| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 0 | 1,516,454 | +1,516,454 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,051,222 | 2,245,673 | +1,194,451 | 0.00 | 0.01 | +0.01 | buy |
| Redmile Group, LLC | 3,879,415 | 4,889,554 | +1,010,139 | 1.48 | 4.43 | +2.94 | buy |
| Point72 Asset Management, L.P. | 682,619 | 1,641,900 | +959,281 | 0.02 | 0.12 | +0.10 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 720,000 | +720,000 | 0.00 | 1.85 | +1.85 | buy |
| BROWN ADVISORY INC | 0 | 669,760 | +669,760 | 0.00 | 0.02 | +0.02 | buy |
| FMR LLC | 3,906,143 | 4,534,643 | +628,500 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 0 | 625,083 | +625,083 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 594,396 | +594,396 | 0.00 | 0.87 | +0.87 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 594,000 | +594,000 | 0.00 | 0.09 | +0.09 | buy |
| MARSHALL WACE, LLP | 0 | 521,551 | +521,551 | 0.00 | 0.02 | +0.02 | buy |
| LORD, ABBETT & CO. LLC | 0 | 445,435 | +445,435 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 36,018 | 465,286 | +429,268 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 922,892 | 1,318,056 | +395,164 | 0.11 | 0.30 | +0.19 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 354,762 | +354,762 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 331,764 | +331,764 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 203,548 | 530,462 | +326,914 | 0.00 | 0.02 | +0.02 | buy |
| Atika Capital Management LLC | 0 | 315,000 | +315,000 | 0.00 | 0.87 | +0.87 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,827 | 319,514 | +284,687 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 1,740,026 | 2,019,738 | +279,712 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 263,869 | +263,869 | 0.00 | 0.00 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 0 | 213,000 | +213,000 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 0 | 185,000 | +185,000 | 0.00 | 0.02 | +0.02 | buy |
| STATE STREET CORP | 30,591 | 200,691 | +170,100 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 127,280 | 285,806 | +158,526 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 0 | 149,397 | +149,397 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,391,471 | 1,538,414 | +146,943 | 0.01 | 0.02 | +0.01 | buy |
| Monashee Investment Management LLC | 0 | 132,500 | +132,500 | 0.00 | 0.39 | +0.39 | buy |
| Informed Momentum Co LLC | 0 | 127,980 | +127,980 | 0.00 | 0.49 | +0.49 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 28,649 | 154,488 | +125,839 | 0.00 | 0.01 | +0.01 | buy |
| Cetera Investment Advisers | 0 | 123,098 | +123,098 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 119,772 | +119,772 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 19,005 | 133,438 | +114,433 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 320,838 | 432,479 | +111,641 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 103,475 | 197,767 | +94,292 | 0.00 | 0.01 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 78,207 | +78,207 | 0.00 | 0.09 | +0.09 | buy |
| Zimmer Partners, LP | 0 | 75,000 | +75,000 | 0.00 | 0.04 | +0.04 | buy |
| Swiss National Bank | 0 | 71,400 | +71,400 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 69,305 | +69,305 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 10,246 | 73,538 | +63,292 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 53,746 | 109,686 | +55,940 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 54,749 | +54,749 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 43,400 | +43,400 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 42,300 | +42,300 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 100,228 | 135,488 | +35,260 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 32,681 | +32,681 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 31,878 | +31,878 | 0.00 | 0.07 | +0.07 | buy |
| Legal & General Group Plc | 0 | 30,728 | +30,728 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 26,736 | +26,736 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 24,651 | +24,651 | 0.00 | 0.00 | +0.00 | buy |
| Marathon Trading Investment Management LLC | 0 | 23,500 | +23,500 | 0.00 | 0.23 | +0.23 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 23,031 | +23,031 | 0.00 | 0.01 | +0.01 | buy |
| Clear Creek Financial Management, LLC | 0 | 22,153 | +22,153 | 0.00 | 0.07 | +0.07 | buy |
| Man Group plc | 23,490 | 44,853 | +21,363 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 20,777 | +20,777 | 0.00 | 0.02 | +0.02 | buy |
| Denver PWM, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.16 | +0.16 | buy |
| Ovata Capital Management Ltd | 0 | 20,000 | +20,000 | 0.00 | 0.26 | +0.26 | buy |
| SEI INVESTMENTS CO | 0 | 18,990 | +18,990 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 17,976 | +17,976 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 61,346 | 79,223 | +17,877 | 0.00 | 0.01 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 17,800 | +17,800 | 0.00 | 0.01 | +0.01 | buy |
| Polymer Capital Management (HK) LTD | 0 | 12,726 | +12,726 | 0.00 | 0.08 | +0.08 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 11,935 | +11,935 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 11,700 | +11,700 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 10,536 | +10,536 | 0.00 | 0.01 | +0.01 | buy |
| Arizona State Retirement System | 0 | 9,944 | +9,944 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 9,367 | +9,367 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 8,740 | +8,740 | 0.00 | 0.00 | +0.00 | buy |
| BRIGHTON JONES LLC | 0 | 8,477 | +8,477 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 7,489 | +7,489 | 0.00 | 0.05 | +0.05 | buy |
| EntryPoint Capital, LLC | 25 | 5,491 | +5,466 | 0.00 | 0.12 | +0.12 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 4,214 | +4,214 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 528 | 4,255 | +3,727 | 0.00 | 0.03 | +0.03 | buy |
| MACQUARIE GROUP LTD | 0 | 3,518 | +3,518 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 33,142 | 34,991 | +1,849 | 0.00 | 0.01 | +0.01 | buy |
| US BANCORP \DE\ | 0 | 1,380 | +1,380 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,093 | +1,093 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 0 | 1,011 | +1,011 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 858 | +858 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 452 | +452 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 2,717 | 3,165 | +448 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 87 | 335 | +248 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 34 | +34 | 0.00 | 0.00 | +0.00 | buy |
| Baldwin Investment Management, LLC | 25,394 | 25,394 | 0 | 0.04 | 0.09 | +0.04 | hold |
| Laurion Capital Management LP | 102,954 | 102,954 | 0 | 0.04 | 0.07 | +0.03 | hold |
| EcoR1 Capital, LLC | 3,879,415 | 3,879,415 | 0 | 1.08 | 2.43 | +1.35 | hold |
| Magnus Financial Group LLC | 25,759 | 25,759 | 0 | 0.04 | 0.08 | +0.04 | hold |
| Farther Finance Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MB, LEVIS & ASSOCIATES, LLC | 2,373 | 2,373 | 0 | 0.01 | 0.03 | +0.02 | hold |
| Newbridge Financial Services Group, Inc. | 225 | 0 | -225 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 29,484 | 27,919 | -1,565 | 0.00 | 0.00 | +0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 13,000 | 10,953 | -2,047 | 0.00 | 0.00 | +0.00 | sell |
| Sterling Investment Advisors, Ltd. | 16,965 | 12,465 | -4,500 | 0.06 | 0.09 | +0.03 | sell |
| LAZARD ASSET MANAGEMENT LLC | 7,700 | 0 | -7,700 | 0.00 | 0.00 | -0.00 | sell |
| MIRABELLA FINANCIAL SERVICES LLP | 12,200 | 0 | -12,200 | 0.02 | 0.00 | -0.02 | sell |
| DIMENSIONAL FUND ADVISORS LP | 14,054 | 0 | -14,054 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 15,844 | 0 | -15,844 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 16,100 | 0 | -16,100 | 0.01 | 0.00 | -0.01 | sell |
| HighTower Advisors, LLC | 16,818 | 0 | -16,818 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 18,302 | 0 | -18,302 | 0.00 | 0.00 | -0.00 | sell |