| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARK Investment Management LLC | 11,509,308 | 12,806,513 | +1,297,205 | 0.48 | 0.37 | -0.11 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,971,460 | 2,603,500 | +632,040 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 967,690 | 1,357,490 | +389,800 | 0.17 | 0.24 | +0.08 | buy |
| PDT Partners, LLC | 15,959 | 116,804 | +100,845 | 0.01 | 0.06 | +0.05 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 210,220 | 271,913 | +61,693 | 0.19 | 0.26 | +0.08 | buy |
| AVENIR CORP | 30,565 | 66,365 | +35,800 | 0.02 | 0.03 | +0.01 | buy |
| Nebula Research & Development LLC | 41,073 | 64,503 | +23,430 | 0.12 | 0.10 | -0.02 | buy |
| DDD Partners, LLC | 783,697 | 800,922 | +17,225 | 0.49 | 0.53 | +0.04 | buy |
| China Universal Asset Management Co., Ltd. | 3,719 | 16,747 | +13,028 | 0.01 | 0.02 | +0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 1,224,118 | 1,233,514 | +9,396 | 0.10 | 0.08 | -0.02 | buy |
| JENNISON ASSOCIATES LLC | 134,625 | 143,220 | +8,595 | 0.00 | 0.00 | -0.00 | buy |
| Versor Investments LP | 19,000 | 25,100 | +6,100 | 0.02 | 0.03 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 54,808 | 58,708 | +3,900 | 0.01 | 0.01 | -0.00 | buy |
| Bouvel Investment Partners, LLC | 44,199 | 45,200 | +1,001 | 0.13 | 0.10 | -0.03 | buy |
| Headlands Technologies LLC | 2,800 | 1,818 | -982 | 0.01 | 0.00 | -0.00 | sell |
| Savant Capital, LLC | 17,993 | 16,493 | -1,500 | 0.00 | 0.00 | -0.00 | sell |
| Aristotle Atlantic Partners, LLC | 3,058,206 | 3,050,684 | -7,522 | 0.67 | 0.53 | -0.14 | sell |
| Pier Capital, LLC | 719,067 | 711,107 | -7,960 | 0.63 | 0.50 | -0.13 | sell |
| BRIGHTON JONES LLC | 40,780 | 25,885 | -14,895 | 0.01 | 0.01 | -0.01 | sell |
| Robertson Stephens Wealth Management, LLC | 199,786 | 183,786 | -16,000 | 0.07 | 0.06 | -0.02 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 56,100 | 39,200 | -16,900 | 0.00 | 0.00 | -0.00 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 894,071 | 868,448 | -25,623 | 0.01 | 0.01 | -0.00 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 76,495 | 24,795 | -51,700 | 0.10 | 0.03 | -0.07 | sell |
| Nikko Asset Management Americas, Inc. | 6,570,939 | 6,511,659 | -59,280 | 0.43 | 0.31 | -0.12 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 439,955 | 375,638 | -64,317 | 0.07 | 0.06 | -0.02 | sell |
| Blue Water Life Science Advisors, LP | 2,377,665 | 1,687,665 | -690,000 | 12.23 | 7.24 | -4.99 | sell |