| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JACOBS LEVY EQUITY MANAGEMENT, INC | 252,605 | 723,675 | +471,070 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,636,621 | 1,908,302 | +271,681 | 0.01 | 0.02 | +0.01 | buy |
| TCG Crossover Management, LLC | 0 | 267,941 | +267,941 | 0.00 | 0.09 | +0.09 | buy |
| D. E. Shaw & Co., Inc. | 996,133 | 1,208,973 | +212,840 | 0.00 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 134,295 | 333,099 | +198,804 | 0.00 | 0.00 | +0.00 | buy |
| Newtyn Management, LLC | 1,608,694 | 1,771,241 | +162,547 | 0.71 | 1.06 | +0.34 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 114,200 | +114,200 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 312,881 | 412,881 | +100,000 | 0.21 | 0.34 | +0.13 | buy |
| Acuitas Investments, LLC | 147,049 | 234,092 | +87,043 | 0.16 | 0.37 | +0.22 | buy |
| Atom Investors LP | 20,975 | 105,007 | +84,032 | 0.01 | 0.06 | +0.05 | buy |
| TWO SIGMA ADVISERS, LP | 228,000 | 305,900 | +77,900 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 48,161 | 121,419 | +73,258 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 3,704 | 72,416 | +68,712 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 656,564 | 720,435 | +63,871 | 0.00 | 0.00 | +0.00 | buy |
| Aristides Capital LLC | 0 | 57,035 | +57,035 | 0.00 | 0.09 | +0.09 | buy |
| HRT FINANCIAL LP | 0 | 45,643 | +45,643 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 43,122 | +43,122 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 63,384 | 102,261 | +38,877 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 672,244 | 708,245 | +36,001 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 6,800 | 34,000 | +27,200 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 67,445 | 94,155 | +26,710 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 22,288 | +22,288 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Middle East FZE | 0 | 21,067 | +21,067 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 131,896 | 152,015 | +20,119 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 50,386 | 68,464 | +18,078 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 14,321 | 32,115 | +17,794 | 0.00 | 0.00 | +0.00 | buy |
| Marquette Asset Management, LLC | 30,258 | 47,944 | +17,686 | 0.01 | 0.03 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 16,201 | +16,201 | 0.00 | 0.00 | +0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 0 | 15,079 | +15,079 | 0.00 | 0.03 | +0.03 | buy |
| Graham Capital Management, L.P. | 0 | 14,333 | +14,333 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 12,800 | +12,800 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 21,170 | 33,628 | +12,458 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,633,016 | 1,643,470 | +10,454 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 118,633 | 128,313 | +9,680 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 20,654 | 29,835 | +9,181 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 2,400 | 10,400 | +8,000 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 53,799 | 57,830 | +4,031 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 679 | 4,663 | +3,984 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 237,916 | 240,996 | +3,080 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 202 | 2,896 | +2,694 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 15,237 | 16,461 | +1,224 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 78,715 | 79,195 | +480 | 0.00 | 0.00 | +0.00 | buy |
| Avion Wealth | 0 | 352 | +352 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 54,755 | 55,069 | +314 | 0.00 | 0.00 | +0.00 | buy |
| Glassman Wealth Services | 0 | 241 | +241 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 0 | 69 | +69 | 0.00 | 0.00 | 0.00 | buy |
| HSBC HOLDINGS PLC | 40,795 | 40,821 | +26 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 5,752 | 5,752 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 2,568 | 2,568 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 30,808 | 30,808 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 154,099 | 154,099 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 17,310,490 | 17,310,490 | 0 | 0.18 | 0.60 | +0.42 | hold |
| Board of Trustees of The Leland Stanford Junior University | 691,767 | 691,767 | 0 | 0.10 | 0.14 | +0.04 | hold |
| Janney Montgomery Scott LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bruce & Co., Inc. | 473,000 | 473,000 | 0 | 0.29 | 0.50 | +0.21 | hold |
| Colonial Trust Advisors | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ICONIQ Capital, LLC | 1,016,864 | 1,016,864 | 0 | 0.04 | 0.06 | +0.02 | hold |
| Vontobel Holding Ltd. | 14,000 | 14,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GPS Wealth Strategies Group, LLC | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Global Retirement Partners, LLC | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nan Fung Group Holdings Ltd | 19,622 | 19,622 | 0 | 0.03 | 0.04 | +0.01 | hold |
| Continuum Advisory, LLC | 13,852 | 13,852 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Eagle Bay Advisors LLC | 282 | 282 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WEST PACES ADVISORS INC. | 12 | 12 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Erste Asset Management GmbH | 11,300 | 11,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 2,747 | 2,747 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Newbridge Financial Services Group, Inc. | 8 | 0 | -8 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 16,186 | 16,122 | -64 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,708 | 1,642 | -66 | 0.00 | 0.00 | +0.00 | sell |
| Daiwa Securities Group Inc. | 151 | 0 | -151 | 0.00 | 0.00 | 0.00 | sell |
| AMALGAMATED BANK | 3,233 | 2,890 | -343 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 779 | 0 | -779 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 1,295 | 0 | -1,295 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 1,349 | 0 | -1,349 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 1,396 | 0 | -1,396 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7,156 | 5,338 | -1,818 | 0.00 | 0.00 | +0.00 | sell |
| LJI Wealth Management, LLC | 18,200 | 16,100 | -2,100 | 0.01 | 0.01 | +0.00 | sell |
| SG Americas Securities, LLC | 20,345 | 17,689 | -2,656 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 2,836 | 0 | -2,836 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 70,930 | 66,030 | -4,900 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 16,994 | 10,848 | -6,146 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 261,374 | 254,453 | -6,921 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Trading LLC | 8,254 | 0 | -8,254 | 0.00 | 0.00 | -0.00 | sell |
| RIA Advisory Group LLC | 10,265 | 0 | -10,265 | 0.01 | 0.00 | -0.01 | sell |
| VIRTUS ADVISERS, LLC | 10,947 | 0 | -10,947 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA SECURITIES, LLC | 13,528 | 0 | -13,528 | 0.00 | 0.00 | -0.00 | sell |
| Parkwood LLC | 29,255 | 0 | -29,255 | 0.01 | 0.00 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 435,093 | 393,520 | -41,573 | 0.00 | 0.00 | +0.00 | sell |
| Capital Impact Advisors, LLC | 44,926 | 0 | -44,926 | 0.14 | 0.00 | -0.14 | sell |
| AQR CAPITAL MANAGEMENT LLC | 45,118 | 0 | -45,118 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 59,129 | 0 | -59,129 | 0.02 | 0.00 | -0.02 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 60,234 | 0 | -60,234 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 61,104 | 0 | -61,104 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 68,750 | 0 | -68,750 | 0.01 | 0.00 | -0.01 | sell |
| Wellington Shields & Co., LLC | 80,000 | 0 | -80,000 | 0.04 | 0.00 | -0.04 | sell |
| Monaco Asset Management SAM | 493,726 | 380,610 | -113,116 | 0.44 | 0.44 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,114,461 | 1,000,000 | -114,461 | 0.75 | 0.94 | +0.19 | sell |
| Wellington Shields Capital Management, LLC | 153,320 | 0 | -153,320 | 0.04 | 0.00 | -0.04 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 792,931 | 620,299 | -172,632 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 637,454 | 437,007 | -200,447 | 0.00 | 0.00 | +0.00 | sell |