| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| First Turn Management, LLC | 0 | 537,338 | +537,338 | 0.00 | 1.66 | +1.66 | buy |
| Ikarian Capital, LLC | 0 | 506,665 | +506,665 | 0.00 | 1.03 | +1.03 | buy |
| Polar Capital Holdings Plc | 500,000 | 940,164 | +440,164 | 0.06 | 0.11 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 409,418 | 782,941 | +373,523 | 0.01 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 7,000 | 343,196 | +336,196 | 0.00 | 0.04 | +0.04 | buy |
| JANUS HENDERSON GROUP PLC | 625,864 | 818,978 | +193,114 | 0.01 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 150,480 | +150,480 | 0.00 | 0.30 | +0.30 | buy |
| CANTOR FITZGERALD, L. P. | 103,483 | 247,966 | +144,483 | 0.53 | 0.95 | +0.42 | buy |
| Point72 Asset Management, L.P. | 8,200 | 146,500 | +138,300 | 0.00 | 0.01 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 0 | 124,866 | +124,866 | 0.00 | 0.70 | +0.70 | buy |
| CITADEL ADVISORS LLC | 42,682 | 116,760 | +74,078 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 242,770 | 303,993 | +61,223 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 244,471 | 289,841 | +45,370 | 0.65 | 0.75 | +0.10 | buy |
| NEOS Investment Management LLC | 11,656 | 37,164 | +25,508 | 0.02 | 0.03 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 24,066 | +24,066 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 127,224 | 146,852 | +19,628 | 0.08 | 0.08 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 17,155 | +17,155 | 0.00 | 0.02 | +0.02 | buy |
| Lombard Odier Asset Management (USA) Corp | 2,388,912 | 2,405,998 | +17,086 | 5.99 | 13.89 | +7.90 | buy |
| Quantum Portfolio Management LLC | 0 | 14,836 | +14,836 | 0.00 | 0.16 | +0.16 | buy |
| BIT Capital GmbH | 89,000 | 101,235 | +12,235 | 0.17 | 0.17 | +0.00 | buy |
| MARSHALL WACE, LLP | 139,191 | 149,397 | +10,206 | 0.00 | 0.00 | -0.00 | buy |
| Vestcor Inc | 0 | 8,800 | +8,800 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 22,427 | 29,417 | +6,990 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 6,000 | +6,000 | 0.00 | 0.05 | +0.05 | buy |
| ROYAL BANK OF CANADA | 0 | 4,716 | +4,716 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 72,223 | 76,840 | +4,617 | 0.04 | 0.04 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 4,591 | +4,591 | 0.00 | 0.04 | +0.04 | buy |
| Advisors Preferred, LLC | 1,109 | 5,315 | +4,206 | 0.00 | 0.02 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 10,922 | 12,841 | +1,919 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 71,918 | 73,806 | +1,888 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 21,047 | 21,803 | +756 | 0.01 | 0.01 | -0.00 | buy |
| RHUMBLINE ADVISERS | 15 | 469 | +454 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 40,090 | 40,290 | +200 | 0.24 | 0.15 | -0.08 | buy |
| Artal Group S.A. | 2,779,619 | 2,779,619 | 0 | 1.55 | 1.36 | -0.19 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 600,000 | 600,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Nantahala Capital Management, LLC | 200,000 | 200,000 | 0 | 0.42 | 0.38 | -0.04 | hold |
| MANGROVE PARTNERS IM, LLC | 385,408 | 385,408 | 0 | 0.58 | 0.56 | -0.02 | hold |
| Duquesne Family Office LLC | 387,400 | 387,400 | 0 | 0.22 | 0.26 | +0.04 | hold |
| Cormorant Asset Management, LP | 625,000 | 625,000 | 0 | 0.59 | 0.69 | +0.10 | hold |
| Vivo Capital, LLC | 1,105,454 | 1,105,454 | 0 | 1.88 | 1.94 | +0.06 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Logos Global Management LP | 1,476,061 | 1,476,061 | 0 | 3.27 | 3.23 | -0.04 | hold |
| 5AM Venture Management, LLC | 476,200 | 476,200 | 0 | 2.30 | 2.02 | -0.28 | hold |
| TCG Crossover Management, LLC | 3,295,350 | 3,295,350 | 0 | 5.63 | 6.53 | +0.90 | hold |
| Frazier Life Sciences Management, L.P. | 1,148,591 | 1,148,591 | 0 | 1.05 | 1.02 | -0.03 | hold |
| Artia Global Partners LP | 52,476 | 52,476 | 0 | 0.28 | 0.26 | -0.02 | hold |
| BARCLAYS PLC | 5,570 | 5,570 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 58,333 | 58,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSBC HOLDINGS PLC | 177,834 | 177,834 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BLAIR WILLIAM & CO/IL | 25,432 | 25,432 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GAMMA Investing LLC | 876 | 859 | -17 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 77,400 | 76,200 | -1,200 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 1,415 | 60 | -1,355 | 0.00 | 0.00 | -0.00 | sell |
| Rathbones Group PLC | 19,906 | 18,421 | -1,485 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 3,942 | 0 | -3,942 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 21,739 | 16,256 | -5,483 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 18,800 | 12,342 | -6,458 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 107,212 | 99,107 | -8,105 | 0.01 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 9,610 | 0 | -9,610 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 11,992 | 0 | -11,992 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 2,027,669 | 2,014,296 | -13,373 | 1.61 | 2.31 | +0.71 | sell |
| Shay Capital LLC | 15,150 | 0 | -15,150 | 0.10 | 0.00 | -0.10 | sell |
| Walleye Capital LLC | 91,819 | 74,220 | -17,599 | 0.02 | 0.01 | -0.01 | sell |
| Cubist Systematic Strategies, LLC | 36,281 | 9,438 | -26,843 | 0.01 | 0.00 | -0.01 | sell |
| Schonfeld Strategic Advisors LLC | 133,000 | 75,037 | -57,963 | 0.02 | 0.01 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 103,900 | 39,100 | -64,800 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 276,590 | 208,064 | -68,526 | 0.05 | 0.03 | -0.02 | sell |
| Aquilo Capital Management, LLC | 574,214 | 500,214 | -74,000 | 9.30 | 9.16 | -0.13 | sell |
| M28 Capital Management LP | 299,400 | 185,100 | -114,300 | 4.78 | 4.56 | -0.22 | sell |
| Octagon Capital Advisors LP | 315,000 | 176,000 | -139,000 | 0.83 | 0.55 | -0.28 | sell |
| Woodline Partners LP | 238,380 | 90,862 | -147,518 | 0.05 | 0.02 | -0.03 | sell |
| Deep Track Capital, LP | 1,643,881 | 1,359,745 | -284,136 | 1.02 | 0.77 | -0.25 | sell |
| Lynx1 Capital Management LP | 526,642 | 0 | -526,642 | 2.93 | 0.00 | -2.93 | sell |
| Lombard Odier Asset Management (Europe) Ltd | 2,238,039 | 0 | -2,238,039 | 3.08 | 0.00 | -3.08 | sell |