| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 5,604,876 | 5,594,353 | -10,523 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 4,545,738 | 5,235,429 | +689,691 | 0.00 | 0.00 | -0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 5,781,066 | 5,159,505 | -621,561 | 1.31 | 0.73 | -0.58 | sell |
| STATE STREET CORP | 2,262,712 | 3,108,145 | +845,433 | 0.00 | 0.00 | -0.00 | buy |
| ARMISTICE CAPITAL, LLC | 764,000 | 3,036,000 | +2,272,000 | 0.96 | 2.02 | +1.06 | buy |
| Erste Asset Management GmbH | 2,764,900 | 2,804,900 | +40,000 | 1.05 | 0.64 | -0.41 | buy |
| D. E. Shaw & Co., Inc. | 367,749 | 1,837,186 | +1,469,437 | 0.01 | 0.04 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,416,315 | 1,413,538 | -2,777 | 0.00 | 0.00 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 987,339 | 1,360,730 | +373,391 | 0.10 | 0.04 | -0.06 | buy |
| CITADEL ADVISORS LLC | 491,982 | 1,348,968 | +856,986 | 0.02 | 0.02 | +0.01 | buy |
| MPM BioImpact LLC | 0 | 1,303,373 | +1,303,373 | 0.00 | 4.06 | +4.06 | buy |
| Frazier Life Sciences Management, L.P. | 1,279,754 | 1,279,754 | 0 | 1.54 | 0.94 | -0.60 | hold |
| GW&K Investment Management, LLC | 852,942 | 1,207,301 | +354,359 | 0.30 | 0.28 | -0.02 | buy |
| TCG Crossover Management, LLC | 1,430,041 | 1,181,841 | -248,200 | 2.82 | 1.06 | -1.76 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 1,142,432 | +1,142,432 | 0.00 | 0.04 | +0.04 | buy |
| JANE STREET GROUP, LLC | 395,120 | 1,121,050 | +725,930 | 0.02 | 0.04 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 804,766 | 1,033,974 | +229,208 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,021,201 | 1,004,341 | -16,860 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 416,998 | 894,037 | +477,039 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 958,542 | 799,163 | -159,379 | 2.25 | 1.12 | -1.13 | sell |
| Capital International Investors | 0 | 703,865 | +703,865 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,656,938 | 637,886 | -1,019,052 | 0.01 | 0.00 | -0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 495,491 | 635,069 | +139,578 | 0.04 | 0.03 | -0.01 | buy |
| SCS Capital Management LLC | 598,765 | 598,765 | 0 | 0.26 | 0.17 | -0.09 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 2,471,416 | 597,826 | -1,873,590 | 0.02 | 0.00 | -0.01 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 530,098 | 562,642 | +32,544 | 0.07 | 0.04 | -0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 1,130,000 | 539,341 | -590,659 | 0.00 | 0.00 | -0.00 | sell |
| Foresite Capital Management VI LLC | 0 | 530,000 | +530,000 | 0.00 | 4.36 | +4.36 | buy |
| NORTHERN TRUST CORP | 555,410 | 511,901 | -43,509 | 0.00 | 0.00 | -0.00 | sell |
| Artisan Partners Limited Partnership | 402,943 | 504,485 | +101,542 | 0.02 | 0.02 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 482,186 | 482,622 | +436 | 0.00 | 0.00 | -0.00 | buy |
| ArrowMark Colorado Holdings LLC | 679,922 | 466,151 | -213,771 | 0.51 | 0.28 | -0.23 | sell |
| ALGERT GLOBAL LLC | 35,770 | 414,218 | +378,448 | 0.02 | 0.18 | +0.15 | buy |
| MILLENNIUM MANAGEMENT LLC | 5,049 | 398,267 | +393,218 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 378,373 | +378,373 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 226,824 | 353,639 | +126,815 | 0.01 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 322,934 | 328,211 | +5,277 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 127,000 | 325,000 | +198,000 | 0.23 | 0.32 | +0.09 | buy |
| BARCLAYS PLC | 216,040 | 320,352 | +104,312 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 59,629 | 300,156 | +240,527 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 119,580 | 297,908 | +178,328 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 183,100 | 251,777 | +68,677 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 14,698 | 242,670 | +227,972 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 226,600 | +226,600 | 0.00 | 0.05 | +0.05 | buy |
| Palo Alto Investors LP | 265,497 | 212,499 | -52,998 | 1.97 | 0.81 | -1.17 | sell |
| Pictet Asset Management Holding SA | 272,161 | 205,019 | -67,142 | 0.01 | 0.01 | -0.00 | sell |
| Point72 Asset Management, L.P. | 6,507 | 200,000 | +193,493 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 270,096 | 196,893 | -73,203 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 37,000 | 188,000 | +151,000 | 0.15 | 0.38 | +0.24 | buy |
| Edgestream Partners, L.P. | 0 | 167,998 | +167,998 | 0.00 | 0.13 | +0.13 | buy |
| GROUP ONE TRADING LLC | 0 | 166,614 | +166,614 | 0.00 | 0.13 | +0.13 | buy |
| TFG Asset Management GP Ltd | 0 | 162,018 | +162,018 | 0.00 | 0.93 | +0.93 | buy |
| AMERICAN CENTURY COMPANIES INC | 145,121 | 151,486 | +6,365 | 0.00 | 0.00 | -0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 55,000 | 150,000 | +95,000 | 0.04 | 0.08 | +0.04 | buy |
| Allianz Asset Management GmbH | 146,643 | 147,950 | +1,307 | 0.01 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 195,298 | 147,662 | -47,636 | 1.92 | 1.04 | -0.89 | sell |
| HRT FINANCIAL LP | 0 | 146,469 | +146,469 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 126,976 | 142,580 | +15,604 | 0.00 | 0.00 | -0.00 | buy |
| Exome Asset Management LLC | 0 | 136,942 | +136,942 | 0.00 | 1.84 | +1.84 | buy |
| UBS Group AG | 242,813 | 126,665 | -116,148 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 926,734 | 122,875 | -803,859 | 0.01 | 0.00 | -0.01 | sell |
| Squarepoint Ops LLC | 0 | 121,763 | +121,763 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 126,979 | 115,489 | -11,490 | 1.03 | 0.41 | -0.62 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 111,150 | +111,150 | 0.00 | 0.01 | +0.01 | buy |
| Assenagon Asset Management S.A. | 67,153 | 110,440 | +43,287 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 106,660 | 108,860 | +2,200 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 68,220 | 107,490 | +39,270 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 106,875 | 106,996 | +121 | 0.00 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 122,500 | 100,000 | -22,500 | 0.03 | 0.02 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 100,380 | 99,604 | -776 | 0.44 | 0.26 | -0.18 | sell |
| Caption Management, LLC | 17,494 | 93,486 | +75,992 | 0.04 | 0.11 | +0.07 | buy |
| CITIGROUP INC | 43,620 | 88,238 | +44,618 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 13,600 | 85,200 | +71,600 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 98,239 | 81,055 | -17,184 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 0 | 79,840 | +79,840 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 7,932 | 79,831 | +71,899 | 0.01 | 0.05 | +0.04 | buy |
| Lynx1 Capital Management LP | 0 | 79,624 | +79,624 | 0.00 | 0.44 | +0.44 | buy |
| FIRST TRUST ADVISORS LP | 74,429 | 78,656 | +4,227 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 73,996 | 74,423 | +427 | 0.01 | 0.01 | -0.01 | buy |
| RHUMBLINE ADVISERS | 87,702 | 74,153 | -13,549 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 71,146 | +71,146 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 96,012 | 70,256 | -25,756 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 24,641 | 65,655 | +41,014 | 0.02 | 0.04 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 44,754 | 64,772 | +20,018 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 61,503 | 61,494 | -9 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 61,345 | +61,345 | 0.00 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 71,213 | 60,560 | -10,653 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 128,294 | 57,292 | -71,002 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 61,296 | 53,239 | -8,057 | 0.00 | 0.00 | -0.00 | sell |
| Headlands Technologies LLC | 0 | 52,739 | +52,739 | 0.00 | 0.12 | +0.12 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 49,790 | 51,707 | +1,917 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 49,128 | +49,128 | 0.00 | 0.02 | +0.02 | buy |
| ALPS ADVISORS INC | 27,554 | 47,881 | +20,327 | 0.01 | 0.01 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 47,414 | +47,414 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 27,650 | 46,451 | +18,801 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 46,242 | +46,242 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 46,039 | +46,039 | 0.00 | 0.03 | +0.03 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 41,061 | 41,361 | +300 | 0.01 | 0.01 | -0.00 | buy |
| Freestone Grove Partners LP | 15,424 | 40,841 | +25,417 | 0.00 | 0.01 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 40,000 | 40,000 | 0 | 0.00 | 0.00 | -0.00 | hold |