| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 17,310,490 | 19,919,186 | +2,608,696 | 2.05 | 3.26 | +1.21 | buy |
| BlackRock, Inc. | 2,952,381 | 3,954,603 | +1,002,222 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,950,292 | 2,313,395 | +363,103 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 2,837,116 | 2,166,929 | -670,187 | 0.10 | 0.09 | -0.01 | sell |
| BRAIDWELL LP | 0 | 2,072,788 | +2,072,788 | 0.00 | 1.85 | +1.85 | buy |
| STATE STREET CORP | 832,443 | 1,732,015 | +899,572 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 1,487,933 | +1,487,933 | 0.00 | 0.42 | +0.42 | buy |
| TCG Crossover Management, LLC | 1,145,538 | 1,445,538 | +300,000 | 0.92 | 1.34 | +0.42 | buy |
| GOLDMAN SACHS GROUP INC | 326,776 | 1,303,030 | +976,254 | 0.00 | 0.01 | +0.00 | buy |
| ICONIQ Capital, LLC | 1,266,563 | 1,266,563 | 0 | 0.26 | 0.53 | +0.28 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 502,222 | 1,170,179 | +667,957 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 750,000 | 1,136,000 | +386,000 | 3.91 | 6.95 | +3.04 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,000,000 | 1,023,122 | +23,122 | 2.37 | 4.14 | +1.77 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 801,440 | 897,692 | +96,252 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 634,577 | 848,900 | +214,323 | 0.30 | 0.43 | +0.13 | buy |
| Artisan Partners Limited Partnership | 0 | 836,506 | +836,506 | 0.00 | 0.04 | +0.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,335,000 | 785,000 | -550,000 | 0.03 | 0.03 | -0.00 | sell |
| Ikarian Capital, LLC | 413,841 | 719,787 | +305,946 | 1.37 | 2.61 | +1.23 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 969,906 | 709,818 | -260,088 | 0.03 | 0.03 | +0.00 | sell |
| MORGAN STANLEY | 647,587 | 699,772 | +52,185 | 0.00 | 0.00 | +0.00 | buy |
| Board of Trustees of The Leland Stanford Junior University | 691,767 | 691,767 | 0 | 1.33 | 3.90 | +2.57 | hold |
| Invesco Ltd. | 100,179 | 555,073 | +454,894 | 0.00 | 0.00 | +0.00 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 715,877 | 503,830 | -212,047 | 3.84 | 4.42 | +0.58 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 117,059 | 473,796 | +356,737 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 409,126 | +409,126 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 461,300 | 359,800 | -101,500 | 0.01 | 0.02 | +0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 279,481 | 340,657 | +61,176 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 337,904 | 333,668 | -4,236 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 518,000 | 327,482 | -190,518 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 457,856 | 320,647 | -137,209 | 0.01 | 0.01 | +0.00 | sell |
| CITADEL ADVISORS LLC | 45,455 | 290,479 | +245,024 | 0.00 | 0.01 | +0.00 | buy |
| Jain Global LLC | 0 | 284,899 | +284,899 | 0.00 | 0.08 | +0.08 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 15,419 | 263,278 | +247,859 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 244,231 | 244,231 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Atom Investors LP | 0 | 207,495 | +207,495 | 0.00 | 0.46 | +0.46 | buy |
| FMR LLC | 263,053 | 199,190 | -63,863 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 309,071 | 196,689 | -112,382 | 0.00 | 0.00 | +0.00 | sell |
| Trexquant Investment LP | 47,255 | 190,505 | +143,250 | 0.01 | 0.05 | +0.04 | buy |
| PANAGORA ASSET MANAGEMENT INC | 154,905 | 180,718 | +25,813 | 0.01 | 0.02 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 175,500 | +175,500 | 0.00 | 1.03 | +1.03 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 116,435 | 173,221 | +56,786 | 0.05 | 0.12 | +0.08 | buy |
| UBS Group AG | 56,709 | 168,562 | +111,853 | 0.00 | 0.00 | +0.00 | buy |
| Bruce & Co., Inc. | 279,308 | 165,000 | -114,308 | 1.42 | 1.43 | +0.01 | sell |
| TD ASSET MANAGEMENT INC | 60,600 | 133,918 | +73,318 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 165,220 | 127,230 | -37,990 | 0.01 | 0.01 | +0.00 | sell |
| BARCLAYS PLC | 68,849 | 124,334 | +55,485 | 0.00 | 0.00 | +0.00 | buy |
| RIA Advisory Group LLC | 165,534 | 113,473 | -52,061 | 0.70 | 0.77 | +0.07 | sell |
| TWO SIGMA ADVISERS, LP | 209,400 | 103,100 | -106,300 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 104,453 | 102,713 | -1,740 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 26,419 | 92,143 | +65,724 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 41,261 | 91,508 | +50,247 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 10,099 | 83,421 | +73,322 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 62,348 | 78,320 | +15,972 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 121,412 | 73,044 | -48,368 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,631 | 67,260 | +65,629 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 0 | 61,983 | +61,983 | 0.00 | 0.33 | +0.33 | buy |
| MILLENNIUM MANAGEMENT LLC | 155,255 | 60,621 | -94,634 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 19,644 | 60,000 | +40,356 | 0.02 | 0.07 | +0.05 | buy |
| Rafferty Asset Management, LLC | 0 | 59,520 | +59,520 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 41,173 | 57,693 | +16,520 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 138,261 | 51,671 | -86,590 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 44,047 | +44,047 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 29,804 | 43,369 | +13,565 | 0.04 | 0.06 | +0.02 | buy |
| RHUMBLINE ADVISERS | 48,459 | 43,244 | -5,215 | 0.00 | 0.00 | +0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 72,200 | 43,200 | -29,000 | 0.03 | 0.03 | +0.00 | sell |
| POLEN CAPITAL MANAGEMENT LLC | 21,567 | 41,340 | +19,773 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 37,965 | +37,965 | 0.00 | 0.02 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 42,688 | 36,775 | -5,913 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 171,404 | 36,722 | -134,682 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 30,724 | 35,317 | +4,593 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 55,060 | 35,180 | -19,880 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 35,957 | 31,717 | -4,240 | 0.00 | 0.00 | +0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 12,458 | 29,419 | +16,961 | 0.03 | 0.13 | +0.10 | buy |
| J. Goldman & Co LP | 0 | 28,949 | +28,949 | 0.00 | 0.03 | +0.03 | buy |
| Aries Wealth Management | 25,000 | 25,000 | 0 | 0.10 | 0.15 | +0.06 | hold |
| SG Americas Securities, LLC | 13,903 | 24,125 | +10,222 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 22,092 | +22,092 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 0 | 20,664 | +20,664 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 48,853 | 19,896 | -28,957 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 0 | 19,529 | +19,529 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 19,427 | 19,427 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14,950 | 18,666 | +3,716 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 18,399 | +18,399 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 13,194 | 17,905 | +4,711 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 17,207 | +17,207 | 0.00 | 0.01 | +0.01 | buy |
| Artia Global Partners LP | 0 | 17,019 | +17,019 | 0.00 | 0.08 | +0.08 | buy |
| CITIGROUP INC | 8,574 | 16,617 | +8,043 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 15,307 | 16,446 | +1,139 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 29,736 | 16,278 | -13,458 | 0.04 | 0.04 | -0.00 | sell |
| Continuum Advisory, LLC | 14,852 | 14,852 | 0 | 0.03 | 0.04 | +0.02 | hold |
| Vanguard Personalized Indexing Management, LLC | 14,955 | 14,809 | -146 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 13,939 | +13,939 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 13,560 | +13,560 | 0.00 | 0.09 | +0.09 | buy |
| Jefferies Financial Group Inc. | 0 | 13,134 | +13,134 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 11,173 | +11,173 | 0.00 | 0.08 | +0.08 | buy |
| Creative Planning | 0 | 10,787 | +10,787 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 57,539 | 10,627 | -46,912 | 0.02 | 0.01 | -0.01 | sell |
| Scientech Research LLC | 0 | 10,329 | +10,329 | 0.00 | 0.18 | +0.18 | buy |