| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Telemark Asset Management, LLC | 1,326,000 | 8,282,490 | +6,956,490 | 0.20 | 1.14 | +0.95 | buy |
| Soleus Capital Management, L.P. | 0 | 6,111,964 | +6,111,964 | 0.00 | 0.82 | +0.82 | buy |
| Sio Capital Management, LLC | 0 | 4,347,855 | +4,347,855 | 0.00 | 2.51 | +2.51 | buy |
| Opaleye Management Inc. | 534,657 | 4,020,000 | +3,485,343 | 0.17 | 1.41 | +1.24 | buy |
| Monashee Investment Management LLC | 0 | 3,260,879 | +3,260,879 | 0.00 | 0.65 | +0.65 | buy |
| AIGH Capital Management LLC | 3,321,085 | 5,779,812 | +2,458,727 | 2.29 | 4.32 | +2.03 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 2,173,880 | +2,173,880 | 0.00 | 0.08 | +0.08 | buy |
| VANGUARD GROUP INC | 807,928 | 2,906,504 | +2,098,576 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 1,878,175 | +1,878,175 | 0.00 | 0.02 | +0.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 1,808,959 | +1,808,959 | 0.00 | 0.68 | +0.68 | buy |
| LMR Partners LLP | 0 | 1,600,000 | +1,600,000 | 0.00 | 0.05 | +0.05 | buy |
| AMH Equity Ltd | 0 | 696,073 | +696,073 | 0.00 | 1.58 | +1.58 | buy |
| PERKINS CAPITAL MANAGEMENT INC | 0 | 414,782 | +414,782 | 0.00 | 0.60 | +0.60 | buy |
| Birchview Capital, LP | 5,348,273 | 5,696,113 | +347,840 | 6.22 | 8.04 | +1.82 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 385,145 | 533,852 | +148,707 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 15,497 | 58,975 | +43,478 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 925,614 | 968,617 | +43,003 | 0.26 | 0.28 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 0 | 41,446 | +41,446 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 893,203 | 931,181 | +37,978 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 29,800 | +29,800 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 13,100 | 29,337 | +16,237 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 14,002 | +14,002 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 275,350 | 288,550 | +13,200 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 11,063 | +11,063 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 32,805 | 43,764 | +10,959 | 0.00 | 0.00 | +0.00 | buy |
| Ferguson Shapiro LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| BLAIR WILLIAM & CO/IL | 79,800 | 83,400 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| Cannell & Spears LLC | 205,605 | 205,605 | 0 | 0.01 | 0.01 | +0.00 | hold |
| HighTower Advisors, LLC | 131,434 | 131,434 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allworth Financial LP | 99,331 | 99,331 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cetera Investment Advisers | 78,000 | 78,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 20,622 | 20,622 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 1,071 | 860 | -211 | 0.00 | 0.00 | +0.00 | sell |
| MACQUARIE GROUP LTD | 512 | 0 | -512 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 1,401 | 0 | -1,401 | 0.00 | 0.00 | -0.00 | sell |
| ORACLE INVESTMENT MANAGEMENT INC | 30,351 | 28,916 | -1,435 | 0.03 | 0.05 | +0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 13,200 | 11,100 | -2,100 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 9,291 | 1,857 | -7,434 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 7,728 | 0 | -7,728 | 0.00 | 0.00 | -0.00 | sell |
| NWAM LLC | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 10,525 | 0 | -10,525 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 11,221 | 0 | -11,221 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 11,400 | 0 | -11,400 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 13,644 | 0 | -13,644 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 16,313 | 0 | -16,313 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 27,538 | 0 | -27,538 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 229,663 | 185,063 | -44,600 | 0.01 | 0.01 | -0.00 | sell |
| Qube Research & Technologies Ltd | 69,497 | 3,068 | -66,429 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 71,286 | 0 | -71,286 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 100,755 | 0 | -100,755 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 190,376 | 0 | -190,376 | 0.00 | 0.00 | -0.00 | sell |