| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 8,418,163 | 13,421,987 | +5,003,824 | 0.06 | 0.18 | +0.12 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 696,551 | 3,705,974 | +3,009,423 | 0.06 | 0.54 | +0.48 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 3,018,009 | 4,685,441 | +1,667,432 | 0.03 | 0.08 | +0.05 | buy |
| Sofinnova Investments, Inc. | 436,051 | 1,618,477 | +1,182,426 | 0.28 | 1.50 | +1.22 | buy |
| Redmile Group, LLC | 5,023,385 | 5,718,385 | +695,000 | 5.72 | 9.05 | +3.32 | buy |
| READYSTATE ASSET MANAGEMENT LP | 1,318,290 | 1,843,210 | +524,920 | 0.75 | 1.75 | +1.00 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 502,512 | 732,512 | +230,000 | 3.40 | 6.08 | +2.68 | buy |
| NAN FUNG TRINITY (HK) Ltd | 592,103 | 714,553 | +122,450 | 0.69 | 1.22 | +0.52 | buy |
| TD ASSET MANAGEMENT INC | 701,280 | 759,192 | +57,912 | 0.01 | 0.01 | +0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 133,112 | 174,861 | +41,749 | 0.02 | 0.04 | +0.02 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 257,426 | 286,355 | +28,929 | 0.07 | 0.13 | +0.06 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 87,102 | 59,417 | +27,685 | 0.00 | 0.00 | 0.00 | sell |
| Rafferty Asset Management, LLC | 86,490 | 113,395 | +26,905 | 0.00 | 0.01 | +0.01 | buy |
| Birchview Capital, LP | 105,000 | 130,000 | +25,000 | 0.93 | 1.63 | +0.71 | buy |
| PROFUND ADVISORS LLC | 19,260 | 42,700 | +23,440 | 0.01 | 0.03 | 0.00 | buy |
| Baldwin Investment Management, LLC | 25,394 | 47,167 | +21,773 | 0.03 | 0.11 | +0.08 | buy |
| Palumbo Wealth Management LLC | 21,844 | 30,978 | +9,134 | 0.08 | 0.16 | +0.08 | buy |
| Granahan Investment Management, LLC | 426,219 | 435,123 | +8,904 | 0.20 | 0.40 | +0.20 | buy |
| AlphaQuest LLC | 45,060 | 48,968 | +3,908 | 0.04 | 0.07 | 0.00 | buy |
| Virtus Investment Advisers, LLC | 11,623 | 13,593 | +1,970 | 0.04 | 0.08 | +0.04 | buy |
| Freestone Capital Holdings, LLC | 61,627 | 61,549 | -78 | 0.02 | 0.04 | +0.02 | sell |
| ANTIPODES PARTNERS Ltd | 10,892 | 8,834 | -2,058 | 0.00 | 0.00 | +0.00 | sell |
| Magnus Financial Group LLC | 53,536 | 45,759 | -7,777 | 0.05 | 0.08 | +0.03 | sell |
| NEOS Investment Management LLC | 162,186 | 103,585 | -58,601 | 0.01 | 0.01 | -0.00 | sell |
| TEMA ETFS LLC | 162,186 | 102,055 | -60,131 | 0.16 | 0.17 | +0.01 | sell |
| Parkman Healthcare Partners LLC | 351,131 | 277,812 | -73,319 | 0.45 | 0.57 | +0.12 | sell |
| Private Capital Advisors, Inc. | 118,046 | 23,540 | -94,506 | 0.15 | 0.05 | -0.10 | sell |
| Polar Capital Holdings Plc | 1,058,776 | 793,364 | -265,412 | 0.06 | 0.08 | +0.02 | sell |
| Candriam S.C.A. | 859,527 | 539,882 | -319,645 | 0.05 | 0.06 | +0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,742,770 | 3,380,240 | -362,530 | 0.00 | 0.01 | +0.00 | sell |
| EcoR1 Capital, LLC | 4,079,415 | 2,855,590 | -1,223,825 | 2.29 | 2.78 | +0.49 | sell |