| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 688,790 | 4,360,675 | +3,671,885 | 0.02 | 0.08 | +0.06 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 280,800 | 3,413,700 | +3,132,900 | 0.00 | 0.02 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 5,499,954 | 7,554,594 | +2,054,640 | 0.04 | 0.03 | -0.00 | buy |
| BlackRock, Inc. | 4,124,988 | 5,662,699 | +1,537,711 | 0.00 | 0.00 | -0.00 | buy |
| Opaleye Management Inc. | 2,040,000 | 3,550,000 | +1,510,000 | 3.79 | 5.32 | +1.53 | buy |
| VANGUARD GROUP INC | 3,003,438 | 4,307,191 | +1,303,753 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 82,595 | 1,377,053 | +1,294,458 | 0.00 | 0.02 | +0.01 | buy |
| Enavate Sciences GP, LLC | 3,478,261 | 4,768,583 | +1,290,322 | 26.53 | 24.18 | -2.35 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,282,754 | 3,069,607 | +786,853 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 0 | 750,000 | +750,000 | 0.00 | 0.23 | +0.23 | buy |
| Woodline Partners LP | 980,925 | 1,657,729 | +676,804 | 0.07 | 0.07 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 610,551 | +610,551 | 0.00 | 0.04 | +0.04 | buy |
| Redmile Group, LLC | 4,828,026 | 5,361,187 | +533,161 | 3.57 | 3.41 | -0.16 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,228,851 | 1,743,057 | +514,206 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 2,126,835 | 2,640,443 | +513,608 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 398,867 | 864,223 | +465,356 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 1,216,182 | 1,610,708 | +394,526 | 0.02 | 0.01 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 158,428 | 461,059 | +302,631 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 43,917 | 344,391 | +300,474 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 2,000,000 | 2,288,000 | +288,000 | 0.24 | 0.27 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 775,000 | +275,000 | 0.01 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 263,867 | +263,867 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 263,841 | +263,841 | 0.00 | 1.59 | +1.59 | buy |
| CITADEL ADVISORS LLC | 95,866 | 340,103 | +244,237 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 224,240 | +224,240 | 0.00 | 0.08 | +0.08 | buy |
| EcoR1 Capital, LLC | 3,879,415 | 4,079,415 | +200,000 | 1.65 | 1.63 | -0.02 | buy |
| TD ASSET MANAGEMENT INC | 423,302 | 606,762 | +183,460 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 516,491 | 698,401 | +181,910 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 457,252 | 614,387 | +157,135 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 188,197 | 344,051 | +155,854 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 153,500 | +153,500 | 0.00 | 1.06 | +1.06 | buy |
| Granahan Investment Management, LLC | 314,239 | 419,271 | +105,032 | 0.14 | 0.14 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 102,153 | +102,153 | 0.00 | 0.01 | +0.01 | buy |
| Zimmer Partners, LP | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 189,060 | 271,130 | +82,070 | 0.00 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 80,742 | +80,742 | 0.00 | 0.05 | +0.05 | buy |
| Main Management ETF Advisors, LLC | 0 | 75,696 | +75,696 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 123,203 | 193,147 | +69,944 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 77,236 | 145,016 | +67,780 | 0.00 | 0.00 | -0.00 | buy |
| Freestone Capital Holdings, LLC | 0 | 61,681 | +61,681 | 0.00 | 0.02 | +0.02 | buy |
| Lido Advisors, LLC | 0 | 53,000 | +53,000 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 76,400 | 128,000 | +51,600 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 46,044 | +46,044 | 0.00 | 0.01 | +0.01 | buy |
| AlphaQuest LLC | 7,868 | 53,788 | +45,920 | 0.01 | 0.04 | +0.03 | buy |
| Sofinnova Investments, Inc. | 746,824 | 788,666 | +41,842 | 0.58 | 0.40 | -0.18 | buy |
| Private Capital Advisors, Inc. | 0 | 38,501 | +38,501 | 0.00 | 0.03 | +0.03 | buy |
| Walleye Capital LLC | 0 | 37,114 | +37,114 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 30,220 | +30,220 | 0.00 | 0.03 | +0.03 | buy |
| Johnson Financial Group, LLC | 20,000 | 48,000 | +28,000 | 0.02 | 0.03 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 26,599 | +26,599 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 22,545 | +22,545 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 104,314 | 126,579 | +22,265 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 81,391 | 102,475 | +21,084 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 68,167 | 88,888 | +20,721 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 41,993 | 62,503 | +20,510 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 58,193 | 78,344 | +20,151 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.03 | +0.03 | buy |
| CITIZENS FINANCIAL GROUP INC/RI | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 19,900 | +19,900 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 46,075 | 63,682 | +17,607 | 0.00 | 0.00 | -0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 15,733 | +15,733 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 18,961 | 34,424 | +15,463 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,423 | 46,821 | +14,398 | 0.00 | 0.00 | -0.00 | buy |
| ANTIPODES PARTNERS Ltd | 0 | 14,164 | +14,164 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 12,561 | +12,561 | 0.00 | 0.02 | +0.02 | buy |
| ALPS ADVISORS INC | 50,470 | 62,544 | +12,074 | 0.00 | 0.00 | -0.00 | buy |
| Gotham Asset Management, LLC | 0 | 10,200 | +10,200 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 10,181 | +10,181 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 41,505 | 51,544 | +10,039 | 0.00 | 0.00 | -0.00 | buy |
| KLP KAPITALFORVALTNING AS | 7,100 | 17,100 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Three Bridge Wealth Advisors, LLC | 27,615 | 37,615 | +10,000 | 0.10 | 0.09 | -0.01 | buy |
| WELLS FARGO & COMPANY/MN | 26,207 | 36,100 | +9,893 | 0.00 | 0.00 | -0.00 | buy |
| Corebridge Financial, Inc. | 25,556 | 34,735 | +9,179 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 11,288 | 18,764 | +7,476 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 145,564 | 153,011 | +7,447 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 35,619 | 42,411 | +6,792 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 6,280 | 12,154 | +5,874 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 11,648 | 17,360 | +5,712 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 16,094 | 21,601 | +5,507 | 0.01 | 0.01 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 10,335 | 15,387 | +5,052 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 15,600 | 18,905 | +3,305 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,036 | 7,173 | +2,137 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 1,950 | +1,950 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 26,661 | 28,379 | +1,718 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 1,700 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 307 | 1,957 | +1,650 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 19,017 | 20,545 | +1,528 | 0.00 | 0.00 | -0.00 | buy |
| Versant Capital Management, Inc | 0 | 1,170 | +1,170 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 14,477 | 15,348 | +871 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 210 | 912 | +702 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,778 | 2,444 | +666 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 14,521 | 14,725 | +204 | 0.00 | 0.00 | -0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 141 | +141 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 35,721 | 35,848 | +127 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 0 | 120 | +120 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 120 | +120 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 106 | 191 | +85 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 69 | +69 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 69 | +69 | 0.00 | 0.00 | +0.00 | buy |
| Stephens Consulting, LLC | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |