| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VIKING GLOBAL INVESTORS LP | 29,993,708 | 29,993,708 | 0 | 0.56 | 0.58 | +0.02 | hold |
| Rubric Capital Management LP | 14,400,000 | 14,600,000 | +200,000 | 1.21 | 1.59 | +0.39 | buy |
| BlackRock, Inc. | 11,932,841 | 12,120,846 | +188,005 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 10,639,440 | 10,714,888 | +75,448 | 0.00 | 0.00 | +0.00 | buy |
| ARK Investment Management LLC | 11,601,134 | 9,424,074 | -2,177,060 | 0.54 | 0.47 | -0.07 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 7,733,884 | 6,833,137 | -900,747 | 0.03 | 0.03 | +0.00 | sell |
| Nikko Asset Management Americas, Inc. | 7,733,884 | 6,833,137 | -900,747 | 0.45 | 0.44 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 9,400,573 | 6,292,634 | -3,107,939 | 0.04 | 0.03 | -0.01 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 2,881,364 | 3,370,919 | +489,555 | 0.00 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 1,112,749 | 2,983,142 | +1,870,393 | 0.47 | 1.35 | +0.88 | buy |
| Aristotle Atlantic Partners, LLC | 3,001,201 | 2,886,702 | -114,499 | 0.48 | 0.54 | +0.07 | sell |
| STATE STREET CORP | 2,551,785 | 2,729,901 | +178,116 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,661,878 | 2,684,506 | +22,628 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 39,036 | 2,428,710 | +2,389,674 | 0.00 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,749,147 | 2,238,126 | +488,979 | 0.00 | 0.00 | +0.00 | buy |
| Blue Water Life Science Advisors, LP | 2,145,145 | 2,145,145 | 0 | 9.66 | 11.39 | +1.73 | hold |
| DIMENSIONAL FUND ADVISORS LP | 1,420,995 | 1,604,876 | +183,881 | 0.00 | 0.00 | +0.00 | buy |
| Pier Capital, LLC | 1,275,885 | 1,274,293 | -1,592 | 0.92 | 1.09 | +0.17 | sell |
| MORGAN STANLEY | 1,048,132 | 1,193,835 | +145,703 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 963,532 | 1,093,981 | +130,449 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 1,029,447 | 1,004,059 | -25,388 | 0.01 | 0.01 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 916,743 | 956,574 | +39,831 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 495,492 | 937,331 | +441,839 | 0.01 | 0.02 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 435,294 | 846,171 | +410,877 | 0.02 | 0.04 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 82,411 | 736,720 | +654,309 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 887,833 | 659,206 | -228,627 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 126,735 | 630,577 | +503,842 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 718,656 | 625,838 | -92,818 | 0.64 | 0.67 | +0.03 | sell |
| Clearline Capital LP | 614,593 | 586,780 | -27,813 | 0.28 | 0.47 | +0.19 | sell |
| PRUDENTIAL FINANCIAL INC | 14,214 | 481,965 | +467,751 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 694,417 | 478,448 | -215,969 | 0.01 | 0.01 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 515,772 | 458,488 | -57,284 | 0.03 | 0.03 | +0.00 | sell |
| ALGERT GLOBAL LLC | 76,323 | 430,514 | +354,191 | 0.01 | 0.06 | +0.05 | buy |
| JANE STREET GROUP, LLC | 504,277 | 406,587 | -97,690 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 73,151 | 397,258 | +324,107 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 369,686 | 363,906 | -5,780 | 0.00 | 0.00 | +0.00 | sell |
| PDT Partners, LLC | 280,382 | 316,281 | +35,899 | 0.13 | 0.17 | +0.04 | buy |
| Cubist Systematic Strategies, LLC | 299,281 | 315,098 | +15,817 | 0.02 | 0.03 | +0.01 | buy |
| Man Group plc | 160,372 | 288,689 | +128,317 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 230,177 | 266,066 | +35,889 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 233,566 | 255,738 | +22,172 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 246,865 | +246,865 | 0.00 | 0.02 | +0.02 | buy |
| Cinctive Capital Management LP | 0 | 241,316 | +241,316 | 0.00 | 0.08 | +0.08 | buy |
| BANK OF AMERICA CORP /DE/ | 779,131 | 240,996 | -538,135 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 169,400 | 229,785 | +60,385 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 209,426 | 226,982 | +17,556 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 165,274 | 213,829 | +48,555 | 0.02 | 0.03 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 261,964 | 212,828 | -49,136 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 0 | 203,100 | +203,100 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 185,868 | +185,868 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 52,360 | 183,838 | +131,478 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 175,841 | 181,202 | +5,361 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 231,531 | 177,858 | -53,673 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 168,606 | 173,591 | +4,985 | 0.00 | 0.00 | +0.00 | buy |
| Robertson Stephens Wealth Management, LLC | 183,686 | 172,186 | -11,500 | 0.03 | 0.04 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 143,679 | 150,071 | +6,392 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 143,444 | +143,444 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 177,689 | 127,055 | -50,634 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 128,387 | 126,497 | -1,890 | 0.00 | 0.00 | +0.00 | sell |
| US BANCORP \DE\ | 163,106 | 119,287 | -43,819 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 118,593 | +118,593 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 126,086 | 117,616 | -8,470 | 0.00 | 0.00 | -0.00 | sell |
| Campbell & CO Investment Adviser LLC | 0 | 114,052 | +114,052 | 0.00 | 0.05 | +0.05 | buy |
| Legal & General Group Plc | 10,832 | 108,630 | +97,798 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 108,526 | 108,526 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 108,541 | 99,612 | -8,929 | 0.00 | 0.00 | +0.00 | sell |
| HRT FINANCIAL LP | 44,969 | 98,357 | +53,388 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8,392 | 97,388 | +88,996 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 159,823 | 93,892 | -65,931 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 91,700 | 91,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Edge Wealth Management LLC | 90,000 | 90,000 | 0 | 0.09 | 0.11 | +0.02 | hold |
| D.A. DAVIDSON & CO. | 81,725 | 88,450 | +6,725 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 87,005 | 87,648 | +643 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 78,831 | 80,994 | +2,163 | 0.00 | 0.00 | +0.00 | buy |
| AVENIR CORP | 76,365 | 76,365 | 0 | 0.04 | 0.05 | +0.01 | hold |
| FRANKLIN RESOURCES INC | 0 | 73,844 | +73,844 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 54,479 | 69,286 | +14,807 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 65,326 | 68,976 | +3,650 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 63,291 | 65,916 | +2,625 | 0.00 | 0.00 | +0.00 | buy |
| DDD Partners, LLC | 769,166 | 64,747 | -704,419 | 0.43 | 0.05 | -0.38 | sell |
| OSAIC HOLDINGS, INC. | 57,453 | 59,990 | +2,537 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 58,621 | 58,621 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Corebridge Financial, Inc. | 61,930 | 57,583 | -4,347 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 53,170 | +53,170 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 52,275 | +52,275 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 51,694 | +51,694 | 0.00 | 0.05 | +0.05 | buy |
| Leeward Financial Partners, LLC | 51,650 | 51,650 | 0 | 0.10 | 0.11 | +0.01 | hold |
| TWO SIGMA ADVISERS, LP | 10,400 | 51,600 | +41,200 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 110,139 | 51,565 | -58,574 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 49,324 | 51,558 | +2,234 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 36,111 | 47,276 | +11,165 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 46,900 | +46,900 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 34,293 | 46,158 | +11,865 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 41,145 | 45,944 | +4,799 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 45,578 | 45,628 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 12,154 | 44,401 | +32,247 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 44,069 | 44,069 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Private Advisor Group, LLC | 0 | 43,977 | +43,977 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 47,283 | 43,962 | -3,321 | 0.00 | 0.00 | +0.00 | sell |
| Bouvel Investment Partners, LLC | 43,882 | 43,805 | -77 | 0.08 | 0.09 | +0.01 | sell |