| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 510,776 | 2,851,830 | +2,341,054 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 375,767 | +375,767 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 259,696 | 629,423 | +369,727 | 1.09 | 1.52 | +0.43 | buy |
| GREAT POINT PARTNERS LLC | 0 | 200,000 | +200,000 | 0.00 | 0.97 | +0.97 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 98,565 | +98,565 | 0.00 | 0.04 | +0.04 | buy |
| 683 Capital Management, LLC | 0 | 75,431 | +75,431 | 0.00 | 0.12 | +0.12 | buy |
| Erste Asset Management GmbH | 122,233 | 173,566 | +51,333 | 0.04 | 0.03 | -0.01 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 49,497 | +49,497 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 30,924 | 63,115 | +32,191 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Capital Holdings, LLC | 8,000 | 25,921 | +17,921 | 0.01 | 0.01 | +0.01 | buy |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 0 | 14,631 | +14,631 | 0.00 | 0.11 | +0.11 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 12,911 | +12,911 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 11,336 | +11,336 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 10,393 | +10,393 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 3,762 | 11,611 | +7,849 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 236,657 | 243,089 | +6,432 | 0.00 | 0.00 | -0.00 | buy |
| Johnson Financial Group, Inc. | 0 | 4,618 | +4,618 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 153,665 | 157,495 | +3,830 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 1,572 | 5,217 | +3,645 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 132,963 | 135,700 | +2,737 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 306,330 | 309,018 | +2,688 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 1,627 | 3,997 | +2,370 | 0.00 | 0.00 | +0.00 | buy |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 10,000 | 12,000 | +2,000 | 0.04 | 0.03 | -0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 1,761 | +1,761 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 742 | 1,651 | +909 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 8,487 | 9,274 | +787 | 0.00 | 0.00 | -0.00 | buy |
| RPg Family Wealth Advisory, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 16 | +16 | 0.00 | 0.00 | 0.00 | buy |
| CoreCap Advisors, LLC | 0 | 1 | +1 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 708 | 708 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 524 | 524 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 10,193 | 10,193 | 0 | 0.01 | 0.00 | -0.00 | hold |
| HALL LAURIE J TRUSTEE | 1,759 | 1,759 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Mirae Asset Global Investments Co., Ltd. | 3,715 | 3,715 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Arax Advisory Partners | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Activest Wealth Management | 66 | 66 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 18 | 18 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HAZLETT, BURT & WATSON, INC. | 12 | 12 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 801 | 801 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,102 | 5,102 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DELPHI FINANCIAL GROUP, INC. | 22,028 | 22,028 | 0 | 0.33 | 0.20 | -0.13 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 19,048 | 19,048 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 130 | 130 | 0 | 0.00 | 0.00 | -0.00 | hold |
| YALE UNIVERSITY | 100,000 | 100,000 | 0 | 77.59 | 66.30 | -11.30 | hold |
| DEUTSCHE BANK AG\ | 3,638 | 3,638 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FNY Investment Advisers, LLC | 3 | 0 | -3 | 0.00 | 0.00 | 0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 14 | 11 | -3 | 0.00 | 0.00 | -0.00 | sell |
| Capital Advisors, Ltd. LLC | 5 | 0 | -5 | 0.00 | 0.00 | 0.00 | sell |
| Corebridge Financial, Inc. | 3,888 | 3,864 | -24 | 0.00 | 0.00 | -0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 40 | 0 | -40 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 152 | 0 | -152 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,765 | 567 | -1,198 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 1,725 | 0 | -1,725 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 1,824 | 0 | -1,824 | 0.01 | 0.00 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 2,367 | 0 | -2,367 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 2,428 | 0 | -2,428 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 19,916 | 15,102 | -4,814 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 13,010 | 0 | -13,010 | 0.01 | 0.00 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 17,052 | 0 | -17,052 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 25,070 | 0 | -25,070 | 0.11 | 0.00 | -0.11 | sell |
| MARSHALL WACE, LLP | 30,038 | 0 | -30,038 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 68,540 | 14,518 | -54,022 | 0.06 | 0.01 | -0.05 | sell |
| Logos Global Management LP | 90,000 | 0 | -90,000 | 0.28 | 0.00 | -0.28 | sell |
| Ikarian Capital, LLC | 242,370 | 52,193 | -190,177 | 2.04 | 0.26 | -1.78 | sell |
| Artal Group S.A. | 304,554 | 0 | -304,554 | 0.21 | 0.00 | -0.21 | sell |