| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 5,767,466 | 5,781,066 | +13,600 | 0.87 | 1.31 | +0.44 | buy |
| VANGUARD GROUP INC | 5,682,019 | 5,604,876 | -77,143 | 0.00 | 0.00 | +0.00 | sell |
| BlackRock, Inc. | 4,833,760 | 4,545,738 | -288,022 | 0.00 | 0.00 | +0.00 | sell |
| Bellevue Group AG | 3,590,150 | 3,714,736 | +124,586 | 2.63 | 3.10 | +0.47 | buy |
| Erste Asset Management GmbH | 2,326,489 | 2,764,900 | +438,411 | 0.65 | 1.05 | +0.40 | buy |
| Paradigm Biocapital Advisors LP | 1,142,511 | 2,673,555 | +1,531,044 | 1.62 | 3.18 | +1.55 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 422,129 | 2,471,416 | +2,049,287 | 0.00 | 0.02 | +0.01 | buy |
| Commodore Capital LP | 2,325,000 | 2,338,287 | +13,287 | 5.46 | 4.58 | -0.88 | buy |
| STATE STREET CORP | 1,951,113 | 2,262,712 | +311,599 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 1,900,596 | 1,958,101 | +57,505 | 0.08 | 0.09 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,274,249 | 1,656,938 | -617,311 | 0.01 | 0.01 | -0.00 | sell |
| TCG Crossover Management, LLC | 697,003 | 1,430,041 | +733,038 | 2.65 | 2.82 | +0.18 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,405,755 | 1,416,315 | +10,560 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 1,279,754 | 1,279,754 | 0 | 1.70 | 1.54 | -0.16 | hold |
| Caligan Partners LP | 1,071,258 | 1,131,205 | +59,947 | 6.92 | 6.30 | -0.62 | buy |
| BANK OF AMERICA CORP /DE/ | 1,120,308 | 1,130,000 | +9,692 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,106,093 | 1,021,201 | -84,892 | 0.01 | 0.01 | +0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,016,891 | 987,339 | -29,552 | 0.08 | 0.10 | +0.02 | sell |
| Rock Springs Capital Management LP | 989,745 | 958,542 | -31,203 | 2.05 | 2.25 | +0.20 | sell |
| DEUTSCHE BANK AG\ | 921,586 | 926,734 | +5,148 | 0.01 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 877,540 | 870,145 | -7,395 | 0.01 | 0.01 | +0.00 | sell |
| GW&K Investment Management, LLC | 868,618 | 852,942 | -15,676 | 0.26 | 0.30 | +0.04 | sell |
| GOLDMAN SACHS GROUP INC | 648,061 | 804,766 | +156,705 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 791,000 | 800,000 | +9,000 | 0.04 | 0.05 | +0.01 | buy |
| ARMISTICE CAPITAL, LLC | 1,168,000 | 764,000 | -404,000 | 1.47 | 0.96 | -0.51 | sell |
| ArrowMark Colorado Holdings LLC | 658,691 | 679,922 | +21,231 | 0.39 | 0.51 | +0.11 | buy |
| SCS Capital Management LLC | 604,085 | 598,765 | -5,320 | 0.22 | 0.26 | +0.04 | sell |
| NORTHERN TRUST CORP | 556,805 | 555,410 | -1,395 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 505,225 | 530,098 | +24,873 | 0.06 | 0.07 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 495,491 | +495,491 | 0.00 | 0.04 | +0.04 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 447,019 | 495,341 | +48,322 | 0.45 | 0.50 | +0.05 | buy |
| CITADEL ADVISORS LLC | 1,081,470 | 491,982 | -589,488 | 0.03 | 0.02 | -0.02 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 476,041 | 482,186 | +6,145 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 291,965 | 416,998 | +125,033 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 389,984 | 402,943 | +12,959 | 0.02 | 0.02 | +0.00 | buy |
| JANE STREET GROUP, LLC | 33,489 | 395,120 | +361,631 | 0.00 | 0.02 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 596,202 | 367,749 | -228,453 | 0.02 | 0.01 | -0.01 | sell |
| Legal & General Group Plc | 64,305 | 322,934 | +258,629 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 294,740 | 272,161 | -22,579 | 0.01 | 0.01 | +0.00 | sell |
| Bank of New York Mellon Corp | 266,654 | 270,096 | +3,442 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 268,783 | 265,497 | -3,286 | 1.90 | 1.97 | +0.07 | sell |
| SummitTX Capital, L.P. | 0 | 262,977 | +262,977 | 0.00 | 0.44 | +0.44 | buy |
| Eagle Health Investments LP | 330,830 | 246,230 | -84,600 | 2.72 | 2.59 | -0.12 | sell |
| UBS Group AG | 118,834 | 242,813 | +123,979 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 684,669 | 226,824 | -457,845 | 0.03 | 0.01 | -0.02 | sell |
| BARCLAYS PLC | 180,704 | 216,040 | +35,336 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 70,127 | 195,298 | +125,171 | 0.86 | 1.92 | +1.06 | buy |
| BAKER BROS. ADVISORS LP | 189,866 | 189,866 | 0 | 0.06 | 0.06 | -0.01 | hold |
| JPMORGAN CHASE & CO | 1,027,417 | 183,100 | -844,317 | 0.00 | 0.00 | -0.00 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 162,905 | +162,905 | 0.00 | 0.20 | +0.20 | buy |
| Allianz Asset Management GmbH | 138,898 | 146,643 | +7,745 | 0.01 | 0.01 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 146,514 | +146,514 | 0.00 | 0.02 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 127,647 | 145,121 | +17,474 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 139,732 | 133,827 | -5,905 | 1.68 | 1.44 | -0.24 | sell |
| TD ASSET MANAGEMENT INC | 168,194 | 128,294 | -39,900 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 0 | 127,000 | +127,000 | 0.00 | 0.23 | +0.23 | buy |
| Ikarian Capital, LLC | 0 | 126,979 | +126,979 | 0.00 | 1.03 | +1.03 | buy |
| Invesco Ltd. | 112,617 | 126,976 | +14,359 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 130,000 | 122,500 | -7,500 | 0.03 | 0.03 | +0.00 | sell |
| Nuveen, LLC | 119,580 | 119,580 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 217,402 | 106,875 | -110,527 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 109,460 | 106,660 | -2,800 | 0.00 | 0.00 | +0.00 | sell |
| Parkman Healthcare Partners LLC | 0 | 100,380 | +100,380 | 0.00 | 0.44 | +0.44 | buy |
| Nantahala Capital Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.25 | +0.25 | buy |
| PRUDENTIAL FINANCIAL INC | 158,359 | 98,239 | -60,120 | 0.01 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 132,083 | 96,012 | -36,071 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 96,896 | 91,635 | -5,261 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 0 | 87,900 | +87,900 | 0.00 | 0.05 | +0.05 | buy |
| RHUMBLINE ADVISERS | 89,881 | 87,702 | -2,179 | 0.00 | 0.00 | +0.00 | sell |
| FIRST TRUST ADVISORS LP | 36,427 | 74,429 | +38,002 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 233,068 | 73,996 | -159,072 | 0.04 | 0.01 | -0.03 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 55,284 | 71,213 | +15,929 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 49,403 | 68,220 | +18,817 | 0.01 | 0.01 | +0.00 | buy |
| Assenagon Asset Management S.A. | 0 | 67,153 | +67,153 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 61,470 | 61,503 | +33 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 47,659 | 61,296 | +13,637 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 59,629 | +59,629 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 80,000 | 55,000 | -25,000 | 0.05 | 0.04 | -0.01 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 39,093 | 49,790 | +10,697 | 0.00 | 0.00 | +0.00 | buy |
| Phocas Financial Corp. | 0 | 46,608 | +46,608 | 0.00 | 0.24 | +0.24 | buy |
| WELLS FARGO & COMPANY/MN | 37,694 | 44,754 | +7,060 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 56,489 | 43,620 | -12,869 | 0.00 | 0.00 | -0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 49,661 | 41,061 | -8,600 | 0.01 | 0.01 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERIPRISE FINANCIAL INC | 52,252 | 38,428 | -13,824 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 35,900 | 37,000 | +1,100 | 0.19 | 0.15 | -0.05 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 39,579 | 36,592 | -2,987 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 88,830 | 35,770 | -53,060 | 0.06 | 0.02 | -0.04 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 59,100 | 35,573 | -23,527 | 0.00 | 0.00 | -0.00 | sell |
| EDGEWOOD MANAGEMENT LLC | 35,000 | 35,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOR CAPITAL ADVISORS, INC. | 37,024 | 34,835 | -2,189 | 0.05 | 0.11 | +0.06 | sell |
| MetLife Investment Management, LLC | 34,032 | 34,032 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SEI INVESTMENTS CO | 10,326 | 32,300 | +21,974 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 29,414 | 30,232 | +818 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 27,650 | +27,650 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 31,274 | 27,554 | -3,720 | 0.01 | 0.01 | +0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 15,005 | 25,501 | +10,496 | 0.02 | 0.04 | +0.02 | buy |
| OAK RIDGE INVESTMENTS LLC | 37,252 | 25,385 | -11,867 | 0.09 | 0.07 | -0.02 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 36,705 | 24,641 | -12,064 | 0.03 | 0.02 | -0.01 | sell |
| JANUS HENDERSON GROUP PLC | 23,797 | 23,797 | 0 | 0.00 | 0.00 | +0.00 | hold |