| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 22,919,857 | 23,037,335 | +117,478 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 22,038,097 | 19,538,555 | -2,499,542 | 0.00 | 0.00 | -0.00 | sell |
| Sarissa Capital Management LP | 16,390,000 | 16,390,000 | 0 | 16.78 | 22.49 | +5.70 | hold |
| Pacer Advisors, Inc. | 11,279,822 | 11,730,771 | +450,949 | 0.10 | 0.11 | +0.01 | buy |
| ARMISTICE CAPITAL, LLC | 8,200,000 | 9,468,000 | +1,268,000 | 0.88 | 0.98 | +0.09 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 8,597,198 | 9,066,241 | +469,043 | 0.05 | 0.06 | +0.01 | buy |
| STATE STREET CORP | 9,919,865 | 8,328,817 | -1,591,048 | 0.00 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 4,438,232 | 5,440,277 | +1,002,045 | 0.52 | 0.71 | +0.20 | buy |
| Kynam Capital Management, LP | 3,685,563 | 4,685,563 | +1,000,000 | 1.18 | 1.37 | +0.19 | buy |
| LSV ASSET MANAGEMENT | 5,051,601 | 4,081,501 | -970,100 | 0.04 | 0.04 | -0.00 | sell |
| MORGAN STANLEY | 4,321,589 | 4,024,693 | -296,896 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 4,265,100 | 3,623,026 | -642,074 | 0.07 | 0.06 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,293,542 | 3,306,570 | +13,028 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 925,872 | 2,180,443 | +1,254,571 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 946,884 | 2,179,261 | +1,232,377 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,904,271 | 1,983,240 | +78,969 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,506,148 | 1,625,110 | +118,962 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,063,199 | 1,567,535 | +504,336 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 1,260,500 | 1,234,000 | -26,500 | 0.01 | 0.01 | +0.00 | sell |
| JUPITER ASSET MANAGEMENT LTD | 1,448,435 | 1,223,275 | -225,160 | 0.05 | 0.05 | +0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 1,151,008 | +1,151,008 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 306,865 | 1,074,506 | +767,641 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 786,292 | 1,014,463 | +228,171 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 912,778 | 978,135 | +65,357 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,223,137 | 915,272 | -307,865 | 0.00 | 0.00 | -0.00 | sell |
| Sio Capital Management, LLC | 0 | 907,783 | +907,783 | 0.00 | 1.13 | +1.13 | buy |
| TWO SIGMA INVESTMENTS, LP | 890,963 | 863,428 | -27,535 | 0.01 | 0.01 | +0.00 | sell |
| Saturn V Capital Management LP | 1,120,409 | 814,533 | -305,876 | 1.65 | 1.41 | -0.24 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 735,727 | 765,356 | +29,629 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 662,934 | 735,436 | +72,502 | 0.02 | 0.03 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 419,773 | 678,145 | +258,372 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 1,000,000 | 648,785 | -351,215 | 2.60 | 2.32 | -0.28 | sell |
| Walleye Capital LLC | 280,299 | 580,097 | +299,798 | 0.01 | 0.02 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 598,202 | 565,618 | -32,584 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 697,426 | 560,464 | -136,962 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 527,694 | 521,988 | -5,706 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 573,426 | 476,619 | -96,807 | 0.01 | 0.01 | -0.00 | sell |
| Legal & General Group Plc | 408,922 | 420,686 | +11,764 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 463,047 | 420,451 | -42,596 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 323,638 | 417,642 | +94,004 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 455,477 | 408,535 | -46,942 | 0.24 | 0.24 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 564,113 | 396,986 | -167,127 | 0.00 | 0.00 | -0.00 | sell |
| Robeco Institutional Asset Management B.V. | 380,960 | 380,960 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FEDERATED HERMES, INC. | 0 | 370,476 | +370,476 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 416,320 | 369,276 | -47,044 | 0.00 | 0.00 | +0.00 | sell |
| Man Group plc | 894,726 | 354,824 | -539,902 | 0.01 | 0.00 | -0.01 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 298,286 | 352,106 | +53,820 | 0.01 | 0.01 | -0.00 | buy |
| RHUMBLINE ADVISERS | 337,965 | 348,006 | +10,041 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 126,289 | 341,455 | +215,166 | 0.00 | 0.01 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 12,172 | 331,700 | +319,528 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 313,048 | 309,236 | -3,812 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 169,681 | 303,273 | +133,592 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 186,173 | 295,961 | +109,788 | 0.00 | 0.00 | +0.00 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 314,843 | 289,023 | -25,820 | 0.02 | 0.02 | +0.00 | sell |
| AXA S.A. | 0 | 288,471 | +288,471 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 269,725 | 286,990 | +17,265 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 276,700 | 282,700 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 570,775 | 257,730 | -313,045 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 181,593 | 255,040 | +73,447 | 0.01 | 0.01 | +0.00 | buy |
| NORGES BANK | 394,266 | 252,291 | -141,975 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 396,664 | 236,732 | -159,932 | 0.01 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 27,300 | 223,938 | +196,638 | 0.01 | 0.09 | +0.08 | buy |
| DIMENSIONAL FUND ADVISORS LP | 208,273 | 218,422 | +10,149 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 320,410 | 215,110 | -105,300 | 0.01 | 0.01 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 218,009 | 213,292 | -4,717 | 0.00 | 0.00 | +0.00 | sell |
| Alberta Investment Management Corp | 210,731 | 210,731 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 81,674 | 192,291 | +110,617 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 170,811 | 187,773 | +16,962 | 0.03 | 0.04 | +0.00 | buy |
| MACQUARIE GROUP LTD | 167,200 | 167,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 163,070 | 163,070 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vestcor Inc | 159,466 | 148,614 | -10,852 | 0.02 | 0.02 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 150,788 | 145,588 | -5,200 | 0.00 | 0.00 | +0.00 | sell |
| SEI INVESTMENTS CO | 410,680 | 141,915 | -268,765 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 135,142 | 134,137 | -1,005 | 0.00 | 0.00 | +0.00 | sell |
| CANADA LIFE ASSURANCE Co | 148,510 | 129,507 | -19,003 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 117,535 | 129,397 | +11,862 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 154,660 | 122,640 | -32,020 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 150,191 | 122,083 | -28,108 | 0.00 | 0.00 | -0.00 | sell |
| MYDA Advisors LLC | 0 | 115,200 | +115,200 | 0.00 | 0.15 | +0.15 | buy |
| Siren, L.L.C. | 110,532 | 110,532 | 0 | 0.02 | 0.02 | -0.00 | hold |
| THRIVENT FINANCIAL FOR LUTHERANS | 110,389 | 108,850 | -1,539 | 0.00 | 0.00 | +0.00 | sell |
| Mariner, LLC | 45,213 | 105,964 | +60,751 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 42,151 | 103,550 | +61,399 | 0.00 | 0.00 | +0.00 | buy |
| Cercano Management LLC | 101,378 | 101,378 | 0 | 0.01 | 0.01 | +0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 109,848 | 100,172 | -9,676 | 0.00 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 168,071 | 99,610 | -68,461 | 0.03 | 0.02 | -0.01 | sell |
| VIRTUS ADVISERS, LLC | 55,075 | 98,218 | +43,143 | 0.11 | 0.18 | +0.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 103,356 | 95,898 | -7,458 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 93,260 | 89,876 | -3,384 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 80,696 | 89,255 | +8,559 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 101,029 | 89,251 | -11,778 | 0.04 | 0.04 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 85,392 | 85,392 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Voleon Capital Management LP | 0 | 82,728 | +82,728 | 0.00 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 64,970 | 82,565 | +17,595 | 0.00 | 0.00 | +0.00 | buy |
| State of Alaska, Department of Revenue | 80,217 | 80,212 | -5 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 76,600 | 76,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Corebridge Financial, Inc. | 81,171 | 75,304 | -5,867 | 0.00 | 0.00 | +0.00 | sell |
| Verition Fund Management LLC | 17,425 | 74,330 | +56,905 | 0.00 | 0.00 | +0.00 | buy |
| Louisiana State Employees Retirement System | 68,000 | 68,100 | +100 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 244,681 | 67,753 | -176,928 | 0.00 | 0.00 | -0.00 | sell |