| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 17,310,490 | 17,310,490 | 0 | 0.63 | 2.05 | +1.42 | hold |
| BlackRock, Inc. | 3,579,442 | 2,952,381 | -627,061 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asset Management, L.P. | 452,696 | 2,837,116 | +2,384,420 | 0.00 | 0.10 | +0.10 | buy |
| VANGUARD GROUP INC | 1,822,301 | 1,950,292 | +127,991 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,055,707 | 1,335,000 | -720,707 | 0.01 | 0.03 | +0.02 | sell |
| ICONIQ Capital, LLC | 1,266,563 | 1,266,563 | 0 | 0.08 | 0.26 | +0.18 | hold |
| TCG Crossover Management, LLC | 1,145,538 | 1,145,538 | 0 | 0.49 | 0.92 | +0.43 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 401,540 | 1,000,000 | +598,460 | 0.31 | 2.37 | +2.06 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,969,876 | 969,906 | -999,970 | 0.02 | 0.03 | +0.01 | sell |
| STATE STREET CORP | 837,221 | 832,443 | -4,778 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 789,682 | 801,440 | +11,758 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 750,000 | 750,000 | 0 | 1.41 | 3.91 | +2.51 | hold |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 715,877 | +715,877 | 0.00 | 3.84 | +3.84 | buy |
| Board of Trustees of The Leland Stanford Junior University | 691,767 | 691,767 | 0 | 0.28 | 1.33 | +1.05 | hold |
| MORGAN STANLEY | 0 | 647,587 | +647,587 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 634,577 | +634,577 | 0.00 | 0.30 | +0.30 | buy |
| DIMENSIONAL FUND ADVISORS LP | 731,545 | 518,000 | -213,545 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 38,561 | 502,222 | +463,661 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 764,137 | 461,300 | -302,837 | 0.00 | 0.01 | +0.01 | sell |
| D. E. Shaw & Co., Inc. | 601,629 | 457,856 | -143,773 | 0.00 | 0.01 | +0.00 | sell |
| Ikarian Capital, LLC | 599,534 | 413,841 | -185,693 | 0.74 | 1.37 | +0.63 | sell |
| NORTHERN TRUST CORP | 344,597 | 337,904 | -6,693 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 199,011 | 326,776 | +127,765 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 309,071 | +309,071 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 590,884 | 290,884 | -300,000 | 0.16 | 0.29 | +0.14 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 271,823 | 279,481 | +7,658 | 0.00 | 0.00 | +0.00 | buy |
| Bruce & Co., Inc. | 323,000 | 279,308 | -43,692 | 0.39 | 1.42 | +1.03 | sell |
| FMR LLC | 252,269 | 263,053 | +10,784 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 250,000 | +250,000 | 0.00 | 0.19 | +0.19 | buy |
| FEDERATED HERMES, INC. | 244,231 | 244,231 | 0 | 0.00 | 0.01 | +0.01 | hold |
| TWO SIGMA ADVISERS, LP | 224,600 | 209,400 | -15,200 | 0.00 | 0.01 | +0.01 | sell |
| ROYAL BANK OF CANADA | 116,267 | 200,894 | +84,627 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 171,404 | +171,404 | 0.00 | 0.00 | +0.00 | buy |
| RIA Advisory Group LLC | 163,465 | 165,534 | +2,069 | 0.18 | 0.70 | +0.52 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 420,705 | 165,220 | -255,485 | 0.01 | 0.01 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 0 | 155,255 | +155,255 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 131,122 | 154,905 | +23,783 | 0.00 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 138,303 | +138,303 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 53,397 | 138,261 | +84,864 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 126,613 | +126,613 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 121,412 | 121,412 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 92,505 | 117,059 | +24,554 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 161,264 | 116,435 | -44,829 | 0.02 | 0.05 | +0.03 | sell |
| Bank of New York Mellon Corp | 97,357 | 104,453 | +7,096 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 76,866 | 100,179 | +23,313 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.02 | 0.06 | +0.04 | hold |
| GSA CAPITAL PARTNERS LLP | 164,432 | 87,697 | -76,735 | 0.04 | 0.12 | +0.08 | sell |
| AMERICAN CENTURY COMPANIES INC | 79,745 | 78,178 | -1,567 | 0.00 | 0.00 | +0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 101,900 | 72,200 | -29,700 | 0.01 | 0.03 | +0.02 | sell |
| BARCLAYS PLC | 87,416 | 68,849 | -18,567 | 0.00 | 0.00 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 0 | 62,348 | +62,348 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 60,600 | +60,600 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 57,539 | 57,539 | 0 | 0.03 | 0.02 | -0.01 | hold |
| UBS Group AG | 0 | 56,709 | +56,709 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 72,610 | 55,060 | -17,550 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 266,354 | 48,853 | -217,501 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 48,934 | 48,459 | -475 | 0.00 | 0.00 | +0.00 | sell |
| Trexquant Investment LP | 0 | 47,255 | +47,255 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 45,455 | +45,455 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 40,294 | 42,688 | +2,394 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 41,261 | +41,261 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 56,601 | 41,173 | -15,428 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 20,526 | 35,957 | +15,431 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 73,564 | 30,724 | -42,840 | 0.00 | 0.00 | +0.00 | sell |
| Campbell & CO Investment Adviser LLC | 0 | 29,804 | +29,804 | 0.00 | 0.04 | +0.04 | buy |
| Headlands Technologies LLC | 8,083 | 29,736 | +21,653 | 0.00 | 0.04 | +0.04 | buy |
| WELLS FARGO & COMPANY/MN | 26,128 | 26,419 | +291 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 40,405 | 25,078 | -15,327 | 0.01 | 0.02 | +0.02 | sell |
| Aries Wealth Management | 25,000 | 25,000 | 0 | 0.02 | 0.10 | +0.07 | hold |
| Virtu Financial LLC | 0 | 24,082 | +24,082 | 0.00 | 0.02 | +0.02 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 0 | 21,567 | +21,567 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 19,644 | +19,644 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 0 | 19,427 | +19,427 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 15,419 | +15,419 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 16,498 | 15,307 | -1,191 | 0.00 | 0.00 | +0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 15,070 | 14,955 | -115 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,563 | 14,950 | -3,613 | 0.00 | 0.00 | +0.00 | sell |
| Continuum Advisory, LLC | 14,852 | 14,852 | 0 | 0.01 | 0.03 | +0.02 | hold |
| SG Americas Securities, LLC | 0 | 13,903 | +13,903 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 4,875 | 13,878 | +9,003 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 13,194 | +13,194 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 12,458 | +12,458 | 0.00 | 0.03 | +0.03 | buy |
| OSAIC HOLDINGS, INC. | 0 | 10,099 | +10,099 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 6,254 | 9,097 | +2,843 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 11,157 | 8,574 | -2,583 | 0.00 | 0.00 | +0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 8,085 | 8,235 | +150 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,364 | 6,373 | +3,009 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 2,935 | 2,985 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 6,485 | 2,817 | -3,668 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 2,747 | 2,747 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 2,568 | 2,568 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Point72 (DIFC) Ltd | 0 | 2,516 | +2,516 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 874 | 2,259 | +1,385 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 8,056 | 2,212 | -5,844 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 2,038 | +2,038 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 9,282 | 1,841 | -7,441 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,631 | 1,631 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,154 | 1,154 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 274 | 1,074 | +800 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 1,052 | +1,052 | 0.00 | 0.00 | +0.00 | buy |