| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CITADEL ADVISORS LLC | 244,061 | 1,234,807 | +990,746 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 1,542,427 | 2,146,731 | +604,304 | 0.56 | 0.71 | +0.15 | buy |
| MILLENNIUM MANAGEMENT LLC | 659,592 | 1,074,191 | +414,599 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 365,369 | 630,161 | +264,792 | 0.47 | 0.65 | +0.18 | buy |
| GREAT POINT PARTNERS LLC | 808,032 | 1,020,489 | +212,457 | 1.59 | 1.32 | -0.28 | buy |
| ADAR1 Capital Management, LLC | 23,643 | 172,157 | +148,514 | 0.01 | 0.05 | +0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 12,027 | 147,668 | +135,641 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 73,153 | 204,777 | +131,624 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 115,281 | +115,281 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 100,927 | +100,927 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 11,718 | 106,002 | +94,284 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 89,469 | +89,469 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 34,962 | 104,555 | +69,593 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 160,474 | 202,901 | +42,427 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 207,513 | 246,937 | +39,424 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 256,340 | 286,698 | +30,358 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 155,680 | 169,616 | +13,936 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 11,994 | +11,994 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 10,490 | +10,490 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 114,070 | 119,711 | +5,641 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 4,818 | +4,818 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 12,999 | 13,935 | +936 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 1,621 | 1,835 | +214 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,282 | 2,450 | +168 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 922 | 1,047 | +125 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 29,538 | 29,538 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Redmile Group, LLC | 2,164,777 | 2,164,777 | 0 | 0.97 | 0.76 | -0.21 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 209,088 | 209,088 | 0 | 0.03 | 0.03 | -0.01 | hold |
| Nextech Invest, Ltd. | 952,400 | 952,400 | 0 | 0.56 | 0.35 | -0.21 | hold |
| Parallel Advisors, LLC | 1,300 | 1,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rockefeller Capital Management L.P. | 45 | 45 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ikarian Capital, LLC | 865,784 | 865,784 | 0 | 0.22 | 0.25 | +0.02 | hold |
| 5AM Venture Management, LLC | 476,200 | 476,200 | 0 | 0.91 | 0.70 | -0.21 | hold |
| TCG Crossover Management, LLC | 3,033,560 | 3,033,560 | 0 | 0.61 | 0.46 | -0.15 | hold |
| SBI Securities Co., Ltd. | 28 | 28 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Siren, L.L.C. | 2,911,438 | 2,911,438 | 0 | 0.53 | 0.43 | -0.10 | hold |
| RAYMOND JAMES FINANCIAL INC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 2,500 | 2,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SageView Advisory Group, LLC | 11 | 0 | -11 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,448 | 2,313 | -135 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 10,112 | 9,365 | -747 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 5,065 | 2,937 | -2,128 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 3,991 | 612 | -3,379 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,653 | 8,335 | -5,318 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 15,900 | 0 | -15,900 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 39,344 | 16,203 | -23,141 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 172,834 | 122,834 | -50,000 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 54,380 | 0 | -54,380 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 78,926 | 0 | -78,926 | 0.06 | 0.00 | -0.06 | sell |
| M28 Capital Management LP | 185,100 | 101,203 | -83,897 | 0.82 | 0.99 | +0.17 | sell |
| Lombard Odier Asset Management (USA) Corp | 255,901 | 0 | -255,901 | 0.47 | 0.00 | -0.47 | sell |
| MORGAN STANLEY | 324,630 | 0 | -324,630 | 0.00 | 0.00 | -0.00 | sell |
| Vivo Capital, LLC | 1,105,454 | 0 | -1,105,454 | 0.43 | 0.00 | -0.43 | sell |