| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 16,549,716 | 16,969,954 | +420,238 | 0.02 | 0.02 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 13,421,987 | 16,364,011 | +2,942,024 | 0.18 | 0.25 | +0.06 | buy |
| BlackRock, Inc. | 7,594,996 | 8,168,674 | +573,678 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 5,718,385 | 5,558,885 | -159,500 | 9.05 | 8.05 | -1.00 | sell |
| STATE STREET CORP | 3,868,000 | 5,399,901 | +1,531,901 | 0.00 | 0.00 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 4,685,441 | 4,788,231 | +102,790 | 0.08 | 0.08 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 934,463 | 4,731,977 | +3,797,514 | 0.00 | 0.02 | +0.02 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 3,705,974 | 4,099,901 | +393,927 | 0.54 | 0.66 | +0.12 | buy |
| Enavate Sciences GP, LLC | 4,768,583 | 3,613,799 | -1,154,784 | 20.21 | 22.48 | +2.27 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,380,240 | 2,858,863 | -521,377 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 1,709,089 | 2,841,589 | +1,132,500 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 2,855,747 | 2,777,836 | -77,911 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,361,381 | 2,560,664 | +199,283 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,126,210 | 1,850,278 | +724,068 | 3.50 | 4.77 | +1.27 | buy |
| Sofinnova Investments, Inc. | 1,618,477 | 1,701,904 | +83,427 | 1.50 | 1.86 | +0.37 | buy |
| Woodline Partners LP | 1,575,398 | 1,575,398 | 0 | 0.13 | 0.13 | -0.00 | hold |
| MARSHALL WACE, LLP | 737,116 | 1,480,788 | +743,672 | 0.02 | 0.03 | +0.02 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,404,450 | 1,376,867 | -27,583 | 0.02 | 0.02 | +0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 1,843,210 | 1,301,862 | -541,348 | 1.75 | 1.66 | -0.09 | sell |
| Jefferies Financial Group Inc. | 2,000,000 | 1,160,715 | -839,285 | 0.35 | 0.31 | -0.04 | sell |
| GOLDMAN SACHS GROUP INC | 752,725 | 1,101,476 | +348,751 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 182,379 | 1,097,836 | +915,457 | 0.00 | 0.03 | +0.02 | buy |
| NORTHERN TRUST CORP | 828,701 | 899,146 | +70,445 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 840,689 | 851,789 | +11,100 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 793,364 | 849,479 | +56,115 | 0.08 | 0.08 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 832,078 | 808,019 | -24,059 | 0.01 | 0.01 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 202,717 | 781,607 | +578,890 | 0.00 | 0.00 | +0.00 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 732,512 | 732,512 | 0 | 6.08 | 5.73 | -0.36 | hold |
| NAN FUNG TRINITY (HK) Ltd | 714,553 | 714,553 | 0 | 1.22 | 1.72 | +0.50 | hold |
| TD ASSET MANAGEMENT INC | 759,192 | 694,934 | -64,258 | 0.01 | 0.01 | -0.00 | sell |
| Candriam S.C.A. | 539,882 | 539,882 | 0 | 0.06 | 0.06 | +0.00 | hold |
| UBS Group AG | 307,194 | 432,912 | +125,718 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 277,812 | 403,487 | +125,675 | 0.57 | 0.91 | +0.35 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 11,130 | 362,621 | +351,491 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 347,666 | 347,666 | 0 | 0.38 | 0.45 | +0.06 | hold |
| Granahan Investment Management, LLC | 435,123 | 307,021 | -128,102 | 0.40 | 0.32 | -0.08 | sell |
| Atom Investors LP | 175,767 | 306,880 | +131,113 | 0.30 | 0.48 | +0.18 | buy |
| Nuveen, LLC | 169,346 | 305,254 | +135,908 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 286,355 | 287,030 | +675 | 0.13 | 0.13 | +0.00 | buy |
| Bank of New York Mellon Corp | 263,374 | 276,066 | +12,692 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 0 | 275,896 | +275,896 | 0.00 | 0.02 | +0.02 | buy |
| TEMA ETFS LLC | 102,055 | 275,896 | +173,841 | 0.17 | 0.41 | +0.24 | buy |
| Atika Capital Management LLC | 334,341 | 262,900 | -71,441 | 1.00 | 0.91 | -0.09 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,429,680 | 251,396 | -1,178,284 | 0.06 | 0.01 | -0.05 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 170,002 | 230,738 | +60,736 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 237,270 | 206,799 | -30,471 | 0.00 | 0.00 | -0.00 | sell |
| Burkehill Global Management, LP | 200,000 | 200,000 | 0 | 0.28 | 0.22 | -0.07 | hold |
| Qube Research & Technologies Ltd | 0 | 188,229 | +188,229 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 123,749 | 187,011 | +63,262 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 185,000 | 185,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GILDER GAGNON HOWE & CO LLC | 174,861 | 169,267 | -5,594 | 0.04 | 0.04 | +0.00 | sell |
| Trexquant Investment LP | 130,834 | 166,812 | +35,978 | 0.03 | 0.03 | +0.00 | buy |
| Sio Capital Management, LLC | 0 | 165,110 | +165,110 | 0.00 | 0.52 | +0.52 | buy |
| ALLIANCEBERNSTEIN L.P. | 92,990 | 163,450 | +70,460 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 113,395 | 156,220 | +42,825 | 0.01 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 18,796 | 130,367 | +111,571 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 190,562 | 129,515 | -61,047 | 0.00 | 0.00 | -0.00 | sell |
| Aristotle Atlantic Partners, LLC | 0 | 125,018 | +125,018 | 0.00 | 0.13 | +0.13 | buy |
| RHUMBLINE ADVISERS | 113,565 | 120,900 | +7,335 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 779,578 | 115,370 | -664,208 | 0.19 | 0.03 | -0.16 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 67,012 | 111,444 | +44,432 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 111,183 | +111,183 | 0.00 | 0.01 | +0.01 | buy |
| LMR Partners LLP | 100,000 | 101,401 | +1,401 | 0.02 | 0.02 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 46,569 | 96,374 | +49,805 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 127,613 | 92,880 | -34,733 | 0.08 | 0.06 | -0.02 | sell |
| DEUTSCHE BANK AG\ | 76,242 | 89,137 | +12,895 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 42,792 | 83,581 | +40,789 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 94,958 | 81,588 | -13,370 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,740,705 | 80,197 | -1,660,508 | 0.03 | 0.00 | -0.02 | sell |
| Informed Momentum Co LLC | 0 | 71,757 | +71,757 | 0.00 | 0.18 | +0.18 | buy |
| PROFUND ADVISORS LLC | 42,700 | 69,918 | +27,218 | 0.03 | 0.06 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 68,902 | +68,902 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 29,333 | 67,778 | +38,445 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 270,065 | 66,565 | -203,500 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 32,099 | 62,436 | +30,337 | 0.00 | 0.01 | +0.01 | buy |
| Freestone Capital Holdings, LLC | 61,549 | 61,514 | -35 | 0.04 | 0.04 | +0.00 | sell |
| XTX Topco Ltd | 17,802 | 60,498 | +42,696 | 0.01 | 0.02 | +0.01 | buy |
| Edgestream Partners, L.P. | 0 | 59,888 | +59,888 | 0.00 | 0.04 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 170,914 | 58,985 | -111,929 | 0.01 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 50,137 | 58,962 | +8,825 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 52,034 | 55,857 | +3,823 | 0.01 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 27,719 | 52,770 | +25,051 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 52,000 | 52,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Birchview Capital, LP | 130,000 | 50,000 | -80,000 | 1.63 | 0.62 | -1.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 45,743 | 48,983 | +3,240 | 0.00 | 0.00 | +0.00 | buy |
| Lido Advisors, LLC | 59,051 | 48,950 | -10,101 | 0.00 | 0.00 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 80,228 | 47,951 | -32,277 | 0.01 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 10,273 | 47,360 | +37,087 | 0.00 | 0.00 | +0.00 | buy |
| Magnus Financial Group LLC | 45,759 | 45,759 | 0 | 0.08 | 0.08 | +0.01 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 35,431 | 44,488 | +9,057 | 0.00 | 0.00 | +0.00 | buy |
| SCHARF INVESTMENTS, LLC | 44,389 | 44,389 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 44,164 | 44,164 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Corient Private Wealth LLC | 43,203 | 43,477 | +274 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 108,115 | 41,754 | -66,361 | 0.00 | 0.00 | -0.00 | sell |
| Three Bridge Wealth Advisors, LLC | 37,615 | 37,615 | 0 | 0.21 | 0.23 | +0.01 | hold |
| FRANKLIN RESOURCES INC | 0 | 36,022 | +36,022 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 162,168 | 35,970 | -126,198 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 35,500 | +35,500 | 0.00 | 0.00 | +0.00 | buy |
| Private Capital Advisors, Inc. | 23,540 | 34,082 | +10,542 | 0.05 | 0.09 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 316,383 | 33,408 | -282,975 | 0.00 | 0.00 | -0.00 | sell |