| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 73,114,592 | 73,114,592 | 0 | 1.65 | 1.57 | -0.08 | hold |
| Altium Capital Management LLC | 8,027,593 | 7,647,873 | -379,720 | 6.25 | 4.00 | -2.26 | sell |
| Nantahala Capital Management, LLC | 4,000,000 | 4,000,000 | 0 | 0.45 | 0.46 | +0.01 | hold |
| VANGUARD GROUP INC | 1,499,993 | 1,548,312 | +48,319 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 740,910 | 763,310 | +22,400 | 0.00 | 0.00 | +0.00 | buy |
| AMH Equity Ltd | 594,029 | 500,000 | -94,029 | 0.72 | 0.64 | -0.07 | sell |
| AWM Investment Company, Inc. | 468,680 | 378,206 | -90,474 | 0.07 | 0.06 | -0.01 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 368,500 | 368,500 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 367,391 | +367,391 | 0.00 | 0.00 | +0.00 | buy |
| Juniper Investment Company, LLC | 0 | 348,399 | +348,399 | 0.00 | 0.20 | +0.20 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 261,905 | 316,158 | +54,253 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 159,350 | 238,605 | +79,255 | 0.00 | 0.00 | +0.00 | buy |
| Crescent Grove Advisors, LLC | 212,024 | 212,024 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Qube Research & Technologies Ltd | 1,278 | 115,548 | +114,270 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 58,666 | 58,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Advisor Group, LLC | 10,000 | 37,500 | +27,500 | 0.00 | 0.00 | +0.00 | buy |
| Midwest Professional Planners, LTD. | 35,744 | 35,744 | 0 | 0.02 | 0.01 | -0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 29,000 | 29,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jefferies Financial Group Inc. | 0 | 25,200 | +25,200 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 32,866 | 22,266 | -10,600 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 62,455 | 15,962 | -46,493 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 0 | 14,879 | +14,879 | 0.00 | 0.00 | +0.00 | buy |
| OLD POINT TRUST & FINANCIAL SERVICES N A | 0 | 2,500 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,132 | 1,132 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cornerstone Planning Group LLC | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 10,348 | 0 | -10,348 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 43,361 | 0 | -43,361 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 33,176 | 0 | -33,176 | 0.00 | 0.00 | -0.00 | sell |