| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 6,167,666 | 13,056,709 | +6,889,043 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 404,357 | 1,833,818 | +1,429,461 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 1,040,700 | +1,040,700 | 0.00 | 0.71 | +0.71 | buy |
| CITADEL ADVISORS LLC | 0 | 841,138 | +841,138 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 342,791 | 1,104,938 | +762,147 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,982,080 | 3,742,770 | +760,690 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 318,086 | 859,527 | +541,441 | 0.02 | 0.05 | +0.04 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 0 | 502,512 | +502,512 | 0.00 | 3.40 | +3.40 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 221,000 | 696,551 | +475,551 | 0.02 | 0.06 | +0.04 | buy |
| VANGUARD GROUP INC | 4,524,952 | 4,893,626 | +368,674 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 351,131 | +351,131 | 0.00 | 0.45 | +0.45 | buy |
| STATE STREET CORP | 2,520,916 | 2,803,973 | +283,057 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 104,784 | 338,355 | +233,571 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 425,915 | 583,942 | +158,027 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 4,872,225 | 5,023,385 | +151,160 | 4.82 | 5.72 | +0.90 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 109,352 | 257,426 | +148,074 | 0.02 | 0.07 | +0.04 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 147,200 | +147,200 | 0.00 | 0.41 | +0.41 | buy |
| T. Rowe Price Investment Management, Inc. | 8,275,257 | 8,418,163 | +142,906 | 0.05 | 0.06 | +0.01 | buy |
| Point72 Asset Management, L.P. | 4,685,803 | 4,824,504 | +138,701 | 0.10 | 0.12 | +0.02 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 133,112 | +133,112 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 99,372 | 202,300 | +102,928 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 605,530 | 701,280 | +95,750 | 0.00 | 0.01 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,226 | 80,426 | +78,200 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 73,058 | +73,058 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 70,514 | +70,514 | 0.00 | 0.04 | +0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 63,306 | +63,306 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 61,344 | +61,344 | 0.00 | 0.03 | +0.03 | buy |
| ROYAL BANK OF CANADA | 0 | 61,153 | +61,153 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 60,708 | +60,708 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 1,000,000 | 1,058,776 | +58,776 | 0.05 | 0.06 | +0.01 | buy |
| BlackRock, Inc. | 5,770,692 | 5,822,736 | +52,044 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 115,431 | 162,186 | +46,755 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 115,431 | 162,186 | +46,755 | 0.29 | 0.16 | -0.13 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 41,857 | 87,102 | +45,245 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 60,000 | 105,000 | +45,000 | 0.55 | 0.93 | +0.37 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 44,164 | +44,164 | 0.00 | 0.01 | +0.01 | buy |
| NAN FUNG TRINITY (HK) Ltd | 548,850 | 592,103 | +43,253 | 0.61 | 0.69 | +0.08 | buy |
| Corient Private Wealth LLC | 0 | 43,203 | +43,203 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 211,829 | 254,068 | +42,239 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 27,599 | 61,693 | +34,094 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,860,580 | 1,894,575 | +33,995 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 392,751 | 426,219 | +33,468 | 0.15 | 0.20 | +0.06 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,240 | 65,845 | +27,605 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 28,792 | 56,016 | +27,224 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 25,361 | +25,361 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 25,217 | +25,217 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 640,249 | 663,612 | +23,363 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 0 | 21,844 | +21,844 | 0.00 | 0.08 | +0.08 | buy |
| Legal & General Group Plc | 63,029 | 81,073 | +18,044 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 691,557 | 706,515 | +14,958 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 14,619 | +14,619 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 2,085,660 | 2,100,000 | +14,340 | 0.32 | 0.23 | -0.09 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 46,000 | 58,400 | +12,400 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 205,257 | 217,038 | +11,781 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,700 | 23,500 | +10,800 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 10,300 | +10,300 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 76,402 | 86,490 | +10,088 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 10,000 | +10,000 | 0.00 | 0.11 | +0.11 | buy |
| Quarry LP | 0 | 10,000 | +10,000 | 0.00 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 41,761 | 51,415 | +9,654 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 280,816 | 290,442 | +9,626 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 8,769 | +8,769 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6,464 | 15,129 | +8,665 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 53,742 | 60,951 | +7,209 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 6,482 | +6,482 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 5,927 | +5,927 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 15,387 | 20,317 | +4,930 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 0 | 3,364 | +3,364 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 16,537 | 19,260 | +2,723 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 132,800 | 135,000 | +2,200 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 9,605 | 11,623 | +2,018 | 0.03 | 0.04 | +0.01 | buy |
| GROUP ONE TRADING LLC | 3,046 | 4,789 | +1,743 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 17,954 | 18,664 | +710 | 0.00 | 0.00 | +0.00 | buy |
| ANTIPODES PARTNERS Ltd | 10,261 | 10,892 | +631 | 0.00 | 0.00 | -0.00 | buy |
| STONERIDGE INVESTMENT PARTNERS LLC | 11,554 | 12,174 | +620 | 0.08 | 0.10 | +0.02 | buy |
| Optiver Holding B.V. | 0 | 554 | +554 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 20,266 | 20,536 | +270 | 0.00 | 0.00 | +0.00 | buy |
| Steigerwald, Gordon & Koch Inc. | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 120 | +120 | 0.00 | 0.00 | +0.00 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 84 | +84 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 6,938 | 7,001 | +63 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Capital Holdings, LLC | 61,599 | 61,627 | +28 | 0.02 | 0.02 | +0.00 | buy |
| Larson Financial Group LLC | 67 | 90 | +23 | 0.00 | 0.00 | +0.00 | buy |
| BRIGHTON JONES LLC | 10,491 | 10,513 | +22 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 180 | 187 | +7 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 931 | 938 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Sequoia Financial Advisors, LLC | 19,065 | 19,071 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 1,120 | 1,122 | +2 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 280 | 281 | +1 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 7,173 | 7,173 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 55,260 | 55,260 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CIBC Private Wealth Group LLC | 32 | 32 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Baldwin Investment Management, LLC | 25,394 | 25,394 | 0 | 0.03 | 0.03 | +0.01 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 21,154 | 21,154 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parkside Financial Bank & Trust | 75 | 75 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 204 | 204 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SCHARF INVESTMENTS, LLC | 44,389 | 44,389 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Gotham Asset Management, LLC | 10,200 | 10,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP Paribas Asset Management Holding S.A. | 637 | 637 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 42,411 | 42,411 | 0 | 0.00 | 0.00 | +0.00 | hold |