| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 16,364,011 | 19,676,883 | +3,312,872 | 0.25 | 0.27 | +0.03 | buy |
| FMR LLC | 16,969,954 | 16,987,553 | +17,599 | 0.02 | 0.02 | -0.00 | buy |
| BlackRock, Inc. | 8,168,674 | 8,805,492 | +636,818 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 5,399,901 | 5,494,625 | +94,724 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,731,977 | 5,210,216 | +478,239 | 0.02 | 0.02 | -0.00 | buy |
| Redmile Group, LLC | 5,558,885 | 4,911,590 | -647,295 | 8.05 | 6.99 | -1.06 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 4,788,231 | 4,581,431 | -206,800 | 0.08 | 0.06 | -0.03 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,099,901 | 4,346,139 | +246,238 | 0.66 | 0.53 | -0.13 | buy |
| Enavate Sciences GP, LLC | 3,613,799 | 3,613,799 | 0 | 22.48 | 22.17 | -0.31 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 2,560,664 | 2,754,889 | +194,225 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 2,841,589 | 2,407,942 | -433,647 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,850,278 | 2,017,009 | +166,731 | 4.77 | 4.76 | -0.01 | buy |
| JPMORGAN CHASE & CO | 2,777,836 | 1,848,548 | -929,288 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,858,863 | 1,773,229 | -1,085,634 | 0.01 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 1,701,904 | 1,720,316 | +18,412 | 1.86 | 1.95 | +0.08 | buy |
| READYSTATE ASSET MANAGEMENT LP | 1,301,862 | 1,605,820 | +303,958 | 1.66 | 1.38 | -0.28 | buy |
| GOLDMAN SACHS GROUP INC | 1,101,476 | 1,512,489 | +411,013 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,376,867 | 1,347,358 | -29,509 | 0.02 | 0.01 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,097,836 | 1,250,275 | +152,439 | 0.03 | 0.03 | -0.00 | buy |
| Woodline Partners LP | 1,575,398 | 1,000,398 | -575,000 | 0.13 | 0.07 | -0.06 | sell |
| NORTHERN TRUST CORP | 899,146 | 968,346 | +69,200 | 0.00 | 0.00 | -0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 886,193 | +886,193 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 851,789 | 886,193 | +34,404 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 55,857 | 859,076 | +803,219 | 0.01 | 0.08 | +0.08 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 732,512 | 732,512 | 0 | 5.73 | 5.04 | -0.68 | hold |
| TD ASSET MANAGEMENT INC | 694,934 | 719,272 | +24,338 | 0.01 | 0.01 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 714,553 | 714,553 | 0 | 1.72 | 1.50 | -0.22 | hold |
| Candriam S.C.A. | 539,882 | 680,132 | +140,250 | 0.06 | 0.06 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 781,607 | 647,888 | -133,719 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 403,487 | 594,202 | +190,715 | 0.91 | 1.29 | +0.38 | buy |
| MARSHALL WACE, LLP | 1,480,788 | 500,537 | -980,251 | 0.03 | 0.01 | -0.03 | sell |
| Qube Research & Technologies Ltd | 188,229 | 439,186 | +250,957 | 0.01 | 0.01 | +0.00 | buy |
| ALERUS FINANCIAL NA | 0 | 383,421 | +383,421 | 0.00 | 0.36 | +0.36 | buy |
| Granahan Investment Management, LLC | 307,021 | 378,542 | +71,521 | 0.32 | 0.29 | -0.04 | buy |
| DIMENSIONAL FUND ADVISORS LP | 33,408 | 367,967 | +334,559 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 362,621 | 359,780 | -2,841 | 0.01 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 347,666 | 347,666 | 0 | 0.45 | 0.36 | -0.09 | hold |
| UBS Group AG | 432,912 | 328,493 | -104,419 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 276,066 | 298,866 | +22,800 | 0.00 | 0.00 | -0.00 | buy |
| Atom Investors LP | 306,880 | 297,489 | -9,391 | 0.48 | 0.56 | +0.08 | sell |
| Nuveen, LLC | 305,254 | 288,922 | -16,332 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 287,030 | 277,064 | -9,966 | 0.13 | 0.10 | -0.03 | sell |
| Tidal Investments LLC | 275,896 | 268,167 | -7,729 | 0.02 | 0.01 | -0.01 | sell |
| TEMA ETFS LLC | 275,896 | 268,167 | -7,729 | 0.41 | 0.18 | -0.22 | sell |
| Atika Capital Management LLC | 262,900 | 262,900 | 0 | 0.91 | 0.55 | -0.35 | hold |
| FIRST TRUST ADVISORS LP | 0 | 262,823 | +262,823 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 68,902 | 251,102 | +182,200 | 0.00 | 0.01 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 230,738 | 231,861 | +1,123 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 80,197 | 224,079 | +143,882 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 200,000 | 200,000 | 0 | 0.22 | 0.15 | -0.06 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 187,011 | 188,636 | +1,625 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 185,000 | 181,600 | -3,400 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 206,799 | 172,893 | -33,906 | 0.00 | 0.00 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 169,267 | 152,265 | -17,002 | 0.04 | 0.03 | -0.01 | sell |
| CITIGROUP INC | 25,955 | 142,201 | +116,246 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 142,097 | +142,097 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 163,450 | 133,500 | -29,950 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 129,515 | 132,906 | +3,391 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 120,900 | 132,479 | +11,579 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 62,436 | 132,091 | +69,655 | 0.01 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 60,498 | 126,648 | +66,150 | 0.02 | 0.03 | +0.01 | buy |
| Sio Capital Management, LLC | 165,110 | 124,168 | -40,942 | 0.52 | 0.45 | -0.07 | sell |
| Aristotle Atlantic Partners, LLC | 125,018 | 122,675 | -2,343 | 0.13 | 0.11 | -0.02 | sell |
| ALPS ADVISORS INC | 0 | 114,440 | +114,440 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 89,137 | 111,593 | +22,456 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 111,444 | 108,234 | -3,210 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 41,754 | 101,394 | +59,640 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 81,588 | 89,623 | +8,035 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 166,812 | 88,391 | -78,421 | 0.03 | 0.01 | -0.01 | sell |
| BIT Capital GmbH | 0 | 83,400 | +83,400 | 0.00 | 0.06 | +0.06 | buy |
| Rafferty Asset Management, LLC | 156,220 | 83,170 | -73,050 | 0.01 | 0.00 | -0.01 | sell |
| Neo Ivy Capital Management | 0 | 80,876 | +80,876 | 0.00 | 0.39 | +0.39 | buy |
| Cerity Partners LLC | 83,581 | 77,561 | -6,020 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 44,164 | 74,324 | +30,160 | 0.01 | 0.03 | +0.01 | buy |
| Edgestream Partners, L.P. | 59,888 | 71,885 | +11,997 | 0.04 | 0.05 | +0.00 | buy |
| Invesco Ltd. | 66,565 | 68,938 | +2,373 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 52,770 | 62,483 | +9,713 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Capital Holdings, LLC | 61,514 | 60,589 | -925 | 0.04 | 0.03 | -0.01 | sell |
| CAPTRUST FINANCIAL ADVISORS | 0 | 60,046 | +60,046 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 60,000 | +60,000 | 0.00 | 0.21 | +0.21 | buy |
| SummitTX Capital, L.P. | 92,880 | 59,476 | -33,404 | 0.06 | 0.03 | -0.03 | sell |
| FRANKLIN RESOURCES INC | 36,022 | 58,998 | +22,976 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 58,962 | 58,200 | -762 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 44,488 | 57,673 | +13,185 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 0 | 55,306 | +55,306 | 0.00 | 0.01 | +0.01 | buy |
| Erste Asset Management GmbH | 52,000 | 52,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Birchview Capital, LP | 50,000 | 50,000 | 0 | 0.62 | 0.50 | -0.13 | hold |
| Lido Advisors, LLC | 48,950 | 49,341 | +391 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 47,360 | 47,524 | +164 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 47,951 | 47,227 | -724 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 48,983 | 45,443 | -3,540 | 0.00 | 0.00 | -0.00 | sell |
| Mitsubishi UFJ Asset Management (UK) Ltd. | 8,000 | 45,000 | +37,000 | 0.09 | 0.44 | +0.35 | buy |
| SCHARF INVESTMENTS, LLC | 44,389 | 44,389 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Corient Private Wealth LLC | 43,477 | 43,227 | -250 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 69,918 | 42,635 | -27,283 | 0.06 | 0.02 | -0.03 | sell |
| Magnus Financial Group LLC | 45,759 | 41,759 | -4,000 | 0.08 | 0.06 | -0.02 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 29,500 | 37,000 | +7,500 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 32,051 | 32,659 | +608 | 0.17 | 0.14 | -0.03 | buy |
| Magnetar Financial LLC | 0 | 32,589 | +32,589 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 58,985 | 32,007 | -26,978 | 0.00 | 0.00 | -0.00 | sell |