 | 50,366 | -110,514 | 0.09 | 0.02 | -0.07 | sell |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0 | 49,764 | +49,764 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 52,438 | 48,300 | -4,138 | 0.00 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 43,005 | 46,550 | +3,545 | 0.12 | 0.12 | -0.00 | buy |
| Quantinno Capital Management LP | 27,591 | 43,514 | +15,923 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 35,814 | 43,009 | +7,195 | 0.03 | 0.04 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,071 | 41,455 | -616 | 0.00 | 0.00 | -0.00 | sell |
| IEQ CAPITAL, LLC | 0 | 40,404 | +40,404 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 30,959 | 39,473 | +8,514 | 0.29 | 0.34 | +0.05 | buy |
| Caption Management, LLC | 12,349 | 39,249 | +26,900 | 0.02 | 0.05 | +0.03 | buy |
| FMR LLC | 9,121 | 39,072 | +29,951 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 11,322 | 38,627 | +27,305 | 0.01 | 0.05 | +0.04 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 50,046 | 37,727 | -12,319 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 63,550 | 35,089 | -28,461 | 0.00 | 0.00 | -0.00 | sell |
| EDGEWOOD MANAGEMENT LLC | 35,000 | 35,000 | 0 | 0.01 | 0.01 | +0.01 | hold |
| MetLife Investment Management, LLC | 32,858 | 34,470 | +1,612 | 0.01 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 57,247 | 34,348 | -22,899 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 33,868 | 33,574 | -294 | 0.04 | 0.04 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 27,810 | 32,235 | +4,425 | 0.00 | 0.00 | +0.00 | buy |
| Bridgefront Capital, LLC | 6,551 | 31,097 | +24,546 | 0.06 | 0.30 | +0.25 | buy |
| Mariner, LLC | 0 | 29,139 | +29,139 | 0.00 | 0.00 | +0.00 | buy |