| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 1,237,500 | 2,040,000 | +802,500 | 3.02 | 3.79 | +0.77 | buy |
| JPMORGAN CHASE & CO | 24,565 | 648,610 | +624,045 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 0 | 314,239 | +314,239 | 0.00 | 0.14 | +0.14 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 11,300 | 316,000 | +304,700 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 220,000 | 500,000 | +280,000 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,036,307 | 2,282,754 | +246,447 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 470,647 | 688,790 | +218,143 | 0.02 | 0.02 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 158,428 | +158,428 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 154,467 | +154,467 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 3,981,782 | 4,124,988 | +143,206 | 0.00 | 0.00 | -0.00 | buy |
| Jefferies Financial Group Inc. | 1,875,892 | 2,000,000 | +124,108 | 0.45 | 0.24 | -0.21 | buy |
| MORGAN STANLEY | 289,078 | 398,867 | +109,789 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 79,240 | 188,197 | +108,957 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 95,866 | +95,866 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 84,930 | +84,930 | 0.00 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 676,766 | 746,824 | +70,058 | 0.82 | 0.58 | -0.24 | buy |
| Woodline Partners LP | 924,392 | 980,925 | +56,533 | 0.11 | 0.07 | -0.04 | buy |
| ALPS ADVISORS INC | 0 | 50,470 | +50,470 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 48,200 | +48,200 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 45,743 | +45,743 | 0.00 | 0.03 | +0.03 | buy |
| SCHARF INVESTMENTS, LLC | 0 | 44,389 | +44,389 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 473,345 | 516,491 | +43,146 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 37,569 | 77,236 | +39,667 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 35,721 | +35,721 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 51,631 | 82,595 | +30,964 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 394,618 | 423,302 | +28,684 | 0.01 | 0.00 | -0.00 | buy |
| Magnus Financial Group LLC | 25,759 | 53,536 | +27,777 | 0.04 | 0.05 | +0.02 | buy |
| Three Bridge Wealth Advisors, LLC | 0 | 27,615 | +27,615 | 0.00 | 0.10 | +0.10 | buy |
| Crestline Management, LP | 0 | 24,744 | +24,744 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 165,491 | 189,060 | +23,569 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,207,455 | 1,228,851 | +21,396 | 0.00 | 0.00 | -0.00 | buy |
| Johnson Financial Group, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.02 | +0.02 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 19,017 | +19,017 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 30,561 | 46,075 | +15,514 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 39,135 | 54,342 | +15,207 | 0.15 | 0.16 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 442,477 | 457,252 | +14,775 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 14,521 | +14,521 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 14,477 | +14,477 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 43,865 | 58,193 | +14,328 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 11,648 | +11,648 | 0.00 | 0.00 | +0.00 | buy |
| STONERIDGE INVESTMENT PARTNERS LLC | 0 | 11,554 | +11,554 | 0.00 | 0.04 | +0.04 | buy |
| Engineers Gate Manager LP | 11,633 | 22,960 | +11,327 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 11,175 | +11,175 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 8,935 | +8,935 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 18,017 | 26,207 | +8,190 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 1 | 7,868 | +7,867 | 0.00 | 0.01 | +0.01 | buy |
| Point72 (DIFC) Ltd | 0 | 7,275 | +7,275 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 1,479 | 8,608 | +7,129 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 6,584 | +6,584 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 30,265 | 35,619 | +5,354 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 1,326 | 6,280 | +4,954 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 140,690 | 145,564 | +4,874 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 14,987 | 18,961 | +3,974 | 0.00 | 0.00 | -0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 39,500 | 41,505 | +2,005 | 0.00 | 0.00 | -0.00 | buy |
| Sequoia Financial Advisors, LLC | 17,065 | 19,065 | +2,000 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,731 | 32,423 | +692 | 0.00 | 0.00 | -0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 327 | +327 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 233 | +233 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 199 | 307 | +108 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 129 | 210 | +81 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 78 | +78 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 28 | 93 | +65 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 11,225 | 11,288 | +63 | 0.00 | 0.00 | -0.00 | buy |
| Bear Mountain Capital, Inc. | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,036 | 5,036 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 53,790 | 53,790 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 53 | 53 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Baldwin Investment Management, LLC | 25,394 | 25,394 | 0 | 0.05 | 0.04 | -0.01 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8,011 | 8,011 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Swiss National Bank | 76,400 | 76,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 3,879,415 | 3,879,415 | 0 | 1.94 | 1.65 | -0.30 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sterling Investment Advisors, Ltd. | 11,065 | 11,065 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Farther Finance Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MB, LEVIS & ASSOCIATES, LLC | 2,373 | 2,373 | 0 | 0.02 | 0.01 | -0.00 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 280,800 | 280,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,700 | 12,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,778 | 1,778 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 22 | 17 | -5 | 0.00 | 0.00 | 0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 75 | 60 | -15 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 46 | 0 | -46 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 84 | 13 | -71 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 82 | 0 | -82 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 42,083 | 41,993 | -90 | 0.00 | 0.00 | -0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| AXA S.A. | 179,741 | 179,458 | -283 | 0.01 | 0.01 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 5,743 | 5,440 | -303 | 0.04 | 0.02 | -0.02 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,753 | 37,368 | -385 | 0.00 | 0.00 | -0.00 | sell |
| Cerity Partners LLC | 53,103 | 52,678 | -425 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 69,019 | 68,167 | -852 | 0.00 | 0.00 | -0.00 | sell |
| BESSEMER GROUP INC | 1,388 | 0 | -1,388 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 1,389 | 0 | -1,389 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 17,039 | 15,600 | -1,439 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 17,547 | 16,094 | -1,453 | 0.01 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 105,886 | 104,314 | -1,572 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 124,939 | 123,203 | -1,736 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 27,485 | 25,556 | -1,929 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 3,237 | 0 | -3,237 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 87,089 | 81,391 | -5,698 | 0.00 | 0.00 | -0.00 | sell |