| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Saturn V Capital Management LP | 395,024 | 732,463 | +337,439 | 1.06 | 1.04 | -0.02 | buy |
| MORGAN STANLEY | 1,663,068 | 2,000,105 | +337,037 | 0.00 | 0.00 | -0.00 | buy |
| CANTOR FITZGERALD, L. P. | 539,726 | 773,845 | +234,119 | 0.14 | 0.08 | -0.06 | buy |
| Walleye Capital LLC | 36,397 | 136,150 | +99,753 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 65,007 | 158,593 | +93,586 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 47,728 | +47,728 | 0.00 | 0.04 | +0.04 | buy |
| JPMORGAN CHASE & CO | 0 | 35,414 | +35,414 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 40,867 | 71,497 | +30,630 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 123,200 | 149,996 | +26,796 | 0.01 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 0 | 26,351 | +26,351 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 24,872 | +24,872 | 0.00 | 0.02 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,784 | 4,788 | +3,004 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 2,500 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 632 | 2,367 | +1,735 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 1,300 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 841 | 1,875 | +1,034 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 6,126 | 6,854 | +728 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 18,000 | 18,643 | +643 | 0.03 | 0.01 | -0.02 | buy |
| CITIGROUP INC | 60,502 | 61,071 | +569 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 51 | 251 | +200 | 0.00 | 0.00 | 0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 987 | 1,165 | +178 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,566 | 1,573 | +7 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 29,417 | 29,417 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rathbones Group PLC | 18,421 | 18,421 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vivo Capital, LLC | 1,105,454 | 1,105,454 | 0 | 0.85 | 0.41 | -0.44 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 476,200 | 476,200 | 0 | 0.78 | 0.51 | -0.27 | hold |
| M28 Capital Management LP | 185,100 | 185,100 | 0 | 1.25 | 0.72 | -0.54 | hold |
| TCG Crossover Management, LLC | 3,033,560 | 3,033,560 | 0 | 2.04 | 1.17 | -0.87 | hold |
| SBI Securities Co., Ltd. | 28 | 28 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Frazier Life Sciences Management, L.P. | 1,148,591 | 1,148,591 | 0 | 0.33 | 0.15 | -0.18 | hold |
| HSBC HOLDINGS PLC | 172,834 | 172,834 | 0 | 0.00 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 9,963 | 9,432 | -531 | 0.01 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 6,092 | 3,560 | -2,532 | 0.00 | 0.00 | -0.00 | sell |
| Lombard Odier Asset Management (USA) Corp | 1,856,023 | 1,849,734 | -6,289 | 3.92 | 1.36 | -2.56 | sell |
| Nantahala Capital Management, LLC | 1,049,676 | 1,042,427 | -7,249 | 0.51 | 0.24 | -0.26 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 19,467 | 12,153 | -7,314 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 317,628 | 308,289 | -9,339 | 0.01 | 0.00 | -0.01 | sell |
| FNY Investment Advisers, LLC | 17,515 | 7,000 | -10,515 | 0.06 | 0.01 | -0.05 | sell |
| VIRTUS ADVISERS, LLC | 10,772 | 0 | -10,772 | 0.03 | 0.00 | -0.03 | sell |
| Quantum Portfolio Management LLC | 11,861 | 0 | -11,861 | 0.04 | 0.00 | -0.04 | sell |
| GOLDMAN SACHS GROUP INC | 36,885 | 24,375 | -12,510 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 16,360 | 0 | -16,360 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 19,467 | 0 | -19,467 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 21,217 | 0 | -21,217 | 0.01 | 0.00 | -0.01 | sell |
| Verition Fund Management LLC | 24,123 | 0 | -24,123 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 211,507 | 180,435 | -31,072 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 54,746 | 18,913 | -35,833 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 356,071 | 319,514 | -36,557 | 0.00 | 0.00 | -0.00 | sell |
| Siren, L.L.C. | 2,831,770 | 2,789,833 | -41,937 | 0.86 | 0.44 | -0.42 | sell |
| TWO SIGMA ADVISERS, LP | 98,800 | 49,200 | -49,600 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 63,663 | 0 | -63,663 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 142,052 | 76,008 | -66,044 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 128,990 | 62,639 | -66,351 | 0.02 | 0.00 | -0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 473,552 | 396,862 | -76,690 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 491,080 | 401,746 | -89,334 | 0.45 | 0.13 | -0.32 | sell |
| Cubist Systematic Strategies, LLC | 106,320 | 7,364 | -98,956 | 0.01 | 0.00 | -0.01 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 351,527 | 250,012 | -101,515 | 0.07 | 0.02 | -0.05 | sell |
| Redmile Group, LLC | 2,399,317 | 2,214,947 | -184,370 | 1.15 | 0.59 | -0.56 | sell |
| Integral Health Asset Management, LLC | 200,000 | 0 | -200,000 | 0.12 | 0.00 | -0.12 | sell |
| CITADEL ADVISORS LLC | 282,737 | 62,441 | -220,296 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 488,889 | 228,418 | -260,471 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 498,732 | 134,492 | -364,240 | 0.02 | 0.00 | -0.02 | sell |
| Aquilo Capital Management, LLC | 367,214 | 0 | -367,214 | 4.33 | 0.00 | -4.33 | sell |
| BANK OF AMERICA CORP /DE/ | 499,066 | 0 | -499,066 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 633,100 | 16,032 | -617,068 | 0.01 | 0.00 | -0.01 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 640,000 | 0 | -640,000 | 0.08 | 0.00 | -0.08 | sell |