| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 5,654,502 | 5,660,866 | +6,364 | 1.44 | 1.38 | -0.06 | buy |
| VANGUARD GROUP INC | 5,496,737 | 5,545,982 | +49,245 | 0.00 | 0.00 | -0.00 | buy |
| Bellevue Group AG | 3,879,548 | 3,735,915 | -143,633 | 2.72 | 2.69 | -0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,777,259 | 2,832,512 | +55,253 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 2,114,949 | 2,331,433 | +216,484 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 2,079,151 | 2,207,070 | +127,919 | 2.35 | 2.56 | +0.22 | buy |
| Erste Asset Management GmbH | 2,254,900 | 2,184,900 | -70,000 | 1.29 | 1.16 | -0.12 | sell |
| JPMORGAN CHASE & CO | 1,776,145 | 1,712,990 | -63,155 | 0.01 | 0.01 | -0.00 | sell |
| MACQUARIE GROUP LTD | 1,729,729 | 1,690,801 | -38,928 | 0.09 | 0.08 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 2,196,085 | 1,562,183 | -633,902 | 0.02 | 0.02 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,351,430 | 1,357,531 | +6,101 | 0.01 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 1,133,735 | 1,263,285 | +129,550 | 0.07 | 0.07 | +0.00 | buy |
| BVF INC/IL | 1,190,107 | 1,190,107 | 0 | 1.44 | 1.55 | +0.11 | hold |
| Frazier Life Sciences Management, L.P. | 871,974 | 1,044,154 | +172,180 | 1.76 | 1.86 | +0.10 | buy |
| Polar Capital Holdings Plc | 0 | 1,002,036 | +1,002,036 | 0.00 | 0.21 | +0.21 | buy |
| BNP Paribas Asset Management Holding S.A. | 911,175 | 907,044 | -4,131 | 0.10 | 0.10 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 1,019,357 | 882,731 | -136,626 | 0.52 | 0.50 | -0.02 | sell |
| Fisher Asset Management, LLC | 709,912 | 855,328 | +145,416 | 0.01 | 0.02 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 760,000 | +760,000 | 0.00 | 2.66 | +2.66 | buy |
| Rock Springs Capital Management LP | 1,044,261 | 699,389 | -344,872 | 1.36 | 1.01 | -0.35 | sell |
| DEUTSCHE BANK AG\ | 662,236 | 669,615 | +7,379 | 0.01 | 0.01 | -0.00 | buy |
| GW&K Investment Management, LLC | 595,066 | 630,946 | +35,880 | 0.23 | 0.24 | +0.01 | buy |
| LOOMIS SAYLES & CO L P | 448,863 | 612,366 | +163,503 | 0.03 | 0.04 | +0.01 | buy |
| NORTHERN TRUST CORP | 586,266 | 590,108 | +3,842 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 514,711 | 579,717 | +65,006 | 5.19 | 8.16 | +2.98 | buy |
| D. E. Shaw & Co., Inc. | 678,234 | 532,404 | -145,830 | 0.04 | 0.03 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 549,003 | 476,657 | -72,346 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 457,527 | 465,620 | +8,093 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 422,044 | 400,849 | -21,195 | 0.02 | 0.02 | -0.00 | sell |
| Artisan Partners Limited Partnership | 320,467 | 391,842 | +71,375 | 0.02 | 0.03 | +0.01 | buy |
| MORGAN STANLEY | 596,675 | 348,973 | -247,702 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 326,780 | 333,075 | +6,295 | 0.00 | 0.00 | -0.00 | buy |
| Eagle Health Investments LP | 330,830 | 330,830 | 0 | 2.55 | 2.83 | +0.28 | hold |
| Parkman Healthcare Partners LLC | 446,416 | 285,099 | -161,317 | 2.62 | 1.62 | -1.00 | sell |
| Candriam S.C.A. | 322,882 | 261,505 | -61,377 | 0.08 | 0.07 | -0.02 | sell |
| AXA S.A. | 238,682 | 238,750 | +68 | 0.03 | 0.03 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 223,979 | 233,056 | +9,077 | 0.29 | 0.31 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 210,472 | 227,272 | +16,800 | 0.01 | 0.01 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 224,855 | 212,976 | -11,879 | 0.01 | 0.01 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 320,531 | 196,399 | -124,132 | 0.05 | 0.03 | -0.02 | sell |
| Cutter Capital Management, LP | 0 | 186,623 | +186,623 | 0.00 | 2.45 | +2.45 | buy |
| BARCLAYS PLC | 109,881 | 180,417 | +70,536 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 223,151 | 178,425 | -44,726 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 242,734 | 175,855 | -66,879 | 0.00 | 0.00 | -0.00 | sell |
| CenterBook Partners LP | 249,311 | 154,088 | -95,223 | 0.67 | 0.42 | -0.25 | sell |
| Granahan Investment Management, LLC | 136,838 | 150,785 | +13,947 | 0.24 | 0.26 | +0.03 | buy |
| Walleye Capital LLC | 19,910 | 144,020 | +124,110 | 0.01 | 0.07 | +0.06 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 137,844 | 143,431 | +5,587 | 0.01 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 33,164 | 138,142 | +104,978 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 176,815 | 126,505 | -50,310 | 0.01 | 0.01 | +0.00 | sell |
| Invesco Ltd. | 118,020 | 118,947 | +927 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 94,486 | 114,220 | +19,734 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 69,359 | 114,186 | +44,827 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 125,470 | 113,229 | -12,241 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 130,411 | 110,923 | -19,488 | 0.01 | 0.00 | -0.00 | sell |
| Allianz Asset Management GmbH | 111,558 | 109,058 | -2,500 | 0.01 | 0.01 | -0.00 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 101,730 | +101,730 | 0.00 | 0.20 | +0.20 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 60,000 | 100,000 | +40,000 | 0.06 | 0.13 | +0.07 | buy |
| Swiss National Bank | 99,460 | 99,760 | +300 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 101,180 | 94,223 | -6,957 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 76,853 | 89,498 | +12,645 | 0.01 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 24,830 | 84,417 | +59,587 | 0.00 | 0.01 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 0 | 79,885 | +79,885 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 31,087 | 77,930 | +46,843 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 74,142 | 74,273 | +131 | 0.52 | 0.49 | -0.03 | buy |
| AMERIPRISE FINANCIAL INC | 71,889 | 73,402 | +1,513 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 24,317 | 72,064 | +47,747 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 55,737 | 68,113 | +12,376 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 174,870 | 67,985 | -106,885 | 0.04 | 0.01 | -0.02 | sell |
| SECTOR GAMMA AS | 121,844 | 67,908 | -53,936 | 1.96 | 0.92 | -1.05 | sell |
| Exome Asset Management LLC | 0 | 66,200 | +66,200 | 0.00 | 1.99 | +1.99 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 35,634 | 63,740 | +28,106 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 65,122 | 60,792 | -4,330 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 115,000 | 60,000 | -55,000 | 0.04 | 0.02 | -0.02 | sell |
| PDT Partners, LLC | 75,280 | 56,735 | -18,545 | 0.31 | 0.22 | -0.08 | sell |
| PRUDENTIAL FINANCIAL INC | 107,852 | 49,522 | -58,330 | 0.01 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 49,830 | 48,729 | -1,101 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 0 | 46,162 | +46,162 | 0.00 | 0.22 | +0.22 | buy |
| FMR LLC | 11,847 | 45,393 | +33,546 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 43,708 | +43,708 | 0.00 | 0.18 | +0.18 | buy |
| ALPS ADVISORS INC | 44,292 | 43,006 | -1,286 | 0.01 | 0.01 | -0.00 | sell |
| State of New Jersey Common Pension Fund D | 48,943 | 42,593 | -6,350 | 0.01 | 0.01 | -0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 35,236 | 40,378 | +5,142 | 0.14 | 0.16 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 36,140 | 40,124 | +3,984 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOR CAPITAL ADVISORS, INC. | 32,770 | 39,090 | +6,320 | 0.11 | 0.08 | -0.03 | buy |
| WELLS FARGO & COMPANY/MN | 39,979 | 38,608 | -1,371 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 41,772 | 38,142 | -3,630 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 40,256 | 37,356 | -2,900 | 0.06 | 0.04 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 0 | 36,317 | +36,317 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 35,293 | 35,293 | 0 | 0.03 | 0.04 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,195 | 34,430 | -3,765 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 32,663 | 32,663 | 0 | 0.01 | 0.01 | -0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 36,498 | 32,461 | -4,037 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 31,920 | 31,920 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Schonfeld Strategic Advisors LLC | 464,121 | 31,022 | -433,099 | 0.16 | 0.01 | -0.14 | sell |
| Corebridge Financial, Inc. | 30,406 | 30,220 | -186 | 0.01 | 0.01 | -0.00 | sell |
| EDGEWOOD MANAGEMENT LLC | 30,000 | 30,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 36,419 | 29,448 | -6,971 | 0.00 | 0.00 | -0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 29,360 | 29,360 | 0 | 0.01 | 0.01 | -0.00 | hold |