| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GSA CAPITAL PARTNERS LLP | 0 | 287,756 | +287,756 | 0.00 | 0.06 | +0.06 | buy |
| Lynx1 Capital Management LP | 0 | 271,177 | +271,177 | 0.00 | 0.25 | +0.25 | buy |
| DIMENSIONAL FUND ADVISORS LP | 368,199 | 495,179 | +126,980 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 899,999 | 1,008,158 | +108,159 | 0.22 | 0.22 | +0.00 | buy |
| Nantahala Capital Management, LLC | 0 | 68,857 | +68,857 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 0 | 44,648 | +44,648 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 158,984 | 200,971 | +41,987 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 35,537 | +35,537 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 300,400 | 333,300 | +32,900 | 0.00 | 0.00 | +0.00 | buy |
| Acuitas Investments, LLC | 132,502 | 164,984 | +32,482 | 0.17 | 0.19 | +0.03 | buy |
| BARCLAYS PLC | 48,131 | 79,658 | +31,527 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,655,439 | 1,685,129 | +29,690 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 12,757 | 32,972 | +20,215 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 244,519 | 261,919 | +17,400 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 7,429 | 24,431 | +17,002 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 16,759 | +16,759 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 801,923 | 816,634 | +14,711 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 12,813 | +12,813 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 755,957 | 768,740 | +12,783 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 11,446 | +11,446 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 75,467 | 80,375 | +4,908 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,697 | 6,566 | +3,869 | 0.00 | 0.00 | +0.00 | buy |
| LJI Wealth Management, LLC | 14,100 | 17,100 | +3,000 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 54,323 | 56,452 | +2,129 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,270 | 18,107 | +1,837 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 21 | 793 | +772 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 318,229 | 318,797 | +568 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 42,171 | 42,645 | +474 | 0.00 | 0.00 | +0.00 | buy |
| Cornerstone Planning Group LLC | 0 | 210 | +210 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 88,030 | 88,074 | +44 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 48 | 71 | +23 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 58,094 | 58,113 | +19 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 5,199 | 5,199 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 2,568 | 2,568 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,364 | 2,364 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 139,200 | 139,200 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 71,470 | 71,470 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 79,108 | 79,108 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 17,310,490 | 17,310,490 | 0 | 0.52 | 0.47 | -0.05 | hold |
| Board of Trustees of The Leland Stanford Junior University | 691,767 | 691,767 | 0 | 0.11 | 0.15 | +0.04 | hold |
| Janney Montgomery Scott LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bruce & Co., Inc. | 423,000 | 423,000 | 0 | 0.33 | 0.32 | -0.01 | hold |
| Marquette Asset Management, LLC | 23,930 | 23,930 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 129,438 | 129,438 | 0 | 0.01 | 0.01 | +0.00 | hold |
| PDT Partners, LLC | 16,310 | 16,310 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ICONIQ Capital, LLC | 1,016,864 | 1,016,864 | 0 | 0.05 | 0.06 | +0.01 | hold |
| Vontobel Holding Ltd. | 11,000 | 11,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Global Retirement Partners, LLC | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ikarian Capital, LLC | 476,586 | 476,586 | 0 | 0.35 | 0.39 | +0.04 | hold |
| Avion Wealth | 352 | 352 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Continuum Advisory, LLC | 14,852 | 14,852 | 0 | 0.01 | 0.01 | +0.01 | hold |
| Eagle Bay Advisors LLC | 582 | 582 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Activest Wealth Management | 1,001 | 1,001 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WEST PACES ADVISORS INC. | 12 | 12 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SEI INVESTMENTS CO | 143,841 | 143,841 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 2,747 | 2,747 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MEEDER ASSET MANAGEMENT INC | 15,137 | 15,137 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,631 | 1,631 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 28,800 | 28,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,154 | 1,154 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MATHER GROUP, LLC. | 4 | 0 | -4 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 7 | 0 | -7 | 0.00 | 0.00 | -0.00 | sell |
| INNEALTA CAPITAL, LLC | 10 | 0 | -10 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 17,553 | 17,445 | -108 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 276,550 | 276,412 | -138 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 5,309 | 4,998 | -311 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 25,335 | 24,979 | -356 | 0.00 | 0.00 | +0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 47,869 | 46,738 | -1,131 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 1,338 | 0 | -1,338 | 0.00 | 0.00 | -0.00 | sell |
| JGP Global Gestao de Recursos Ltda. | 14,957 | 12,950 | -2,007 | 0.04 | 0.07 | +0.02 | sell |
| AMERIPRISE FINANCIAL INC | 33,628 | 30,628 | -3,000 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 6,690 | 2,272 | -4,418 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 56,511 | 50,237 | -6,274 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 7,108 | 0 | -7,108 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 9,046 | 0 | -9,046 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 10,037 | 0 | -10,037 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 10,171 | 0 | -10,171 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 10,351 | 0 | -10,351 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 1,965,449 | 1,954,198 | -11,251 | 0.01 | 0.02 | +0.00 | sell |
| Erste Asset Management GmbH | 11,300 | 0 | -11,300 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 14,637 | 3,124 | -11,513 | 0.00 | 0.00 | -0.00 | sell |
| OXFORD ASSET MANAGEMENT LLP | 11,695 | 0 | -11,695 | 0.03 | 0.00 | -0.03 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 119,129 | 105,370 | -13,759 | 0.00 | 0.00 | +0.00 | sell |
| ZACKS INVESTMENT MANAGEMENT | 15,015 | 0 | -15,015 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 29,682 | 12,354 | -17,328 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 19,400 | 0 | -19,400 | 0.00 | 0.00 | -0.00 | sell |
| RIA Advisory Group LLC | 92,931 | 73,257 | -19,674 | 0.20 | 0.07 | -0.13 | sell |
| Squarepoint Ops LLC | 53,988 | 33,468 | -20,520 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 24,098 | 0 | -24,098 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 117,447 | 93,175 | -24,272 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 945,152 | 918,760 | -26,392 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 295,156 | 263,602 | -31,554 | 0.00 | 0.00 | -0.00 | sell |
| Nan Fung Group Holdings Ltd | 31,922 | 0 | -31,922 | 0.08 | 0.00 | -0.08 | sell |
| Hudson Bay Capital Management LP | 538,374 | 493,548 | -44,826 | 0.01 | 0.01 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 88,016 | 10,473 | -77,543 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 124,411 | 39,465 | -84,946 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 99,335 | 0 | -99,335 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 708,800 | 607,750 | -101,050 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 699,158 | 580,783 | -118,375 | 0.01 | 0.01 | -0.00 | sell |
| MARSHALL WACE, LLP | 166,425 | 40,015 | -126,410 | 0.00 | 0.00 | -0.00 | sell |