| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 1,516,454 | 3,878,595 | +2,362,141 | 0.02 | 0.03 | +0.01 | buy |
| STATE STREET CORP | 200,691 | 2,364,234 | +2,163,543 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,538,414 | 3,163,507 | +1,625,093 | 0.02 | 0.02 | -0.00 | buy |
| MARSHALL WACE, LLP | 521,551 | 1,713,325 | +1,191,774 | 0.02 | 0.03 | +0.01 | buy |
| Opaleye Management Inc. | 0 | 1,102,500 | +1,102,500 | 0.00 | 3.05 | +3.05 | buy |
| Vestal Point Capital, LP | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.90 | +0.90 | buy |
| VANGUARD GROUP INC | 2,019,738 | 2,921,212 | +901,474 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 432,479 | 1,062,898 | +630,419 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 9,367 | 239,582 | +230,215 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 149,397 | 371,958 | +222,561 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 154,488 | 375,242 | +220,754 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 220,000 | +220,000 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 0 | 179,688 | +179,688 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 0 | 150,100 | +150,100 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 354,762 | 493,288 | +138,526 | 0.01 | 0.01 | -0.00 | buy |
| Jump Financial, LLC | 0 | 134,300 | +134,300 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 17,976 | 139,561 | +121,585 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 116,045 | +116,045 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 0 | 113,934 | +113,934 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 107,846 | +107,846 | 0.00 | 0.00 | +0.00 | buy |
| HHLR ADVISORS, LTD. | 0 | 107,626 | +107,626 | 0.00 | 0.03 | +0.03 | buy |
| SG Americas Securities, LLC | 0 | 90,504 | +90,504 | 0.00 | 0.01 | +0.01 | buy |
| Northeast Financial Consultants Inc | 0 | 72,953 | +72,953 | 0.00 | 0.04 | +0.04 | buy |
| RHUMBLINE ADVISERS | 0 | 67,184 | +67,184 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 0 | 65,000 | +65,000 | 0.00 | 0.24 | +0.24 | buy |
| TITLEIST ASSET MANAGEMENT, LLC | 0 | 63,967 | +63,967 | 0.00 | 0.12 | +0.12 | buy |
| Sofinnova Investments, Inc. | 594,396 | 655,680 | +61,284 | 0.87 | 0.50 | -0.37 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 109,686 | 166,928 | +57,242 | 0.00 | 0.00 | -0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 213,000 | 268,800 | +55,800 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 53,790 | +53,790 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 24,651 | 77,683 | +53,032 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 45,518 | 93,300 | +47,782 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 185,000 | 230,000 | +45,000 | 0.02 | 0.01 | -0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 11,700 | 52,054 | +40,354 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 285,806 | 325,206 | +39,400 | 0.01 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 135,488 | 170,249 | +34,761 | 0.00 | 0.00 | -0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 10,953 | 41,570 | +30,617 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 30,400 | +30,400 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 0 | 25,457 | +25,457 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 21,629 | +21,629 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 452 | 22,026 | +21,574 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 20,800 | +20,800 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 20,282 | +20,282 | 0.00 | 0.00 | +0.00 | buy |
| Denver PWM, LLC | 20,000 | 39,116 | +19,116 | 0.16 | 0.19 | +0.03 | buy |
| BARCLAYS PLC | 28,994 | 46,870 | +17,876 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 17,395 | +17,395 | 0.00 | 0.00 | +0.00 | buy |
| Sequoia Financial Advisors, LLC | 0 | 17,065 | +17,065 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 5,491 | 20,120 | +14,629 | 0.12 | 0.11 | -0.01 | buy |
| WELLS FARGO & COMPANY/MN | 4,214 | 18,543 | +14,329 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 13,212 | +13,212 | 0.00 | 0.00 | +0.00 | buy |
| BROWN ADVISORY INC | 669,760 | 682,389 | +12,629 | 0.02 | 0.01 | -0.01 | buy |
| Legal & General Group Plc | 30,728 | 41,861 | +11,133 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 8,011 | +8,011 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 6,669 | +6,669 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,681 | 38,861 | +6,180 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 5,644 | +5,644 | 0.00 | 0.03 | +0.03 | buy |
| Ameritas Investment Partners, Inc. | 0 | 5,036 | +5,036 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 71,400 | 76,400 | +5,000 | 0.00 | 0.00 | -0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 4,860 | +4,860 | 0.00 | 0.04 | +0.04 | buy |
| ROYAL BANK OF CANADA | 27,919 | 32,754 | +4,835 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 54,749 | 59,336 | +4,587 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 11,935 | 16,064 | +4,129 | 0.00 | 0.00 | -0.00 | buy |
| Clear Creek Financial Management, LLC | 22,153 | 26,188 | +4,035 | 0.07 | 0.04 | -0.03 | buy |
| Polar Asset Management Partners Inc. | 17,800 | 21,800 | +4,000 | 0.01 | 0.01 | -0.00 | buy |
| AMALGAMATED BANK | 0 | 1,778 | +1,778 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 9,944 | 10,862 | +918 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,093 | 2,002 | +909 | 0.00 | 0.00 | -0.00 | buy |
| Pacer Advisors, Inc. | 0 | 660 | +660 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 10 | +10 | 0.00 | 0.00 | 0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 858 | 858 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 720,000 | 720,000 | 0 | 1.85 | 0.89 | -0.96 | hold |
| Baldwin Investment Management, LLC | 25,394 | 25,394 | 0 | 0.09 | 0.04 | -0.04 | hold |
| Redmile Group, LLC | 4,889,554 | 4,889,554 | 0 | 4.43 | 3.58 | -0.85 | hold |
| Zimmer Partners, LP | 75,000 | 75,000 | 0 | 0.04 | 0.02 | -0.02 | hold |
| EcoR1 Capital, LLC | 3,879,415 | 3,879,415 | 0 | 2.43 | 1.44 | -0.99 | hold |
| Magnus Financial Group LLC | 25,759 | 25,759 | 0 | 0.08 | 0.04 | -0.04 | hold |
| Avidity Partners Management LP | 873,891 | 873,891 | 0 | 0.77 | 0.45 | -0.32 | hold |
| Farther Finance Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MB, LEVIS & ASSOCIATES, LLC | 2,373 | 2,373 | 0 | 0.03 | 0.02 | -0.02 | hold |
| US BANCORP \DE\ | 1,380 | 1,380 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMERICA BANK | 34 | 34 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 335 | 0 | -335 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 26,736 | 26,074 | -662 | 0.00 | 0.00 | -0.00 | sell |
| KBC Group NV | 1,011 | 0 | -1,011 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Investment Advisors, Ltd. | 12,465 | 11,065 | -1,400 | 0.09 | 0.04 | -0.05 | sell |
| SIMPLEX TRADING, LLC | 3,165 | 0 | -3,165 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 3,518 | 0 | -3,518 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 4,255 | 0 | -4,255 | 0.03 | 0.00 | -0.03 | sell |
| SEI INVESTMENTS CO | 18,990 | 12,538 | -6,452 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 7,489 | 0 | -7,489 | 0.05 | 0.00 | -0.05 | sell |
| BRIGHTON JONES LLC | 8,477 | 0 | -8,477 | 0.01 | 0.00 | -0.01 | sell |
| Jefferies Financial Group Inc. | 8,740 | 0 | -8,740 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 10,536 | 0 | -10,536 | 0.01 | 0.00 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 263,869 | 252,912 | -10,957 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 33,421 | 22,412 | -11,009 | 0.00 | 0.00 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 445,435 | 432,714 | -12,721 | 0.04 | 0.02 | -0.02 | sell |
| Polymer Capital Management (HK) LTD | 12,726 | 0 | -12,726 | 0.08 | 0.00 | -0.08 | sell |
| Ovata Capital Management Ltd | 20,000 | 0 | -20,000 | 0.26 | 0.00 | -0.26 | sell |