| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 5,660,866 | 5,674,466 | +13,600 | 1.38 | 0.98 | -0.40 | buy |
| VANGUARD GROUP INC | 5,545,982 | 5,631,321 | +85,339 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 5,021,767 | 5,016,260 | -5,507 | 0.00 | 0.00 | -0.00 | sell |
| Bellevue Group AG | 3,735,915 | 3,515,150 | -220,765 | 2.69 | 2.22 | -0.47 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,832,512 | 2,423,537 | -408,975 | 0.01 | 0.01 | -0.01 | sell |
| ARMISTICE CAPITAL, LLC | 2,207,070 | 2,264,304 | +57,234 | 2.56 | 1.73 | -0.83 | buy |
| STATE STREET CORP | 2,331,433 | 2,152,277 | -179,156 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 2,184,900 | 2,009,900 | -175,000 | 1.16 | 0.81 | -0.35 | sell |
| MACQUARIE GROUP LTD | 1,690,801 | 1,684,993 | -5,808 | 0.08 | 0.07 | -0.01 | sell |
| Jefferies Financial Group Inc. | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.55 | +0.55 | buy |
| CITADEL ADVISORS LLC | 11,736 | 1,433,676 | +1,421,940 | 0.00 | 0.04 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,357,531 | 1,349,651 | -7,880 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,562,183 | 1,329,065 | -233,118 | 0.02 | 0.01 | -0.01 | sell |
| BVF INC/IL | 1,190,107 | 1,073,755 | -116,352 | 1.55 | 1.20 | -0.35 | sell |
| Frazier Life Sciences Management, L.P. | 1,044,154 | 1,069,754 | +25,600 | 1.86 | 1.46 | -0.40 | buy |
| JPMORGAN CHASE & CO | 1,712,990 | 1,015,360 | -697,630 | 0.01 | 0.00 | -0.00 | sell |
| Fisher Asset Management, LLC | 855,328 | 960,661 | +105,333 | 0.02 | 0.01 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 907,044 | 942,189 | +35,145 | 0.10 | 0.08 | -0.02 | buy |
| DEUTSCHE BANK AG\ | 669,615 | 935,252 | +265,637 | 0.01 | 0.01 | -0.00 | buy |
| ArrowMark Colorado Holdings LLC | 882,731 | 917,420 | +34,689 | 0.50 | 0.41 | -0.10 | buy |
| GW&K Investment Management, LLC | 630,946 | 683,463 | +52,517 | 0.24 | 0.19 | -0.05 | buy |
| MARSHALL WACE, LLP | 1,263,285 | 631,628 | -631,657 | 0.07 | 0.03 | -0.05 | sell |
| Polar Capital Holdings Plc | 1,002,036 | 627,036 | -375,000 | 0.21 | 0.12 | -0.10 | sell |
| Caligan Partners LP | 579,717 | 626,280 | +46,563 | 8.16 | 5.21 | -2.95 | buy |
| NORTHERN TRUST CORP | 590,108 | 595,480 | +5,372 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 476,657 | 567,170 | +90,513 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 532,404 | 516,475 | -15,929 | 0.03 | 0.02 | -0.01 | sell |
| Artisan Partners Limited Partnership | 391,842 | 499,134 | +107,292 | 0.03 | 0.03 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 465,620 | 472,547 | +6,927 | 0.00 | 0.00 | -0.00 | buy |
| Rock Springs Capital Management LP | 699,389 | 471,086 | -228,303 | 1.01 | 0.59 | -0.42 | sell |
| LOOMIS SAYLES & CO L P | 612,366 | 417,208 | -195,158 | 0.04 | 0.02 | -0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 333,075 | 404,902 | +71,827 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 348,973 | 378,089 | +29,116 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 400,849 | 354,455 | -46,394 | 0.02 | 0.01 | -0.01 | sell |
| Eagle Health Investments LP | 330,830 | 330,830 | 0 | 2.83 | 2.67 | -0.17 | hold |
| CenterBook Partners LP | 154,088 | 305,599 | +151,511 | 0.42 | 0.60 | +0.18 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 303,000 | +303,000 | 0.00 | 0.02 | +0.02 | buy |
| Cutter Capital Management, LP | 186,623 | 301,623 | +115,000 | 2.45 | 4.06 | +1.61 | buy |
| Paradigm Biocapital Advisors LP | 0 | 276,439 | +276,439 | 0.00 | 0.32 | +0.32 | buy |
| Bank of New York Mellon Corp | 178,425 | 265,514 | +87,089 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 233,056 | 251,774 | +18,718 | 0.31 | 0.25 | -0.06 | buy |
| Casdin Capital, LLC | 0 | 250,000 | +250,000 | 0.00 | 0.55 | +0.55 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 248,038 | +248,038 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 114,186 | 234,343 | +120,157 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 212,976 | 220,569 | +7,593 | 0.01 | 0.01 | -0.00 | buy |
| JANE STREET GROUP, LLC | 126,505 | 214,027 | +87,522 | 0.01 | 0.01 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 196,399 | 200,481 | +4,082 | 0.03 | 0.02 | -0.01 | buy |
| Qube Research & Technologies Ltd | 84,417 | 199,970 | +115,553 | 0.01 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 144,020 | 199,538 | +55,518 | 0.07 | 0.06 | -0.01 | buy |
| CITIGROUP INC | 72,064 | 193,152 | +121,088 | 0.00 | 0.01 | +0.00 | buy |
| AXA S.A. | 238,750 | 175,377 | -63,373 | 0.03 | 0.02 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 19,220 | 170,504 | +151,284 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 261,505 | 169,550 | -91,955 | 0.07 | 0.03 | -0.03 | sell |
| TD ASSET MANAGEMENT INC | 227,272 | 165,672 | -61,600 | 0.01 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 162,415 | +162,415 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 175,855 | 145,092 | -30,763 | 0.00 | 0.00 | -0.00 | sell |
| TWINBEECH CAPITAL LP | 0 | 141,073 | +141,073 | 0.00 | 0.08 | +0.08 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 22,273 | 125,678 | +103,405 | 0.00 | 0.02 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 113,229 | 122,835 | +9,606 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 143,431 | 122,094 | -21,337 | 0.01 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 180,417 | 121,753 | -58,664 | 0.00 | 0.00 | -0.00 | sell |
| Patient Square Capital LP | 0 | 121,732 | +121,732 | 0.00 | 1.50 | +1.50 | buy |
| Allianz Asset Management GmbH | 109,058 | 118,580 | +9,522 | 0.01 | 0.01 | -0.00 | buy |
| Granahan Investment Management, LLC | 150,785 | 115,687 | -35,098 | 0.26 | 0.16 | -0.10 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 29,127 | 111,098 | +81,971 | 0.03 | 0.08 | +0.05 | buy |
| Hudson Bay Capital Management LP | 60,000 | 110,000 | +50,000 | 0.02 | 0.02 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 109,373 | +109,373 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 49,522 | 104,922 | +55,400 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 114,220 | 104,837 | -9,383 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 46,162 | 104,404 | +58,242 | 0.22 | 0.14 | -0.08 | buy |
| Swiss National Bank | 99,760 | 100,760 | +1,000 | 0.00 | 0.00 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 110,923 | 97,259 | -13,664 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 94,223 | 94,508 | +285 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 118,947 | 83,515 | -35,432 | 0.00 | 0.00 | -0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 79,885 | 83,157 | +3,272 | 0.02 | 0.02 | -0.01 | buy |
| Legal & General Group Plc | 68,113 | 71,677 | +3,564 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 89,498 | 70,313 | -19,185 | 0.01 | 0.01 | -0.01 | sell |
| Trexquant Investment LP | 24,966 | 69,971 | +45,005 | 0.01 | 0.03 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 32,461 | 68,321 | +35,860 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 36,317 | 66,461 | +30,144 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 60,792 | 61,500 | +708 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 24,013 | 60,205 | +36,192 | 0.02 | 0.03 | +0.01 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 100,000 | 60,000 | -40,000 | 0.13 | 0.04 | -0.09 | sell |
| GSA CAPITAL PARTNERS LLP | 0 | 53,229 | +53,229 | 0.00 | 0.13 | +0.13 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,729 | 48,255 | -474 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 10,727 | 47,326 | +36,599 | 0.02 | 0.04 | +0.02 | buy |
| PANAGORA ASSET MANAGEMENT INC | 67,985 | 47,221 | -20,764 | 0.01 | 0.01 | -0.01 | sell |
| Verition Fund Management LLC | 7,097 | 46,825 | +39,728 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 43,006 | 46,111 | +3,105 | 0.01 | 0.01 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 45,817 | +45,817 | 0.00 | 0.10 | +0.10 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 21,087 | 43,330 | +22,243 | 0.02 | 0.04 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,124 | 40,407 | +283 | 0.00 | 0.00 | -0.00 | buy |
| DekaBank Deutsche Girozentrale | 40,000 | 40,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERIPRISE FINANCIAL INC | 73,402 | 39,262 | -34,140 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 34,430 | 39,093 | +4,663 | 0.00 | 0.00 | -0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 40,378 | 38,869 | -1,509 | 0.16 | 0.10 | -0.06 | sell |
| State of New Jersey Common Pension Fund D | 42,593 | 38,580 | -4,013 | 0.01 | 0.01 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 38,608 | 34,808 | -3,800 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 32,663 | 34,579 | +1,916 | 0.01 | 0.01 | -0.00 | buy |
| ROYAL BANK OF CANADA | 38,142 | 34,343 | -3,799 | 0.00 | 0.00 | -0.00 | sell |