| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| READYSTATE ASSET MANAGEMENT LP | 224,240 | 1,353,586 | +1,129,346 | 0.08 | 0.52 | +0.45 | buy |
| JANUS HENDERSON GROUP PLC | 2,088,495 | 1,040,414 | +1,048,081 | 0.01 | 0.00 | 0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 7,554,594 | 8,275,257 | +720,663 | 0.03 | 0.05 | +0.01 | buy |
| Private Capital Advisors, Inc. | 38,501 | 189,844 | +151,343 | 0.03 | 0.22 | +0.18 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 14,725 | 109,352 | +94,627 | 0.00 | 0.02 | +0.02 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 19,900 | 46,000 | +26,100 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 62,544 | 46,935 | +15,609 | 0.00 | 0.00 | 0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 35,848 | 41,857 | +6,009 | 0.00 | 0.00 | 0.00 | buy |
| AlphaQuest LLC | 53,788 | 51,139 | +2,649 | 0.04 | 0.05 | 0.00 | sell |
| Main Management ETF Advisors, LLC | 75,696 | 76,944 | +1,248 | 0.02 | 0.03 | +0.01 | buy |
| Woodline Partners LP | 1,657,729 | 1,658,663 | +934 | 0.07 | 0.08 | +0.01 | buy |
| Freestone Capital Holdings, LLC | 61,681 | 61,599 | -82 | 0.02 | 0.02 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 606,762 | 605,530 | -1,232 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 12,561 | 9,605 | -2,956 | 0.02 | 0.03 | +0.01 | sell |
| ANTIPODES PARTNERS Ltd | 14,164 | 10,261 | -3,903 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 21,601 | 16,537 | -5,064 | 0.01 | 0.01 | -0.00 | sell |
| SummitTX Capital, L.P. | 20,876 | 10,695 | -10,181 | 0.01 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 788,666 | 778,476 | -10,190 | 0.35 | 0.44 | +0.10 | sell |
| Opaleye Management Inc. | 3,550,000 | 3,529,581 | -20,419 | 5.32 | 6.64 | +1.32 | sell |
| Rafferty Asset Management, LLC | 102,475 | 76,402 | -26,073 | 0.00 | 0.00 | -0.00 | sell |
| Granahan Investment Management, LLC | 419,271 | 392,751 | -26,520 | 0.14 | 0.15 | +0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,069,607 | 2,982,080 | -87,527 | 0.00 | 0.00 | +0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 610,551 | 221,000 | -389,551 | 0.04 | 0.02 | -0.02 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 3,413,700 | 3,020,210 | -393,490 | 0.02 | 0.02 | +0.00 | sell |
| Redmile Group, LLC | 5,361,187 | 4,872,225 | -488,962 | 3.41 | 4.82 | +1.41 | sell |