| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 0 | 1,613,600 | +1,613,600 | 0.00 | 0.22 | +0.22 | buy |
| MORGAN STANLEY | 0 | 908,851 | +908,851 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 267,941 | 899,999 | +632,058 | 0.09 | 0.37 | +0.28 | buy |
| Invesco Ltd. | 79,195 | 705,317 | +626,122 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 625,000 | +625,000 | 0.00 | 0.03 | +0.03 | buy |
| Avidity Partners Management LP | 0 | 300,000 | +300,000 | 0.00 | 0.06 | +0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 287,014 | +287,014 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,000,000 | 1,238,822 | +238,822 | 0.94 | 1.83 | +0.89 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 146,839 | +146,839 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 117,495 | +117,495 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 113,158 | +113,158 | 0.00 | 0.00 | +0.00 | buy |
| RIA Advisory Group LLC | 0 | 92,931 | +92,931 | 0.00 | 0.20 | +0.20 | buy |
| Cubist Systematic Strategies, LLC | 32,115 | 112,678 | +80,563 | 0.00 | 0.01 | +0.01 | buy |
| Atom Investors LP | 105,007 | 171,495 | +66,488 | 0.06 | 0.11 | +0.06 | buy |
| Ikarian Capital, LLC | 412,881 | 476,586 | +63,705 | 0.34 | 0.68 | +0.34 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 47,528 | +47,528 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 46,262 | +46,262 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 44,916 | +44,916 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 94,155 | 129,438 | +35,283 | 0.01 | 0.02 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 0 | 32,361 | +32,361 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 29,663 | +29,663 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 720,435 | 747,495 | +27,060 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 26,174 | +26,174 | 0.00 | 0.01 | +0.01 | buy |
| Harvest Investment Services, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.05 | +0.05 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 23,246 | +23,246 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 23,173 | +23,173 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 240,996 | 263,276 | +22,280 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 18,060 | +18,060 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 305,900 | 323,600 | +17,700 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 16,306 | +16,306 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 29,835 | 45,853 | +16,018 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 0 | 15,712 | +15,712 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 15,116 | +15,116 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 708,245 | 722,961 | +14,716 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 14,402 | +14,402 | 0.00 | 0.01 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 13,932 | +13,932 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 19,622 | 31,922 | +12,300 | 0.04 | 0.16 | +0.12 | buy |
| AMERIPRISE FINANCIAL INC | 33,628 | 45,263 | +11,635 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,643,470 | 1,654,448 | +10,978 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 10,595 | +10,595 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 10,366 | +10,366 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 30,808 | 41,008 | +10,200 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 9,537 | +9,537 | 0.00 | 0.01 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 0 | 8,245 | +8,245 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 254,453 | 256,919 | +2,466 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 152,015 | 154,109 | +2,094 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,663 | 6,606 | +1,943 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 1,861 | +1,861 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 1,061 | +1,061 | 0.00 | 0.00 | +0.00 | buy |
| Continuum Advisory, LLC | 13,852 | 14,852 | +1,000 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 55,069 | 55,925 | +856 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 0 | 699 | +699 | 0.00 | 0.00 | +0.00 | buy |
| Eagle Bay Advisors LLC | 282 | 582 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Capital Advisors, Ltd. LLC | 0 | 145 | +145 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 7 | +7 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,568 | 2,568 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 114,200 | 114,200 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 66,030 | 66,030 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 17,310,490 | 17,310,490 | 0 | 0.60 | 1.14 | +0.54 | hold |
| Board of Trustees of The Leland Stanford Junior University | 691,767 | 691,767 | 0 | 0.14 | 0.32 | +0.18 | hold |
| Janney Montgomery Scott LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Colonial Trust Advisors | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ICONIQ Capital, LLC | 1,016,864 | 1,016,864 | 0 | 0.06 | 0.09 | +0.04 | hold |
| Global Retirement Partners, LLC | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avion Wealth | 352 | 352 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 102,369 | 102,369 | 0 | 0.01 | 0.01 | +0.01 | hold |
| WEST PACES ADVISORS INC. | 12 | 12 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Erste Asset Management GmbH | 11,300 | 11,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| THRIVENT FINANCIAL FOR LUTHERANS | 12,800 | 12,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 2,747 | 2,747 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GPS Wealth Strategies Group, LLC | 6 | 0 | -6 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,642 | 1,591 | -51 | 0.00 | 0.00 | +0.00 | sell |
| Blue Trust, Inc. | 69 | 0 | -69 | 0.00 | 0.00 | 0.00 | sell |
| JGP Global Gestao de Recursos Ltda. | 15,079 | 14,957 | -122 | 0.03 | 0.05 | +0.02 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 16,122 | 15,984 | -138 | 0.00 | 0.00 | +0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 5,752 | 5,514 | -238 | 0.00 | 0.00 | +0.00 | sell |
| Glassman Wealth Services | 241 | 0 | -241 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 40,821 | 40,326 | -495 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 2,890 | 1,154 | -1,736 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 16,461 | 14,486 | -1,975 | 0.00 | 0.00 | +0.00 | sell |
| LJI Wealth Management, LLC | 16,100 | 14,100 | -2,000 | 0.01 | 0.02 | +0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,338 | 3,261 | -2,077 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 2,896 | 0 | -2,896 | 0.00 | 0.00 | -0.00 | sell |
| Vontobel Holding Ltd. | 14,000 | 11,000 | -3,000 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 43,122 | 38,699 | -4,423 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 34,000 | 28,800 | -5,200 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 16,201 | 10,966 | -5,235 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 17,689 | 11,294 | -6,395 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 128,313 | 120,095 | -8,218 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 10,848 | 2,423 | -8,425 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 437,007 | 426,705 | -10,302 | 0.00 | 0.00 | +0.00 | sell |
| Quantbot Technologies LP | 10,400 | 0 | -10,400 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 72,416 | 60,585 | -11,831 | 0.00 | 0.00 | +0.00 | sell |
| OXFORD ASSET MANAGEMENT LLP | 13,540 | 0 | -13,540 | 0.06 | 0.00 | -0.06 | sell |
| Graham Capital Management, L.P. | 14,333 | 0 | -14,333 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Middle East FZE | 21,067 | 0 | -21,067 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 154,099 | 132,529 | -21,570 | 0.00 | 0.00 | +0.00 | sell |
| Engineers Gate Manager LP | 22,288 | 0 | -22,288 | 0.00 | 0.00 | -0.00 | sell |