| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 1,237,500 | 2,040,000 | +802,500 | 3.02 | 3.79 | +0.77 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 220,000 | 500,000 | +280,000 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,036,307 | 2,282,754 | +246,447 | 0.00 | 0.00 | -0.00 | buy |
| Sofinnova Investments, Inc. | 676,766 | 746,824 | +70,058 | 0.79 | 0.58 | -0.21 | buy |
| Woodline Partners LP | 924,392 | 980,925 | +56,533 | 0.11 | 0.07 | -0.04 | buy |
| JANUS HENDERSON GROUP PLC | 3,488,121 | 3,455,939 | +32,182 | 0.03 | 0.02 | 0.00 | sell |
| TD ASSET MANAGEMENT INC | 394,618 | 423,302 | +28,684 | 0.01 | 0.00 | -0.00 | buy |
| Magnus Financial Group LLC | 25,759 | 53,536 | +27,777 | 0.04 | 0.05 | +0.02 | buy |
| Prosight Management, LP | 39,135 | 54,342 | +15,207 | 0.14 | 0.16 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 5,743 | 5,440 | -303 | 0.04 | 0.02 | -0.02 | sell |
| Rafferty Asset Management, LLC | 87,089 | 81,391 | -5,698 | 0.00 | 0.00 | -0.00 | sell |
| Northeast Financial Consultants Inc | 72,953 | 42,953 | -30,000 | 0.05 | 0.02 | -0.03 | sell |
| Redmile Group, LLC | 4,889,554 | 4,828,026 | -61,528 | 4.21 | 3.57 | -0.64 | sell |
| T. Rowe Price Investment Management, Inc. | 5,762,013 | 5,499,954 | -262,059 | 0.05 | 0.04 | -0.01 | sell |