| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VIKING GLOBAL INVESTORS LP | 29,993,708 | 29,993,708 | 0 | 1.29 | 1.16 | -0.13 | hold |
| BlackRock, Inc. | 13,333,559 | 13,303,025 | -30,534 | 0.00 | 0.00 | -0.00 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 4,060,481 | 5,436,718 | +1,376,237 | 0.27 | 0.32 | +0.04 | buy |
| Invesco Ltd. | 3,107,653 | 4,450,066 | +1,342,413 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,165,327 | 3,857,422 | +1,692,095 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,511,855 | 3,636,054 | +124,199 | 0.00 | 0.00 | -0.00 | buy |
| LORD, ABBETT & CO. LLC | 3,080,759 | 3,536,103 | +455,344 | 0.15 | 0.16 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 2,902,269 | 3,242,077 | +339,808 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 3,181,644 | 3,227,245 | +45,601 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 2,590,984 | 3,017,341 | +426,357 | 0.01 | 0.01 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 2,688,081 | +2,688,081 | 0.00 | 0.04 | +0.04 | buy |
| ARK Investment Management LLC | 2,138,960 | 2,092,969 | -45,991 | 0.23 | 0.23 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 2,245,418 | 2,063,146 | -182,272 | 0.14 | 0.13 | -0.02 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 2,422,089 | 1,995,202 | -426,887 | 0.02 | 0.01 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 1,902,685 | 1,965,610 | +62,925 | 0.02 | 0.02 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,760,387 | 1,750,601 | -1,009,786 | 0.30 | 0.18 | -0.13 | sell |
| Aristotle Atlantic Partners, LLC | 1,842,444 | 1,714,346 | -128,098 | 1.37 | 1.11 | -0.25 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 1,552,509 | 1,704,887 | +152,378 | 0.01 | 0.01 | -0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 1,947,963 | 1,595,370 | -352,593 | 0.02 | 0.01 | -0.00 | sell |
| Nikko Asset Management Americas, Inc. | 1,947,963 | 1,595,370 | -352,593 | 0.37 | 0.31 | -0.05 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,387,361 | 1,566,213 | -2,821,148 | 0.01 | 0.00 | -0.01 | sell |
| NORTHERN TRUST CORP | 1,172,794 | 1,392,332 | +219,538 | 0.00 | 0.00 | +0.00 | buy |
| Divisadero Street Capital Management, LP | 361,344 | 1,318,661 | +957,317 | 0.33 | 0.86 | +0.52 | buy |
| Nuveen, LLC | 786,647 | 1,304,160 | +517,513 | 0.00 | 0.00 | +0.00 | buy |
| Capricorn Fund Managers Ltd | 0 | 1,291,773 | +1,291,773 | 0.00 | 2.80 | +2.80 | buy |
| BANK OF AMERICA CORP /DE/ | 806,272 | 1,227,917 | +421,645 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,173,535 | 1,145,682 | -27,853 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 18,357 | 1,081,366 | +1,063,009 | 0.00 | 0.01 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 922,501 | 1,072,331 | +149,830 | 0.00 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 1,046,510 | 1,070,627 | +24,117 | 0.03 | 0.02 | -0.00 | buy |
| Point72 Asset Management, L.P. | 203,075 | 1,021,808 | +818,733 | 0.01 | 0.02 | +0.02 | buy |
| Blue Water Life Science Advisors, LP | 1,765,145 | 1,010,145 | -755,000 | 17.99 | 11.24 | -6.75 | sell |
| MORGAN STANLEY | 1,149,082 | 967,120 | -181,962 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 900,231 | 931,522 | +31,291 | 0.31 | 0.27 | -0.04 | buy |
| T. Rowe Price Investment Management, Inc. | 3,128 | 919,278 | +916,150 | 0.00 | 0.01 | +0.01 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 744,500 | 806,951 | +62,451 | 0.44 | 0.33 | -0.11 | buy |
| TUDOR INVESTMENT CORP ET AL | 554,037 | 786,281 | +232,244 | 0.05 | 0.06 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 1,734,465 | 785,783 | -948,682 | 0.01 | 0.00 | -0.01 | sell |
| JENNISON ASSOCIATES LLC | 2,674,668 | 753,073 | -1,921,595 | 0.03 | 0.01 | -0.02 | sell |
| Catalio Capital Management, LP | 821,195 | 722,784 | -98,411 | 2.36 | 2.10 | -0.26 | sell |
| Rhenman & Partners Asset Management AB | 605,000 | 720,000 | +115,000 | 0.92 | 1.23 | +0.31 | buy |
| JANE STREET GROUP, LLC | 0 | 682,182 | +682,182 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 591,324 | 649,627 | +58,303 | 0.03 | 0.02 | -0.00 | buy |
| Qube Research & Technologies Ltd | 914,160 | 639,377 | -274,783 | 0.02 | 0.01 | -0.01 | sell |
| Hillsdale Investment Management Inc. | 616,950 | 625,217 | +8,267 | 0.28 | 0.24 | -0.04 | buy |
| Trexquant Investment LP | 263,962 | 571,584 | +307,622 | 0.04 | 0.06 | +0.02 | buy |
| FMR LLC | 386,084 | 567,032 | +180,948 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 316,569 | 560,554 | +243,985 | 0.01 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 555,020 | +555,020 | 0.00 | 0.08 | +0.08 | buy |
| FIRST TRUST ADVISORS LP | 539,076 | 554,584 | +15,508 | 0.01 | 0.01 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 401,730 | 551,815 | +150,085 | 0.62 | 0.79 | +0.17 | buy |
| PANAGORA ASSET MANAGEMENT INC | 164,737 | 515,926 | +351,189 | 0.01 | 0.03 | +0.02 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 943,597 | 504,346 | -439,251 | 1.06 | 0.51 | -0.56 | sell |
| Granite Investment Partners, LLC | 0 | 500,061 | +500,061 | 0.00 | 0.43 | +0.43 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 624,217 | 493,403 | -130,814 | 1.55 | 1.08 | -0.46 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 452,502 | 486,641 | +34,139 | 0.23 | 0.25 | +0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 468,440 | 485,233 | +16,793 | 0.00 | 0.00 | -0.00 | buy |
| Cerity Partners LLC | 512,869 | 445,588 | -67,281 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 413,253 | 401,901 | -11,352 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 487,706 | 390,855 | -96,851 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 327,295 | 382,295 | +55,000 | 0.00 | 0.00 | -0.00 | buy |
| Allianz Asset Management GmbH | 324,385 | 379,805 | +55,420 | 0.01 | 0.01 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 229,113 | 374,269 | +145,156 | 0.06 | 0.08 | +0.02 | buy |
| CITADEL ADVISORS LLC | 56,952 | 363,333 | +306,381 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 884,371 | 362,710 | -521,661 | 0.22 | 0.08 | -0.15 | sell |
| PRUDENTIAL FINANCIAL INC | 448,080 | 359,100 | -88,980 | 0.01 | 0.01 | -0.00 | sell |
| Legal & General Group Plc | 362,381 | 324,605 | -37,776 | 0.00 | 0.00 | -0.00 | sell |
| AFFINITY WEALTH MANAGEMENT LLC | 314,351 | 323,153 | +8,802 | 0.73 | 0.68 | -0.05 | buy |
| SummitTX Capital, L.P. | 0 | 317,624 | +317,624 | 0.00 | 0.14 | +0.14 | buy |
| Counterpoint Mutual Funds LLC | 0 | 307,268 | +307,268 | 0.00 | 0.64 | +0.64 | buy |
| 1492 Capital Management LLC | 91,375 | 281,096 | +189,721 | 0.57 | 1.49 | +0.92 | buy |
| Russell Investments Group, Ltd. | 452,207 | 274,416 | -177,791 | 0.01 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 110,452 | 262,199 | +151,747 | 0.01 | 0.03 | +0.02 | buy |
| JPMORGAN CHASE & CO | 265,751 | 259,176 | -6,575 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 211,290 | 245,944 | +34,654 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 239,800 | +239,800 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 511,927 | 225,986 | -285,941 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 225,200 | 225,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 202,725 | 222,524 | +19,799 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 122,964 | 194,503 | +71,539 | 0.06 | 0.08 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,382,924 | 188,338 | -1,194,586 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 184,636 | 182,872 | -1,764 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 282,404 | 174,330 | -108,074 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 370,676 | 170,928 | -199,748 | 0.12 | 0.02 | -0.09 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 36,815 | 157,817 | +121,002 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 152,500 | +152,500 | 0.00 | 0.04 | +0.04 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 111,876 | 143,658 | +31,782 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 99,935 | 137,758 | +37,823 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 89,609 | 136,731 | +47,122 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 86,466 | 136,089 | +49,623 | 0.00 | 0.01 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 124,318 | 135,994 | +11,676 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 124,230 | 131,241 | +7,011 | 0.01 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 69,735 | 121,986 | +52,251 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 159,590 | 121,228 | -38,362 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 140,167 | 120,840 | -19,327 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 118,200 | +118,200 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 131,478 | 116,456 | -15,022 | 0.00 | 0.00 | -0.00 | sell |
| POLEN CAPITAL MANAGEMENT LLC | 325,767 | 116,051 | -209,716 | 0.02 | 0.01 | -0.01 | sell |
| Neuberger Berman Group LLC | 451,569 | 110,664 | -340,905 | 0.01 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 74,526 | 104,698 | +30,172 | 0.00 | 0.00 | +0.00 | buy |