| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bain Capital Life Sciences Investors, LLC | 10,448,158 | 8,448,158 | -2,000,000 | 22.93 | 14.74 | -8.19 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 11,982,283 | 7,864,226 | -4,118,057 | 0.05 | 0.04 | -0.01 | sell |
| BlackRock, Inc. | 1,462,584 | 5,197,747 | +3,735,163 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 5,397,802 | 4,820,944 | -576,858 | 0.01 | 0.01 | -0.00 | sell |
| BAMCO INC /NY/ | 3,827,531 | 3,225,133 | -602,398 | 0.28 | 0.14 | -0.14 | sell |
| Invesco Ltd. | 1,913,090 | 2,298,718 | +385,628 | 0.01 | 0.01 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,224,326 | 1,924,268 | +699,942 | 0.01 | 0.02 | +0.00 | buy |
| Point72 Asset Management, L.P. | 538,351 | 1,721,279 | +1,182,928 | 0.02 | 0.08 | +0.05 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 892,093 | 1,694,651 | +802,558 | 1.00 | 1.29 | +0.29 | buy |
| STATE STREET CORP | 450,550 | 1,465,895 | +1,015,345 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,414,828 | 1,465,650 | +50,822 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 541,659 | 1,360,391 | +818,732 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 23,239 | 1,353,168 | +1,329,929 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 851,932 | 1,054,889 | +202,957 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 429,084 | 975,510 | +546,426 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 931,160 | +931,160 | 0.00 | 0.03 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,093,417 | 922,893 | -170,524 | 0.02 | 0.02 | -0.00 | sell |
| 12 West Capital Management LP | 640,000 | 902,500 | +262,500 | 2.63 | 4.95 | +2.32 | buy |
| FRANKLIN RESOURCES INC | 793,721 | 817,701 | +23,980 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 756,605 | 799,883 | +43,278 | 0.01 | 0.01 | +0.00 | buy |
| Champlain Investment Partners, LLC | 567,424 | 733,607 | +166,183 | 0.18 | 0.55 | +0.38 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 727,667 | 733,183 | +5,516 | 0.02 | 0.02 | +0.00 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 652,969 | 671,404 | +18,435 | 1.15 | 1.04 | -0.11 | buy |
| NZS Capital, LLC | 290,133 | 656,014 | +365,881 | 0.24 | 0.50 | +0.26 | buy |
| Bank of New York Mellon Corp | 61,048 | 650,849 | +589,801 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 756,956 | 636,942 | -120,014 | 0.30 | 0.25 | -0.05 | sell |
| GOLDMAN SACHS GROUP INC | 220,540 | 607,387 | +386,847 | 0.00 | 0.00 | +0.00 | buy |
| XXEC, Inc. | 278,681 | 599,194 | +320,513 | 1.42 | 2.38 | +0.96 | buy |
| Catalio Capital Management, LP | 403,588 | 583,055 | +179,467 | 2.05 | 3.21 | +1.16 | buy |
| Rock Springs Capital Management LP | 572,500 | 573,500 | +1,000 | 0.82 | 0.82 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 111,702 | 567,030 | +455,328 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 638,306 | 539,160 | -99,146 | 0.07 | 0.05 | -0.02 | sell |
| NORTHERN TRUST CORP | 158,338 | 537,902 | +379,564 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 342,809 | 511,523 | +168,714 | 0.01 | 0.01 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 498,812 | +498,812 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 446,985 | 441,237 | -5,748 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 382,700 | +382,700 | 0.00 | 0.02 | +0.02 | buy |
| Alyeska Investment Group, L.P. | 225,000 | 350,000 | +125,000 | 0.02 | 0.03 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 208,814 | 303,220 | +94,406 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 19,464 | 298,568 | +279,104 | 0.00 | 0.04 | +0.04 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 297,254 | +297,254 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 149,113 | 297,254 | +148,141 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 495,000 | 295,000 | -200,000 | 0.12 | 0.07 | -0.05 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,975 | 238,268 | +206,293 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 450,364 | 200,536 | -249,828 | 0.04 | 0.02 | -0.02 | sell |
| Lisanti Capital Growth, LLC | 123,805 | 189,675 | +65,870 | 0.76 | 1.22 | +0.47 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 133,991 | 167,206 | +33,215 | 0.01 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 67,048 | 163,009 | +95,961 | 0.00 | 0.00 | +0.00 | buy |
| Temasek Holdings (Private) Ltd | 0 | 157,644 | +157,644 | 0.00 | 0.01 | +0.01 | buy |
| EMERALD ADVISERS, LLC | 221,302 | 154,196 | -67,106 | 0.17 | 0.11 | -0.06 | sell |
| ROYAL BANK OF CANADA | 137,421 | 145,773 | +8,352 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 80,416 | 136,584 | +56,168 | 0.02 | 0.06 | +0.04 | buy |
| WELLS FARGO & COMPANY/MN | 39,146 | 118,330 | +79,184 | 0.00 | 0.00 | +0.00 | buy |
| INTREPID FAMILY OFFICE LLC | 110,000 | 110,000 | 0 | 2.33 | 2.97 | +0.65 | hold |
| Neuberger Berman Group LLC | 0 | 106,115 | +106,115 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 74,626 | 104,017 | +29,391 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 0 | 102,482 | +102,482 | 0.00 | 0.01 | +0.01 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 131,262 | 94,099 | -37,163 | 0.15 | 0.10 | -0.06 | sell |
| RHUMBLINE ADVISERS | 23,747 | 93,820 | +70,073 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 2,888 | 93,212 | +90,324 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 183,866 | 88,615 | -95,251 | 0.05 | 0.03 | -0.03 | sell |
| Squarepoint Ops LLC | 50,611 | 87,052 | +36,441 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 53,629 | 82,295 | +28,666 | 0.00 | 0.00 | +0.00 | buy |
| BROWN CAPITAL MANAGEMENT LLC | 0 | 82,091 | +82,091 | 0.00 | 0.48 | +0.48 | buy |
| DEUTSCHE BANK AG\ | 15,718 | 79,080 | +63,362 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 41,100 | 77,400 | +36,300 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 71,271 | 75,587 | +4,316 | 0.00 | 0.00 | -0.00 | buy |
| IEQ CAPITAL, LLC | 30,327 | 69,778 | +39,451 | 0.00 | 0.01 | +0.01 | buy |
| Legato Capital Management LLC | 34,575 | 69,525 | +34,950 | 0.08 | 0.17 | +0.09 | buy |
| Russell Investments Group, Ltd. | 1,628 | 67,622 | +65,994 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 65,000 | 65,000 | 0 | 0.08 | 0.07 | -0.01 | hold |
| Ensign Peak Advisors, Inc | 690,466 | 64,602 | -625,864 | 0.03 | 0.00 | -0.03 | sell |
| TFC Financial Management, Inc. | 55,598 | 55,598 | 0 | 0.17 | 0.18 | +0.01 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 55,449 | 55,167 | -282 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 26,237 | 54,797 | +28,560 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 54,760 | +54,760 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 53,061 | +53,061 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 50,321 | 52,724 | +2,403 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 38,822 | 50,826 | +12,004 | 0.02 | 0.02 | +0.00 | buy |
| Jump Financial, LLC | 0 | 50,022 | +50,022 | 0.00 | 0.01 | +0.01 | buy |
| Ghisallo Capital Management LLC | 50,000 | 50,000 | 0 | 0.03 | 0.03 | -0.00 | hold |
| MetLife Investment Management, LLC | 11,035 | 47,011 | +35,976 | 0.00 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 148,200 | 46,722 | -101,478 | 0.01 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29,371 | 43,981 | +14,610 | 0.00 | 0.00 | +0.00 | buy |
| Intellectus Partners, LLC | 41,159 | 41,159 | 0 | 0.20 | 0.21 | +0.00 | hold |
| Quantbot Technologies LP | 120,847 | 41,128 | -79,719 | 0.12 | 0.05 | -0.07 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,227 | 38,924 | +19,697 | 0.00 | 0.00 | +0.00 | buy |
| AlpInvest Partners B.V. | 37,655 | 36,504 | -1,151 | 1.84 | 1.79 | -0.06 | sell |
| LAZARD ASSET MANAGEMENT LLC | 38,126 | 34,362 | -3,764 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 15,780 | 34,020 | +18,240 | 0.00 | 0.00 | +0.00 | buy |
| BCWM, LLC | 31,310 | 31,878 | +568 | 0.22 | 0.27 | +0.06 | buy |
| Handelsbanken Fonder AB | 0 | 31,000 | +31,000 | 0.00 | 0.00 | +0.00 | buy |
| ALLSTATE CORP | 29,000 | 29,078 | +78 | 0.01 | 0.01 | +0.00 | buy |
| Aquatic Capital Management LLC | 73,099 | 28,584 | -44,515 | 0.05 | 0.03 | -0.02 | sell |
| BANK OF MONTREAL /CAN/ | 27,439 | 27,439 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Trexquant Investment LP | 0 | 26,778 | +26,778 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 26,758 | +26,758 | 0.00 | 0.04 | +0.04 | buy |
| BARCLAYS PLC | 12,980 | 24,811 | +11,831 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 14,200 | 24,525 | +10,325 | 0.01 | 0.01 | +0.01 | buy |
| BRIDGES INVESTMENT MANAGEMENT INC | 17,313 | 23,869 | +6,556 | 0.01 | 0.01 | +0.00 | buy |