| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 19,919,186 | 19,919,186 | 0 | 4.36 | 3.89 | -0.47 | hold |
| BlackRock, Inc. | 3,935,302 | 4,135,355 | +200,053 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,039,350 | 3,248,611 | +1,209,261 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 2,250,920 | 2,419,417 | +168,497 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,689,003 | 2,316,014 | +627,011 | 0.01 | 0.01 | +0.00 | buy |
| BRAIDWELL LP | 1,818,665 | 1,787,318 | -31,347 | 2.31 | 2.58 | +0.26 | sell |
| RTW INVESTMENTS, LP | 1,487,934 | 1,487,934 | 0 | 0.56 | 0.49 | -0.07 | hold |
| Boxer Capital Management, LLC | 1,361,000 | 1,477,600 | +116,600 | 6.81 | 4.34 | -2.48 | buy |
| T. Rowe Price Investment Management, Inc. | 836,944 | 1,477,033 | +640,089 | 0.02 | 0.04 | +0.02 | buy |
| TCG Crossover Management, LLC | 1,445,538 | 1,445,538 | 0 | 1.58 | 1.35 | -0.22 | hold |
| ICONIQ Capital, LLC | 1,266,563 | 1,266,563 | 0 | 1.08 | 1.42 | +0.34 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,000,411 | 1,062,955 | +62,544 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 1,265,795 | 1,059,730 | -206,065 | 6.90 | 6.76 | -0.14 | sell |
| Artisan Partners Limited Partnership | 690,322 | 968,037 | +277,715 | 0.04 | 0.06 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 436,329 | 793,613 | +357,284 | 0.00 | 0.01 | +0.00 | buy |
| Board of Trustees of The Leland Stanford Junior University | 691,767 | 691,767 | 0 | 3.11 | 5.06 | +1.95 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 991,930 | 546,256 | -445,674 | 4.46 | 2.37 | -2.09 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 575,000 | 500,000 | -75,000 | 0.03 | 0.03 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 99,468 | 473,001 | +373,533 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 515,864 | 435,029 | -80,835 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 300,356 | 383,709 | +83,353 | 0.00 | 0.00 | +0.00 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 281,332 | 378,010 | +96,678 | 3.29 | 3.44 | +0.16 | buy |
| NORTHERN TRUST CORP | 391,349 | 366,827 | -24,522 | 0.00 | 0.00 | -0.00 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 358,056 | +358,056 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 349,803 | 358,056 | +8,253 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 315,400 | 312,595 | -2,805 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 183,919 | 276,984 | +93,065 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 328,670 | 265,524 | -63,146 | 0.29 | 0.19 | -0.10 | sell |
| DIADEMA PARTNERS LP | 192,962 | 218,117 | +25,155 | 3.04 | 3.00 | -0.04 | buy |
| D. E. Shaw & Co., Inc. | 229,955 | 211,300 | -18,655 | 0.01 | 0.01 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 162,298 | 194,132 | +31,834 | 0.01 | 0.01 | +0.00 | buy |
| PFM Health Sciences, LP | 114,719 | 193,315 | +78,596 | 0.46 | 0.65 | +0.19 | buy |
| UBS Group AG | 153,166 | 190,115 | +36,949 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 294,300 | 189,200 | -105,100 | 0.02 | 0.01 | -0.01 | sell |
| ALGERT GLOBAL LLC | 147,930 | 186,476 | +38,546 | 0.08 | 0.09 | +0.00 | buy |
| Nuveen, LLC | 95,292 | 174,730 | +79,438 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 870,788 | 157,524 | -713,264 | 0.02 | 0.00 | -0.02 | sell |
| Squarepoint Ops LLC | 71,056 | 151,098 | +80,042 | 0.01 | 0.01 | +0.01 | buy |
| Ghisallo Capital Management LLC | 0 | 150,000 | +150,000 | 0.00 | 0.11 | +0.11 | buy |
| Bruce & Co., Inc. | 145,000 | 145,000 | 0 | 1.58 | 1.53 | -0.05 | hold |
| FEDERATED HERMES, INC. | 210,210 | 144,065 | -66,145 | 0.01 | 0.01 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 80,215 | 120,495 | +40,280 | 0.00 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 120,629 | 114,089 | -6,540 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 111,341 | 111,935 | +594 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 77,137 | 100,845 | +23,708 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 71,349 | 97,846 | +26,497 | 0.50 | 0.59 | +0.09 | buy |
| Point72 Asset Management, L.P. | 459,723 | 97,597 | -362,126 | 0.03 | 0.01 | -0.02 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 69,860 | 96,898 | +27,038 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 94,015 | +94,015 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 37,638 | 89,610 | +51,972 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 79,708 | 87,824 | +8,116 | 0.00 | 0.00 | +0.00 | buy |
| RIA Advisory Group LLC | 84,672 | 87,229 | +2,557 | 0.79 | 0.75 | -0.03 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 114,796 | 81,796 | -33,000 | 0.75 | 0.46 | -0.30 | sell |
| Atom Investors LP | 190,773 | 76,843 | -113,930 | 0.52 | 0.27 | -0.25 | sell |
| STEMPOINT CAPITAL LP | 0 | 75,872 | +75,872 | 0.00 | 0.51 | +0.51 | buy |
| Invesco Ltd. | 305,074 | 74,465 | -230,609 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 0 | 73,978 | +73,978 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 29,348 | 71,096 | +41,748 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 85,818 | 67,757 | -18,061 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 67,672 | +67,672 | 0.00 | 0.02 | +0.02 | buy |
| Pictet Asset Management Holding SA | 0 | 66,015 | +66,015 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 10,686 | 62,380 | +51,694 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 57,400 | 62,000 | +4,600 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 51,336 | 56,052 | +4,716 | 0.76 | 0.69 | -0.07 | buy |
| DEUTSCHE BANK AG\ | 41,264 | 55,347 | +14,083 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 52,569 | 55,213 | +2,644 | 0.03 | 0.03 | -0.00 | buy |
| Resolute Capital Asset Partners LLC | 100,000 | 51,385 | -48,615 | 2.01 | 0.86 | -1.15 | sell |
| RHUMBLINE ADVISERS | 47,958 | 50,198 | +2,240 | 0.00 | 0.00 | -0.00 | buy |
| Informed Momentum Co LLC | 88,369 | 48,618 | -39,751 | 0.39 | 0.17 | -0.22 | sell |
| ALLIANCEBERNSTEIN L.P. | 38,480 | 47,220 | +8,740 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 726,547 | 46,446 | -680,101 | 0.05 | 0.00 | -0.05 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 49,259 | 44,074 | -5,185 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 71,504 | 41,563 | -29,941 | 0.01 | 0.00 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 43,751 | 41,551 | -2,200 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 18,200 | 40,700 | +22,500 | 0.01 | 0.03 | +0.01 | buy |
| HighVista Strategies LLC | 43,569 | 40,590 | -2,979 | 0.46 | 0.36 | -0.10 | sell |
| POLEN CAPITAL MANAGEMENT LLC | 41,354 | 35,469 | -5,885 | 0.01 | 0.01 | +0.00 | sell |
| Russell Investments Group, Ltd. | 18,629 | 34,603 | +15,974 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29,396 | 34,291 | +4,895 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 29,717 | 34,190 | +4,473 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 14,267 | 31,154 | +16,887 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 123,402 | 30,065 | -93,337 | 0.03 | 0.01 | -0.03 | sell |
| Engineers Gate Manager LP | 12,017 | 29,537 | +17,520 | 0.01 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 20,173 | 29,309 | +9,136 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 17,977 | 29,261 | +11,284 | 0.01 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 27,525 | +27,525 | 0.00 | 0.07 | +0.07 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 25,419 | +25,419 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,661 | 25,318 | +14,657 | 0.00 | 0.00 | +0.00 | buy |
| Aries Wealth Management | 25,000 | 25,000 | 0 | 0.21 | 0.19 | -0.02 | hold |
| State of Wyoming | 0 | 23,244 | +23,244 | 0.00 | 0.09 | +0.09 | buy |
| MetLife Investment Management, LLC | 20,363 | 22,983 | +2,620 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 22,833 | 22,956 | +123 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 11,305 | 21,040 | +9,735 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 31,844 | 21,035 | -10,809 | 0.04 | 0.02 | -0.02 | sell |
| SG Americas Securities, LLC | 17,124 | 20,057 | +2,933 | 0.00 | 0.00 | -0.00 | buy |
| Handelsbanken Fonder AB | 0 | 18,600 | +18,600 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 10,006 | 18,561 | +8,555 | 0.01 | 0.01 | +0.01 | buy |
| Optimize Financial Inc | 17,828 | 17,767 | -61 | 0.33 | 0.25 | -0.09 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 15,103 | 17,525 | +2,422 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 17,019 | 17,019 | 0 | 0.15 | 0.13 | -0.02 | hold |