| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VIKING GLOBAL INVESTORS LP | 29,993,708 | 29,993,708 | 0 | 1.17 | 1.29 | +0.13 | hold |
| BlackRock, Inc. | 13,357,977 | 13,333,559 | -24,418 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 11,275,169 | 11,282,152 | +6,983 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,087,726 | 4,387,361 | +3,299,635 | 0.00 | 0.01 | +0.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 4,060,481 | +4,060,481 | 0.00 | 0.27 | +0.27 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,401,030 | 3,511,855 | +110,825 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 3,079,282 | 3,181,644 | +102,362 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 891,058 | 3,107,653 | +2,216,595 | 0.00 | 0.01 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 1,226,404 | 3,080,759 | +1,854,355 | 0.05 | 0.15 | +0.10 | buy |
| GOLDMAN SACHS GROUP INC | 1,879,852 | 2,902,269 | +1,022,417 | 0.00 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 3,019,940 | 2,760,387 | -259,553 | 0.32 | 0.30 | -0.02 | sell |
| JENNISON ASSOCIATES LLC | 1,311,487 | 2,674,668 | +1,363,181 | 0.01 | 0.03 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 5,971,706 | 2,590,984 | -3,380,722 | 0.02 | 0.01 | -0.01 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 2,441,402 | 2,422,089 | -19,313 | 0.02 | 0.02 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 2,514,234 | 2,245,418 | -268,816 | 0.15 | 0.14 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 501,084 | 2,165,327 | +1,664,243 | 0.00 | 0.01 | +0.00 | buy |
| ARK Investment Management LLC | 3,165,636 | 2,138,960 | -1,026,676 | 0.28 | 0.23 | -0.05 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 3,650,646 | 1,947,963 | -1,702,683 | 0.03 | 0.02 | -0.01 | sell |
| Nikko Asset Management Americas, Inc. | 3,650,646 | 1,947,963 | -1,702,683 | 0.53 | 0.37 | -0.16 | sell |
| D. E. Shaw & Co., Inc. | 738,176 | 1,902,685 | +1,164,509 | 0.01 | 0.02 | +0.01 | buy |
| Aristotle Atlantic Partners, LLC | 3,126,719 | 1,842,444 | -1,284,275 | 1.36 | 1.37 | +0.01 | sell |
| Blue Water Life Science Advisors, LP | 2,145,145 | 1,765,145 | -380,000 | 29.28 | 17.99 | -11.29 | sell |
| DEUTSCHE BANK AG\ | 1,713,139 | 1,734,465 | +21,326 | 0.01 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 608,342 | 1,552,509 | +944,167 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,386,363 | 1,382,924 | -3,439 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,152,561 | 1,173,535 | +20,974 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,231,805 | 1,172,794 | -59,011 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 1,072,070 | 1,149,082 | +77,012 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 993,967 | 1,046,510 | +52,543 | 0.02 | 0.03 | +0.00 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 531,317 | 943,597 | +412,280 | 0.58 | 1.06 | +0.48 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,239,625 | 922,501 | -317,124 | 0.01 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 952,229 | 914,160 | -38,069 | 0.02 | 0.02 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,273,646 | 900,231 | -373,415 | 0.42 | 0.31 | -0.11 | sell |
| ALGERT GLOBAL LLC | 522,020 | 884,371 | +362,351 | 0.13 | 0.22 | +0.09 | buy |
| Catalio Capital Management, LP | 884,890 | 821,195 | -63,695 | 2.45 | 2.36 | -0.09 | sell |
| BANK OF AMERICA CORP /DE/ | 1,597,999 | 806,272 | -791,727 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 1,176,336 | 786,647 | -389,689 | 0.00 | 0.00 | -0.00 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 726,500 | 744,500 | +18,000 | 0.42 | 0.44 | +0.03 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 638,461 | 624,217 | -14,244 | 1.46 | 1.55 | +0.08 | sell |
| Hillsdale Investment Management Inc. | 621,790 | 616,950 | -4,840 | 0.28 | 0.28 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 0 | 606,825 | +606,825 | 0.00 | 1.69 | +1.69 | buy |
| Rhenman & Partners Asset Management AB | 495,000 | 605,000 | +110,000 | 0.82 | 0.92 | +0.10 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 55,944 | 591,324 | +535,380 | 0.00 | 0.03 | +0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 686,393 | 554,037 | -132,356 | 0.07 | 0.05 | -0.02 | sell |
| FIRST TRUST ADVISORS LP | 543,137 | 539,076 | -4,061 | 0.01 | 0.01 | +0.00 | sell |
| Cerity Partners LLC | 432,538 | 512,869 | +80,331 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 253,980 | 511,927 | +257,947 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 1,246,573 | 487,706 | -758,867 | 0.01 | 0.00 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 609,001 | 468,440 | -140,561 | 0.01 | 0.00 | -0.00 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 522,802 | 452,502 | -70,300 | 0.24 | 0.23 | -0.01 | sell |
| Russell Investments Group, Ltd. | 384,710 | 452,207 | +67,497 | 0.01 | 0.01 | +0.00 | buy |
| Neuberger Berman Group LLC | 103,124 | 451,569 | +348,445 | 0.00 | 0.01 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 310,125 | 448,080 | +137,955 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 426,462 | +426,462 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 424,509 | 413,253 | -11,256 | 0.00 | 0.00 | +0.00 | sell |
| Parkman Healthcare Partners LLC | 0 | 401,730 | +401,730 | 0.00 | 0.62 | +0.62 | buy |
| CASTLEARK MANAGEMENT LLC | 298,074 | 390,874 | +92,800 | 0.13 | 0.19 | +0.06 | buy |
| FMR LLC | 324,496 | 386,084 | +61,588 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 16,442 | 370,676 | +354,234 | 0.00 | 0.12 | +0.11 | buy |
| JUPITER ASSET MANAGEMENT LTD | 271,128 | 362,811 | +91,683 | 0.03 | 0.05 | +0.01 | buy |
| Legal & General Group Plc | 245,927 | 362,381 | +116,454 | 0.00 | 0.00 | +0.00 | buy |
| Divisadero Street Capital Management, LP | 0 | 361,344 | +361,344 | 0.00 | 0.33 | +0.33 | buy |
| Harvest Investment Services, LLC | 344,512 | 356,114 | +11,602 | 1.04 | 1.09 | +0.05 | buy |
| Informed Momentum Co LLC | 358,654 | 351,297 | -7,357 | 0.61 | 0.64 | +0.03 | sell |
| RAYMOND JAMES FINANCIAL INC | 281,551 | 327,295 | +45,744 | 0.00 | 0.00 | +0.00 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 291,197 | 325,767 | +34,570 | 0.01 | 0.02 | +0.01 | buy |
| Allianz Asset Management GmbH | 321,774 | 324,385 | +2,611 | 0.01 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 119,723 | 316,569 | +196,846 | 0.00 | 0.01 | +0.00 | buy |
| AFFINITY WEALTH MANAGEMENT LLC | 303,533 | 314,351 | +10,818 | 0.66 | 0.73 | +0.06 | buy |
| BRAIDWELL LP | 736,014 | 311,991 | -424,023 | 0.33 | 0.16 | -0.16 | sell |
| Bellevue Group AG | 168,476 | 298,090 | +129,614 | 0.05 | 0.09 | +0.04 | buy |
| FRANKLIN RESOURCES INC | 165,520 | 282,404 | +116,884 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 287,274 | 279,122 | -8,152 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 235,668 | 265,751 | +30,083 | 0.00 | 0.00 | +0.00 | buy |
| Bridgewater Associates, LP | 151,254 | 265,491 | +114,237 | 0.01 | 0.02 | +0.01 | buy |
| Trexquant Investment LP | 666,916 | 263,962 | -402,954 | 0.10 | 0.04 | -0.06 | sell |
| Pier Capital, LLC | 635,083 | 234,848 | -400,235 | 1.49 | 0.61 | -0.88 | sell |
| Susquehanna Portfolio Strategies, LLC | 229,113 | 229,113 | 0 | 0.05 | 0.06 | +0.00 | hold |
| Swiss National Bank | 206,100 | 225,200 | +19,100 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 91,161 | 211,290 | +120,129 | 0.00 | 0.01 | +0.00 | buy |
| Jump Financial, LLC | 42,900 | 204,500 | +161,600 | 0.01 | 0.04 | +0.03 | buy |
| Point72 Asset Management, L.P. | 319,471 | 203,075 | -116,396 | 0.01 | 0.01 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 144,635 | 202,725 | +58,090 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 114,785 | 190,384 | +75,599 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 203,943 | 184,636 | -19,307 | 0.00 | 0.00 | -0.00 | sell |
| Calamos Advisors LLC | 210,277 | 184,024 | -26,253 | 0.01 | 0.01 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 162,792 | 164,737 | +1,945 | 0.01 | 0.01 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 156,290 | 159,590 | +3,300 | 0.00 | 0.00 | +0.00 | buy |
| Neo Ivy Capital Management | 0 | 153,826 | +153,826 | 0.00 | 0.39 | +0.39 | buy |
| Lisanti Capital Growth, LLC | 299,180 | 142,515 | -156,665 | 1.09 | 0.55 | -0.55 | sell |
| Gotham Asset Management, LLC | 127,064 | 140,756 | +13,692 | 0.01 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 149,977 | 140,167 | -9,810 | 0.00 | 0.00 | +0.00 | sell |
| US BANCORP \DE\ | 127,153 | 131,478 | +4,325 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 128,100 | +128,100 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 114,420 | 124,318 | +9,898 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 124,230 | +124,230 | 0.00 | 0.01 | +0.01 | buy |
| Aquatic Capital Management LLC | 138,496 | 122,964 | -15,532 | 0.04 | 0.06 | +0.02 | sell |
| MARSHALL WACE, LLP | 0 | 112,295 | +112,295 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 98,328 | 111,876 | +13,548 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 20,944 | 110,452 | +89,508 | 0.00 | 0.01 | +0.01 | buy |