| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 13,056,709 | 16,549,716 | +3,493,007 | 0.01 | 0.02 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 8,418,163 | 13,421,987 | +5,003,824 | 0.06 | 0.18 | +0.12 | buy |
| BlackRock, Inc. | 5,822,736 | 7,594,996 | +1,772,260 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 4,824,504 | 7,034,952 | +2,210,448 | 0.12 | 0.24 | +0.11 | buy |
| VANGUARD GROUP INC | 4,893,626 | 6,038,414 | +1,144,788 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 5,023,385 | 5,718,385 | +695,000 | 5.72 | 9.05 | +3.32 | buy |
| Enavate Sciences GP, LLC | 4,768,583 | 4,768,583 | 0 | 17.05 | 20.21 | +3.16 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 3,018,009 | 4,685,441 | +1,667,432 | 0.03 | 0.08 | +0.05 | buy |
| STATE STREET CORP | 2,803,973 | 3,868,000 | +1,064,027 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 696,551 | 3,705,974 | +3,009,423 | 0.06 | 0.54 | +0.48 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,742,770 | 3,380,240 | -362,530 | 0.00 | 0.01 | +0.00 | sell |
| JPMORGAN CHASE & CO | 32,603 | 2,855,747 | +2,823,144 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 4,079,415 | 2,855,590 | -1,223,825 | 2.29 | 2.80 | +0.51 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,894,575 | 2,361,381 | +466,806 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 2,100,000 | 2,000,000 | -100,000 | 0.23 | 0.35 | +0.13 | sell |
| READYSTATE ASSET MANAGEMENT LP | 1,318,290 | 1,843,210 | +524,920 | 0.75 | 1.75 | +1.00 | buy |
| CITADEL ADVISORS LLC | 841,138 | 1,740,705 | +899,567 | 0.01 | 0.03 | +0.02 | buy |
| MORGAN STANLEY | 1,833,818 | 1,709,089 | -124,729 | 0.00 | 0.00 | +0.00 | sell |
| Sofinnova Investments, Inc. | 436,051 | 1,618,477 | +1,182,426 | 0.31 | 1.50 | +1.19 | buy |
| Woodline Partners LP | 1,274,729 | 1,575,398 | +300,669 | 0.07 | 0.13 | +0.06 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,429,680 | +1,429,680 | 0.00 | 0.06 | +0.06 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,104,938 | 1,404,450 | +299,512 | 0.01 | 0.02 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 1,126,210 | +1,126,210 | 0.00 | 3.50 | +3.50 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 254,068 | 934,463 | +680,395 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 663,612 | 840,689 | +177,077 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 763,175 | 832,078 | +68,903 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 706,515 | 828,701 | +122,186 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 1,058,776 | 793,364 | -265,412 | 0.06 | 0.08 | +0.02 | sell |
| ExodusPoint Capital Management, LP | 0 | 779,578 | +779,578 | 0.00 | 0.19 | +0.19 | buy |
| TD ASSET MANAGEMENT INC | 701,280 | 759,192 | +57,912 | 0.01 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 208,946 | 752,725 | +543,779 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 692,179 | 737,116 | +44,937 | 0.01 | 0.02 | +0.01 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 502,512 | 732,512 | +230,000 | 3.40 | 6.08 | +2.68 | buy |
| NAN FUNG TRINITY (HK) Ltd | 592,103 | 714,553 | +122,450 | 0.69 | 1.22 | +0.52 | buy |
| Candriam S.C.A. | 859,527 | 539,882 | -319,645 | 0.05 | 0.06 | +0.01 | sell |
| Granahan Investment Management, LLC | 426,219 | 435,123 | +8,904 | 0.20 | 0.40 | +0.20 | buy |
| Rock Springs Capital Management LP | 0 | 347,666 | +347,666 | 0.00 | 0.38 | +0.38 | buy |
| Atika Capital Management LLC | 0 | 334,341 | +334,341 | 0.00 | 1.00 | +1.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 338,355 | 316,383 | -21,972 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 583,942 | 307,194 | -276,748 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 0 | 293,750 | +293,750 | 0.00 | 0.02 | +0.02 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 257,426 | 286,355 | +28,929 | 0.07 | 0.13 | +0.06 | buy |
| Parkman Healthcare Partners LLC | 351,131 | 277,812 | -73,319 | 0.45 | 0.57 | +0.12 | sell |
| Monashee Investment Management LLC | 0 | 274,861 | +274,861 | 0.00 | 3.33 | +3.33 | buy |
| Invesco Ltd. | 56,016 | 270,065 | +214,049 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 217,038 | 263,374 | +46,336 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 208,513 | 246,065 | +37,552 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 290,442 | 237,270 | -53,172 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 92,155 | 202,717 | +110,562 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 200,000 | +200,000 | 0.00 | 0.28 | +0.28 | buy |
| Neo Ivy Capital Management | 0 | 192,635 | +192,635 | 0.00 | 0.65 | +0.65 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 190,562 | +190,562 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 135,000 | 185,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 637 | 182,379 | +181,742 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 175,767 | +175,767 | 0.00 | 0.30 | +0.30 | buy |
| GILDER GAGNON HOWE & CO LLC | 133,112 | 174,861 | +41,749 | 0.02 | 0.04 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70,165 | 170,914 | +100,749 | 0.00 | 0.01 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 170,002 | +170,002 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 145,344 | 169,346 | +24,002 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 8,769 | 162,168 | +153,399 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 130,834 | +130,834 | 0.00 | 0.03 | +0.03 | buy |
| Birchview Capital, LP | 105,000 | 130,000 | +25,000 | 0.93 | 1.63 | +0.71 | buy |
| SummitTX Capital, L.P. | 0 | 127,613 | +127,613 | 0.00 | 0.08 | +0.08 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 112,298 | 123,749 | +11,451 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 108,080 | 113,565 | +5,485 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 86,490 | 113,395 | +26,905 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 51,415 | 108,115 | +56,700 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 162,186 | 103,585 | -58,601 | 0.01 | 0.01 | -0.00 | sell |
| Longaeva Partners L.P. | 0 | 102,500 | +102,500 | 0.00 | 0.26 | +0.26 | buy |
| TEMA ETFS LLC | 162,186 | 102,055 | -60,131 | 0.16 | 0.17 | +0.01 | sell |
| LMR Partners LLP | 0 | 100,000 | +100,000 | 0.00 | 0.02 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 63,306 | 98,136 | +34,830 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 81,073 | 94,958 | +13,885 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 55,260 | 92,990 | +37,730 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 80,426 | 80,228 | -198 | 0.00 | 0.01 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 60,951 | 76,242 | +15,291 | 0.00 | 0.00 | +0.00 | buy |
| Maven Securities LTD | 0 | 75,000 | +75,000 | 0.00 | 0.20 | +0.20 | buy |
| Verition Fund Management LLC | 0 | 72,864 | +72,864 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 65,845 | 67,012 | +1,167 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Capital Holdings, LLC | 61,627 | 61,549 | -78 | 0.02 | 0.04 | +0.02 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 87,102 | 59,417 | -27,685 | 0.00 | 0.00 | -0.00 | sell |
| Lido Advisors, LLC | 59,051 | 59,051 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 57,153 | +57,153 | 0.00 | 0.06 | +0.06 | buy |
| MetLife Investment Management, LLC | 42,411 | 52,034 | +9,623 | 0.00 | 0.01 | +0.00 | buy |
| Erste Asset Management GmbH | 0 | 52,000 | +52,000 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,299 | 50,137 | +9,838 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 45,060 | 48,968 | +3,908 | 0.03 | 0.06 | +0.02 | buy |
| Baldwin Investment Management, LLC | 25,394 | 47,167 | +21,773 | 0.03 | 0.11 | +0.08 | buy |
| RAYMOND JAMES FINANCIAL INC | 10,300 | 46,569 | +36,269 | 0.00 | 0.00 | +0.00 | buy |
| Magnus Financial Group LLC | 53,536 | 45,759 | -7,777 | 0.05 | 0.08 | +0.03 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 45,743 | +45,743 | 0.00 | 0.00 | +0.00 | buy |
| SCHARF INVESTMENTS, LLC | 44,389 | 44,389 | 0 | 0.01 | 0.03 | +0.01 | hold |
| Susquehanna Portfolio Strategies, LLC | 44,164 | 44,164 | 0 | 0.01 | 0.01 | +0.01 | hold |
| Corient Private Wealth LLC | 43,203 | 43,203 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cerity Partners LLC | 45,878 | 42,792 | -3,086 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 19,260 | 42,700 | +23,440 | 0.01 | 0.03 | +0.02 | buy |
| Three Bridge Wealth Advisors, LLC | 37,615 | 37,615 | 0 | 0.11 | 0.21 | +0.10 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 21,154 | 35,431 | +14,277 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 73,058 | 32,099 | -40,959 | 0.01 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 0 | 31,323 | +31,323 | 0.00 | 0.02 | +0.02 | buy |