| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 3,878,595 | 5,762,013 | +1,883,418 | 0.03 | 0.05 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 3,163,507 | 3,488,121 | +324,614 | 0.02 | 0.03 | 0.00 | buy |
| Opaleye Management Inc. | 1,102,500 | 1,237,500 | +135,000 | 3.05 | 3.02 | -0.03 | buy |
| TD ASSET MANAGEMENT INC | 325,206 | 394,618 | +69,412 | 0.00 | 0.01 | +0.00 | buy |
| Sofinnova Investments, Inc. | 655,680 | 676,766 | +21,086 | 0.41 | 0.79 | +0.37 | buy |
| LORD, ABBETT & CO. LLC | 432,714 | 450,280 | +17,566 | 0.02 | 0.02 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,021,119 | 2,036,307 | +15,188 | 0.00 | 0.00 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 268,800 | 280,800 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 21,629 | 17,547 | +4,082 | 0.01 | 0.01 | 0.00 | sell |
| Woodline Partners LP | 922,892 | 924,392 | +1,500 | 0.11 | 0.11 | +0.01 | buy |
| Clear Creek Financial Management, LLC | 26,188 | 26,783 | +595 | 0.04 | 0.04 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 5,644 | 5,743 | +99 | 0.03 | 0.04 | +0.01 | buy |
| TITLEIST ASSET MANAGEMENT, LLC | 63,967 | 44,767 | -19,200 | 0.12 | 0.09 | -0.02 | sell |
| Prosight Management, LP | 65,000 | 39,135 | -25,865 | 0.24 | 0.14 | -0.09 | sell |
| Rafferty Asset Management, LLC | 116,045 | 87,089 | -28,956 | 0.01 | 0.00 | -0.00 | sell |