| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Ikarian Capital, LLC | 0 | 873,568 | +873,568 | 0.00 | 0.46 | +0.46 | buy |
| Siren, L.L.C. | 2,789,833 | 2,911,438 | +121,605 | 0.44 | 0.87 | +0.43 | buy |
| JANE STREET GROUP, LLC | 0 | 37,813 | +37,813 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 0 | 27,149 | +27,149 | 0.00 | 0.04 | +0.04 | buy |
| Massar Capital Management, LP | 0 | 19,863 | +19,863 | 0.00 | 0.09 | +0.09 | buy |
| CANTOR FITZGERALD, L. P. | 773,845 | 789,039 | +15,194 | 0.08 | 0.11 | +0.03 | buy |
| Beacon Pointe Advisors, LLC | 0 | 11,615 | +11,615 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 10,194 | +10,194 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 3,560 | 8,333 | +4,773 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 1,875 | 6,196 | +4,321 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 250,012 | 252,421 | +2,409 | 0.02 | 0.04 | +0.02 | buy |
| SIMPLEX TRADING, LLC | 251 | 667 | +416 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,573 | 1,817 | +244 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 6,854 | 7,035 | +181 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 29,417 | 29,538 | +121 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,367 | 2,428 | +61 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 308,289 | 308,331 | +42 | 0.00 | 0.01 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,432 | 9,446 | +14 | 0.00 | 0.01 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Rathbones Group PLC | 18,421 | 18,421 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nantahala Capital Management, LLC | 1,042,427 | 1,042,427 | 0 | 0.24 | 0.43 | +0.18 | hold |
| Lombard Odier Asset Management (USA) Corp | 1,849,734 | 1,849,734 | 0 | 1.36 | 1.96 | +0.59 | hold |
| Nextech Invest, Ltd. | 952,400 | 952,400 | 0 | 0.62 | 1.05 | +0.42 | hold |
| Vivo Capital, LLC | 1,105,454 | 1,105,454 | 0 | 0.41 | 0.66 | +0.24 | hold |
| Parallel Advisors, LLC | 1,300 | 1,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| 5AM Venture Management, LLC | 476,200 | 476,200 | 0 | 0.51 | 1.06 | +0.55 | hold |
| M28 Capital Management LP | 185,100 | 185,100 | 0 | 0.72 | 1.83 | +1.12 | hold |
| TCG Crossover Management, LLC | 3,033,560 | 3,033,560 | 0 | 1.17 | 2.01 | +0.84 | hold |
| SBI Securities Co., Ltd. | 28 | 28 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAR1 Capital Management, LLC | 18,643 | 18,643 | 0 | 0.01 | 0.02 | +0.01 | hold |
| GF FUND MANAGEMENT CO. LTD. | 1,165 | 1,165 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 2,500 | 2,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 172,834 | 172,834 | 0 | 0.00 | 0.00 | +0.00 | hold |
| OSAIC HOLDINGS, INC. | 71,497 | 69,381 | -2,116 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 4,788 | 700 | -4,088 | 0.00 | 0.00 | -0.00 | sell |
| FNY Investment Advisers, LLC | 7,000 | 0 | -7,000 | 0.01 | 0.00 | -0.01 | sell |
| Cubist Systematic Strategies, LLC | 7,364 | 0 | -7,364 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 24,872 | 16,837 | -8,035 | 0.02 | 0.03 | +0.01 | sell |
| TWO SIGMA ADVISERS, LP | 49,200 | 39,600 | -9,600 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 12,153 | 0 | -12,153 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 180,435 | 168,235 | -12,200 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF MONTREAL /CAN/ | 158,593 | 145,812 | -12,781 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asset Management, L.P. | 16,032 | 0 | -16,032 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 76,008 | 59,312 | -16,696 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 18,913 | 0 | -18,913 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 24,375 | 0 | -24,375 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 26,351 | 0 | -26,351 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 35,414 | 0 | -35,414 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 47,728 | 0 | -47,728 | 0.04 | 0.00 | -0.04 | sell |
| Redmile Group, LLC | 2,214,947 | 2,164,777 | -50,170 | 0.59 | 1.34 | +0.75 | sell |
| MARSHALL WACE, LLP | 228,418 | 175,862 | -52,556 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 61,071 | 3,474 | -57,597 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 62,441 | 0 | -62,441 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 62,639 | 0 | -62,639 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 134,492 | 62,459 | -72,033 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 319,514 | 228,509 | -91,005 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Capital LLC | 136,150 | 0 | -136,150 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 149,996 | 0 | -149,996 | 0.00 | 0.00 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 1,148,591 | 970,130 | -178,461 | 0.15 | 0.23 | +0.08 | sell |
| MILLENNIUM MANAGEMENT LLC | 396,862 | 198,647 | -198,215 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 401,746 | 0 | -401,746 | 0.13 | 0.00 | -0.13 | sell |
| Saturn V Capital Management LP | 732,463 | 34,737 | -697,726 | 1.04 | 0.08 | -0.96 | sell |
| MORGAN STANLEY | 2,000,105 | 1,211,758 | -788,347 | 0.00 | 0.00 | +0.00 | sell |