| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 871,974 | 1,044,154 | +172,180 | 1.76 | 1.86 | +0.10 | buy |
| LOOMIS SAYLES & CO L P | 448,863 | 612,366 | +163,503 | 0.03 | 0.04 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 678,234 | 532,404 | +145,830 | 0.05 | 0.04 | 0.00 | sell |
| Fisher Asset Management, LLC | 709,912 | 855,328 | +145,416 | 0.01 | 0.02 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 2,079,151 | 2,207,070 | +127,919 | 1.13 | 1.57 | +0.44 | buy |
| Artisan Partners Limited Partnership | 320,467 | 391,842 | +71,375 | 0.02 | 0.03 | +0.01 | buy |
| Caligan Partners LP | 514,711 | 579,717 | +65,006 | 5.19 | 8.16 | +2.98 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,777,259 | 2,832,512 | +55,253 | 0.01 | 0.01 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 60,000 | 100,000 | +40,000 | 0.04 | 0.08 | +0.04 | buy |
| GW&K Investment Management, LLC | 595,066 | 630,946 | +35,880 | 0.23 | 0.24 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 210,472 | 227,272 | +16,800 | 0.01 | 0.01 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 37,281 | 22,273 | +15,008 | 0.01 | 0.00 | -0.00 | sell |
| Granahan Investment Management, LLC | 136,838 | 150,785 | +13,947 | 0.24 | 0.26 | +0.03 | buy |
| Rafferty Asset Management, LLC | 76,853 | 89,498 | +12,645 | 0.01 | 0.01 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 30,013 | 21,087 | +8,926 | 0.08 | 0.07 | 0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 32,770 | 39,090 | +6,320 | 0.11 | 0.08 | 0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 35,236 | 40,378 | +5,142 | 0.14 | 0.16 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 6,670 | 10,942 | +4,272 | 0.04 | 0.05 | +0.01 | buy |
| Gallagher Fiduciary Advisors, LLC | 6,940 | 10,322 | +3,382 | 0.07 | 0.09 | +0.03 | buy |
| PROFUND ADVISORS LLC | 14,773 | 18,111 | +3,338 | 0.02 | 0.03 | 0.00 | buy |
| ALGERT GLOBAL LLC | 40,256 | 37,356 | +2,900 | 0.06 | 0.04 | 0.00 | sell |
| NEOS Investment Management LLC | 21,745 | 23,208 | +1,463 | 0.04 | 0.03 | -0.01 | buy |
| Inspire Investing, LLC | 8,115 | 9,228 | +1,113 | 0.04 | 0.04 | +0.00 | buy |
| E Fund Management Co., Ltd. | 4,668 | 5,751 | +1,083 | 0.01 | 0.01 | +0.00 | buy |
| Informed Momentum Co LLC | 74,142 | 74,273 | +131 | 0.52 | 0.49 | -0.03 | buy |
| ALPS ADVISORS INC | 44,292 | 43,006 | -1,286 | 0.01 | 0.01 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 911,175 | 907,044 | -4,131 | 0.10 | 0.10 | -0.00 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 224,855 | 212,976 | -11,879 | 0.01 | 0.01 | -0.00 | sell |
| PDT Partners, LLC | 75,280 | 56,735 | -18,545 | 0.31 | 0.22 | -0.08 | sell |
| SECTOR GAMMA AS | 121,844 | 67,908 | -53,936 | 1.96 | 0.92 | -1.05 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 83,661 | 29,127 | -54,534 | 0.08 | 0.03 | -0.05 | sell |
| Hudson Bay Capital Management LP | 115,000 | 60,000 | -55,000 | 0.02 | 0.01 | -0.01 | sell |
| Candriam S.C.A. | 322,882 | 261,505 | -61,377 | 0.08 | 0.07 | -0.02 | sell |
| Erste Asset Management GmbH | 2,254,900 | 2,184,900 | -70,000 | 1.29 | 1.16 | -0.12 | sell |
| CenterBook Partners LP | 249,311 | 154,088 | -95,223 | 0.67 | 0.42 | -0.25 | sell |
| ArrowMark Colorado Holdings LLC | 1,019,357 | 882,731 | -136,626 | 0.52 | 0.50 | -0.02 | sell |
| Bellevue Group AG | 3,879,548 | 3,735,915 | -143,633 | 2.72 | 2.69 | -0.03 | sell |
| Parkman Healthcare Partners LLC | 446,416 | 285,099 | -161,317 | 2.62 | 1.62 | -1.00 | sell |
| Rock Springs Capital Management LP | 1,044,261 | 699,389 | -344,872 | 1.36 | 1.01 | -0.34 | sell |