| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VIKING GLOBAL INVESTORS LP | 29,993,708 | 29,993,708 | 0 | 1.01 | 1.17 | +0.16 | hold |
| BlackRock, Inc. | 13,666,850 | 13,357,977 | -308,873 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 11,279,195 | 11,275,169 | -4,026 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 3,240,058 | 5,971,706 | +2,731,648 | 0.01 | 0.02 | +0.01 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 4,299,684 | 3,650,646 | -649,038 | 0.03 | 0.03 | +0.00 | sell |
| Nikko Asset Management Americas, Inc. | 4,299,684 | 3,650,646 | -649,038 | 0.50 | 0.53 | +0.03 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,215,171 | 3,401,030 | +185,859 | 0.00 | 0.00 | +0.00 | buy |
| ARK Investment Management LLC | 4,016,485 | 3,165,636 | -850,849 | 0.34 | 0.28 | -0.06 | sell |
| Aristotle Atlantic Partners, LLC | 2,879,317 | 3,126,719 | +247,402 | 1.02 | 1.36 | +0.34 | buy |
| STATE STREET CORP | 3,027,173 | 3,079,282 | +52,109 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,423,590 | 3,019,940 | +596,350 | 0.23 | 0.32 | +0.10 | buy |
| FRED ALGER MANAGEMENT, LLC | 2,355,427 | 2,514,234 | +158,807 | 0.12 | 0.15 | +0.02 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 379,120 | 2,441,402 | +2,062,282 | 0.00 | 0.02 | +0.02 | buy |
| Blue Water Life Science Advisors, LP | 2,145,145 | 2,145,145 | 0 | 19.78 | 29.28 | +9.50 | hold |
| MACQUARIE GROUP LTD | 660,056 | 2,104,414 | +1,444,358 | 0.01 | 0.04 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 1,927,443 | 1,879,852 | -47,591 | 0.00 | 0.00 | +0.00 | sell |
| Iron Triangle Partners LP | 1,495,883 | 1,820,915 | +325,032 | 2.76 | 3.87 | +1.12 | buy |
| DEUTSCHE BANK AG\ | 170,454 | 1,713,139 | +1,542,685 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 1,857,168 | 1,597,999 | -259,169 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,389,688 | 1,386,363 | -3,325 | 0.00 | 0.00 | +0.00 | sell |
| JENNISON ASSOCIATES LLC | 95,772 | 1,311,487 | +1,215,715 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 1,559,906 | 1,304,609 | -255,297 | 0.02 | 0.02 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,297,903 | 1,273,646 | -24,257 | 0.36 | 0.42 | +0.06 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 1,703,200 | 1,246,573 | -456,627 | 0.01 | 0.01 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,462,111 | 1,239,625 | -222,486 | 0.01 | 0.01 | +0.00 | sell |
| NORTHERN TRUST CORP | 1,233,944 | 1,231,805 | -2,139 | 0.00 | 0.00 | +0.00 | sell |
| LORD, ABBETT & CO. LLC | 1,196,895 | 1,226,404 | +29,509 | 0.04 | 0.05 | +0.01 | buy |
| Nuveen, LLC | 1,243,024 | 1,176,336 | -66,688 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,042,450 | 1,152,561 | +110,111 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 122,202 | 1,087,726 | +965,524 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,297,944 | 1,072,070 | -225,874 | 0.00 | 0.00 | -0.00 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 998,252 | +998,252 | 0.00 | 0.49 | +0.49 | buy |
| Aberdeen Group plc | 1,031,059 | 993,967 | -37,092 | 0.02 | 0.02 | +0.00 | sell |
| Qube Research & Technologies Ltd | 364,768 | 952,229 | +587,461 | 0.01 | 0.02 | +0.01 | buy |
| Invesco Ltd. | 908,414 | 891,058 | -17,356 | 0.00 | 0.00 | +0.00 | sell |
| Catalio Capital Management, LP | 1,396,445 | 884,890 | -511,555 | 3.41 | 2.45 | -0.96 | sell |
| D. E. Shaw & Co., Inc. | 608,280 | 738,176 | +129,896 | 0.01 | 0.01 | +0.00 | buy |
| BRAIDWELL LP | 3,863,107 | 736,014 | -3,127,093 | 1.54 | 0.33 | -1.21 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 589,400 | 726,500 | +137,100 | 0.30 | 0.42 | +0.12 | buy |
| TUDOR INVESTMENT CORP ET AL | 686,567 | 686,393 | -174 | 0.06 | 0.07 | +0.01 | sell |
| Trexquant Investment LP | 810,643 | 666,916 | -143,727 | 0.11 | 0.10 | -0.00 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 617,299 | 638,461 | +21,162 | 1.31 | 1.46 | +0.15 | buy |
| Pier Capital, LLC | 1,016,886 | 635,083 | -381,803 | 1.81 | 1.49 | -0.32 | sell |
| Hillsdale Investment Management Inc. | 568,090 | 621,790 | +53,700 | 0.24 | 0.28 | +0.04 | buy |
| AQR CAPITAL MANAGEMENT LLC | 432,403 | 609,001 | +176,598 | 0.00 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 911,627 | 608,342 | -303,285 | 0.01 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 741,306 | 543,137 | -198,169 | 0.01 | 0.01 | -0.00 | sell |
| NEXT CENTURY GROWTH INVESTORS LLC | 0 | 531,317 | +531,317 | 0.00 | 0.58 | +0.58 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 702,711 | 522,802 | -179,909 | 0.25 | 0.24 | -0.01 | sell |
| ALGERT GLOBAL LLC | 165,343 | 522,020 | +356,677 | 0.04 | 0.13 | +0.09 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 501,084 | +501,084 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 0 | 495,000 | +495,000 | 0.00 | 0.82 | +0.82 | buy |
| Cerity Partners LLC | 454,736 | 432,538 | -22,198 | 0.01 | 0.01 | +0.00 | sell |
| Bank of New York Mellon Corp | 410,552 | 424,509 | +13,957 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,014,642 | 397,310 | -617,332 | 0.01 | 0.00 | -0.01 | sell |
| Russell Investments Group, Ltd. | 589,611 | 384,710 | -204,901 | 0.01 | 0.01 | -0.00 | sell |
| Informed Momentum Co LLC | 321,573 | 358,654 | +37,081 | 0.57 | 0.61 | +0.04 | buy |
| Harvest Investment Services, LLC | 168,277 | 344,512 | +176,235 | 0.44 | 1.04 | +0.60 | buy |
| Zimmer Partners, LP | 252,900 | 330,834 | +77,934 | 0.07 | 0.12 | +0.05 | buy |
| FMR LLC | 291,108 | 324,496 | +33,388 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 79,300 | 321,774 | +242,474 | 0.00 | 0.01 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,373,923 | 319,471 | -1,054,452 | 0.04 | 0.01 | -0.03 | sell |
| Cinctive Capital Management LP | 615,744 | 310,313 | -305,431 | 0.40 | 0.23 | -0.17 | sell |
| PRUDENTIAL FINANCIAL INC | 413,855 | 310,125 | -103,730 | 0.01 | 0.01 | -0.00 | sell |
| AFFINITY WEALTH MANAGEMENT LLC | 0 | 303,533 | +303,533 | 0.00 | 0.66 | +0.66 | buy |
| Lisanti Capital Growth, LLC | 0 | 299,180 | +299,180 | 0.00 | 1.09 | +1.09 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 298,074 | +298,074 | 0.00 | 0.13 | +0.13 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 142,257 | 291,197 | +148,940 | 0.01 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 458,871 | 290,088 | -168,783 | 0.06 | 0.06 | +0.00 | sell |
| BARCLAYS PLC | 362,634 | 287,274 | -75,360 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 268,153 | 281,551 | +13,398 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 49,900 | 279,700 | +229,800 | 0.00 | 0.01 | +0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 49,970 | 271,128 | +221,158 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 455,406 | 253,980 | -201,426 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 249,120 | 245,927 | -3,193 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 1,034,914 | 235,668 | -799,246 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 218,858 | 229,113 | +10,255 | 0.06 | 0.05 | -0.00 | buy |
| Calamos Advisors LLC | 214,605 | 210,277 | -4,328 | 0.01 | 0.01 | +0.00 | sell |
| Swiss National Bank | 200,100 | 206,100 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 210,001 | 203,943 | -6,058 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 217,951 | 191,109 | -26,842 | 0.01 | 0.01 | +0.00 | sell |
| BEACONLIGHT CAPITAL, LLC | 0 | 171,599 | +171,599 | 0.00 | 1.27 | +1.27 | buy |
| Bellevue Group AG | 0 | 168,476 | +168,476 | 0.00 | 0.05 | +0.05 | buy |
| FRANKLIN RESOURCES INC | 112,302 | 165,520 | +53,218 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 158,576 | 162,792 | +4,216 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 152,190 | 156,290 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| Robertson Stephens Wealth Management, LLC | 152,218 | 152,218 | 0 | 0.06 | 0.07 | +0.01 | hold |
| Bridgewater Associates, LP | 0 | 151,254 | +151,254 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 0 | 149,977 | +149,977 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 266,893 | 144,635 | -122,258 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 108,190 | 138,496 | +30,306 | 0.03 | 0.04 | +0.01 | buy |
| US BANCORP \DE\ | 118,415 | 127,153 | +8,738 | 0.00 | 0.00 | +0.00 | buy |
| Gotham Asset Management, LLC | 71,887 | 127,064 | +55,177 | 0.01 | 0.01 | +0.00 | buy |
| Hedeker Wealth, LLC | 121,667 | 121,667 | 0 | 0.33 | 0.38 | +0.05 | hold |
| PDT Partners, LLC | 272,303 | 121,517 | -150,786 | 0.18 | 0.11 | -0.06 | sell |
| SEI INVESTMENTS CO | 146,892 | 119,723 | -27,169 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 78,772 | 114,785 | +36,013 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 95,493 | 114,420 | +18,927 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 134,469 | 110,151 | -24,318 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 109,312 | +109,312 | 0.00 | 0.00 | +0.00 | buy |