| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 0 | 2,027,669 | +2,027,669 | 0.00 | 1.61 | +1.61 | buy |
| TCG Crossover Management, LLC | 2,104,875 | 3,295,350 | +1,190,475 | 4.05 | 5.63 | +1.57 | buy |
| Logos Global Management LP | 400,000 | 1,476,061 | +1,076,061 | 0.77 | 3.27 | +2.50 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 625,864 | +625,864 | 0.00 | 0.01 | +0.01 | buy |
| Cormorant Asset Management, LP | 0 | 625,000 | +625,000 | 0.00 | 0.59 | +0.59 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 600,000 | +600,000 | 0.00 | 0.02 | +0.02 | buy |
| Vivo Capital, LLC | 510,204 | 1,105,454 | +595,250 | 0.73 | 1.88 | +1.15 | buy |
| Polar Capital Holdings Plc | 0 | 500,000 | +500,000 | 0.00 | 0.06 | +0.06 | buy |
| 5AM Venture Management, LLC | 0 | 476,200 | +476,200 | 0.00 | 2.30 | +2.30 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 409,418 | +409,418 | 0.00 | 0.01 | +0.01 | buy |
| Duquesne Family Office LLC | 0 | 387,400 | +387,400 | 0.00 | 0.22 | +0.22 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 385,408 | +385,408 | 0.00 | 0.58 | +0.58 | buy |
| Octagon Capital Advisors LP | 0 | 315,000 | +315,000 | 0.00 | 0.83 | +0.83 | buy |
| Lynx1 Capital Management LP | 235,787 | 526,642 | +290,855 | 1.61 | 2.93 | +1.32 | buy |
| Hudson Bay Capital Management LP | 0 | 276,590 | +276,590 | 0.00 | 0.05 | +0.05 | buy |
| Frazier Life Sciences Management, L.P. | 881,173 | 1,148,591 | +267,418 | 0.82 | 1.05 | +0.23 | buy |
| Nantahala Capital Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.42 | +0.42 | buy |
| Woodline Partners LP | 49,272 | 238,380 | +189,108 | 0.01 | 0.05 | +0.04 | buy |
| MORGAN STANLEY | 62,808 | 242,770 | +179,962 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 139,191 | +139,191 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 127,224 | +127,224 | 0.00 | 0.08 | +0.08 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 107,212 | +107,212 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 0 | 91,819 | +91,819 | 0.00 | 0.02 | +0.02 | buy |
| BIT Capital GmbH | 0 | 89,000 | +89,000 | 0.00 | 0.17 | +0.17 | buy |
| Schonfeld Strategic Advisors LLC | 49,200 | 133,000 | +83,800 | 0.01 | 0.02 | +0.02 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 77,400 | +77,400 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 27,102 | 103,900 | +76,798 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 52,476 | +52,476 | 0.00 | 0.28 | +0.28 | buy |
| ADAR1 Capital Management, LLC | 190 | 40,090 | +39,900 | 0.00 | 0.24 | +0.23 | buy |
| Cubist Systematic Strategies, LLC | 0 | 36,281 | +36,281 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 21,739 | +21,739 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 21,047 | +21,047 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 21,737 | 42,682 | +20,945 | 0.00 | 0.00 | +0.00 | buy |
| Rathbones Group PLC | 0 | 19,906 | +19,906 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 18,800 | +18,800 | 0.00 | 0.01 | +0.01 | buy |
| Shay Capital LLC | 0 | 15,150 | +15,150 | 0.00 | 0.10 | +0.10 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 11,992 | +11,992 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 11,656 | +11,656 | 0.00 | 0.02 | +0.02 | buy |
| Parkman Healthcare Partners LLC | 232,942 | 244,471 | +11,529 | 0.57 | 0.65 | +0.08 | buy |
| OSAIC HOLDINGS, INC. | 0 | 10,922 | +10,922 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 9,610 | +9,610 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 8,200 | +8,200 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 5,570 | +5,570 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 178 | 3,942 | +3,764 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 69,946 | 71,918 | +1,972 | 0.00 | 0.00 | +0.00 | buy |
| Advisors Preferred, LLC | 0 | 1,109 | +1,109 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 6,333 | 7,000 | +667 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 5 | 15 | +10 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 22,427 | 22,427 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 58,333 | 58,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 177,834 | 177,834 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GAMMA Investing LLC | 918 | 876 | -42 | 0.01 | 0.00 | -0.00 | sell |
| BLAIR WILLIAM & CO/IL | 25,548 | 25,432 | -116 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 707 | 0 | -707 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 2,270 | 1,415 | -855 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 93,198 | 72,223 | -20,975 | 0.05 | 0.04 | -0.01 | sell |
| CANTOR FITZGERALD, L. P. | 146,777 | 103,483 | -43,294 | 0.52 | 0.53 | +0.01 | sell |
| M28 Capital Management LP | 363,800 | 299,400 | -64,400 | 5.24 | 4.78 | -0.46 | sell |
| Artal Group S.A. | 3,000,000 | 2,779,619 | -220,381 | 1.78 | 1.55 | -0.23 | sell |
| Deep Track Capital, LP | 1,951,580 | 1,643,881 | -307,699 | 1.19 | 1.02 | -0.17 | sell |
| Aquilo Capital Management, LLC | 1,043,284 | 574,214 | -469,070 | 12.71 | 9.30 | -3.41 | sell |
| Lombard Odier Asset Management (Europe) Ltd | 3,612,877 | 2,238,039 | -1,374,838 | 4.21 | 3.08 | -1.12 | sell |
| Lombard Odier Asset Management (USA) Corp | 3,879,173 | 2,388,912 | -1,490,261 | 7.93 | 5.99 | -1.94 | sell |
| BVF INC/IL | 1,508,416 | 0 | -1,508,416 | 0.66 | 0.00 | -0.66 | sell |