| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,446 | 1,268,509 | +1,257,063 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,139,527 | +1,139,527 | 0.00 | 0.02 | +0.02 | buy |
| Point72 Asset Management, L.P. | 0 | 523,751 | +523,751 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 500,000 | 1,000,000 | +500,000 | 0.29 | 2.22 | +1.93 | buy |
| Invesco Ltd. | 80,375 | 519,010 | +438,635 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 339,238 | +339,238 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 68,857 | 266,613 | +197,756 | 0.02 | 0.19 | +0.17 | buy |
| UBS Group AG | 0 | 167,561 | +167,561 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 166,400 | +166,400 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 1,008,158 | 1,145,538 | +137,380 | 0.22 | 1.11 | +0.89 | buy |
| Ikarian Capital, LLC | 476,586 | 576,166 | +99,580 | 0.39 | 1.64 | +1.25 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 90,691 | +90,691 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 44,648 | 131,646 | +86,998 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 32,972 | 81,991 | +49,019 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 47,880 | +47,880 | 0.00 | 0.06 | +0.06 | buy |
| RIA Advisory Group LLC | 73,257 | 118,546 | +45,289 | 0.07 | 0.40 | +0.33 | buy |
| Trexquant Investment LP | 0 | 40,736 | +40,736 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 33,779 | +33,779 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 129,438 | 157,858 | +28,420 | 0.01 | 0.05 | +0.04 | buy |
| DIMENSIONAL FUND ADVISORS LP | 495,179 | 521,237 | +26,058 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 25,681 | +25,681 | 0.00 | 0.03 | +0.03 | buy |
| ADAR1 Capital Management, LLC | 0 | 23,700 | +23,700 | 0.00 | 0.05 | +0.05 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 21,443 | +21,443 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 21,040 | +21,040 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 200,971 | 220,532 | +19,561 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 14,737 | +14,737 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 816,634 | 831,169 | +14,535 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 11,841 | +11,841 | 0.00 | 0.02 | +0.02 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 11,818 | +11,818 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 10,638 | +10,638 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 39,465 | 49,406 | +9,941 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 5,199 | 14,759 | +9,560 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 58,113 | 67,546 | +9,433 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 9,070 | +9,070 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 30,628 | 38,624 | +7,996 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 12,813 | 20,684 | +7,871 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 261,919 | 269,597 | +7,678 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 88,074 | 94,585 | +6,511 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 93,175 | 98,102 | +4,927 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 4,006 | +4,006 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 3,935 | +3,935 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 56,452 | 59,967 | +3,515 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 2,988 | +2,988 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 50,237 | 51,469 | +1,232 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 102 | 1,046 | +944 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 24,431 | 25,231 | +800 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,107 | 18,563 | +456 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 2,272 | 2,535 | +263 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 71 | 217 | +146 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 68 | +68 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 793 | 857 | +64 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,568 | 2,568 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,364 | 2,364 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 139,200 | 139,200 | 0 | 0.01 | 0.03 | +0.02 | hold |
| ALLIANCEBERNSTEIN L.P. | 71,470 | 71,470 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 17,310,490 | 17,310,490 | 0 | 0.47 | 1.84 | +1.37 | hold |
| Board of Trustees of The Leland Stanford Junior University | 691,767 | 691,767 | 0 | 0.15 | 0.59 | +0.43 | hold |
| Marquette Asset Management, LLC | 23,930 | 23,930 | 0 | 0.01 | 0.04 | +0.03 | hold |
| JGP Global Gestao de Recursos Ltda. | 12,950 | 12,950 | 0 | 0.07 | 0.29 | +0.23 | hold |
| Cerity Partners LLC | 16,759 | 16,759 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ICONIQ Capital, LLC | 1,016,864 | 1,016,864 | 0 | 0.06 | 0.16 | +0.10 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Global Retirement Partners, LLC | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avion Wealth | 352 | 352 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cornerstone Planning Group LLC | 210 | 210 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Continuum Advisory, LLC | 14,852 | 14,852 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Eagle Bay Advisors LLC | 582 | 582 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Activest Wealth Management | 1,001 | 1,001 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WEST PACES ADVISORS INC. | 12 | 12 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 2,747 | 2,747 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MEEDER ASSET MANAGEMENT INC | 15,137 | 15,137 | 0 | 0.00 | 0.01 | +0.01 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,631 | 1,631 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,154 | 1,154 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 768,740 | 768,694 | -46 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 17,445 | 16,221 | -1,224 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,124 | 1,709 | -1,415 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 6,566 | 5,004 | -1,562 | 0.00 | 0.00 | +0.00 | sell |
| PDT Partners, LLC | 16,310 | 13,759 | -2,551 | 0.00 | 0.01 | +0.01 | sell |
| WELLS FARGO & COMPANY/MN | 24,979 | 22,269 | -2,710 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 1,685,129 | 1,682,209 | -2,920 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 47,616 | 44,256 | -3,360 | 0.00 | 0.01 | +0.00 | sell |
| LJI Wealth Management, LLC | 17,100 | 13,100 | -4,000 | 0.01 | 0.03 | +0.02 | sell |
| SIMPLEX TRADING, LLC | 4,998 | 169 | -4,829 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 79,658 | 73,927 | -5,731 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 276,412 | 269,654 | -6,758 | 0.00 | 0.00 | +0.00 | sell |
| Janney Montgomery Scott LLC | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 10,473 | 0 | -10,473 | 0.00 | 0.00 | -0.00 | sell |
| Vontobel Holding Ltd. | 11,000 | 0 | -11,000 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 12,354 | 0 | -12,354 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 42,645 | 28,967 | -13,678 | 0.00 | 0.00 | +0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 105,370 | 88,070 | -17,300 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 28,800 | 0 | -28,800 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 33,468 | 0 | -33,468 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 35,537 | 0 | -35,537 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 40,015 | 0 | -40,015 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 318,797 | 272,253 | -46,544 | 0.00 | 0.00 | +0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 46,738 | 0 | -46,738 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 333,300 | 284,200 | -49,100 | 0.00 | 0.01 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 79,108 | 13,708 | -65,400 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 918,760 | 852,076 | -66,684 | 0.00 | 0.01 | +0.01 | sell |