| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 0 | 630,000 | +630,000 | 0.00 | 0.24 | +0.24 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 610,980 | +610,980 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 0 | 403,172 | +403,172 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 2,911,438 | 3,311,438 | +400,000 | 0.43 | 0.74 | +0.31 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 370,052 | +370,052 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 326,648 | +326,648 | 0.00 | 0.09 | +0.09 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 269,348 | +269,348 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 100,927 | 369,151 | +268,224 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 0 | 191,733 | +191,733 | 0.00 | 1.10 | +1.10 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 177,000 | +177,000 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 172,157 | 338,373 | +166,216 | 0.05 | 0.17 | +0.12 | buy |
| Caption Management, LLC | 0 | 162,476 | +162,476 | 0.00 | 0.06 | +0.06 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 155,929 | +155,929 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 630,161 | 764,256 | +134,095 | 0.65 | 1.37 | +0.71 | buy |
| Quadrature Capital Ltd | 0 | 118,129 | +118,129 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 16,203 | 121,004 | +104,801 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,234,807 | 1,329,625 | +94,818 | 0.00 | 0.01 | +0.00 | buy |
| Birchview Capital, LP | 0 | 71,218 | +71,218 | 0.00 | 0.37 | +0.37 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 115,281 | 184,519 | +69,238 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 104,555 | 163,945 | +59,390 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 89,469 | 115,918 | +26,449 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 25,641 | +25,641 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 0 | 23,842 | +23,842 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 19,133 | +19,133 | 0.00 | 0.17 | +0.17 | buy |
| HRT FINANCIAL LP | 11,994 | 30,748 | +18,754 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 16,930 | +16,930 | 0.00 | 0.00 | +0.00 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0 | 16,334 | +16,334 | 0.00 | 0.05 | +0.05 | buy |
| Persistent Asset Partners Ltd | 0 | 15,170 | +15,170 | 0.00 | 0.05 | +0.05 | buy |
| BlackRock, Inc. | 204,777 | 219,917 | +15,140 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 12,566 | +12,566 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 1,835 | 13,217 | +11,382 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 147,668 | 158,950 | +11,282 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 0 | 10,416 | +10,416 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 4,818 | 11,836 | +7,018 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 9,365 | 11,063 | +1,698 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 106,002 | 107,579 | +1,577 | 0.01 | 0.02 | +0.01 | buy |
| Rialto Wealth Management, LLC | 0 | 1,021 | +1,021 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 2,937 | 3,418 | +481 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 3 | 41 | +38 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 29,538 | 29,538 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Redmile Group, LLC | 2,164,777 | 2,164,777 | 0 | 0.76 | 1.60 | +0.84 | hold |
| Nextech Invest, Ltd. | 952,400 | 952,400 | 0 | 0.35 | 0.50 | +0.14 | hold |
| Parallel Advisors, LLC | 1,300 | 1,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 45 | 45 | 0 | 0.00 | 0.00 | +0.00 | hold |
| 5AM Venture Management, LLC | 476,200 | 476,200 | 0 | 0.70 | 1.82 | +1.12 | hold |
| M28 Capital Management LP | 101,203 | 101,203 | 0 | 0.99 | 2.36 | +1.37 | hold |
| TCG Crossover Management, LLC | 3,033,560 | 3,033,560 | 0 | 0.46 | 0.80 | +0.34 | hold |
| SBI Securities Co., Ltd. | 28 | 28 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 2,500 | 2,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 122,834 | 122,834 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 1,047 | 975 | -72 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 13,935 | 13,815 | -120 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,450 | 2,101 | -349 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 612 | 0 | -612 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,313 | 1,639 | -674 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 8,335 | 7,475 | -860 | 0.00 | 0.00 | +0.00 | sell |
| Global Retirement Partners, LLC | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 202,901 | 201,734 | -1,167 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 246,937 | 243,152 | -3,785 | 0.00 | 0.00 | +0.00 | sell |
| Dynamic Technology Lab Private Ltd | 10,490 | 0 | -10,490 | 0.01 | 0.00 | -0.01 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 209,088 | 198,347 | -10,741 | 0.03 | 0.04 | +0.02 | sell |
| RAYMOND JAMES FINANCIAL INC | 25,000 | 0 | -25,000 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 865,784 | 830,784 | -35,000 | 0.25 | 0.30 | +0.05 | sell |
| MARSHALL WACE, LLP | 169,616 | 72,039 | -97,577 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 119,711 | 0 | -119,711 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,074,191 | 909,279 | -164,912 | 0.00 | 0.01 | +0.00 | sell |
| SG Americas Securities, LLC | 286,698 | 12,056 | -274,642 | 0.00 | 0.00 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 1,020,489 | 450,000 | -570,489 | 1.32 | 1.16 | -0.15 | sell |
| Nantahala Capital Management, LLC | 2,146,731 | 1,346,731 | -800,000 | 0.71 | 0.89 | +0.19 | sell |