| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VIKING GLOBAL INVESTORS LP | 29,993,708 | 29,993,708 | 0 | 0.54 | 0.36 | -0.18 | hold |
| VANGUARD GROUP INC | 12,767,684 | 12,869,818 | +102,134 | 0.00 | 0.00 | -0.00 | buy |
| Matrix Capital Management Company, LP | 11,572,590 | 11,572,590 | 0 | 0.58 | 0.35 | -0.24 | hold |
| ARK Investment Management LLC | 12,806,513 | 10,561,296 | -2,245,217 | 0.37 | 0.23 | -0.14 | sell |
| Rubric Capital Management LP | 2,862,729 | 10,500,000 | +7,637,271 | 0.52 | 1.00 | +0.47 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 6,511,659 | 6,176,707 | -334,952 | 0.02 | 0.01 | -0.01 | sell |
| Nikko Asset Management Americas, Inc. | 6,511,659 | 6,176,707 | -334,952 | 0.31 | 0.20 | -0.11 | sell |
| Pictet Asset Management Holding SA | 3,422,356 | 3,500,964 | +78,608 | 0.02 | 0.01 | -0.01 | buy |
| Aristotle Atlantic Partners, LLC | 3,050,684 | 2,992,563 | -58,121 | 0.53 | 0.31 | -0.21 | sell |
| STATE STREET CORP | 2,591,653 | 2,680,546 | +88,893 | 0.00 | 0.00 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 2,603,500 | 2,592,318 | -11,182 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,523,642 | 2,579,126 | +55,484 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,138,191 | 1,743,616 | -394,575 | 0.00 | 0.00 | -0.00 | sell |
| Blue Water Life Science Advisors, LP | 1,687,665 | 1,687,665 | 0 | 7.24 | 5.10 | -2.15 | hold |
| BRAIDWELL LP | 1,357,490 | 1,357,490 | 0 | 0.24 | 0.14 | -0.10 | hold |
| FEDERATED HERMES, INC. | 1,212,660 | 1,301,717 | +89,057 | 0.01 | 0.01 | -0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 1,233,514 | 1,245,111 | +11,597 | 0.08 | 0.05 | -0.03 | buy |
| Pier Capital, LLC | 711,107 | 1,103,441 | +392,334 | 0.50 | 0.49 | -0.01 | buy |
| Aberdeen Group plc | 933,794 | 1,029,447 | +95,653 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 1,042,985 | 1,024,131 | -18,854 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 755,932 | 869,782 | +113,850 | 0.00 | 0.00 | -0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 868,448 | 859,214 | -9,234 | 0.01 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 54,934 | 846,379 | +791,445 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 844,852 | 844,852 | 0 | 0.01 | 0.01 | -0.01 | hold |
| MILLENNIUM MANAGEMENT LLC | 0 | 835,761 | +835,761 | 0.00 | 0.00 | +0.00 | buy |
| DDD Partners, LLC | 800,922 | 739,739 | -61,183 | 0.53 | 0.29 | -0.24 | sell |
| Cerity Partners LLC | 135,652 | 676,244 | +540,592 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 943,799 | 669,130 | -274,669 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 804,060 | 626,721 | -177,339 | 0.00 | 0.00 | -0.00 | sell |
| Newtyn Management, LLC | 322,000 | 623,690 | +301,690 | 0.31 | 0.40 | +0.09 | buy |
| DEUTSCHE BANK AG\ | 603,056 | 604,506 | +1,450 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 98,818 | 517,272 | +418,454 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 414,982 | 395,344 | -19,638 | 0.00 | 0.00 | -0.00 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 375,638 | 375,716 | +78 | 0.06 | 0.03 | -0.02 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 271,913 | 277,096 | +5,183 | 0.26 | 0.18 | -0.09 | buy |
| Point72 Asset Management, L.P. | 3,722,500 | 274,700 | -3,447,800 | 0.06 | 0.00 | -0.05 | sell |
| Tejara Capital Ltd | 0 | 269,014 | +269,014 | 0.00 | 0.32 | +0.32 | buy |
| PDT Partners, LLC | 116,804 | 215,004 | +98,200 | 0.06 | 0.07 | +0.00 | buy |
| JPMORGAN CHASE & CO | 281,968 | 213,507 | -68,461 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 171,292 | 203,941 | +32,649 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 199,600 | 199,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jump Financial, LLC | 35,666 | 184,779 | +149,113 | 0.01 | 0.02 | +0.01 | buy |
| Robertson Stephens Wealth Management, LLC | 183,786 | 183,786 | 0 | 0.06 | 0.03 | -0.02 | hold |
| Man Group plc | 171,069 | 178,007 | +6,938 | 0.00 | 0.00 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 191,607 | 175,821 | -15,786 | 0.00 | 0.00 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 143,220 | 174,767 | +31,547 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 108,541 | 174,556 | +66,015 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 169,565 | 173,855 | +4,290 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 167,486 | 167,486 | 0 | 0.03 | 0.02 | -0.01 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 162,137 | +162,137 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 292,884 | 155,229 | -137,655 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 227,855 | 151,505 | -76,350 | 0.00 | 0.00 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 146,190 | 146,190 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS Group AG | 132,520 | 143,615 | +11,095 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 26,351 | 140,922 | +114,571 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 123,298 | 121,185 | -2,113 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 131,366 | 119,196 | -12,170 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 121,860 | 109,653 | -12,207 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 101,229 | 107,440 | +6,211 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 106,193 | 106,177 | -16 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 689,150 | 103,311 | -585,839 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 98,097 | 102,916 | +4,819 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 108,862 | 102,470 | -6,392 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 15,064 | 101,449 | +86,385 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 110,977 | 101,104 | -9,873 | 0.00 | 0.00 | -0.00 | sell |
| Neuberger Berman Group LLC | 149,696 | 100,804 | -48,892 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 176,230 | 97,685 | -78,545 | 0.00 | 0.00 | -0.00 | sell |
| Edge Wealth Management LLC | 90,000 | 90,000 | 0 | 0.10 | 0.06 | -0.04 | hold |
| STRS OHIO | 87,500 | 82,300 | -5,200 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 81,898 | +81,898 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 82,924 | 79,701 | -3,223 | 0.00 | 0.00 | -0.00 | sell |
| AVENIR CORP | 66,365 | 66,365 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Atom Investors LP | 0 | 65,964 | +65,964 | 0.00 | 0.03 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 165,745 | 65,745 | -100,000 | 0.03 | 0.01 | -0.02 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 65,287 | +65,287 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 64,780 | 64,817 | +37 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 42,431 | 63,141 | +20,710 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 63,132 | +63,132 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 0 | 60,465 | +60,465 | 0.00 | 0.01 | +0.01 | buy |
| Crewe Advisors LLC | 59,738 | 59,138 | -600 | 0.05 | 0.02 | -0.02 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 58,708 | 58,708 | 0 | 0.01 | 0.00 | -0.00 | hold |
| D.A. DAVIDSON & CO. | 46,975 | 58,125 | +11,150 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 58,266 | 57,810 | -456 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 56,464 | 55,983 | -481 | 0.00 | 0.00 | -0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 56,849 | 54,875 | -1,974 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 55,805 | 54,491 | -1,314 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 39,525 | 52,875 | +13,350 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 52,583 | +52,583 | 0.00 | 0.00 | +0.00 | buy |
| Leeward Financial Partners, LLC | 54,097 | 51,650 | -2,447 | 0.13 | 0.07 | -0.06 | sell |
| Cubist Systematic Strategies, LLC | 88,483 | 50,502 | -37,981 | 0.01 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 54,411 | 50,479 | -3,932 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 62,804 | 46,124 | -16,680 | 0.00 | 0.00 | -0.00 | sell |
| Bouvel Investment Partners, LLC | 45,200 | 46,030 | +830 | 0.10 | 0.06 | -0.04 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 46,288 | 45,961 | -327 | 0.00 | 0.00 | -0.00 | sell |
| Versor Investments LP | 25,100 | 45,200 | +20,100 | 0.03 | 0.03 | +0.00 | buy |
| Amundi | 43,930 | 43,930 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SHERBROOKE PARK ADVISERS LLC | 0 | 43,859 | +43,859 | 0.00 | 0.03 | +0.03 | buy |
| JANUS HENDERSON GROUP PLC | 42,680 | 42,686 | +6 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 47,711 | 39,618 | -8,093 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 34,378 | 38,523 | +4,145 | 0.00 | 0.00 | -0.00 | buy |