| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 6,167,666 | 13,056,709 | +6,889,043 | 0.00 | 0.01 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 8,275,257 | 8,418,163 | +142,906 | 0.05 | 0.06 | +0.01 | buy |
| BlackRock, Inc. | 5,770,692 | 5,822,736 | +52,044 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 4,872,225 | 5,023,385 | +151,160 | 4.82 | 5.72 | +0.90 | buy |
| VANGUARD GROUP INC | 4,524,952 | 4,893,626 | +368,674 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 4,685,803 | 4,824,504 | +138,701 | 0.10 | 0.12 | +0.02 | buy |
| Enavate Sciences GP, LLC | 4,768,583 | 4,768,583 | 0 | 25.12 | 17.05 | -8.07 | hold |
| EcoR1 Capital, LLC | 4,079,415 | 4,079,415 | 0 | 2.25 | 2.29 | +0.04 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,982,080 | 3,742,770 | +760,690 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 3,529,581 | 3,185,000 | -344,581 | 6.64 | 5.27 | -1.37 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 3,020,210 | 3,018,009 | -2,201 | 0.02 | 0.03 | +0.00 | sell |
| STATE STREET CORP | 2,520,916 | 2,803,973 | +283,057 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 2,085,660 | 2,100,000 | +14,340 | 0.32 | 0.23 | -0.09 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,860,580 | 1,894,575 | +33,995 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 404,357 | 1,833,818 | +1,429,461 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 1,353,586 | 1,318,290 | -35,296 | 0.52 | 0.75 | +0.23 | sell |
| Woodline Partners LP | 1,658,663 | 1,274,729 | -383,934 | 0.08 | 0.07 | -0.01 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 342,791 | 1,104,938 | +762,147 | 0.00 | 0.01 | +0.00 | buy |
| Polar Capital Holdings Plc | 1,000,000 | 1,058,776 | +58,776 | 0.05 | 0.06 | +0.01 | buy |
| Caption Management, LLC | 0 | 1,040,700 | +1,040,700 | 0.00 | 0.71 | +0.71 | buy |
| TORONTO DOMINION BANK | 2,085,700 | 1,036,056 | -1,049,644 | 0.04 | 0.02 | -0.02 | sell |
| Candriam S.C.A. | 318,086 | 859,527 | +541,441 | 0.02 | 0.05 | +0.04 | buy |
| CITADEL ADVISORS LLC | 0 | 841,138 | +841,138 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 1,040,414 | 763,175 | -277,239 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 691,557 | 706,515 | +14,958 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 605,530 | 701,280 | +95,750 | 0.00 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 221,000 | 696,551 | +475,551 | 0.02 | 0.06 | +0.04 | buy |
| MARSHALL WACE, LLP | 1,297,752 | 692,179 | -605,573 | 0.01 | 0.01 | -0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 640,249 | 663,612 | +23,363 | 0.00 | 0.00 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 548,850 | 592,103 | +43,253 | 0.61 | 0.69 | +0.08 | buy |
| UBS Group AG | 425,915 | 583,942 | +158,027 | 0.00 | 0.00 | +0.00 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 0 | 502,512 | +502,512 | 0.00 | 3.40 | +3.40 | buy |
| Sofinnova Investments, Inc. | 778,476 | 436,051 | -342,425 | 0.49 | 0.31 | -0.18 | sell |
| Granahan Investment Management, LLC | 392,751 | 426,219 | +33,468 | 0.15 | 0.20 | +0.06 | buy |
| Parkman Healthcare Partners LLC | 0 | 351,131 | +351,131 | 0.00 | 0.45 | +0.45 | buy |
| DIMENSIONAL FUND ADVISORS LP | 104,784 | 338,355 | +233,571 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 280,816 | 290,442 | +9,626 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 109,352 | 257,426 | +148,074 | 0.02 | 0.07 | +0.04 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 211,829 | 254,068 | +42,239 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 205,257 | 217,038 | +11,781 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 478,618 | 208,946 | -269,672 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 229,873 | 208,513 | -21,360 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 99,372 | 202,300 | +102,928 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 200,000 | 180,000 | -20,000 | 0.01 | 0.01 | +0.00 | sell |
| NEOS Investment Management LLC | 115,431 | 162,186 | +46,755 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 115,431 | 162,186 | +46,755 | 0.29 | 0.16 | -0.13 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 147,200 | +147,200 | 0.00 | 0.41 | +0.41 | buy |
| Nuveen, LLC | 241,410 | 145,344 | -96,066 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 132,800 | 135,000 | +2,200 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 133,112 | +133,112 | 0.00 | 0.02 | +0.02 | buy |
| Private Capital Advisors, Inc. | 189,844 | 118,046 | -71,798 | 0.22 | 0.15 | -0.06 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 186,698 | 112,298 | -74,400 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 108,414 | 108,080 | -334 | 0.00 | 0.00 | +0.00 | sell |
| Birchview Capital, LP | 60,000 | 105,000 | +45,000 | 0.55 | 0.93 | +0.37 | buy |
| BANK OF AMERICA CORP /DE/ | 99,676 | 92,155 | -7,521 | 0.00 | 0.00 | +0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 41,857 | 87,102 | +45,245 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 76,402 | 86,490 | +10,088 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 63,029 | 81,073 | +18,044 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,226 | 80,426 | +78,200 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 73,058 | +73,058 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 70,514 | +70,514 | 0.00 | 0.04 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 135,162 | 70,165 | -64,997 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 76,046 | 66,420 | -9,626 | 0.05 | 0.06 | +0.02 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,240 | 65,845 | +27,605 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 63,306 | +63,306 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 27,599 | 61,693 | +34,094 | 0.01 | 0.02 | +0.01 | buy |
| Freestone Capital Holdings, LLC | 61,599 | 61,627 | +28 | 0.02 | 0.02 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 61,344 | +61,344 | 0.00 | 0.03 | +0.03 | buy |
| ROYAL BANK OF CANADA | 0 | 61,153 | +61,153 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 53,742 | 60,951 | +7,209 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 60,708 | +60,708 | 0.00 | 0.00 | +0.00 | buy |
| Lido Advisors, LLC | 59,085 | 59,051 | -34 | 0.00 | 0.00 | -0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 46,000 | 58,400 | +12,400 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 28,792 | 56,016 | +27,224 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 55,260 | 55,260 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Magnus Financial Group LLC | 53,536 | 53,536 | 0 | 0.04 | 0.05 | +0.01 | hold |
| WELLS FARGO & COMPANY/MN | 41,761 | 51,415 | +9,654 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 46,532 | 45,878 | -654 | 0.00 | 0.00 | +0.00 | sell |
| AlphaQuest LLC | 51,139 | 45,060 | -6,079 | 0.05 | 0.03 | -0.01 | sell |
| SCHARF INVESTMENTS, LLC | 44,389 | 44,389 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 0 | 44,164 | +44,164 | 0.00 | 0.01 | +0.01 | buy |
| Corient Private Wealth LLC | 0 | 43,203 | +43,203 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 42,411 | 42,411 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 113,552 | 41,884 | -71,668 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 44,093 | 40,299 | -3,794 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 46,935 | 39,261 | -7,674 | 0.00 | 0.00 | +0.00 | sell |
| Three Bridge Wealth Advisors, LLC | 37,615 | 37,615 | 0 | 0.09 | 0.11 | +0.02 | hold |
| JPMORGAN CHASE & CO | 576,130 | 32,603 | -543,527 | 0.00 | 0.00 | -0.00 | sell |
| Baldwin Investment Management, LLC | 25,394 | 25,394 | 0 | 0.03 | 0.03 | +0.01 | hold |
| Cetera Investment Advisers | 0 | 25,361 | +25,361 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 25,217 | +25,217 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 28,099 | 24,355 | -3,744 | 0.02 | 0.01 | -0.01 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,700 | 23,500 | +10,800 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 40,565 | 22,704 | -17,861 | 0.00 | 0.00 | -0.00 | sell |
| Palumbo Wealth Management LLC | 0 | 21,844 | +21,844 | 0.00 | 0.08 | +0.08 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 21,154 | 21,154 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arizona State Retirement System | 20,266 | 20,536 | +270 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 15,387 | 20,317 | +4,930 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 20,917 | 20,118 | -799 | 0.00 | 0.00 | +0.00 | sell |
| CITIZENS FINANCIAL GROUP INC/RI | 20,000 | 20,000 | 0 | 0.00 | 0.00 | +0.00 | hold |