| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VIKING GLOBAL INVESTORS LP | 29,993,708 | 29,993,708 | 0 | 1.16 | 1.83 | +0.67 | hold |
| BlackRock, Inc. | 13,303,025 | 15,139,159 | +1,836,134 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,857,422 | 5,911,366 | +2,053,944 | 0.01 | 0.02 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 1,965,610 | 4,625,859 | +2,660,249 | 0.02 | 0.06 | +0.04 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 5,436,718 | 4,267,645 | -1,169,073 | 0.32 | 0.30 | -0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,636,054 | 3,641,837 | +5,783 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 3,227,245 | 3,458,388 | +231,143 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 4,450,066 | 3,094,011 | -1,356,055 | 0.01 | 0.01 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 3,242,077 | 2,984,227 | -257,850 | 0.01 | 0.01 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,566,213 | 2,665,308 | +1,099,095 | 0.00 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,750,601 | 2,527,703 | +777,102 | 0.18 | 0.31 | +0.14 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1,995,202 | 2,524,620 | +529,418 | 0.01 | 0.02 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 3,536,103 | 2,474,814 | -1,061,289 | 0.16 | 0.15 | -0.01 | sell |
| Nuveen, LLC | 1,304,160 | 2,366,155 | +1,061,995 | 0.00 | 0.01 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 2,688,081 | 2,182,326 | -505,755 | 0.04 | 0.05 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 2,063,146 | 2,092,284 | +29,138 | 0.13 | 0.15 | +0.02 | buy |
| ARK Investment Management LLC | 2,092,969 | 2,090,306 | -2,663 | 0.23 | 0.29 | +0.07 | sell |
| Aristotle Atlantic Partners, LLC | 1,714,346 | 1,838,513 | +124,167 | 1.11 | 1.64 | +0.52 | buy |
| T. Rowe Price Investment Management, Inc. | 919,278 | 1,779,651 | +860,373 | 0.01 | 0.03 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 1,227,917 | 1,730,044 | +502,127 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 682,182 | 1,590,513 | +908,331 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 1,392,332 | 1,507,351 | +115,019 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 1,595,370 | 1,329,856 | -265,514 | 0.01 | 0.02 | +0.00 | sell |
| Nikko Asset Management Americas, Inc. | 1,595,370 | 1,329,856 | -265,514 | 0.31 | 0.37 | +0.05 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 806,951 | 1,258,751 | +451,800 | 0.33 | 0.56 | +0.23 | buy |
| PERCEPTIVE ADVISORS LLC | 152,500 | 1,217,325 | +1,064,825 | 0.04 | 0.41 | +0.36 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,178,552 | +1,178,552 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,145,682 | 1,178,552 | +32,870 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 3,017,341 | 1,087,754 | -1,929,587 | 0.01 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,072,331 | 1,071,935 | -396 | 0.01 | 0.01 | +0.00 | sell |
| Blue Water Life Science Advisors, LP | 1,010,145 | 1,010,145 | 0 | 11.24 | 13.65 | +2.41 | hold |
| Aberdeen Group plc | 1,070,627 | 918,998 | -151,629 | 0.02 | 0.03 | +0.00 | sell |
| Freestone Grove Partners LP | 0 | 881,688 | +881,688 | 0.00 | 0.12 | +0.12 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 931,522 | 849,795 | -81,727 | 0.27 | 0.32 | +0.05 | sell |
| HRT FINANCIAL LP | 131,241 | 795,168 | +663,927 | 0.00 | 0.03 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 649,627 | 785,903 | +136,276 | 0.02 | 0.03 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 515,926 | 777,615 | +261,689 | 0.03 | 0.05 | +0.02 | buy |
| MORGAN STANLEY | 967,120 | 766,230 | -200,890 | 0.00 | 0.00 | +0.00 | sell |
| Granite Investment Partners, LLC | 500,061 | 757,217 | +257,156 | 0.43 | 0.83 | +0.41 | buy |
| Trexquant Investment LP | 571,584 | 736,260 | +164,676 | 0.06 | 0.10 | +0.04 | buy |
| FMR LLC | 567,032 | 709,534 | +142,502 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 753,073 | 686,195 | -66,878 | 0.01 | 0.01 | +0.00 | sell |
| Hillsdale Investment Management Inc. | 625,217 | 684,217 | +59,000 | 0.24 | 0.33 | +0.10 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 504,346 | 609,830 | +105,484 | 0.51 | 0.69 | +0.19 | buy |
| WASATCH ADVISORS LP | 0 | 576,266 | +576,266 | 0.00 | 0.08 | +0.08 | buy |
| TUDOR INVESTMENT CORP ET AL | 786,281 | 543,485 | -242,796 | 0.06 | 0.05 | -0.01 | sell |
| ExodusPoint Capital Management, LP | 555,020 | 518,146 | -36,874 | 0.08 | 0.10 | +0.03 | sell |
| SEI INVESTMENTS CO | 560,554 | 509,797 | -50,757 | 0.01 | 0.01 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,081,366 | 504,909 | -576,457 | 0.01 | 0.01 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 81,382 | 500,455 | +419,073 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 259,176 | 488,395 | +229,219 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 551,815 | 486,984 | -64,831 | 0.79 | 1.07 | +0.28 | sell |
| Qube Research & Technologies Ltd | 639,377 | 479,732 | -159,645 | 0.01 | 0.01 | -0.00 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 493,403 | 472,763 | -20,640 | 1.08 | 1.33 | +0.24 | sell |
| Allianz Asset Management GmbH | 379,805 | 452,537 | +72,732 | 0.01 | 0.01 | +0.00 | buy |
| Cerity Partners LLC | 445,588 | 446,559 | +971 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 401,901 | 429,229 | +27,328 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 554,584 | 417,823 | -136,761 | 0.01 | 0.01 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 382,295 | 404,712 | +22,417 | 0.00 | 0.00 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 486,641 | 393,095 | -93,546 | 0.25 | 0.27 | +0.02 | sell |
| 1492 Capital Management LLC | 281,096 | 382,840 | +101,744 | 1.49 | 2.42 | +0.94 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 390,855 | 381,248 | -9,607 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 485,233 | 362,916 | -122,317 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 324,605 | 355,336 | +30,731 | 0.00 | 0.00 | +0.00 | buy |
| AFFINITY WEALTH MANAGEMENT LLC | 323,153 | 342,569 | +19,416 | 0.68 | 0.95 | +0.27 | buy |
| Jump Financial, LLC | 0 | 338,315 | +338,315 | 0.00 | 0.06 | +0.06 | buy |
| Lisanti Capital Growth, LLC | 0 | 325,155 | +325,155 | 0.00 | 1.53 | +1.53 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 239,800 | 302,800 | +63,000 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 48,832 | 302,141 | +253,309 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 86,347 | 292,079 | +205,732 | 0.00 | 0.01 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 272,571 | +272,571 | 0.00 | 0.11 | +0.11 | buy |
| UBS Group AG | 225,986 | 268,439 | +42,453 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 785,783 | 237,406 | -548,377 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 225,200 | 231,700 | +6,500 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 222,524 | 222,280 | -244 | 0.00 | 0.00 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 374,269 | 219,151 | -155,118 | 0.08 | 0.07 | -0.00 | sell |
| RHUMBLINE ADVISERS | 182,872 | 199,336 | +16,464 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA ADVISORS GROUP, INC. | 0 | 184,200 | +184,200 | 0.00 | 0.11 | +0.11 | buy |
| ARISTEIA CAPITAL, L.L.C. | 0 | 183,500 | +183,500 | 0.00 | 0.06 | +0.06 | buy |
| CITADEL ADVISORS LLC | 363,333 | 181,356 | -181,977 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 174,330 | 174,911 | +581 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 121,228 | 171,828 | +50,600 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 157,817 | 166,081 | +8,264 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 116,456 | 157,346 | +40,890 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 81,795 | 152,727 | +70,932 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 136,731 | 145,946 | +9,215 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 359,100 | 145,800 | -213,300 | 0.01 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 145,722 | +145,722 | 0.00 | 0.21 | +0.21 | buy |
| BLAIR WILLIAM & CO/IL | 136,089 | 140,061 | +3,972 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 143,658 | 138,979 | -4,679 | 0.00 | 0.00 | +0.00 | sell |
| OSAIC HOLDINGS, INC. | 135,994 | 136,331 | +337 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 135,137 | +135,137 | 0.00 | 0.06 | +0.06 | buy |
| ALGERT GLOBAL LLC | 362,710 | 131,830 | -230,880 | 0.08 | 0.03 | -0.04 | sell |
| LPL Financial LLC | 99,889 | 127,312 | +27,423 | 0.00 | 0.00 | +0.00 | buy |
| EP Wealth Advisors, LLC | 0 | 124,451 | +124,451 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 120,840 | 120,770 | -70 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 137,758 | 117,909 | -19,849 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 71,672 | 116,722 | +45,050 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 22,829 | 113,043 | +90,214 | 0.01 | 0.03 | +0.03 | buy |
| Neuberger Berman Group LLC | 110,664 | 110,948 | +284 | 0.00 | 0.00 | +0.00 | buy |