| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 5,894,070 | 11,982,283 | +6,088,213 | 0.03 | 0.05 | +0.02 | buy |
| Bain Capital Life Sciences Investors, LLC | 12,448,158 | 10,448,158 | -2,000,000 | 27.79 | 22.93 | -4.87 | sell |
| FMR LLC | 4,122,853 | 5,397,802 | +1,274,949 | 0.01 | 0.01 | +0.00 | buy |
| BAMCO INC /NY/ | 2,303,877 | 3,827,531 | +1,523,654 | 0.18 | 0.28 | +0.10 | buy |
| JANUS HENDERSON GROUP PLC | 865,560 | 2,180,976 | +1,315,416 | 0.01 | 0.03 | +0.01 | buy |
| Invesco Ltd. | 577,397 | 1,913,090 | +1,335,693 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 1,342,139 | 1,462,584 | +120,445 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,431,011 | 1,414,828 | -16,183 | 0.01 | 0.01 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,089,030 | 1,224,326 | +135,296 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 67,769 | 1,093,417 | +1,025,648 | 0.00 | 0.02 | +0.02 | buy |
| BAILLIE GIFFORD & CO | 3,005,998 | 1,084,652 | -1,921,346 | 0.07 | 0.03 | -0.05 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 1,259,121 | 892,093 | -367,028 | 1.03 | 1.00 | -0.03 | sell |
| MORGAN STANLEY | 745,924 | 851,932 | +106,008 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 685,159 | 793,721 | +108,562 | 0.00 | 0.00 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 505,989 | 756,956 | +250,967 | 0.23 | 0.30 | +0.07 | buy |
| CITADEL ADVISORS LLC | 1,248,898 | 756,605 | -492,293 | 0.02 | 0.01 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 228,617 | 727,667 | +499,050 | 0.01 | 0.02 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 700,805 | 690,466 | -10,339 | 0.04 | 0.03 | -0.00 | sell |
| NEXT CENTURY GROWTH INVESTORS LLC | 0 | 652,969 | +652,969 | 0.00 | 1.15 | +1.15 | buy |
| 12 West Capital Management LP | 0 | 640,000 | +640,000 | 0.00 | 2.63 | +2.63 | buy |
| FRED ALGER MANAGEMENT, LLC | 440,508 | 638,306 | +197,798 | 0.05 | 0.07 | +0.02 | buy |
| Rock Springs Capital Management LP | 277,700 | 572,500 | +294,800 | 0.42 | 0.82 | +0.41 | buy |
| Champlain Investment Partners, LLC | 0 | 567,424 | +567,424 | 0.00 | 0.18 | +0.18 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 499,925 | 541,659 | +41,734 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 304,487 | 538,351 | +233,864 | 0.01 | 0.02 | +0.01 | buy |
| RTW INVESTMENTS, LP | 495,000 | 495,000 | 0 | 0.14 | 0.12 | -0.02 | hold |
| STATE STREET CORP | 322,351 | 450,550 | +128,199 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 790,903 | 450,364 | -340,539 | 0.07 | 0.04 | -0.03 | sell |
| JPMORGAN CHASE & CO | 586,282 | 446,985 | -139,297 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 501,165 | 429,084 | -72,081 | 0.00 | 0.00 | -0.00 | sell |
| Catalio Capital Management, LP | 113,857 | 403,588 | +289,731 | 0.59 | 2.05 | +1.46 | buy |
| Freestone Grove Partners LP | 150,000 | 362,094 | +212,094 | 0.03 | 0.06 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 8,600 | 342,809 | +334,209 | 0.00 | 0.01 | +0.01 | buy |
| NZS Capital, LLC | 209,688 | 290,133 | +80,445 | 0.19 | 0.24 | +0.05 | buy |
| XXEC, Inc. | 41,920 | 278,681 | +236,761 | 1.22 | 1.42 | +0.20 | buy |
| Schusterman Interests, LLC | 1,939,201 | 259,666 | -1,679,535 | 12.94 | 1.61 | -11.32 | sell |
| Capricorn Investment Group LLC | 1,661,601 | 256,701 | -1,404,900 | 5.83 | 1.08 | -4.76 | sell |
| Alyeska Investment Group, L.P. | 225,000 | 225,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| EMERALD ADVISERS, LLC | 221,582 | 221,302 | -280 | 0.20 | 0.17 | -0.03 | sell |
| GOLDMAN SACHS GROUP INC | 147,195 | 220,540 | +73,345 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 208,814 | +208,814 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 185,868 | 183,866 | -2,002 | 0.06 | 0.05 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 176,045 | +176,045 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 138,762 | 158,338 | +19,576 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 153,346 | 149,113 | -4,233 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 148,200 | +148,200 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 110,509 | 137,421 | +26,912 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 133,991 | +133,991 | 0.00 | 0.01 | +0.01 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 131,262 | 131,262 | 0 | 0.19 | 0.15 | -0.03 | hold |
| Lisanti Capital Growth, LLC | 43,789 | 123,805 | +80,016 | 0.30 | 0.76 | +0.46 | buy |
| Quantbot Technologies LP | 0 | 120,847 | +120,847 | 0.00 | 0.12 | +0.12 | buy |
| BANK OF AMERICA CORP /DE/ | 86,738 | 111,702 | +24,964 | 0.00 | 0.00 | +0.00 | buy |
| INTREPID FAMILY OFFICE LLC | 0 | 110,000 | +110,000 | 0.00 | 2.33 | +2.33 | buy |
| JANE STREET GROUP, LLC | 0 | 102,284 | +102,284 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 52,621 | 80,416 | +27,795 | 0.03 | 0.02 | -0.01 | buy |
| AMERIPRISE FINANCIAL INC | 101,537 | 74,626 | -26,911 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 0 | 73,099 | +73,099 | 0.00 | 0.05 | +0.05 | buy |
| Quantinno Capital Management LP | 0 | 71,271 | +71,271 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 15,153 | 67,048 | +51,895 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 65,000 | 65,000 | 0 | 0.12 | 0.08 | -0.05 | hold |
| Bank of New York Mellon Corp | 48,653 | 61,048 | +12,395 | 0.00 | 0.00 | +0.00 | buy |
| TFC Financial Management, Inc. | 0 | 55,598 | +55,598 | 0.00 | 0.17 | +0.17 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 55,449 | +55,449 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,100 | 53,629 | +50,529 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 50,611 | +50,611 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 50,321 | +50,321 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 75,000 | 50,000 | -25,000 | 0.10 | 0.03 | -0.06 | sell |
| Holocene Advisors, LP | 0 | 44,578 | +44,578 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 43,902 | +43,902 | 0.00 | 0.01 | +0.01 | buy |
| Intellectus Partners, LLC | 0 | 41,159 | +41,159 | 0.00 | 0.20 | +0.20 | buy |
| Swiss National Bank | 41,100 | 41,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 21,488 | 39,146 | +17,658 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 43,205 | 38,822 | -4,383 | 0.03 | 0.02 | -0.02 | sell |
| LAZARD ASSET MANAGEMENT LLC | 0 | 38,126 | +38,126 | 0.00 | 0.00 | +0.00 | buy |
| AlpInvest Partners B.V. | 0 | 37,655 | +37,655 | 0.00 | 1.84 | +1.84 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 34,605 | +34,605 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 16,180 | 34,575 | +18,395 | 0.04 | 0.08 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 863,271 | 31,975 | -831,296 | 0.00 | 0.00 | -0.00 | sell |
| BCWM, LLC | 31,139 | 31,310 | +171 | 0.27 | 0.22 | -0.06 | buy |
| IEQ CAPITAL, LLC | 0 | 30,327 | +30,327 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 30,000 | +30,000 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,693 | 29,371 | +8,678 | 0.00 | 0.00 | +0.00 | buy |
| ALLSTATE CORP | 0 | 29,000 | +29,000 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 27,439 | +27,439 | 0.00 | 0.00 | +0.00 | buy |
| TrueMark Investments, LLC | 26,506 | 26,885 | +379 | 0.15 | 0.13 | -0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,773 | 26,237 | -6,536 | 0.00 | 0.00 | -0.00 | sell |
| HB Wealth Management, LLC | 0 | 25,214 | +25,214 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 20,054 | 23,747 | +3,693 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 23,239 | 23,239 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Hudson Bay Capital Management LP | 0 | 22,370 | +22,370 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 22,210 | +22,210 | 0.00 | 0.03 | +0.03 | buy |
| Carlyle Group Inc. | 0 | 20,438 | +20,438 | 0.00 | 0.00 | +0.00 | buy |
| Quent Capital, LLC | 20,000 | 20,000 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Walleye Capital LLC | 0 | 19,464 | +19,464 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 36,877 | 19,227 | -17,650 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 0 | 18,623 | +18,623 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGES INVESTMENT MANAGEMENT INC | 0 | 17,313 | +17,313 | 0.00 | 0.01 | +0.01 | buy |
| BRANDYWINE MANAGERS, LLC | 16,774 | 16,774 | 0 | 0.24 | 0.24 | -0.00 | hold |
| Legal & General Group Plc | 17,718 | 15,780 | -1,938 | 0.00 | 0.00 | -0.00 | sell |
| Perpetual Ltd | 15,741 | 15,741 | 0 | 0.01 | 0.01 | -0.00 | hold |