| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 168,500 | 368,500 | +200,000 | 0.00 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 159,350 | +159,350 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 669,738 | 740,910 | +71,172 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 6,092 | 62,455 | +56,363 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 43,361 | +43,361 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 12,923 | 33,176 | +20,253 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 42,409 | 58,666 | +16,257 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,485,340 | 1,499,993 | +14,653 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 18,800 | 29,000 | +10,200 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 260,504 | 261,905 | +1,401 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 1,278 | +1,278 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 84 | 1,132 | +1,048 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 73,114,592 | 73,114,592 | 0 | 1.73 | 1.65 | -0.07 | hold |
| Nantahala Capital Management, LLC | 4,000,000 | 4,000,000 | 0 | 0.56 | 0.45 | -0.11 | hold |
| AWM Investment Company, Inc. | 468,680 | 468,680 | 0 | 0.08 | 0.07 | -0.01 | hold |
| AMH Equity Ltd | 594,029 | 594,029 | 0 | 0.72 | 0.72 | +0.00 | hold |
| Crescent Grove Advisors, LLC | 212,024 | 212,024 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Midwest Professional Planners, LTD. | 35,744 | 35,744 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Cornerstone Planning Group LLC | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 32,866 | 32,866 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 14,093 | 10,348 | -3,745 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Investment Advisors, Ltd. | 34,928 | 0 | -34,928 | 0.01 | 0.00 | -0.01 | sell |
| Altium Capital Management LLC | 8,934,362 | 8,027,593 | -906,769 | 5.69 | 6.25 | +0.56 | sell |