| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 3,878,595 | 5,762,013 | +1,883,418 | 0.03 | 0.05 | +0.02 | buy |
| Jefferies Financial Group Inc. | 0 | 1,875,892 | +1,875,892 | 0.00 | 0.45 | +0.45 | buy |
| Invesco Ltd. | 25,937 | 432,720 | +406,783 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 184,248 | 568,508 | +384,260 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 3,163,507 | 3,488,121 | +324,614 | 0.02 | 0.03 | +0.01 | buy |
| NORTHERN TRUST CORP | 170,249 | 473,345 | +303,096 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 139,561 | 442,477 | +302,916 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 493,288 | 730,785 | +237,497 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 2,921,212 | 3,131,568 | +210,356 | 0.00 | 0.00 | +0.00 | buy |
| BROWN ADVISORY INC | 682,389 | 860,779 | +178,390 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,062,898 | 1,207,455 | +144,557 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 1,102,500 | 1,237,500 | +135,000 | 3.05 | 3.02 | -0.03 | buy |
| Point72 Asset Management, L.P. | 385,067 | 470,647 | +85,580 | 0.02 | 0.02 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 252,912 | 336,565 | +83,653 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 59,336 | 140,690 | +81,354 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 325,206 | 394,618 | +69,412 | 0.00 | 0.01 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 66,864 | +66,864 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 46,870 | 105,886 | +59,016 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 49,500 | +49,500 | 0.00 | 0.08 | +0.08 | buy |
| Mariner, LLC | 0 | 34,739 | +34,739 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,369 | 31,731 | +27,362 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 24,823 | +24,823 | 0.00 | 0.03 | +0.03 | buy |
| JPMORGAN CHASE & CO | 0 | 24,565 | +24,565 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 24,234 | +24,234 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29,711 | 51,631 | +21,920 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 655,680 | 676,766 | +21,086 | 0.50 | 0.82 | +0.32 | buy |
| LORD, ABBETT & CO. LLC | 432,714 | 450,280 | +17,566 | 0.02 | 0.02 | +0.00 | buy |
| LPL Financial LLC | 0 | 17,450 | +17,450 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 13,212 | 30,265 | +17,053 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,021,119 | 2,036,307 | +15,188 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 22,412 | 37,569 | +15,157 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 14,987 | +14,987 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 4,210,943 | 4,224,700 | +13,757 | 0.00 | 0.00 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 268,800 | 280,800 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 11,633 | +11,633 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 22,026 | 30,561 | +8,535 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 7,616 | +7,616 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 16,064 | 21,979 | +5,915 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 48,060 | 53,103 | +5,043 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 3,237 | +3,237 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 12,538 | 14,918 | +2,380 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 67,184 | 69,019 | +1,835 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 77,683 | 79,240 | +1,557 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 922,892 | 924,392 | +1,500 | 0.11 | 0.11 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,326 | +1,326 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 32,754 | 33,536 | +782 | 0.00 | 0.00 | +0.00 | buy |
| Clear Creek Financial Management, LLC | 26,188 | 26,783 | +595 | 0.04 | 0.04 | +0.01 | buy |
| BESSEMER GROUP INC | 858 | 1,388 | +530 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 10,862 | 11,225 | +363 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 41,861 | 42,083 | +222 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 199 | +199 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 129 | +129 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 5,644 | 5,743 | +99 | 0.03 | 0.04 | +0.01 | buy |
| SIGNATUREFD, LLC | 0 | 84 | +84 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 10 | 75 | +65 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 179,688 | 179,741 | +53 | 0.01 | 0.01 | +0.00 | buy |
| COMERICA BANK | 34 | 82 | +48 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 46 | +46 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 10 | 22 | +12 | 0.00 | 0.00 | 0.00 | buy |
| US BANCORP \DE\ | 1,380 | 1,389 | +9 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,036 | 5,036 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 53,790 | 53,790 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 220,000 | 220,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 720,000 | 720,000 | 0 | 0.89 | 0.75 | -0.14 | hold |
| Polar Asset Management Partners Inc. | 21,800 | 21,800 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Baldwin Investment Management, LLC | 25,394 | 25,394 | 0 | 0.04 | 0.05 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8,011 | 8,011 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Handelsbanken Fonder AB | 230,000 | 230,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Redmile Group, LLC | 4,889,554 | 4,889,554 | 0 | 3.58 | 4.21 | +0.63 | hold |
| Swiss National Bank | 76,400 | 76,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EcoR1 Capital, LLC | 3,879,415 | 3,879,415 | 0 | 1.44 | 1.94 | +0.51 | hold |
| Northeast Financial Consultants Inc | 72,953 | 72,953 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Sequoia Financial Advisors, LLC | 17,065 | 17,065 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Denver PWM, LLC | 39,116 | 39,116 | 0 | 0.19 | 0.18 | -0.01 | hold |
| Parallel Advisors, LLC | 28 | 28 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sterling Investment Advisors, Ltd. | 11,065 | 11,065 | 0 | 0.04 | 0.04 | +0.00 | hold |
| Magnus Financial Group LLC | 25,759 | 25,759 | 0 | 0.04 | 0.04 | +0.00 | hold |
| Avidity Partners Management LP | 873,891 | 873,891 | 0 | 0.45 | 0.65 | +0.20 | hold |
| Farther Finance Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MB, LEVIS & ASSOCIATES, LLC | 2,373 | 2,373 | 0 | 0.02 | 0.02 | +0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 26,074 | 26,074 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,778 | 1,778 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Corebridge Financial, Inc. | 27,655 | 27,485 | -170 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 17,395 | 17,039 | -356 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,002 | 1,479 | -523 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 18,543 | 18,017 | -526 | 0.00 | 0.00 | +0.00 | sell |
| Pacer Advisors, Inc. | 660 | 0 | -660 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,861 | 37,753 | -1,108 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 166,928 | 165,491 | -1,437 | 0.00 | 0.00 | +0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 41,570 | 39,500 | -2,070 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 21,629 | 17,547 | -4,082 | 0.01 | 0.01 | -0.00 | sell |
| FNY Investment Advisers, LLC | 4,860 | 0 | -4,860 | 0.04 | 0.00 | -0.04 | sell |
| AlphaQuest LLC | 6,669 | 1 | -6,668 | 0.01 | 0.00 | -0.01 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 20,800 | 12,700 | -8,100 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 52,054 | 43,865 | -8,189 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 90,504 | 72,627 | -17,877 | 0.01 | 0.00 | -0.00 | sell |
| TITLEIST ASSET MANAGEMENT, LLC | 63,967 | 44,767 | -19,200 | 0.12 | 0.09 | -0.02 | sell |
| Cubist Systematic Strategies, LLC | 19,421 | 0 | -19,421 | 0.00 | 0.00 | -0.00 | sell |