| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CenterBook Partners LP | 154,088 | 305,599 | +151,511 | 0.42 | 0.60 | +0.18 | buy |
| Cutter Capital Management, LP | 186,623 | 301,623 | +115,000 | 2.45 | 4.06 | +1.61 | buy |
| Artisan Partners Limited Partnership | 391,842 | 499,134 | +107,292 | 0.03 | 0.02 | -0.00 | buy |
| Fisher Asset Management, LLC | 855,328 | 960,661 | +105,333 | 0.02 | 0.01 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 22,273 | 125,678 | +103,405 | 0.00 | 0.02 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 29,127 | 111,098 | +81,971 | 0.03 | 0.08 | +0.05 | buy |
| ARMISTICE CAPITAL, LLC | 2,207,070 | 2,264,304 | +57,234 | 1.57 | 1.02 | -0.55 | buy |
| Walleye Capital LLC | 144,020 | 199,538 | +55,518 | 0.09 | 0.07 | 0.00 | buy |
| GW&K Investment Management, LLC | 630,946 | 683,463 | +52,517 | 0.24 | 0.19 | -0.05 | buy |
| Hudson Bay Capital Management LP | 60,000 | 110,000 | +50,000 | 0.01 | 0.01 | +0.00 | buy |
| Caligan Partners LP | 579,717 | 626,280 | +46,563 | 8.16 | 5.21 | -2.95 | buy |
| Brevan Howard Capital Management LP | 10,727 | 47,326 | +36,599 | 0.00 | 0.01 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 907,044 | 942,189 | +35,145 | 0.10 | 0.08 | -0.02 | buy |
| ArrowMark Colorado Holdings LLC | 882,731 | 917,420 | +34,689 | 0.50 | 0.41 | -0.10 | buy |
| Frazier Life Sciences Management, L.P. | 1,044,154 | 1,069,754 | +25,600 | 1.86 | 1.46 | -0.40 | buy |
| ALGERT GLOBAL LLC | 37,356 | 12,240 | +25,116 | 0.04 | 0.01 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 21,087 | 43,330 | +22,243 | 0.07 | 0.11 | 0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 212,976 | 220,569 | +7,593 | 0.01 | 0.01 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 39,090 | 33,767 | +5,323 | 0.08 | 0.05 | 0.00 | sell |
| PROFUND ADVISORS LLC | 18,111 | 14,177 | +3,934 | 0.03 | 0.02 | 0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 29,360 | 32,790 | +3,430 | 9.40 | 46.81 | +37.41 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 79,885 | 83,157 | +3,272 | 0.02 | 0.02 | -0.01 | buy |
| Inspire Investing, LLC | 9,228 | 12,384 | +3,156 | 0.04 | 0.05 | +0.00 | buy |
| ALPS ADVISORS INC | 43,006 | 46,111 | +3,105 | 0.01 | 0.01 | -0.00 | buy |
| NEOS Investment Management LLC | 23,208 | 25,735 | +2,527 | 0.03 | 0.02 | -0.01 | buy |
| VIRTUS ADVISERS, LLC | 7,042 | 9,160 | +2,118 | 0.15 | 0.12 | -0.02 | buy |
| STRS OHIO | 21,400 | 22,900 | +1,500 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,942 | 12,092 | +1,150 | 0.05 | 0.04 | -0.02 | buy |
| Gallagher Fiduciary Advisors, LLC | 10,322 | 11,110 | +788 | 0.09 | 0.07 | -0.02 | buy |
| Johnson Financial Group, Inc. | 76 | 60 | -16 | 0.00 | 0.00 | -0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 40,378 | 38,869 | -1,509 | 0.16 | 0.10 | -0.06 | sell |
| Rafferty Asset Management, LLC | 89,498 | 70,313 | -19,185 | 0.01 | 0.01 | -0.01 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 35,293 | 15,520 | -19,773 | 0.04 | 0.01 | -0.02 | sell |
| Granahan Investment Management, LLC | 150,785 | 115,687 | -35,098 | 0.26 | 0.16 | -0.10 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 100,000 | 60,000 | -40,000 | 0.08 | 0.02 | -0.06 | sell |
| PDT Partners, LLC | 56,735 | 8,485 | -48,250 | 0.22 | 0.02 | -0.20 | sell |
| TD ASSET MANAGEMENT INC | 227,272 | 165,672 | -61,600 | 0.01 | 0.00 | -0.00 | sell |
| BVF INC/IL | 1,190,107 | 1,073,755 | -116,352 | 1.55 | 1.20 | -0.35 | sell |
| Candriam S.C.A. | 322,882 | 169,550 | -153,332 | 0.08 | 0.03 | -0.05 | sell |
| Erste Asset Management GmbH | 2,184,900 | 2,009,900 | -175,000 | 1.16 | 0.81 | -0.35 | sell |
| LOOMIS SAYLES & CO L P | 612,366 | 417,208 | -195,158 | 0.04 | 0.02 | -0.02 | sell |
| Bellevue Group AG | 3,735,915 | 3,515,150 | -220,765 | 2.69 | 2.22 | -0.47 | sell |
| Rock Springs Capital Management LP | 699,389 | 471,086 | -228,303 | 1.01 | 0.59 | -0.42 | sell |
| Polar Capital Holdings Plc | 1,002,036 | 627,036 | -375,000 | 0.21 | 0.12 | -0.10 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,832,512 | 2,423,537 | -408,975 | 0.01 | 0.01 | -0.01 | sell |