| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRIMECAP MANAGEMENT CO/CA/ | 280,800 | 3,413,700 | +3,132,900 | 0.00 | 0.02 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 5,499,954 | 7,554,594 | +2,054,640 | 0.04 | 0.03 | -0.00 | buy |
| Opaleye Management Inc. | 2,040,000 | 3,550,000 | +1,510,000 | 3.79 | 5.32 | +1.53 | buy |
| JANUS HENDERSON GROUP PLC | 3,455,939 | 2,088,495 | +1,367,444 | 0.02 | 0.01 | 0.00 | sell |
| Enavate Sciences GP, LLC | 3,478,261 | 4,768,583 | +1,290,322 | 26.53 | 24.18 | -2.35 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,282,754 | 3,069,607 | +786,853 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 980,925 | 1,657,729 | +676,804 | 0.07 | 0.07 | +0.00 | buy |
| Redmile Group, LLC | 4,828,026 | 5,361,187 | +533,161 | 3.57 | 3.41 | -0.16 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 775,000 | +275,000 | 0.01 | 0.01 | +0.00 | buy |
| EcoR1 Capital, LLC | 3,879,415 | 4,079,415 | +200,000 | 1.56 | 1.63 | +0.07 | buy |
| TD ASSET MANAGEMENT INC | 423,302 | 606,762 | +183,460 | 0.00 | 0.00 | -0.00 | buy |
| Granahan Investment Management, LLC | 314,239 | 419,271 | +105,032 | 0.14 | 0.14 | +0.00 | buy |
| Sofinnova Investments, Inc. | 746,824 | 788,666 | +41,842 | 0.58 | 0.35 | -0.23 | buy |
| Johnson Financial Group, LLC | 20,000 | 48,000 | +28,000 | 0.02 | 0.03 | +0.01 | buy |
| Rafferty Asset Management, LLC | 81,391 | 102,475 | +21,084 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 50,470 | 62,544 | +12,074 | 0.00 | 0.00 | -0.00 | buy |
| Three Bridge Wealth Advisors, LLC | 27,615 | 37,615 | +10,000 | 0.10 | 0.09 | -0.01 | buy |
| PROFUND ADVISORS LLC | 16,094 | 21,601 | +5,507 | 0.01 | 0.01 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 14,521 | 14,725 | +204 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 35,721 | 35,848 | +127 | 0.00 | 0.00 | 0.00 | buy |
| Prosight Management, LP | 54,342 | 23,618 | -30,724 | 0.16 | 0.05 | -0.11 | sell |