| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 0 | 510,776 | +510,776 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 306,330 | +306,330 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 0 | 304,554 | +304,554 | 0.00 | 0.21 | +0.21 | buy |
| MPM BioImpact LLC | 0 | 259,696 | +259,696 | 0.00 | 1.09 | +1.09 | buy |
| Ikarian Capital, LLC | 0 | 242,370 | +242,370 | 0.00 | 2.04 | +2.04 | buy |
| VANGUARD GROUP INC | 0 | 236,657 | +236,657 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 153,665 | +153,665 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 132,963 | +132,963 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 0 | 122,233 | +122,233 | 0.00 | 0.04 | +0.04 | buy |
| YALE UNIVERSITY | 0 | 100,000 | +100,000 | 0.00 | 77.59 | +77.59 | buy |
| Logos Global Management LP | 0 | 90,000 | +90,000 | 0.00 | 0.28 | +0.28 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 68,540 | +68,540 | 0.00 | 0.06 | +0.06 | buy |
| NORTHERN TRUST CORP | 0 | 30,924 | +30,924 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 30,038 | +30,038 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 25,070 | +25,070 | 0.00 | 0.11 | +0.11 | buy |
| DELPHI FINANCIAL GROUP, INC. | 0 | 22,028 | +22,028 | 0.00 | 0.33 | +0.33 | buy |
| Bank of New York Mellon Corp | 0 | 19,916 | +19,916 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 19,048 | +19,048 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 17,052 | +17,052 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 13,010 | +13,010 | 0.00 | 0.01 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 10,193 | +10,193 | 0.00 | 0.01 | +0.01 | buy |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.04 | +0.04 | buy |
| RHUMBLINE ADVISERS | 0 | 8,487 | +8,487 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Capital Holdings, LLC | 0 | 8,000 | +8,000 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 5,102 | +5,102 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 3,762 | +3,762 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 3,715 | +3,715 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 3,638 | +3,638 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 2,428 | +2,428 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 2,367 | +2,367 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 1,824 | +1,824 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,765 | +1,765 | 0.00 | 0.00 | +0.00 | buy |
| HALL LAURIE J TRUSTEE | 0 | 1,759 | +1,759 | 0.00 | 0.02 | +0.02 | buy |
| Point72 (DIFC) Ltd | 0 | 1,725 | +1,725 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 1,572 | +1,572 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 801 | +801 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 742 | +742 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 708 | +708 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 524 | +524 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 152 | +152 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 130 | +130 | 0.00 | 0.00 | +0.00 | buy |
| Activest Wealth Management | 0 | 66 | +66 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| HAZLETT, BURT & WATSON, INC. | 0 | 12 | +12 | 0.00 | 0.00 | 0.00 | buy |
| Capital Advisors, Ltd. LLC | 0 | 5 | +5 | 0.00 | 0.00 | 0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 3 | +3 | 0.00 | 0.00 | 0.00 | buy |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Avior Wealth Management, LLC | 16 | 0 | -16 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 100 | 3 | -97 | 0.00 | 0.00 | +0.00 | sell |
| Farther Finance Advisors, LLC | 539 | 18 | -521 | 0.00 | 0.00 | +0.00 | sell |