| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 3,892,318 | 6,167,666 | +2,275,348 | 0.00 | 0.00 | +0.00 | buy |
| TORONTO DOMINION BANK | 0 | 2,085,700 | +2,085,700 | 0.00 | 0.04 | +0.04 | buy |
| READYSTATE ASSET MANAGEMENT LP | 224,240 | 1,353,586 | +1,129,346 | 0.08 | 0.52 | +0.45 | buy |
| Polar Capital Holdings Plc | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.05 | +0.05 | buy |
| T. Rowe Price Investment Management, Inc. | 7,554,594 | 8,275,257 | +720,663 | 0.03 | 0.05 | +0.01 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 548,850 | +548,850 | 0.00 | 0.61 | +0.61 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 342,791 | +342,791 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 4,360,675 | 4,685,803 | +325,128 | 0.08 | 0.10 | +0.02 | buy |
| Candriam S.C.A. | 0 | 318,086 | +318,086 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 193,302 | 478,618 | +285,316 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 229,305 | +229,305 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 4,307,191 | 4,524,952 | +217,761 | 0.00 | 0.00 | +0.00 | buy |
| Private Capital Advisors, Inc. | 38,501 | 189,844 | +151,343 | 0.03 | 0.22 | +0.18 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,743,057 | 1,860,580 | +117,523 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 115,431 | +115,431 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 0 | 115,431 | +115,431 | 0.00 | 0.29 | +0.29 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 109,754 | +109,754 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 78,344 | 186,698 | +108,354 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 5,662,699 | 5,770,692 | +107,993 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 104,784 | +104,784 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 126,579 | 229,873 | +103,294 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 14,725 | 109,352 | +94,627 | 0.00 | 0.02 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 85,227 | +85,227 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 344,051 | 425,915 | +81,864 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 76,046 | +76,046 | 0.00 | 0.05 | +0.05 | buy |
| Birchview Capital, LP | 0 | 60,000 | +60,000 | 0.00 | 0.55 | +0.55 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 153,011 | 211,829 | +58,818 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 28,099 | +28,099 | 0.00 | 0.02 | +0.02 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 19,900 | 46,000 | +26,100 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 614,387 | 640,249 | +25,862 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 21,000 | +21,000 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 88,888 | 108,414 | +19,526 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 17,954 | +17,954 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 12,154 | 27,599 | +15,445 | 0.00 | 0.01 | +0.00 | buy |
| Whalen Wealth Management Inc. | 0 | 13,722 | +13,722 | 0.00 | 0.08 | +0.08 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8,011 | 21,154 | +13,143 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 12,875 | +12,875 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 0 | 12,658 | +12,658 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 193,147 | 205,257 | +12,110 | 0.00 | 0.00 | +0.00 | buy |
| BRIGHTON JONES LLC | 0 | 10,491 | +10,491 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 271,130 | 280,816 | +9,686 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 48,510 | 55,260 | +6,750 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 34,424 | 40,565 | +6,141 | 0.00 | 0.00 | +0.00 | buy |
| Lido Advisors, LLC | 53,000 | 59,085 | +6,085 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 35,848 | 41,857 | +6,009 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 36,100 | 41,761 | +5,661 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 128,000 | 132,800 | +4,800 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,136 | 6,938 | +3,802 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,555 | 6,464 | +2,909 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 51,544 | 53,187 | +1,643 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 18,764 | 20,266 | +1,502 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 239,940 | 241,410 | +1,470 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 1,700 | 3,046 | +1,346 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 18,905 | 20,213 | +1,308 | 0.00 | 0.00 | +0.00 | buy |
| Main Management ETF Advisors, LLC | 75,696 | 76,944 | +1,248 | 0.02 | 0.03 | +0.01 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 17,360 | 18,548 | +1,188 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 120 | 1,120 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 120 | 1,120 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,657,729 | 1,658,663 | +934 | 0.07 | 0.08 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,368 | 38,240 | +872 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 637 | +637 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 62,503 | 63,029 | +526 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 191 | 610 | +419 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 28,379 | 28,792 | +413 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 20,545 | 20,917 | +372 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 179,232 | 179,519 | +287 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 280 | +280 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,957 | 2,226 | +269 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 141 | 352 | +211 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 204 | +204 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 100 | 250 | +150 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 74 | 180 | +106 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 75 | +75 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 67 | +67 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 50 | 70 | +20 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 912 | 931 | +19 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 8 | 26 | +18 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 6 | +6 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 7,173 | 7,173 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STONERIDGE INVESTMENT PARTNERS LLC | 11,554 | 11,554 | 0 | 0.07 | 0.08 | +0.01 | hold |
| Baldwin Investment Management, LLC | 25,394 | 25,394 | 0 | 0.02 | 0.03 | +0.01 | hold |
| Handelsbanken Fonder AB | 200,000 | 200,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SCHARF INVESTMENTS, LLC | 44,389 | 44,389 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Gotham Asset Management, LLC | 10,200 | 10,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 42,411 | 42,411 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EcoR1 Capital, LLC | 4,079,415 | 4,079,415 | 0 | 1.63 | 2.25 | +0.62 | hold |
| Northeast Financial Consultants Inc | 42,953 | 42,953 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Sequoia Financial Advisors, LLC | 19,065 | 19,065 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sterling Investment Advisors, Ltd. | 11,065 | 11,065 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Magnus Financial Group LLC | 53,536 | 53,536 | 0 | 0.03 | 0.04 | +0.01 | hold |
| Three Bridge Wealth Advisors, LLC | 37,615 | 37,615 | 0 | 0.09 | 0.09 | +0.00 | hold |
| Enavate Sciences GP, LLC | 4,768,583 | 4,768,583 | 0 | 24.18 | 25.12 | +0.94 | hold |
| Bear Mountain Capital, Inc. | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 15,387 | 15,387 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MB, LEVIS & ASSOCIATES, LLC | 2,373 | 2,373 | 0 | 0.01 | 0.01 | +0.00 | hold |
| US BANCORP \DE\ | 21 | 21 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIZENS FINANCIAL GROUP INC/RI | 20,000 | 20,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,700 | 12,700 | 0 | 0.00 | 0.00 | +0.00 | hold |