| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 17,310,490 | 19,919,186 | +2,608,696 | 2.05 | 3.26 | +1.21 | buy |
| Boxer Capital Management, LLC | 750,000 | 1,136,000 | +386,000 | 3.91 | 6.95 | +3.04 | buy |
| Ikarian Capital, LLC | 413,841 | 719,787 | +305,946 | 1.37 | 2.61 | +1.23 | buy |
| TCG Crossover Management, LLC | 1,145,538 | 1,445,538 | +300,000 | 0.92 | 1.34 | +0.42 | buy |
| PERCEPTIVE ADVISORS LLC | 634,577 | 848,900 | +214,323 | 0.30 | 0.42 | +0.12 | buy |
| Soleus Capital Management, L.P. | 19,644 | 60,000 | +40,356 | 0.02 | 0.07 | +0.05 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,000,000 | 1,023,122 | +23,122 | 2.37 | 4.14 | +1.77 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 21,567 | 41,340 | +19,773 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 12,458 | 29,419 | +16,961 | 0.03 | 0.13 | +0.10 | buy |
| Headlands Technologies LLC | 29,736 | 16,278 | -13,458 | 0.04 | 0.04 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 165,220 | 127,230 | -37,990 | 0.01 | 0.01 | +0.00 | sell |
| RIA Advisory Group LLC | 165,534 | 113,473 | -52,061 | 0.70 | 0.77 | +0.07 | sell |
| Bruce & Co., Inc. | 279,308 | 165,000 | -114,308 | 1.42 | 1.43 | +0.01 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 715,877 | 503,830 | -212,047 | 3.84 | 4.42 | +0.58 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,335,000 | 785,000 | -550,000 | 0.03 | 0.03 | -0.00 | sell |