| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Candriam S.C.A. | 539,882 | 680,132 | +140,250 | 0.06 | 0.06 | +0.00 | buy |
| Granahan Investment Management, LLC | 307,021 | 378,542 | +71,521 | 0.32 | 0.29 | -0.04 | buy |
| Mitsubishi UFJ Asset Management (UK) Ltd. | 8,000 | 45,000 | +37,000 | 0.00 | 0.44 | +0.44 | buy |
| Sofinnova Investments, Inc. | 1,701,904 | 1,720,316 | +18,412 | 1.41 | 1.88 | +0.47 | buy |
| Edgestream Partners, L.P. | 59,888 | 71,885 | +11,997 | 0.04 | 0.05 | +0.00 | buy |
| ANTIPODES PARTNERS Ltd | 7,818 | 7,971 | +153 | 0.00 | 0.00 | -0.00 | buy |
| Freestone Capital Holdings, LLC | 61,514 | 60,589 | -925 | 0.04 | 0.03 | -0.01 | sell |
| Aristotle Atlantic Partners, LLC | 125,018 | 122,675 | -2,343 | 0.13 | 0.11 | -0.02 | sell |
| Magnus Financial Group LLC | 45,759 | 41,759 | -4,000 | 0.08 | 0.06 | -0.02 | sell |
| TEMA ETFS LLC | 275,896 | 268,167 | -7,729 | 0.41 | 0.18 | -0.22 | sell |
| SummitTX Capital, L.P. | 92,880 | 59,476 | -33,404 | 0.06 | 0.03 | -0.03 | sell |
| Sio Capital Management, LLC | 165,110 | 124,168 | -40,942 | 0.52 | 0.44 | -0.08 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 4,788,231 | 4,581,431 | -206,800 | 0.08 | 0.06 | -0.03 | sell |
| Redmile Group, LLC | 5,558,885 | 4,911,590 | -647,295 | 8.05 | 6.99 | -1.06 | sell |